Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

IL-23/IL-17 axis in the Chronic Hepatitis C and Nonalcoholic Steatohepatitis – New Insight Into Immunohepatotoxicity of Different Chronic Liver Diseases

Ankica Vujovic
ORCID logo ,
Andjelka M Isakovic
ORCID logo ,
Sonja Misirlic-Dencic
,
Jovan Juloski
ORCID logo ,
Milan Mirkovic
,
Marina Djelic
* ORCID logo ,
Ivana Milošević
*
Version 1 : Received: 28 May 2023 / Approved: 31 May 2023 / Online: 31 May 2023 (07:46:51 CEST)

A peer-reviewed article of this Preprint also exists.

Vujovic, A.; Isakovic, A.M.; Misirlic-Dencic, S.; Juloski, J.; Mirkovic, M.; Cirkovic, A.; Djelic, M.; Milošević, I. IL-23/IL-17 Axis in Chronic Hepatitis C and Non-Alcoholic Steatohepatitis—New Insight into Immunohepatotoxicity of Different Chronic Liver Diseases. Int. J. Mol. Sci. 2023, 24, 12483. Vujovic, A.; Isakovic, A.M.; Misirlic-Dencic, S.; Juloski, J.; Mirkovic, M.; Cirkovic, A.; Djelic, M.; Milošević, I. IL-23/IL-17 Axis in Chronic Hepatitis C and Non-Alcoholic Steatohepatitis—New Insight into Immunohepatotoxicity of Different Chronic Liver Diseases. Int. J. Mol. Sci. 2023, 24, 12483.

Abstract

Considering the relevance of the pathogenesis research of different liver diseases, in our study we investigated the possible activity of IL-23/IL-17 axis on the im-munohepatotoxicity of two etiologically different CLD. A total of patients with CHC infection, 19 with NASH and 20 healthy controls (CG) were recruited. After histological verification from liver tissue obtain by liver biopsy, patients with CHC were divided into two groups: CHC-NSF (F0/F1/F2)-non-significant fibrosis, 20 patients, and CHC-SF (F3/F4)-significant fibrosis/cirrhosis, 16 patients. All anthropometric, biochemical, immunological cytokines (IL-6, IL-10, IL-17 and IL-23) tests were performed accordance to standard procedure. The plasma levels of IL-6, Il-17A and IL-23 were significantly higher in CHC-SF and NASH in compared with CG. Also, plasma levels of IL-23/IL-17A were significantly higher in NASH in compared to CHC-SF. In CHC-SF we had significantly lowest IL-10 level in compared with all three groups. Liver tissue levels of IL-17A and IL-23 in CHC-NSF were significantly lower in compared with NASH. IN CHC-SF and NASH, IL17-A and IL-23 in liver tissue were significantly higher in compare to plasma levels. In conclusan, proinflammatory response of IL-23/17A axis is dominant in plasma and liver tissue in CHC with higher levels of liver fibrosis and in NASH patients.

Keywords

chronic hepatitis C; nonalcoholic steatohepatitis; IL-23/IL-17 axis; immunohepatotoxicity

Subject

Medicine and Pharmacology, Pathology and Pathobiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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