Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Comparative Analysis of Vascular Calcification Risk Factors in Pre-hemodialysis and Prevalent Hemodialysis Adult Patients: Insights into Calcification Biomarker Associations and Implications for Intervention Strategies in Chronic Kidney Disease

Marko Petrović
,
Voin Brković
ORCID logo ,
Marko Baralić
ORCID logo ,
Ivko Marić
,
Nenad Petković
,
Sanja Stanković
ORCID logo ,
Nataša Lalić
,
Danijela Stanisavljević
,
Ljubica Đukanović
ORCID logo ,
Višnja Ležaić
* ORCID logo
Version 1 : Received: 16 February 2024 / Approved: 16 February 2024 / Online: 17 February 2024 (09:04:37 CET)

A peer-reviewed article of this Preprint also exists.

Petrović, M.; Brković, V.; Baralić, M.; Marić, I.; Petković, N.; Stanković, S.; Lalić, N.; Stanisavljević, D.; Đukanović, L.; Ležaić, V. Comparative Analysis of Vascular Calcification Risk Factors in Pre-Hemodialysis and Prevalent Hemodialysis Adult Patients: Insights into Calcification Biomarker Associations and Implications for Intervention Strategies in Chronic Kidney Disease. Diagnostics 2024, 14, 824. Petrović, M.; Brković, V.; Baralić, M.; Marić, I.; Petković, N.; Stanković, S.; Lalić, N.; Stanisavljević, D.; Đukanović, L.; Ležaić, V. Comparative Analysis of Vascular Calcification Risk Factors in Pre-Hemodialysis and Prevalent Hemodialysis Adult Patients: Insights into Calcification Biomarker Associations and Implications for Intervention Strategies in Chronic Kidney Disease. Diagnostics 2024, 14, 824.

Abstract

This retrospective study aimed to compare risk factors for vascular calcification (VC) between pre-hemodialysis (HD) and prevalent HD adult patients while investigating associations with calcification biomarkers. Baseline data from 30 pre-HD and 85 HD patients were analyzed, in-cluding iPTH, vitamin D, FGF-23, fetuin-A, sclerostin and VC scores (Adragao method). Preva-lence of VC was similar in both groups, but HD patients had more frequent VC scores ≥6. Pre-HD patients were older, with higher prevalence of hypertension and less frequent use of calcium phosphate binders. Both groups showed similar patterns of hyperphosphatemia, low vitamin D, and iPTH. Fetuin-A levels were higher in pre-HD, while FGF-23 was elevated in HD patients. Higher VC risk in pre-HD patients was associated with male gender, older age, lower fetuin-A and higher sclerostin, lower ferritin and no vitamin D treatment, while in HD patients with higher sclerostin, FGF23 and urea, and lower iPTH. Conclusion. Progression of CKD from the pre-HD to the HD stage is accompanied by a decreased effect of the inhibitor and an increase in the promoter VC. However, mineral imbalance, hormonal regulation, treatment options, and patient-specific fac-tors should be considered. Further studies are needed to elucidate the underlying pathways.

Keywords

chronic kidney disease; vascular calcifications; FGF-23; Fetuin-A; sclerostin; iPTH; Adragao score

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.