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Preprint ARTICLE | doi:10.20944/preprints201805.0050.v1

The FDA and the State of Chronic Diseases: Cardiovascular, Endocrine, Pulmonary, and Renal Diseases

Mona Fiuzat, Michael P. Gray, Grace Anne Dorney Koppel, Aaron Kowalski, Prabir Roy-Chaudhury, Mary Norine Walsh, Daniel W. Jones, Enid Neptune, Robert Ratner, Melissa West, Brad A. Wong, Robert Califf

Subject: Medicine & Pharmacology, Cardiology Keywords: chronic diseases; cardiovascular; renal; endocrine; diabetes; therapeutic advances; tobacco

Online: 3 May 2018 (05:08:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0416.v1

Chronic Diseases Associated with Malassezia Yeast

Abdourahim Abdillah, Stéphane Ranque

Subject: Life Sciences, Microbiology Keywords: Malassezia; Chronic diseases; psoriasis; atopic dermatitis; chronic rhinosinusitis; asthma; cystic fibrosis; HIV infection; inflammatory bowel disease; colorectal cancer; neurodegenerative diseases

Online: 24 September 2021 (08:13:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0137.v1

Burden of Serious Fungal Diseases in Romania

Mihai Mareș, Valentina Ruxandra Moroti-Constantinescu, David W. Denning

Subject: Medicine & Pharmacology, Other Keywords: mycoses; epidemiology; Romania; candidaemia; aspergillosis; chronic pulmonary conditions

Online: 21 February 2018 (16:41:29 CET)

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Objective: To estimate for the first time the burden of serious fungal infections in Romania; Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations and published annual reports on local epidemiology were used in the present study. When no data was available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016; 3) Results: The estimated number of serious fungal infections in Romanian population was 435,930 in 2016. Recurrent vulvovaginal candidiasis accounts for up to 80% of total cases (more than 350,000 women annually). Concerning the HIV related infections, among 14349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis is rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may be as high as 1229 and 3066, respectively. In immunocompromised and cancer patient population, the annual incidence of candidaemia is 295, and at least 158 invasive aspergillosis cases and 4 mucormycosis cases occur yearly. With 4,966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis is 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. 4) Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.2% of Romanians suffer a serious form of fungal disease.

Preprint SHORT NOTE | doi:10.20944/preprints202005.0035.v1

When Chronic Diseases Meet Infectious Diseases: A Proposal Toward Healthy Aging: Lessons from COVID-19 Outbreak

Juan Carlos Gómez-Verjan, Carmen García-Peña, Nadia A. Rivero-Segura

Subject: Life Sciences, Immunology Keywords: COVID-19; Chronic diseases; Aging; Immune response; Public health; Healthy Aging

Online: 3 May 2020 (08:15:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0190.v1

Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Alessia Mongelli, Sandra Atlante, Tiziana Bacchetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano

Subject: Biology, Other Keywords: epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

Online: 16 November 2019 (00:59:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0577.v1

Association of Edentulism With Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey

Alejandro José Casanova-Rosado, Juan Fernando Casanova-Rosado, Mirna Minaya-Sánchez, José Luís Robles-Minaya, Juan Alejandro Casanova-Sarmiento, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Horacio Isla-Granillo, Mariana Mora-Acosta, Sonia Márquez-Rodríguez, Carlo Eduardo Medina-Solís, Gerardo Maupomé

Subject: Medicine & Pharmacology, Allergology Keywords: Oral health; edentulism; chronic diseases; elders; Mexico

Online: 24 March 2021 (11:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0071.v1

Lysophospholipids, Lysophosphatidic Acids and Monoacylglycerols: New Therapeutic Targets in Cardiovascular Diseases?

Thomas Duflot, Ly Tu, Matthieu Leuillier, Hind Messaoudi, Déborah Groussard, Saïda Azhar, Raphaël Thuillet, Marc Humbert, Vincent Richard, Christophe Guignabert, Jérémy Bellien

Subject: Medicine & Pharmacology, Pharmacology & Toxicology Keywords: lysophospholipids; lysophosphatidic acids; cardiovascular diseases; HPLC-MS/MS; rodent models; pulmonary hypertension; chronic heart failure; hypertension

Online: 3 September 2021 (15:19:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0287.v1

Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases

Luis L. Ayusso, Ana Paula Girol, Emmanuel A. Burdmann

Subject: Medicine & Pharmacology, General Medical Research Keywords: green tea; EGCG; oxidative stress; acute kidney injury; chronic kidney disease; kidney stones; diabetic nephropathy

Online: 15 December 2022 (15:48:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0168.v1

The Impact of Spiritual-Based Care Interventions on the Quality of Life of Children with Chronic Diseases: a Philosophical Perspective

Idyatul Hasanah, Moses Glorino Rumambo Pandin, Tita Rohita

Subject: Medicine & Pharmacology, Nursing & Health Studies Keywords: Nursing; Spiritual care; Quality of life; Chronic disease; Children

Online: 13 June 2022 (05:17:18 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201808.0143.v1

Classic Hodgkin Lymphoproliferative Diseases Clonally Unrelated to B-Chronic Lymphocytic Leukemia Successfully Treated with Bendamustine Plus Rituximab

Shinya Rai, Hirokazu Tanaka, Ko Fujimoto, Takahiro Kumode, Hiroaki Inoue, Yasuhiro Taniguchi, Luis Espinoza, Yasuyoshi Morita, Yoichi Tatsumi, Takashi Ashida, Ryota Matsuoka, Yukie Kikuti, Naoya Nakamura, Itaru Matsumura

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Lymphoproliferative diseases, Hodgkin lymphoma, Chronic Lymphocytic Leukemia, clonality, Hodgkin/Reed–Sternberg cell, Bendamustine

Online: 7 August 2018 (12:02:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine & Pharmacology, Urology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Working Paper HYPOTHESIS

The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable

Jianqing Wu, Ping Zha

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: incurable disease; chronic disease; cancer theory; central nervous system; state memory; mutation; tissue ecosystem; emotion; stress; exercise; baseline biochemical and cellular processes

Online: 24 November 2019 (14:50:49 CET)

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Working Paper ARTICLE

Randomized Clinical Trial Is Biased and Invalid In Studying Chronic Diseases, Compared with Multiple Factors Optimization Trial

Jianqing Wu, Ping Zha

Subject: Medicine & Pharmacology, General Medical Research Keywords: clinical trial; statistical analysis; experimental error; chronic diseases; cancer; health optimization; hypothesis test; variance analysis; covariance; stratification; randomization

Online: 21 November 2019 (04:04:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0478.v1

You + ME Registry: A Research Platform to Facilitate Clinical and Therapeutic Discoveries in ME/CFS and Related Diseases

Allison Ramiller, Kathleen Mudie, Elle Seibert, Sadie Whittaker

Subject: Medicine & Pharmacology, General Medical Research Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Long COVID; data acquisition source; post-infectious; longitudinal cohort study; patient-powered

Online: 25 November 2021 (13:51:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0142.v1

Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Ana C. Gonçalves, Amícal Falcão, Gilberto Alves, João A. Lopes, Luís R. Silva

Subject: Medicine & Pharmacology, Pharmacology & Toxicology Keywords: bioactive compounds; anthocyanins; drug delivery system; nanoparticles; chronic diseases; health benefits

Online: 11 October 2022 (05:04:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0464.v1

Prognosis of COVID-19 in Patients with Liver and Kidney Diseases: An Early Systematic Review and Meta-Analysis

Tope Oyelade, Jaber Alqahtani, Gabriele Canciani

Subject: Keywords: COVID-19; SARS-CoV-19; Hepatitis B and C; Cirrhosis; Chronic Kidney Disease; Alcohol-related Liver Disease; Non-alcoholic Steatohepatitis; Necrosis

Online: 25 April 2020 (16:46:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0188.v1

How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS

Luis Nacul, Shennae O'Boyle, Flavio E. Nacul, Kathleen Mudie, Caroline C. Kingdon, Jacqueline M. Cliff, Taane G. Clark, Hazel M. Dockrell, Eliana M. Lacerda

Subject: Biology, Other Keywords: Chronic Fatigue Syndrome; Chronic Illness; ME/CFS; Management; Research

Online: 17 September 2019 (12:38:57 CEST)

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We propose a framework for the understanding of the pathophysiology and management of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) that considers wider determinants of health and long-term temporal variation in pathophysiological features and disease phenotype throughout the natural history of the disease. As in other chronic diseases, ME/CFS evolves through different stages, from asymptomatic predisposition, progressing to a prodromal stage, and then to symptomatic disease. Disease incidence depends on genetic makeup and environment factors, the exposure to an insult, or repeated insults, and the nature of the host response. In people who develop ME/CFS, normal homeostatic processes in response to adverse insults may be replaced by aberrant responses leading to dysfunctional states. Thus, the predominantly neuro-immune and autonomic manifestations, underlined by a hyper-metabolic state, that characterise early disease, may be followed by various processes leading to multi-systemic related symptoms. This abnormal metabolic state and the effects of a range of mediators such as products of oxidative and nitrosamine stress, may lead to progressive cell and metabolic dysfunction culminating in a hypometabolic state with low energy production. These processes do not seem to happen uniformly; although a spiralling of progressive inter-related and self-sustaining abnormalities may ensue, reversion to states of milder abnormalities is possible if the host is able to restate responses to improve homeostatic equilibrium. Disease management and research efforts should seek to identify and apply strategies targeted at the different pathophysiological dysfunctions that characterise different disease stages. As disease presentation varies over time, no single case description, set of diagnostic criteria, or molecular feature is currently diagnostic for all patients at all times. While acknowledging its limitations due to the incomplete research evidence, we suggest the proposed framework may improve research design and health care interventions for people with ME/CFS.

Preprint REVIEW | doi:10.20944/preprints202111.0253.v1

Personalized Cell Therapy for Patients With Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-based Responder and Non-responder Prediction

Amankeldi Salybekov, Markus Wolfien, Shuzo Kobayashi, Takayuki Asahara

Subject: Medicine & Pharmacology, Cardiology Keywords: Cell therapy; chronic limb-threating ischemia; peripheral artery disease; diabetes; atherosclerosis obliterans; thromboangiitis obliterans; personalized medicine; artificial intelligence; machine learning; genome-wide association studies; transcriptome-wide association studies; clonal hematopoiesis of indeterminate potential.

Online: 15 November 2021 (11:18:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0148.v1

Innate and Adaptive Immune Responses in Chronic Hepatitis C Virus and Hepatitis B Virus Infection with High Viral Loads

Yutaka Kishida

Subject: Life Sciences, Immunology Keywords: chronic hepatitis C; chronic hepatitis B; innate immune response; adaptive immune response; cytokine; chemokine

Online: 12 April 2019 (10:59:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0343.v1

A Theoretical Model Explaining the Development and Maintenance of Clinical Burnout

Niclas Almén

Subject: Behavioral Sciences, Applied Psychology Keywords: Chronic stress; Recovery; Burnout; Exhaustion; Maintenance

Online: 17 February 2021 (07:45:19 CET)

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Preprint REVIEW | doi:10.20944/preprints201905.0177.v1

Incidence and Characteristics of Endophthalmitis after Cataract Surgery in Poland, during 2010-2015

Michal S. Nowak, Andrzej Grzybowski, Katarzyna Michalska-Malecka, Jacek P. Szaflik, Milena Koziol, Wojciech Niemczyk, Iwona Grabska-Liberek

Subject: Medicine & Pharmacology, Ophthalmology Keywords: Cataract surgery, acute endophthalmitis, chronic endophthalmitis

Online: 14 May 2019 (15:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0220.v1

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Miao Long, Qiang-Ming Li, Qing Fang, Li-Hua Pan, Xue-Qiang Zha, Jian-Ping Luo

Subject: Life Sciences, Biochemistry Keywords: Laminaria japonica; polysaccharide; chronic renal failure

Online: 22 January 2019 (11:50:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0609.v1

Treatment-Free Remission in Chronic Myeloid Leukaemia: Can We Identify Prognostic Factors?

Hilbeen Hisham Saifullah, Claire Marie Lucas

Subject: Medicine & Pharmacology, Allergology Keywords: Chronic myeloid leukaemia; chronic phase; Tyrosine kinase inhibitor; Treatment free remission; deep molecular response; BCR-ABL.

Online: 25 June 2021 (08:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0301.v2

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmed, Meng Tang, Junaid Wazir, Xiaohui Zhou

Subject: Medicine & Pharmacology, Urology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 24 April 2020 (04:30:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0168.v1

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

Connie Rojas, Zhandra Entrolezo, Jessica K. Jarett, Guillaume Jospin, Dawn Kingsbury, Alex Martin, Jonathan A. Eisen, Holly H Ganz

Subject: Medicine & Pharmacology, Veterinary Medicine Keywords: fecal microbiota transplant; domestic cat; chronic enteropathies

Online: 10 January 2023 (02:15:25 CET)

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There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effectiveness in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 68 domestic cats with chronic digestive issues that underwent FMT treatment using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after treatment, as well as from their stool donors, and healthy animals. We found that according to their owners, 77% of cats were reported to show improvement in their clinical signs (termed ‘Responders’), and 23% were reported to exhibit no change or a worsening of their clinical signs (termed ‘Non-Responders’). Variation in the fecal microbiomes of FMT recipients most strongly correlated with host clinical signs, diet, and IBD diagnosis. The relative abundances of Collinsella, Negativibacillus, Parabacteroides, and Peptoclostridium changed differentially in FMT recipients. Overall, on average 13% of the bacterial amplicon sequence variants (ASVs) were shared between stool donors and FMT recipients (excluding ASVs already present in FMT recipients prior to treatment). The most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, Collinsella and unclassified Lachnospiraceae. Lastly, FMT recipients that had recently taken antibiotics exhibited increases in microbiome similarity to an age-matched healthy reference set compared to other cats. Cats that had diarrhea or diarrhea with vomiting became more similar to healthy cats than did cats exhibiting other clinical signs. Overall, our results suggest that oral capsule FMT treatment was effective in this group of cats and microbiome responses may be modulated by the FMT recipient’s initial presenting clinical signs, prior IBD diagnosis, recent antibiotic use, and their diet.

Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Life Sciences, Other Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0353.v1

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease: A Narrative Review

Fatkhu Rahman, Syahrul Tuba

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: Diabetic; Chronic Kidney Disease; Metformin; Acidosis Lactate

Online: 28 February 2022 (09:28:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Medicine & Pharmacology, Nutrition Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Working Paper ARTICLE

Gut Microbiota as a Source of Uremic Toxins

Vasily A Popkov, Anastasia A Zharikova, Evgenia A Demchenko, Nadezda V Andrianova, Dmitry B Zorov, Egor Y Plotnikov

Subject: Biology, Anatomy & Morphology Keywords: uremia; uremic toxins; microbiome; chronic kidney disease

Online: 14 July 2021 (13:04:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine & Pharmacology, Sport Sciences & Therapy Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0186.v1

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain

Nuria García-Magro, Yasmina B. Martin, Pilar Negredo, Francisco Zafra, Carlos Avendaño

Subject: Life Sciences, Biochemistry Keywords: chronic pain; allodynia; trigeminocervical complex; glycine transporters

Online: 5 March 2021 (11:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0199.v1

Clinicopathological Variables and Outcome in Chronic Phase Chronic Myeloid Leukemia Associated with BCR-ABL1 Transcript Type and Body Weight

Mohammad Abdulla, Prem Chandra, Susanna El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed Yassin

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: chronic myeloid leukemia; BCR-ABL1 transcript; obesity

Online: 7 August 2020 (13:07:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0143.v1

Income Levels and Mortality Rates in Patients with Chronic Kidney Disease in South Korea: a Population-Based Cohort Study Using National Health Insurance Data

Young Choi

Subject: Medicine & Pharmacology, Other Keywords: chronic kidney disease; low socioeconomic status; mortality

Online: 6 August 2020 (09:46:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0303.v1

Analysis of the Dimensions of Physiotherapy Index of Ventilatory Workload in People with Chronic Obstructive Pulmonary Disease During Stability and Exacerbation in An Outpatient Setting

Rodrigo Muñoz Cofré, Mariano del Sol, Paul Medina González, Jorge Valenzuela Vásquez, Gerardo Molina Vergara, Ramón Pinochet Urzúa, Pablo A. Lizana, Máximo Escobar Cabello

Subject: Medicine & Pharmacology, Other Keywords: ventilatory assessment; physiotherapy; chronic obstructive pulmonary disease

Online: 29 August 2019 (04:52:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0235.v1

The Cost of Chronic Wounds in Argentina: An Estimation of the Burden in a Public Hospital

Romina Chavez-Jara, Nicolas Cerusico, Maria Lazarte, Carla Cabrera, Andrea Herrera Bruno, Eugenia Sesto Cabral, Alberto Nicolas Ramos

Subject: Medicine & Pharmacology, Other Keywords: chronic wound; hospital cost; epidemiology; public health

Online: 20 May 2019 (09:53:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0028.v2

Motivating Diabetic and Hypertensive Patients to Engage in Regular Physical Activity: A Multi-Component Intervention Derived from the Concept of Photovoice

Angela Y. M. Leung, Pui Hing Chau, Isaac S. H. Leung, Michael Tse, Perick Lai Choi Wong, Wai Ming Tam, Doris Y. P. Leung

Subject: Medicine & Pharmacology, Nursing & Health Studies Keywords: photovoice; chronic illness; physical activity; barriers; facilitator

Online: 2 April 2019 (07:48:28 CEST)

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Aims: A community-based multi-component intervention (increasing awareness of the importance of physical activity in chronic illness management through reading comic books, training regarding warm-up stretching exercises, identifying facilitators and barriers to exercise through photosharing, supporting self-reflection and development of action plans) was developed to promote physical activity (PA) among patients with diabetes and hypertension. This study aimed to evaluate the efficacy of this intervention on health behaviour (walking) and health outcomes. Design: A non-randomized controlled trial with waitlisted control and pre- and post-measures. Setting: Community centres for the elderly. Participants: A total of 204 older adults with diabetes and/or hypertension were recruited. They were assigned to either the intervention group (IG) or waitlisted to the control group (CG). Intervention: Under the supervision of a nurse, six weekly group meetings were arranged in community centres for the elderly in which the participants freely exchanged their views regarding the barriers and facilitators of regular physical activity. Participants were encouraged to take photos in their neighbourhood or at home and brought these photos to share at the group meetings. The photos showed both the barriers and the facilitators to PA. In the last meeting, each participant worked out a plan to perform PA in the coming four weeks. Measures: PA referred to the number of steps taken per day and it was measured by a Garmin Accelerometer at baseline, Week 6 and Week 10. Other measures included the nine-item Self-Efficacy Scale for Exercise - Chinese version (SEE-C), the 23-item Chinese Barriers to Exercise Scale and Senior Fitness Tests. Generalised Estimating Equations (GEE) models compared the outcomes over time between IG and CG. Results: A statistically significant difference in the changes in the average number of steps taken daily between the two groups at Week 10 (mean difference = 965.4; 95% confidence interval: 92.2, 1838.6, p = 0.030) was observed, although the difference at Week 6 was non-significant (mean difference = 777.6; 95% confidence interval: −35.3, 1590.5, p = 0.061). IG participants also showed significant improvements in lower body strength (mean difference = 0.967; 95% confidence interval: 0.029, 1.904, p = 0.043) and lower limb flexibility (mean difference = 2.068; 95% confidence interval: 0.404, 3.731, p = 0.015) at Week 10 compared to CG participants. Conclusion: This multi-component intervention improved the participants’ physical activity level and physical fitness, particularly in lower limb flexibility and body strength.

Preprint ARTICLE | doi:10.20944/preprints201807.0545.v1

Can the Mindful Awareness and Resilience Skills for Adolescents (MARS-A) program be provided online? Voices from the Youth

Nicholas Chadi, Elli Weisbaum, Catherine Malboeuf-Hurtubise, Sara Ahola Kohut, Christine Viner, Miriam Kaufman, Jake Locke, Dzung X. Vo

Subject: Medicine & Pharmacology, Pediatrics Keywords: qualitative, mindfulness, meditation, chronic illness, adolescents, eHealth

Online: 27 July 2018 (15:34:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0100.v1

Electrocardiogram, Echocardiogram and NT-proBNP in Screening for Thromboembolism Pulmonary Hypertension in Patients after Pulmonary Embolism

Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Iwona Dudzik-Niewiadomska, Michał Machowski, Marek Roik, Małgorzata Wiśniewska, Jan Siwiec, Izabela Magdalena Staniszewska, Piotr Pruszczyk

Subject: Medicine & Pharmacology, Cardiology Keywords: screening after pulmonary embolism; chronic thromboembolic pulmonary disease; chronic thromboembolic pulmonary hypertension; diagnostic work-up of post-pulmonary syndrome

Online: 9 October 2022 (02:09:20 CEST)

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Background: The annual mortality of patients with untreated chronic thromboembolism pulmonary hypertension (CTEPH) is approximately 50% unless a timely diagnosis is followed by adequate treatment. In pulmonary embolism (PE) survivors with functional limitation the diagnostic work-up starts with echocardiography. It is followed by lung scintigraphy and right heart catheterization. However, noninvasive test providing diagnostic clues to CTEPH, or ascertain this diagnosis as very unlikely, would be extremely useful since the majority of post PE functional limitations is caused by deconditioning. Methods: Patients after acute PE underwent a structured clinical evaluation with electrocardiogram, routine laboratory tests including NT-proBNP and echocardiography. The aim of study was to verify whether the parameters from echocardiographic or perhaps electrocardiographic examination and NT-proBNP concentration best determine the risk of CTEPH. Results: A total (n = 261, male n = 123) patients after PE were included into the study, in group of 155 patients (59.4%) with reported functional impairment 13 patients (8.4%) had CTEPH and 7 PE survivors had chronic thromboembolic pulmonary disease (CTEPD) (4,5%). Echo parameters differed significantly between CTEPH/CTEPD cases and other symptomatic PE survivors. Patients with CTEPH/CTEPD had also higher level of NT-proBNP (p = 0.022) but concentration of NT-proBNP above 125 pg/ml did not differentiate patients with CTEPH/CTEPD (p>0.05). Additionally, proportion of patients with right bundle brunch block registered in ECG was higher in group with CTEPH/CTED (23.5% vs. 5.8%, p = 0.034) but there were no differences between other ECG characteristics of right ventricle overload. Conclusion: Screening for CTEPH/CTEPD should be performed in patients with reduced exercise tolerance compared to pre PE period, It is not effective in asymptomatic PE survivors. Patients with CTEPH/CTED had predominantly abnormalities indicatingchronic thromboembolism in the echocardiographic assessment. NT-proBNP and electrocardiographic characteristics of right ventricle overload proved to be insufficient in predicting CTEPH/CTEPD development.

Preprint ARTICLE | doi:10.20944/preprints202301.0158.v1

Relationship between Joint and Ligament Structures of the Subtalar Joint and Degeneration of the Subtalar Articular Facet

Ryoya Togashi, Mutsuaki Edama, Mayuu Shagawa, Haruki Osanami, Hrotake Yokota, Ryo Hirabayashi, Chie Sekine, Tomonobu Ishigaki, Hiroshi Akuzawa, Yuki Yamada, Taku Toriumi, Ikuo Kageyama

Subject: Physical Sciences, Other Keywords: subtalar joint instability; chronic ankle instability; footprint osteoarthritis

Online: 9 January 2023 (09:22:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0298.v1

Insights of Endocytosis Signaling in Health and Disease

Chandramani Pathak, Foram U. Vaidya, Bhargav N. Waghela, Pradeep Kumar Jaiswara, Vishal Kumar Gupta, Ajay Kumar, Barani Kumar Rajendran, Kishu Ranjan

Subject: Life Sciences, Biochemistry Keywords: Endocytosis; Phagocytosis; Pinocytosis; Receptor endocytosis signaling; Chronic diseases

Online: 16 December 2022 (08:07:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0224.v1

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Varvara A Ryabkova, Natalia Y Gavrilova, Alina A Poletaeva, Aleksandr I Pukhalenko, Irina A Koshkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine & Pharmacology, General Medical Research Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome; autoantibodies; autoimmunity

Online: 13 December 2022 (02:47:48 CET)

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(1) Background: Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, natural AAb network is much more extensive, and has not been previously investigated in these disorders; (2) Methods: The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of a 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens a) in 11 FM patients with comorbid ME/CFS; b) in 11 ME/CFS patients without FM; c) in 11 healthy controls. Individual autoantibody profiles and their correlation with some clinical symptoms were analyzed. (3) Results: both patients with ME/CFS and ME/CFS+FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were changing in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental-health related quality of life. Notably, that widely different correlation patterns were observed between study groups. (4) Conclusions: Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may break down in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system's ability to reflect qualitative and quantitative changes in antigenic composition of the body.

Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine & Pharmacology, Other Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0318.v1

Probiotics Role in Chronic Rhinosinusitis Treatment: an Update of the Current Literature

Maria Rita Bianco, Massimo Ralli, Domenico Michele Modica, Marta Amata, Salvatore Poma, Gianfranco Mattina, Eugenia Allegra

Subject: Medicine & Pharmacology, Other Keywords: Chronic rhinosinusitis; probiotics; microbiome; nasal microbiota; microbiome therapy

Online: 21 October 2021 (23:00:15 CEST)

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Working Paper ARTICLE

Calcineurin Suppresses Cardiomyocyte-protective Autophagy Under Chronic Intermittent Hypoxia by Downregulating the AMPK Pathway

Sheng Xie, Wei Liu, Meng Jin, Xiaochen Li, Tao Wang, Shaolin Zeng, Hanxiang Nie, Zhao Dong, Zhenghua Ke, Ke Hu

Subject: Life Sciences, Biochemistry Keywords: chronic intermittent hypoxia; autophagy; apoptosis; cardiomyocyte damage; calcineurin

Online: 24 June 2021 (14:58:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0493.v1

Long-term recovery of the fecal microbiome and metabolome of dogs with steroid-responsive enteropathy

Rachel Pilla, Blake Guard, Amanda B Blake, Mark Ackermann, Craig Webb, Steve Hill, Jonathan A Lidbury, Joerg M Steiner, Albert Jergens, Jan Suchodolski

Subject: Medicine & Pharmacology, Veterinary Medicine Keywords: Chronic diarrhea, idiopathic inflammatory bowel disease, microbiota, dysbiosis

Online: 21 June 2021 (08:56:30 CEST)

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Working Paper ARTICLE

Effects of Chronic Lithium Treatment on Anxious Behaviors and Serotonergic Genes Expression in the Midbrain Raphe Nuclei of Defeated Male Mice

Dmitriy A. Smagin, Irina L Kovalenko, Anna G. Galyamina, Irina V Belozertseva, Nikolay V Tamkovich, Konstantin O Baranov, Natalia N. Kudryavtseva

Subject: Medicine & Pharmacology, Allergology Keywords: chronic social defeat stress; anxiety; lithium chloride; mice

Online: 3 June 2021 (11:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0599.v1

Development of the Survey of the Concept of Pain: A Measure to Study How Children Conceptualize Pain

Isabel Salvat, Cristina Adillón, Eva Maria Andrés, Sonia Monterde, Jordi Miró

Subject: Medicine & Pharmacology, Allergology Keywords: Survey; children; health knowledge; chronic pain; pain education.

Online: 26 February 2021 (09:30:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0346.v1

A Highly Transparent and Explainable Artificial Intelligence Tool for Chronic Wound Classification: XAI-CWC

Salih Sarp, Murat Kuzlu, Emmanuel Wilson, Umit Cali, Ozgur Guler

Subject: Engineering, Other Keywords: Chronic wound classification; transfer learning; explainable artificial intelligence.

Online: 18 January 2021 (14:28:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0180.v1

Management of Anemia of Chronic Disease: Beyond Iron-Only Supplementation.

Evasio Pasini, Giovanni Corsetti, Claudia Romano, Roberto Aquilani, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi

Subject: Medicine & Pharmacology, Allergology Keywords: Chronic diseases; iron deficiency; haemoglobin; anaemia; aminoacids; rehabilitation

Online: 8 December 2020 (06:58:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0170.v1

Functional Disability in Adolescents with Chronic Pain: Comparing an Interdisciplinary Exposure Program to Usual Care

Carolien Dekker, Mariëlle Goossens, Bjorn Winkens, Silvia Remerie, Caroline Bastiaenen, Jeanine Verbunt

Subject: Behavioral Sciences, Applied Psychology Keywords: Chronic musculoskeletal pain; Adolescents; functional disability; multidisciplinary rehabilitation.

Online: 3 November 2020 (15:41:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0395.v1

Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Antonello Sica, Beniamino Casale, Caterina Sagnelli, Armando Calogero, Maria Teresa Di Dato, Alessandro Spada, Marco Rispoli, Mario Santagata, Pietro Buonavolontà, Alfonso Fiorelli, Vincenzo Tammaro, Massimo Ciccozzi, Anna Salzano, Evangelista Sagnelli, Elisabetta Saracco, Dario Tammaro, Alfonso Papa

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: physical activity; elderly population; chronic pain; mediastinal lymphomas

Online: 30 December 2019 (09:44:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0435.v2

Assessment of Left Ventricular Diastolic Function in Children Undegoing Hemodialysis. A Mini Review

Ljiljana Sulovic, Vladimir Sulovic, Zorica Zivkovic, Maja Vasic, Nenad Sulovic

Subject: Medicine & Pharmacology, Pediatrics Keywords: chronic kidney disease; hemodialysis; cardiovascular disease; echocardiography; child

Online: 4 July 2019 (10:37:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0001.v1

System-level Insights into the Adaptation of Domestic Dairy Buffalo to Chronic Heat Stress

Zhaobing Gu, Shoukun Tang, Xianhai Fu, Chuanbin Liu, Huaming Mao

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: chronic heat stress; dairy buffaloes; proteomics; adaptation mechanisms

Online: 3 January 2019 (08:32:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0448.v1

MERTK rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in HCV-Infected Patients: A Longitudinal Study

Maria Angeles Jimenez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Oscar Brochado-Kith, Juan José Sánchez-Ruano, Tomás Artaza-Varasa, Alicia Gómez-Sanz, Amanda Fernández-Rodríguez, Salvador Resino

Subject: Life Sciences, Virology Keywords: liver stiffness; MERTK; chronic hepatitis C; cirrhosis; SNPs

Online: 19 October 2018 (10:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0392.v1

Amani Zidan, Ahmed Awaisu, Maguy El-Hajj, Samya Al-Abdulla, Dianne Figueroa, Nadir Kheir

Subject: Medicine & Pharmacology, Other Keywords: Medication-related burden; Questionnaire; chronic disease conditions; adherence

Online: 25 June 2018 (14:35:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0396.v1

Smart Wound Dressings for Diabetic Chronic Wounds

Elizabeth Gianino, Craig Miller, Jordon Gilmore

Subject: Engineering, Biomedical & Chemical Engineering Keywords: diabetes; chronic wounds; smart wound dressing; biochemical sensor

Online: 28 May 2018 (10:22:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0146.v2

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina, Enric Espel

Subject: Biology, Other Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment

Online: 29 September 2017 (03:17:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0220.v1

Service Innovations in Health Care Service Ecosystem: A Case Study

Maria Vincenza Ciasullo, Silvia Cosimato

Subject: Social Sciences, Business And Administrative Sciences Keywords: innovation; service innovation; healthcare; chronic diseases; SD Logic

Online: 30 March 2017 (17:10:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine & Pharmacology, General Medical Research Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0392.v1

Incorporating Point-of-Care Bacterial Fluorescence into a Wound Clinic Antimicrobial Stewardship Program

Thomas Serena

Subject: Medicine & Pharmacology, Allergology Keywords: antimicrobial stewardship; detection of bacteria in chronic wounds, chronic wounds, clinical decision support; diagnostic pathway; joint commission; fluorescence imaging; wound clinic

Online: 19 October 2020 (15:35:25 CEST)

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Background: In 2014 the World Health Organization (WHO) warned of an emerging world-wide crisis of antibiotic resistant microorganisms. In response, government and professional organizations recommended that health care systems adopt antimicrobial stewardship programs (ASPs). In the United States, the Centers for Medicare Services (CMS) mandated antimicrobial stewardship in the hospital inpatient setting. Effective January 1, 2020, the Joint Commission required ambulatory centers that prescribe antibiotics, such as wound centers, to institute an ASP. Chronic wounds often remain open for months, during which time patients may receive multiple courses of antibiotics and numerous antimicrobial topical treatments. The wound clinician plays an integral role in reducing antimicrobial resistance in the outpatient setting: antibiotics prescribed for skin and soft tissue infections are among the most common in an outpatient setting. One of the most challenging aspects of antimicrobial stewardship in treating chronic wounds is the inaccuracy of bacterial and infection diagnosis. Methods: Joint Commission lists five elements of performance (EP): (1) Identifying an antimicrobial stewardship leader, (2) establishing an annual antimicrobial stewardship goal, (3) implementing evidence-based practice guidelines related to the antimicrobial stewardship goal, (4) providing clinical staff with educational resources related to the antimicrobial stewardship goal, and (5) collecting, analyzing, and reporting data related to the antimicrobial stewardship goal. This article focuses on choosing and implementing an evidence-based ASP goal for 2020. Discussion: Clinical trials have demonstrated the ability of fluorescence imaging (MLiX) to detect clinically significant levels of bacteria in chronic wounds. Combined with clinical examination of signs and symptoms of infection, the MLiX procedure improves the clinician’s ability to diagnose infection and can guide antimicrobial use. In order to satisfy the elements of performance, the MLiX procedure was incorporated into the annual ASP goal for several wound care centers. Clinicians were educated on the fluorescence imaging device and guidelines were instituted. Collection of antimicrobial utilization data is underway.

Preprint ARTICLE | doi:10.20944/preprints202212.0211.v1

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience

Zhinei Tan, Yongxia Li, Yinzheng Guan, Javed Iqbal, Chenyue Wang, Xinming Ma

Subject: Life Sciences, Molecular Biology Keywords: klotho; estrogen; hippocampus; chronic stress; sex difference; stress resilience

Online: 13 December 2022 (01:09:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine & Pharmacology, General Medical Research Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0171.v1

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

Marco Santoro, Salvatrice Mancuso, Manlio Tolomeo, Rosaria Maria Pipitone, Stefania Grimaudo, Sergio Siragusa

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: chronic myeloid leukemia; dasatinib; ponatinib; pimozide; STAT inhibitors; K562

Online: 11 October 2021 (16:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine & Pharmacology, Clinical Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0233.v1

Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease

Tania Naber, Sharad Purohit

Subject: Medicine & Pharmacology, Allergology Keywords: Diabetes; Chronic Kidney Disease; Proteinuria; Dialysis; Inflammation; Diet; Nutrition

Online: 8 June 2021 (13:33:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0205.v1

Different Lower Extremity Arterial Calcification Patterns in Patients with Chronic Limb-Threatening Ischemia Compared with Asymptomatic Controls

Louise CD Konijn, Richard AP Takx, Willem PThM Mali, Hugo TC Veger, Hendrik van Overhagen

Subject: Medicine & Pharmacology, Allergology Keywords: chronic limb-threatening ischemia; peripheral arterial disease; calcification pattern

Online: 7 April 2021 (14:45:17 CEST)

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Objectives The most severe type of peripheral arterial disease (PAD) is critical limb ischaemia (CLI). In CLI, calcification of the vessel wall plays an important role in symptoms, amputation rate and mortality. However, calcified arteries are also found in asymptomatic persons (non-PAD patients). We investigated whether the calcification pattern in CLI patients and non- PAD patients are different and could possibly explain the symptoms in CLI patients. Materials and Methods 130 CLI and 204 non-PAD patients underwent a CT of the lower extremities. This resulted in 118 CLI patients (mean age 72±12, 70.3% male) that were age-matched with 118 non-PAD patients (mean age 71±11, 51.7% male). The characteristics severity, annularity, thickness and continuity were assessed in the femoral and crural arteries and analysed by binary multiple logistic regression. Results Nearly all CLI patients have calcifications and these are equally frequent in the femoropopliteal (98.3%) and crural arteries (97.5%), while the non-PAD patients had in just 67% any calcifications with more calcifications in the femoropopliteal (70.3%) than in the crural arteries (55.9%, p<0.005). The crural arteries of the CLI patients had significantly more complete annular calcifications (OR 2.92, p=0.001.) while in the non-PAD patients dot-like calcifications dominated. In CLI patients, the femoropopliteal arteries had more severe, irregular / patchy and thick calcifications (OR 2.40, 3.27, 1.81, p≤0.05, respectively) while in non-PAD patients, thin continuous calcifications prevailed. Conclusions Compared with non-PAD patients CLI patients are more frequently and extensively calcified. Annular calcifications were found in the crural arteries of CLI patients while dot-like calcifications were mostly present in the non-PAD patients. These different patterns of calcifications in CLI point at different etiology and can have prognostic and eventually therapeutic consequences.

Working Paper REVIEW

CANOMAD : A Multi-Faceted Disease

Júlia Machado Rickli, Gabriela Pomaleski, Marcus Vinícius Magno Gonçalves

Subject: Medicine & Pharmacology, Clinical Neurology Keywords: chronic-ataxic neuropathy; anti-disialosyl; IgM monoclonal gammopathy; CANOMAD

Online: 5 October 2020 (11:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology, Animal Sciences & Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0261.v1

Diagnostic Imaging in Pediatric Chronic Rhinosinusitis: A Guide for Clinicians

Giorgio Conte, Luca Caschera, Sandro Magnani, Claudia Cinnante, Fabio Maria Triulzi, Lorenzo Pignataro, Sara Torretta

Subject: Medicine & Pharmacology, Pediatrics Keywords: rhinosinusitis; pediatric chronic rhinosinusitis; computed tomography; magnetic resonance imaging

Online: 26 June 2019 (07:21:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0033.v1

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar

Subject: Life Sciences, Immunology Keywords: apoptosis; viral persistence, hepatitis C virus; immunity; chronic infection

Online: 2 October 2018 (16:34:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0320.v1

Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies

Pedro Henrique Franca Gois, Martin Wolley, Dwarakanathan Ranganathan, Antonio Carlos Seguro

Subject: Medicine & Pharmacology, Other Keywords: vitamin D; vitamin D deficiency; chronic kidney disease; proteinuria

Online: 18 July 2018 (08:39:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0104.v1

Myeloperoxidase as an Active Disease Biomarker: Its Recent Biochemical and Pathological Perspectives

Amjad A. Khan, Mohammad A. Alsahli, Arshad H. Rahmani

Subject: Biology, Other Keywords: myeloperoxidase, leukocytes, inflammation, oxidative stress, chronic diseases, disease biomarker

Online: 15 February 2018 (16:54:25 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0177.v1

In Chronic Cardiac Decompensation with Reduced Left Ventricular Ejection Fraction, Phosphodiesterase-5 Inhibition Exerts Significant Effects on some Clinical, Functional and Hemodynamic Outcomes: a Meta-Analysis

Renato De Vecchis, Carmelina Ariano

Subject: Medicine & Pharmacology, Cardiology Keywords: sildenafil; phosphodiesterase-5 inhibitors; chronic heart failure; meta-analysis

Online: 22 March 2017 (18:12:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0039.v1

Genomic Analysis of Adaptation of the MRSA ST239 Strains to the Development of Various Types of the Infectious Process

Olga Alexandrovna Dmitrenko, Andrey Viktorovich Chaplin, Anna Alexandrovna Balbutskaya, Tamara Yakovlevna Pkhakadze, Sergey Vladimirovich Alkhovsky

Subject: Life Sciences, Genetics Keywords: Staphylococcus aureus, MRSA ST239, osteomyelitis, genome features, adaptation; chronic infection

Online: 2 November 2022 (03:34:29 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202209.0035.v2

Application of Amniotic Membrane Allografts in Advanced Venous Leg Ulcer: A Case Study and Literature Review

Naomi Lambert, Eric Vinke, Tyler Barrett, Matthew Regulski

Subject: Life Sciences, Biotechnology Keywords: Chronic Venous Insufficiency; Venous Leg Ulcer; Dehydrated Amniotic Membrane Allograft

Online: 5 September 2022 (10:57:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0008.v1

CRISPR/Cas9-directed Gene Trap Constitutes a Selection System for Corrected BCR/ABL Leukemic Cells in CML

Elena Vuelta, José Luis Ordoñez, David José Sanz, Sandra Ballesteros, Jesús María Hernández-Rivas, Lucía Méndez-Sánchez, Manuel Sánchez-Martín, Ignacio García-Tuñón

Subject: Life Sciences, Molecular Biology Keywords: Chronic Myeloid Leukaemia; BCR/ABL; CRISPR; Gene therapy; CRISPR-Trap.

Online: 4 May 2022 (12:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0217.v1

Factors Associated with the Prevalence of Malnutrition among Haemodialytic Patients: A Two-Centre Study in Jeddah Region, Saudi Arabia

Waad M. Turkistani, Firas S. Azzeh, Mazen M. Ghaith, Lujain A. Bahubaish, Osama A. Kensara, Hussain A. Almasmoum, Abdullah F. Aldairi, Anmar A. Khan, Ahmad A. Alghamdi, Ghalia Shamlan, Maha H. Alhussain, Reham M. Algheshairy, Abdullah M. AlShahrani, Maysoun S. Qutob, Awfa Y. Alazzeh, Haitham M. Qutob

Subject: Medicine & Pharmacology, Nutrition Keywords: Chronic Kidney Disease; Protein-Energy Wasting; Modified-Subjective Global Assessment

Online: 25 April 2022 (04:53:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0290.v3

Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis

Lucia Tejedor-Santamaria, Jose Luis Morgado-Pascual, Laura Marquez-Exposito, Beatriz Suarez-Alvarez, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Sergio Mezzano, Carlos López-Larrea, Anna Sola, Gema Maria Fernandez-Juarez, Alberto Ortiz, Sandra Rayego-Mateos, Marta Ruiz-Ortega

Subject: Life Sciences, Molecular Biology Keywords: crescentic glomerulonephritis; BET proteins; NOTCH; GREMLIN; Chronic kidney disease; Bromodomain

Online: 23 December 2021 (14:40:45 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202108.0267.v1

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

Elia Biganzoli, Romano Demicheli

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Cancer dormancy; Low-grade chronic inflammation; Healthy aging; Physical exercise

Online: 11 August 2021 (17:57:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0362.v1

Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

Hawraa Al-Jassas, Hussein Al-Hakeim, Michael Maes

Subject: Medicine & Pharmacology, Allergology Keywords: COVID-19; depression; chronic fatigue syndrome; inflammation; neuro-immune; psychiatry

Online: 14 June 2021 (13:01:31 CEST)

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Working Paper CONCEPT PAPER

EUROPEAN ME NETWORK (EUROMENE) Expert Consensus on the Diagnosis, Service Provision and Care of People with ME/CFS in Europe

Luis Nacul, Fraçois Jérôme Authier, Carmen Scheibenbogen, Lorenzo Lorusso, Ingrid Helland, Jose Alegre Martin, Carmen Adella Sirbu, Anne Marit Mengshoel, Olli Polo, Uta Behrends, Henrik Nielsen, Patricia Grabowski, Slobodan Sekulic, Nuno Sepulveda., Fernando Esteves Lopez, Pawel Zalewski, Derek Pheby, Jesus Castro-Marrero, Giorgos K Sakkas, Jonas Bergquist, Enrica Capelli, Ivan Brandslund, John Cullinan, Angelika Krumina, Modra Murovska, Ruud Vermuelen, Eliana Lacerda

Subject: Medicine & Pharmacology, Clinical Neurology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; diagnosis; Health services; clinical care

Online: 16 October 2020 (08:58:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0472.v1

Tratment With Folic Acid Increases Paraoxonase 1 Activity Thereby Improving Chronic Kidney Disease

Andressa Matsumoto, Michael Maes, Ana Paula Michelin, Kamila Bonifácio, Laura Semeão, Rafael Martins, João Pedrão, Estefânia Moreira, Vinicius Delfino, Décio Barbosa

Subject: Keywords: chronic kidney disease; folic acid; inflammation; oxidative stress; antioxidants; biomarkers

Online: 31 March 2020 (23:32:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0175.v1

Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments

Abbas F. Almulla, Shatha Rouf Moustafa, Arafat Hussein Al-Dujaili, Hussein Kadhem Al-Hakeim, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: inflammation; neuroimmunomodulation; major depression; chronic fatigue syndrome; myalgic encephalomyelitis; biomarkers

Online: 14 February 2020 (01:53:53 CET)

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Working Paper COMMUNICATION

Dietary Fiber and Gut Microbiota in Renal Diets

carla Camerotto, Adamasco Cupisti, Claudia D'Alessandro, Fulvio Muzio, Maurizio Gallieni

Subject: Medicine & Pharmacology, Nutrition Keywords: renal diets; fiber; renal nutrition; chronic kidney disease; gut microbiota

Online: 26 August 2019 (12:23:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0191.v1

General Anesthetic Agents and Renal Function after Nephrectomy

Ho-Jin Lee, Jinyoung Bae, Yongsuk Kwon, Hwan Suk Jang, Seokha Yoo, Chang Wook Jeong, Jin-Tae Kim, Won Ho Kim

Subject: Medicine & Pharmacology, Urology Keywords: nephrectomy; acute kidney injury; chronic kidney disease; sevoflurane; desflurane; propofol

Online: 19 August 2019 (03:47:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0262.v1

Chronic Fatigue and Fibromyalgia Symptoms are Key Components of Deficit Schizophrenia and are Strongly Associated with Activated Immune-Inflammatory Pathways

Abbas Almulla, Hussein Al-Hakeim, Mokhlad Abed, André Carvalho, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Chronic fatigue syndrome, inflammation, neuro-immune, physio-somatic, schizophrenia, cytokines

Online: 23 July 2019 (11:49:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0253.v1

Chronic Unpredictable Environmental Stress Impair Biochemical and Physiological Homeostatsis: Role in Diabetes Mellitus

Alok Raghav, Jamal Ahmad, Imrana Naseem

Subject: Biology, Animal Sciences & Zoology Keywords: diabetes mellitus; ROS; carbohydrate metabolism; antioxidants; chronic unpredictable environmental stress

Online: 14 September 2018 (05:20:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0381.v1

CLINICAL PROFILE OF PATIENTS WITH CORONARY TORTUOSITY AND ITS RELATION WITH CORONARY ARTERY DISEASE

Ankush Gupta, Prashant Panda, YASH SHARMA, Ashwin Mahesh, Prafull Sharma, Nalin Kumar Mahesh

Subject: Medicine & Pharmacology, Cardiology Keywords: coronary tortuosity; myocardial ischemia; coronary artery disease; chronic stable angina.

Online: 25 June 2018 (11:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0356.v1

Chronification of Tympanic Perforation with Mitomycin C in a Rat Model

Tomás Esteban, Noemí M. Atucha, José María Moraleda, Joaquín García-Estañ, Carmen L. Insausti, Javier Moraleda-Deleito

Subject: Medicine & Pharmacology, Other Keywords: animal model; chronic tympanic membrane perforation; mitomycin C; myringotomy; dexamethasone

Online: 27 April 2018 (08:36:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0062.v1

Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

Marianne J. Middelveen, Eva Sapi, Jennie Burke, Katherine R. Filush, Agustin Franco, Melissa C. Fesler, Raphael B. Stricker

Subject: Medicine & Pharmacology, Pathology & Pathobiology Keywords: Lyme disease; Borrelia burgdorferi; Tickborne disease; Chronic infection; Spirochete culture

Online: 8 March 2018 (07:08:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0342.v1

Factors Associated With Chronic Kidney Disease in Patients With Type 2 Diabetes in Bangladesh

Sheikh Mohammed Shariful Islam, Masudus Salehin, Sojib Bin Zaman, Tania Tansi, Rajat Das Gupta, Lingkan Barua, Palash C Banik, Riaz Uddin

Subject: Medicine & Pharmacology, General Medical Research Keywords: Type 2 Diabetes Mellitus; Chronic Kidney Diseases; Hypertension; Risk Factors; Bangladesh

Online: 19 November 2021 (09:26:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0173.v1

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-based Study

Joaquim Oristrell, Joan C. Oliva, Isaac Subirana, Enrique Casado, Didier Dominguez, Andrea Toloba, Patricia Aguilera, Joan Esplugues, Pilar Fafian, Maria Grau

Subject: Life Sciences, Biochemistry Keywords: calcitriol; vitamin D; COVID-19; SARS-CoV2 infection; chronic kidney disease

Online: 6 April 2021 (11:50:28 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202011.0668.v1

Case Report - Unstable Angina, Coronary Artery Disease, and Cannabis

Brian Entler, Brian Shaffer, Garrison Davis, Marc Incitti, Brian Piper

Subject: Keywords: marijuana; medicinal cannabis (MC); chronic pain (CP); cannabidiol (CBD); tetrahydrocannabinol (THC)

Online: 26 November 2020 (11:22:28 CET)

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Rationale:First discovered in 1990, the endocannabinoid system (ECS) was initially shown to have an intimate relationship with central areas of the nervous system associated with pain, reward, and motivation. Recently, however, the ECS has been extensively implicated in the cardiovascular system with contractility, heart rate, blood pressure, and vasodilation. Emerging data demonstrates modulation of the ECS plays an essential role in cardio metabolic risk, atherosclerosis, and can even limit damage to cardiomyocytes during ischemic events.Patient Concerns:This case describes a 63-year-old male who presented to a primary care physician for a medical cannabis (MC) consult due to unstable angina (UA) not relieved by morphine or cardiac medications; having failed all first- and second-line poly-pharmaceutical therapies. The patient reported frequent, unprovoked, angina and exertional dyspnea.Diagnosis:Having a complex cardiac history, the patient first presented 22 years ago after a suspected myocardial infarction (MI). He re-presented in 2010 and underwent stent placement at that time for inoperable triple-vessel coronary artery disease (CAD) which was identified via percutaneous transluminal coronary angioplasty. UA developed on follow up and, despite medical management over the past 6 years, his UA became progressively debilitating.Interventions and Outcomes:In conjunction with his standard cardiac care, patient had a gradual lessening of UA related pain, including frequency and character, after using an edible form of medical cannabis (MC) (1:1 CBD:THC). Following continued treatment, he ceased long term morphine treatment and describes the pain as no longer crippling. As demonstrated by his exercise tolerance tests, the patient experienced an improved functional capacity and reported an increase in his daily functioning, and overall activity.Lessons:This case uniquely highlights MC in possibly reducing the character, quality, and frequency of UA; while concordantly improving functional cardiac capacity in a patient with CAD. Additional case reports are necessary to verify this.

Preprint REVIEW | doi:10.20944/preprints202009.0706.v1

A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B

Hira Hanif, Muzammil Khan, Mukarram Ali, Pir Shah, Jinendra Satiya, Daryl Lau, Aysha Aslam

Subject: Medicine & Pharmacology, Allergology Keywords: Chronic hepatitis B; NAFLD; NASH; biomarkers; magnetic resonance technology; NAFLD therapy

Online: 29 September 2020 (10:40:21 CEST)

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