Version 1
: Received: 2 January 2024 / Approved: 3 January 2024 / Online: 3 January 2024 (09:43:32 CET)
How to cite:
Martins, I.P.; Nunes Vicente, B.; Nobre, J.B.; Dias da Costa, M.; Dourado Sotero, F. Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate. Preprints2024, 2024010210. https://doi.org/10.20944/preprints202401.0210.v1
Martins, I.P.; Nunes Vicente, B.; Nobre, J.B.; Dias da Costa, M.; Dourado Sotero, F. Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate. Preprints 2024, 2024010210. https://doi.org/10.20944/preprints202401.0210.v1
Martins, I.P.; Nunes Vicente, B.; Nobre, J.B.; Dias da Costa, M.; Dourado Sotero, F. Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate. Preprints2024, 2024010210. https://doi.org/10.20944/preprints202401.0210.v1
APA Style
Martins, I.P., Nunes Vicente, B., Nobre, J.B., Dias da Costa, M., & Dourado Sotero, F. (2024). Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate. Preprints. https://doi.org/10.20944/preprints202401.0210.v1
Chicago/Turabian Style
Martins, I.P., Mariana Dias da Costa and Filipa Dourado Sotero. 2024 "Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate" Preprints. https://doi.org/10.20944/preprints202401.0210.v1
Abstract
Patients with chronic (CM) and high frequency episodic migraine (HFEM) report cognitive complaints that contribute to migraine burden. Although, there is little evidence about the ef-fects of migraine treatments on these symptoms.
Objective: To evaluate the effect of preventive treatment on the impact of cognitive symptoms, specifically the ability to concentrate, in individuals with CM and HFEM.
Methods: Prospective cohort study in patients with CM and HFEM initiating treatment with botulinum toxin (BT) or anti-CGRP/R monoclonal antibodies (mAbs). Patients were evaluated at baseline and after 3 months of treatment, using a headache diary and a question about the im-pact of migraine attacks on concentration (never, rarely, sometimes, often, and always).
Results: 108 patients (105 females, 44.3 years of age on average), 75% with CM and 27% with HFEM were included, 55 received a first session of BT and 53 received 3 injections of a monthly mAb. In both groups, there was a significant decline on the impact of migraine in concentration (related samples Wilcoxon signed rank test <0.001) compared to baseline. Reduction in monthly headache days was the main predictor of any concentration improvement, while treatment group, age, ongoing medication with topiramate or baseline medication overuse were not sig-nificant.
Conclusion: Preventive treatment of HFEM or CM with drugs not acting on central nervous sys-tem is associated with a decrease of the impact of migraine attacks on concentration, predicted by the decline in headache days. These results indicate that migraine preventive treatment also improves non-pain symptoms, which is relevant given the contribution of cognitive complaints to the impact of headache attacks
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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