Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft

How to cite: Dulguerov, F.; Abdurashidova, T.; Christophel-Plathier¹, E.; Pitta-Gros, B.; Nowacka, A.; Gunga, Z.; Pfister, R.; Verdugo-Marchese, M.; Rancati, V.; Niclauss, L.; Tozzi, P.; Adelin, A.; Ltaief, Z.; Rotman, S.; Meyer, P.; Hullin, R.; Kirsch, M. Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft. Preprints 2023, 2023051335. https://doi.org/10.20944/preprints202305.1335.v1 Dulguerov, F.; Abdurashidova, T.; Christophel-Plathier¹, E.; Pitta-Gros, B.; Nowacka, A.; Gunga, Z.; Pfister, R.; Verdugo-Marchese, M.; Rancati, V.; Niclauss, L.; Tozzi, P.; Adelin, A.; Ltaief, Z.; Rotman, S.; Meyer, P.; Hullin, R.; Kirsch, M. Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft. Preprints 2023, 2023051335. https://doi.org/10.20944/preprints202305.1335.v1

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MDPI and ACS Style

Dulguerov, F.; Abdurashidova, T.; Christophel-Plathier¹, E.; Pitta-Gros, B.; Nowacka, A.; Gunga, Z.; Pfister, R.; Verdugo-Marchese, M.; Rancati, V.; Niclauss, L.; Tozzi, P.; Adelin, A.; Ltaief, Z.; Rotman, S.; Meyer, P.; Hullin, R.; Kirsch, M. Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft. Preprints 2023, 2023051335. https://doi.org/10.20944/preprints202305.1335.v1

APA Style

Dulguerov, F., Abdurashidova, T., Christophel-Plathier¹, E., Pitta-Gros, B., Nowacka, A., Gunga, Z., Pfister, R., Verdugo-Marchese, M., Rancati, V., Niclauss, L., Tozzi, P., Adelin, A., Ltaief, Z., Rotman, S., Meyer, P., Hullin, R., & Kirsch, M. (2023). Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft. Preprints. https://doi.org/10.20944/preprints202305.1335.v1

Chicago/Turabian Style

Dulguerov, F., Roger Hullin and Matthias Kirsch. 2023 "Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft" Preprints. https://doi.org/10.20944/preprints202305.1335.v1

Abstract

Introduction: The choice of Cardiac Preservation Solution (CPS) for myocardial protection at the time of heart procurement remains controversial and uncertainties persist regarding its effect on the early and midterm Heart Transplantation (HTx) outcomes. Thus, we retrospectively analyzed our adult HTx performed with two different CPS, during a period of 12 years, in terms of hospital mortality, mid-term survival, inotropic score, primary graft dysfunction and rejection score. Methods: From January 2009 to December 2020, 154 adult HT were performed in our hospital. Patients were divided in two groups according to the CPS used: St. Thomas (n=75, group P 1) and HTK-Custodiol (n=79, group P 2). The choice of CPS was related to an institutional policy; from 2009 to 2015, St. Thomas solution was exclusively used, and after that, HTK-Custodiol alone. Results: There was no significant difference between the two groups in terms of preoperative and intraoperative features. Postoperatively, the Custodiol group showed significantly lower inotropic score (p<0.0001), mean rejection score (p= 0.036) and 30 days mortality (p=0.0068). The use of HTK-Custodiol was the only variable that improved midterm survival (HTK-Custodiol vs St Thomas, HR= 0.20 (95% CI: 0.069 -0.6) p=0.0039). Conclusion: In our single center experience, using HTK-Custodiol as myocardial protection during heart procurement leads to improved outcomes after HTx, including postoperative inotropic score, rejection score, 30-days mortality and midterm survival.

Keywords

Heart Transplantation; Cardiac Preservation Solutions; Inotropic Score; Early Results; Mid-term Results

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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