Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Dilated Cardiomyopathy: A New Era of Treatment

Version 1 : Received: 22 August 2023 / Approved: 22 August 2023 / Online: 23 August 2023 (09:20:43 CEST)

How to cite: Correia, V.M.; Herling de Oliveira, L.L.; Junior, V.M.; Rocha, R.G.; O. Leguizamon, J.A.G.; Alves da Costa, L.M.; Fernandes, F.; Krieger, J.E.; Soares, P.R.; Scudeler, T.L. Dilated Cardiomyopathy: A New Era of Treatment. Preprints 2023, 2023081645. https://doi.org/10.20944/preprints202308.1645.v1 Correia, V.M.; Herling de Oliveira, L.L.; Junior, V.M.; Rocha, R.G.; O. Leguizamon, J.A.G.; Alves da Costa, L.M.; Fernandes, F.; Krieger, J.E.; Soares, P.R.; Scudeler, T.L. Dilated Cardiomyopathy: A New Era of Treatment. Preprints 2023, 2023081645. https://doi.org/10.20944/preprints202308.1645.v1

Abstract

Dilated cardiomyopathy (DCM) is a common form of cardiomyopathy, characterized by ventricular chamber dilatation and systolic dysfunction, in the absence of coronary artery disease, arterial hypertension, valvular or congenital diseases. DCM is a heterogeneous group of disorders of the myocardium caused by genetic factors, environmental factors, or a combination of both. DCM affects mainly men aged between 20 and 50 years, being considered one of the main causes of heart failure (HF) and the main indication for heart transplantation. Guideline-based HF treatment is the mainstay of management for patients with DCM. In recent years, gene therapy and induced pluripotent stem cells have become promising strategies. In this review, we summarize the relevant clinical issues, and current treatment of DCM patients, including the role of genetic evaluation.

Keywords

dilated cardiomyopathy; heart failure; cardiac device therapy; genetic analysis

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.