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Preprint REVIEW | doi:10.20944/preprints202305.1974.v1

Urinary Micro-RNAs As Biomarkers of Urological Cancers: A Systematic Review

Achille Aveta, Simone Cilio, Roberto Contieri, Gianluca Spena, Luigi Napolitano, Celeste Manfredi, Antonio Franco, Fabio Crocerossa, Clara Cerrato, Matteo Ferro, Francesco Paolo Del Giudice, Paolo Verze, Francesco Lasorsa, Andrea Salonia, Rajesh Nair, Jochen Walz, Giuseppe Lucarelli, Savio Domenico Pandolfo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Micro-RNAs; biomarkers; urological cancers; prostate cancer; bladder cancer; Upper Tract Urothelial Carcinoma; renal cancer

Online: 29 May 2023 (05:15:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1970.v1

Insights Into the Therapeutic Uses of Plant Derive Phytocompounds on Diabetic Nephropathy

Palash Mitra, Sahadeb Jana, Suchismita Roy

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Diabetic nephropathy; Hyperglycemia; Phytocompounds; End stage renal disease; Oxidative stress; Inflammation

Online: 29 May 2023 (05:03:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1875.v1

Alterations in the Epigenetic Machinery Associated With Prostate Cancer Health Disparities

Jenna Craddock, Jue Jiang, SEAN PATRICK, Shingai Mutambirwa, Phillip D Stricker, Riana Bornman, Weerachai Jaratlerdsiri, Vanessa M Hayes

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; somatic alteration; epigenomics; epigenetic machinery; African ancestry; southern Africa; health disparity

Online: 26 May 2023 (07:24:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1533.v1

Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience

Masaya Ito, Chiyoko Makita, Takayuki Mori, Hirota Takano, Tomoyasu Kumano, Masayuki Matsuo, Koji Iinuma, Makoto Kawase, Keita Nakane, Masahiro Nakano, Tomoyasu Kumano

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; brachytherapy; lower urinary tract symptom; international prostate symptom score (IPSS); overactive bladder symptom score (OABSS)

Online: 22 May 2023 (16:28:32 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.1119.v1

Adult-Type Granulosa Cell Tumor of the Testis: A Report of a Case and a Discussion of the Literature

Georgios Zervopoulos, Nikolaos Mitsimponas, Filippos Venetsanos, Athanasios Papathanasis

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Testis; granulosa-cell tumor; adult–type; sex cord-stromal tumor of testis; testicular cancer

Online: 16 May 2023 (07:27:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1104.v1

Elucidating the Role of Immune Cell Dysregulation in Atypical Hemolytic Uremic Syndrome: A Comprehensive Single-Cell Sequencing Analysis

I-Ru Chen, Chiu-Ching Huang, Siang‑Jyun Tu, Guei-Jane Wang, Ping-Chin Lai, Ya-Ting Lee, Ju-Chen Yen, Ya-Sian Chang, Jan‑Gowth Chang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: hemolytic uremic syndrome; complement; single cell sequencing

Online: 16 May 2023 (05:36:09 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.1044.v1

Urethral Sheath To Evacuate Blood Clots Through Mitrofanoff Appendicovesicostomy

Marcello Della Corte, Erica Clemente, Mattia Sibona, Elisa Cerchia, Berenice Tulelli, Paolo Gontero, Simona Gerocarni Nappo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Mitrofanoff; appendicovesicostomy; clots; hematuria; augmented bladder; urethral sheath; bladder tamponade

Online: 15 May 2023 (12:35:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0742.v1

Effect of phytate (InsP6) and other inositol-phosphates (InsP5, InsP4, InsP3, InsP2) on crystallization of calcium oxalate, brushite, and hydroxyapatite

Paula Calvó, Antònia Costa-Bauza, Felix Grases

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: renal lithiasis; phytate; lower inositol phosphates; crystallization inhibitors; calcium oxalate; calcium phosphates

Online: 10 May 2023 (10:45:26 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.0486.v1

Necrotic Urethral Prolapse Complicated by Urinary Retention: A Rare Case Report

Mehmet Gürkan Arıkan, Gökhan Ecer, Semih Türk, İlker Özdemir, Ersan Arda

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: estrogen replacement therapy; genitourinary syndrome of menopause; urethral prolapse

Online: 8 May 2023 (09:00:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0383.v1

Erectile Dysfunction Treatment using Stem Cell Delivery Patch in a Cavernous Nerve Injury Rat Model

Hyong Woo Moon, In Gul Kim, Mee Young Kim, Ae Ryang Jung, Kwideok Park, Ji Youl Lee

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: 1; erectile dysfunction 2; stem cell delivery 3; prostate cancer 4; biofabrication

Online: 6 May 2023 (05:37:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0172.v1

How May Longer Console-Time Influence Outcomes After Robot Assisted Radical Prostatectomy (RARP)

Mahmoud Farzat, Mohamed Elsherif, Florian M. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Prostate cancer; robot assisted radical prostatectomy (RARP); console-time.

Online: 4 May 2023 (03:36:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1238.v1

Molecular Mechanisms and Risk Factors Related to Pathogenesis of Peyronie's Disease

Yozo Mitsui, Fumito Yamabe, Shunsuke Hori, Masato Uetani, Hideyuki Kobayashi, Koichi Nagao, Koichi Nakajima

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Peyronie's disease; pathogenesis; risk factors; molecular mechanisms, transforming growth factor-β1

Online: 30 April 2023 (02:21:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1063.v1

Empagliflozin Attenuates Vascular Calcification in Mice with Chronic Kidney Disease by Regulating the NFR2/HO-1 Anti-Inflammatory Pathway through AMPK Activation

Chia-Wen Lu, Chung-Jen Lee, Yi-Jen Hsieh, Bang-Gee Hsu

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: empagliflozin; vascular calcification; AMP-activated protein kinase; nuclear factor erythroid-2-related factor; heme oxygenase 1; chronic kidney disease

Online: 27 April 2023 (09:35:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1055.v1

A Comprehensive Overview of Innovative Approaches to Prevent Kidney Ischemia-Reperfusion Injury: Bibliometric and In Silico Analyses

Myltykbay S. Rysmakhanov, Afshin Zare, Aibolat S. Smagulov, Nurgul A. Abenova, Nadiar M. Mussin, Yerlan B. Sultangereyev, Bazylbek S. Zhakiyev, Gani K. Kuttymuratov, Mehmet Haberal, Nazanin Jafari, Hanieh Baneshi, Shabnam Bakhshalizadeh, Mahdi Mahdipour, Farhad Rahmanifar, Amin Tamadon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Ischemia/reperfusion injury; Molecular docking; Bibliometric analysis; Kidney reperfusion; Kidney transplantation; Renal resection

Online: 27 April 2023 (07:25:20 CEST)

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Ischemia-reperfusion injury (IRI) is a complex pathophysiological process that can lead to severe and irreversible consequences, including the complete loss of renal function. While standardized strategies for preventing IRI during "back-table" and cold preservation are available, various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and reperfusion of the kidney. These methods include pharmacological agents, mechanical interventions, and surgical techniques such as renal capsulotomy, ischemic preconditioning, venous blood reperfusion, renal perfusion, and the use of tissue engineering techniques like mesenchymal stromal/stem cells and/or decellularization. In this comprehensive analysis, we provide a detailed overview of pharmacological agents and intraoperative methods and approaches for the prevention and treatment of renal IRI. We begin by discussing the mechanisms of IRI and the challenges of preventing it during surgery. Then using a bibliometric analysis and molecular docking of brand-new legends we showed eplerenone have the most binding affinity to Aldehyde dehydrogenase (AD), Estrogen receptor (ER), Klotho protein, Mineralocorticoid receptor (MR), and Toll-like receptor 4 (TLR4) for preventing IRI comparing with other available therapeutics, Benzodioxole, Hydrocortisone, Indoles, Nicotinamide adenine dinucleotide, and Niacinamide. Next, we provide a comprehensive analysis of the potential benefits and limitations of various prevention strategies, including an in-depth discussion of the mechanisms of action of pharmacological agents, mechanical interventions, and surgical techniques. Furthermore, we introduce a novel scoring system for the prevention methods of kidney IRI, which takes into account the effectiveness, feasibility, and safety of each method. We then analyze the current state of clinical research in this area and discuss the implications of these methods for future clinical practice. Overall, this article provides a valuable resource for clinicians and researchers seeking to prevent and treat renal IRI in surgical settings, and introduces a new scoring system that can be used to guide the selection of the most effective and safe prevention methods.

Preprint REVIEW | doi:10.20944/preprints202304.0672.v1

Renal Biomarkers in Cardiovascular Patients with Acute Kidney Injury

Rolando Claure-Del Granado, Jonathan S. Chávez-Iñiguez

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Cardiorenal syndromes; Acute kidney injury; Biomarkers; Chronic kidney disease; Heart failure

Online: 21 April 2023 (05:26:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0319.v1

Recent Advances in Urinary Peptide and Proteomic Biomarkers in Chronic Kidney Disease: A Systematic Review

Lorenzo Catanese, Justyna Siwy, Harald Mischak, Ralph Wendt, Joachim Beige, Harald Rupprecht

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: biomarkers; chronic kidney disease; peptide; proteomic; urine

Online: 13 April 2023 (10:51:02 CEST)

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Background: Biomarker development, improvement, and clinical implementation in the context of kidney disease has been a central focus of biomedical research for decades. To this point, only serum creatinine and urinary albumin excretion are well accepted biomarkers in kidney disease. With their known blind spot in early stages of kidney impairment and diagnostic limitations there is a need for better and more specific biomarkers. With the rise of large-scale analysis of thousands of peptides in serum or urine samples using mass spectrometry techniques hopes for biomarker development were high. Advances in proteomic research have led to the discovery of an increasing amount of potential proteomic biomarkers and identification of candidate biomarkers for clinical implementation in the context of kidney disease management. In this review we focus on urinary peptide and especially peptidomic biomarkers emerging from recent research and underline the role of those with the highest potential for clinical implementation. Methods: The Web of Science database (all databases) was searched on October 17th, 2020, using the search terms “marker*” OR biomarker* AND “renal disease” OR “kidney disease” AND “proteome*” OR “peptid*” AND “urin*”. English, full-text original articles on humans published within the last 5 years were included which were cited at least 5 times per year. Studies based on animal models, renal transplant studies, metabolite studies, studies on miRNA and studies on exosomal vesicles were excluded focusing on urinary peptide biomarkers. Results: The described search led to the identification of 3668 articles and application of inclusion and exclusion criteria as well as abstract and consecutive full-text analysis of 3 independent authors to a final number of 62 studies for this manuscript. The 62 manuscripts encompassed 8 established single peptide biomarkers and several proteomic classifiers including CKD273 and IgAN237. Discussion: This review provides a summary of recent evidence on single peptide urinary biomarkers in CKD while emphasizing the increasing role of proteomic biomarker research with new research on established and new proteomic biomarkers. Lessons learned from the last 5 years in this review might encourage future studies hopefully resulting in routine clinical applicability of new biomarkers.

Preprint ARTICLE | doi:10.20944/preprints202304.0280.v1

NanoLuc Binary Technology as a Methodological Approach: An Important New Tool for Studying the Localization of Androgen Receptor and Androgen Receptor Splice Variant V7 Homo- and Heterodimers

Juan Guzman, Katrin Weigelt, Angela Neumann, Philipp Tripal, Benjamin Schmid, Zoltan Winter, Ralph Palmisano, Zoran Culig, Marcus V. Cronauer, Paul Muschler, Bernd Wullich, Helge Taubert, Sven Wach

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Androgen receptor; androgen receptor splice variant 7; prostate cancer; localization; NanoBiT

Online: 13 April 2023 (02:54:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0080.v1

Adapting Clinical Practice Guidelines for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children in the Saudi Arabian context using the GRADE-ADOLOPMENT methodology

Khalid Abdulaziz Alhasan, Juan José Yepes-Nuñez, Sumayah Askandarani, Yasser Sami Amer, Muneera Al-Jelaify, Khalid I. Almatham, Mohammed Al-Ghonaim, Sultan Al Dalbhi, Jameela Abdulaziz Kari, Ahmed Mitwalli, Ziad Memish, Joanna Sara Valson, Ximena Alvira, Khushnam Bilimoria, Ruchi Chawla, Sheila Feit, Skye Bickett, Klara Brunnhuber

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; antihypertensive; practice guidelines; recommendations; performance measures; GRADE; adolopment; AGREE II; RIGHT-Ad@pt; evidence-based healthcare; Saudi Arabia

Online: 6 April 2023 (08:59:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0444.v1

The Matrix Receptor CD44 Is Present in Astrocytes Throughout the Human CNS and Accumulates in Hypoxia and Seizures

Osama Al Dalahmah, Alexander A Sosunov, Yu Sun, Yang Liu, Nsikan Akpan, Nacoya Madden, E. Sander Connolly, Carol M Troy, Guy M McKhann II, James E. Goldman

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: CD44; astrocytes; hypoxia; seizures; interlaminar astrocytes

Online: 27 March 2023 (04:19:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0351.v1

Admission Systolic Blood Pressure and Obesity Correlate with Severe Acute COVID-19 in the Population of New Orleans, LA

Dahlene Fusco, Sharon Liu, Marc Theberge, Peter Reynaud, Arnaud Drouin

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: COVID-19; SARS CoV-2; hypertension; obesity; clinical predictor of outcomes; clinical triage; ClinSeqSer acute COVID-19 observational study

Online: 20 March 2023 (07:46:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0184.v1

CT Rendering and Radiomics Analysis in Post-Chemotherapy Retroperitoneal Lymph Node Dissection for Testicular Cancer To Anticipate Difficulties for Young Surgeons

Anna Scavuzzo, Pavel Figueroa Rodriguez, Alessandro Stefano, Nallely Jimenez Guedulain, Sebastian Muruato Araiza, Jose de Jesus Cendejas Gomez, Alejandro Quiroz Compeán, Dimas Omar Victorio Vargas, Miguel Angel Jimenez Rios

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: testicular cancer; radiomics; retroperitoneal surgery

Online: 10 March 2023 (02:28:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0441.v1

Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)

Iris Viejo-Boyano, Luis Carlos López-Romero, Luis D'Marco, Ana Checa-Ros, María Peris-Fernández, Enrique Garrigós-Almerich, María Carmen Ramos-Tomás, Ana Peris-Domingo, Julio Hernández-Jaras

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; solid organ transplant; nephrology

Online: 27 February 2023 (04:45:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0057.v1

TRPA1 Agonists and Bladder Nociception in Female Rats Suggest Potential for Nutraceutical Benefit from Cinnamon

Timothy J. Ness, Amer Babi, Madeline E. Ness, Cary DeWitte

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: TRPA1; cinnamon; cinnamaldehyde; urinary bladder

Online: 3 February 2023 (04:33:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0287.v1

Protective Effect of Green Tea (Camellia sinensis) against Kidney Diseases

Luis L. Ayusso, Ana Paula Girol, Emmanuel A. Burdmann

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: green tea; EGCG; oxidative stress; acute kidney injury; chronic kidney disease; kidney stones; diabetic nephropathy

Online: 15 December 2022 (15:48:03 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202211.0441.v1

A Dual Primary Malignancy – Ewing Sarcoma and Prostate Adenocarcinoma in A Single Patient

Arsen Shpigelman, David Maman, Benjamin Bernfeld

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Ewing sarcoma; Prostate adenocarcinoma; Cauda equina syndrome; Dual primary malignancy.

Online: 23 November 2022 (07:47:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0483.v1

Diagnostic and Prognostic Biomarkers in Renal Clear Cell Carcinoma

Chaston Weaver, Khaled Bin Satter, Katherine P Richardson, Lynn KH Tran, Paul MH Tran, Sharad Purohit

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Clear cell carcinoma, molecular pathology, biomarkers, gene and protein signatures, machine learning, treatment decision.

Online: 31 October 2022 (10:21:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0475.v1

A Retrospective, Observational Study of Catheter-associated Urinary Tract Infection Events Post-implementation of a Novel Urinary Catheter System with Active Drain Line Clearance and Automated Intra-abdominal Pressure Monitoring

Patrick Brockway, David M. Hill, Vanessa Moll, Kelly Stanton, Manu L.N.G. Malbrain, Sai R. Velamuri

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: catheter-associated infection; CAUTI; urinary tract infection; healthcare-associated infection; active drain line clearance; burns; intra-abdominal pressure; measurement

Online: 30 September 2022 (04:13:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0233.v1

What is New in Prophylaxis and Treatment of Covid- 19 in Renal Transplant Patients?

Maurizio Salvadori

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: COVID-19 prophylaxis; COVID-19 treatment; Kidney transplantation; Vaccination; Monoclonal antibodies; Small antivirus molecules

Online: 16 September 2022 (02:00:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0101.v1

T-cell Response and Antibody Production by Booster COVID-19 Vaccination in Japanese Patients with Chronic Kidney Disease Treated with Hemodialysis

Ayumi Yoshifuji, Masataro Toda, Munekazu Ryuzaki, Emi Oyama, Kan Kikuchi, Toru Kawai, Ken Sakai, Masayoshi Koinuma, Kazuhiko Katayama, Yuki Uehara, Norio Ohmagari, Yoshihiko Kanno, Hirofumi Kon, Junko Tanaka, Toshio Shinoda, Yaoko Takano, Kazuhiko Hora, Yasushi Nakazawa, Naoki Hasegawa, Norio Hanafusa, Fumihiko Hinoshita, Keita Morikane, Shu Wakino, Hidetomo Nakamoto, Yoshiaki Takemoto

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: COVID-19; hemodialysis; vaccination; cellular immunity; humoral immunity; adverse reactions

Online: 7 September 2022 (05:14:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0431.v1

Management of Bladder Cancer Patients with Clinical Evidence of Lymph Node Invasion (cN+)

Bartosz Małkiewicz, Adam Gurwin, Jakub Karwacki, Krystian Nagi, Klaudia Knecht-Gurwin, Krzysztof Hober, Magdalena Łyko, Kamil Kowalczyk, Wojciech Krajewski, Anna Kołodziej, Tomasz Szydełko

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: bladder cancer; clinically positive lymph nodes; diagnosis; treatment; lymphadenectomy

Online: 25 August 2022 (10:05:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0163.v1

STAT3 and Its Pathways Dysregulation – Underestimated Role in Urological Tumors

Maciej Golus, Piotr Bugajski, Joanna Chorbińska, Wojciech Krajewski, Artur Lemiński, Jolanta Saczko, Julita Kulbacka, Tomasz Szydełko, Bartosz Małkiewicz

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: STAT3; prostate cancer; bladder cancer; upper tract urothelial carcinoma; renal cell carcinoma; penile cancer; testicular cancer

Online: 8 August 2022 (15:09:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0464.v1

STEAP1-4 (Six-Transmembrane Epithelial Antigen of the Prostate 1-4) and their Clinical Implications for Prostate Cancer

Michael Xu, Latese Evans, Candice L Bizzaro, Fabio Quaglia, Cecilia E Verrillo, Li Li, Julia Stieglmaier, Matthew J Schiewer, Lucia R Languino, William K Kelly

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; six-transmembrane epithelial antigen of the prostate; biomarker; immunotherapy; cancer vaccine; T-cell engaging antibody

Online: 29 July 2022 (14:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0463.v1

Predictive Values of Nocturia and Its Voiding Frequency on the Aging Males’ Symptoms

John Wai-Man Yuen, Ivy Yuen-Ping Wong, Peter Ka-Fung Chiu, Jeremy Yuen-Chun Teoh, Chi-Kwok Chan, Chi-Hang Yee, Chi-Fai Ng

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Nocturia; aging male symptoms; Quality of life; Health-related Quality of life; Male adults; NQoL; Urinary frequency; Bedtime urination; sleep

Online: 29 July 2022 (13:13:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0393.v1

Boosting the Immune Response – Combining the Local and Immune Therapy for Prostate Cancer Treatment

Jakub Karwacki, Aleksander Kiełbik, Wojciech Szlasa, Natalia Sauer, Kamil Kowalczyk, Wojciech Krajewski, Jolanta Saczko, Julita Kulbacka, Tomasz Szydełko, Bartosz Małkiewicz

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: metastatic castration-resistant prostate cancer; cancer vaccines; immunotherapy; focal therapy; combination immunotherapy; tumor immune microenvironment; in vivo vaccination

Online: 26 July 2022 (08:01:20 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202207.0296.v1

Sintilimab-Induced Diabetic Ketoacidosis in A Patient with Radiation and Multichemorefractory Penile Cancer: A Case Report and Literature Review

Chuan Lv, Can Wu, Yan Zhang, Wen dong Li, Xue song Wang, Li Liang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Autoimmune diabetes; PD-1 inhibitor; Sintilimab; Penile carcinoma

Online: 20 July 2022 (06:09:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0286.v1

Interleukin 17 and Its Involvement in Renal Cell Carcinoma

Michał Jarocki, Julia Karska, Szymon Kowalski, Paweł Kiełb, Łukasz Nowak, Wojciech Krajewski, Jolanta Saczko, Julita Kulbacka, Tomasz Szydełko, Bartosz Małkiewicz

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: interleukin-17; renal cell carcinoma; immunotherapy; inflammation; tumor microenviroment; tumor development; Th17 lymphocytes

Online: 21 June 2022 (05:11:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0166.v1

Mediators of Regional Kidney Perfusion during Surgical Pneumoperitoneum Creation and the Risk of Acute Kidney Injury – A Review of Basic Physiology

Csaba Kopitkó, László Medve, Tibor Gondos, Karim Magdy Mohamed Soliman, Tibor Fülöp

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney injury; intra-abdominal pressure; oxidative stress; renal cortical blood flow; renal medullar blood flow; renal lymphatic drainage; venous congestion

Online: 18 April 2022 (10:45:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0101.v1

Patients with Positive Lymph Nodes after Radical Prostatectomy with Pelvic Lymphadenectomy – Do We Know the Proper Way of Management?

Bartosz Małkiewicz, Miłosz Knura, Małgorzata Łątkowska, Maximilian Kobylański, Krystian Nagi, Dawid Janczak, Joanna Chorbińska, Wojciech Krajewski, Jakub Karwacki, Tomasz Szydełko

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; lymph node invasion; radical prostatectomy

Online: 11 April 2022 (14:13:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0060.v1

Time-Limited Therapy With Belatacept in Kidney Transplant Recipients

Thibault Letellier, Delphine Kervella, Abderrahmane Sadek, Christophe Masset, Claire Garandeau, Cynthia Fourgeux, Victor Gourain, Jeremie Poschmann, Gilles Blancho, Simon Ville

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: kidney transplantation; belatacept; calcineurin inhibitor; transcriptome; RNAseq

Online: 7 April 2022 (12:31:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0273.v1

Alternatives for MRI in Prostate Cancer Diagnostics – Review of Current Ultrasound-Based Techniques

Adam Gurwin, Kamil Kowalczyk, Klaudia Knecht-Gurwin, Paweł Stelmach, Łukasz Nowak, Wojciech Krajewski, Tomasz Szydełko, Bartosz Małkiewicz

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; ultrasonography; biopsy; micro-ultrasound; elastography; contrast-enhanced ultrasound

Online: 21 March 2022 (04:26:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0259.v1

In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3 T: Feasibility and Reliability Study

Ahmad A. Alhulail, Mahsa Servati, Nathan Ooms, Oguz Akin, Alp Dincer, M. Albert Thomas, Ulrike Dydak, Uzay E. Emir

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: kidney; renal; lipid; fast MRSI

Online: 18 March 2022 (02:59:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0197.v1

Utility of Lymphadenectomy in Prostate Cancer: Where do We Stand?

Bartosz Małkiewicz, Paweł Kiełb, Jakub Karwacki, Róża Czerwińska, Paulina Długosz, Artur Lemiński, Łukasz Nowak, Wojciech Krajewski, Tomasz Szydełko

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; lymph node dissection; lymphadenectomy; radical prostatectomy

Online: 16 March 2022 (02:24:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0237.v1

Membranous Glomerulonephritis: A Retrospective Study on Prognostic Outcome

Sadiq Maifata, Fauzah Abd Ghani, Rafidah Hod, Nor Fadhlina Zakaria

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Membranous glomerulonephritis; remission; nephrotic syndrome; chronic kidney disease; end-stage kidney diseases

Online: 18 February 2022 (14:49:32 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202202.0114.v1

Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections Preliminary Considerations and Conclusions from a Non-interventional Study

Florian Wagenlehner, Horst Lorenz, Oda Ewald, Peter Gerke

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: urinary tract infection; cystitis; D-mannose; antibiotics; acute cystitis symptom score

Online: 8 February 2022 (13:25:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0020.v1

OPPORTUNISTIC PATHOGENS IN PATIENTS WITH URINARY TRACT INFECTION

antonella elisa chesca, aigul medetova medetova, Galiya Abdulina Abdulina, aliya Kabduova Kabduova, Gulnara Gulnara Beysembayeva, Dan Dan Moraru, Tim Sandle Sandle

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Urinary tract infections (UTIs); opportunistic pathogens

Online: 1 February 2022 (21:26:23 CET)

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Urinary tract infections (UTIs) remain one of the most important problems of modern urology and medicine. Infections bring great discomfort and significantly reduce the quality of life. UTIs rank second after respiratory tract infections in outpatients. The most common pathogen of UTI are E.coli. The study of the etiology of UTI has great clinical and epidemiological importance in routine practice. Objective: To assess the etiological significance of pathogens in the occurrence of urinary tract infections in the Karaganda region of Kazakhstan. Methods: A total of 2378 patients presenting UTIs were enrolled and each provided a urine sample. The study was carried out in the Clinical Microbiology Laboratory MediTEC-NS between 2 January and 29 December 2018. Identification of isolated microorganisms was carried out on a WalkAway 96 Plus microbiological analyzer, Microscan model manufactured by Beckman Coulter (USA). Statistical Analysis was performed using the STATISTICA-6 package. Results: Out of 2378 patients a total of 1177 (49,5%) urine samples tested positive by culture test. From these samples, 1356 strains of microorganisms were isolated, of which 84.79% were monoculture and 21% were of a mixed culture. Gram-positive bacteria 690 (50, 88%), Gram-negative bacteria 630 (46, 46%), and Candida 36 (2.65%) were identified. Gram-negative rods were represented by Enterobacterales 557 (88.41%) and non-fermenting bacteria 73 (11.59%). In the Enterobacterales group included Escherichia coli 371 (66.61%) of which 108 (29,1%) ESBL strains. The next etiologically significant uropathogens were Klebsiella- 99 (17, 77%), Enterobacter-36 (6,46%) and Proteus-32 (8,09). K.pneumoniae prevailed in comparison with other Klebsiella spp. ESBL producing was 34 (57, 6%) out of 59 K.pneumoniae isolates. Gram-negative non-fermenting rod were represented by Acinetobacter spp-34 (46.57%) and Pseudomonas spp 31 (42.47%). Of 34 Acinetobacter spp. isolates 22 (64.7%) were identified as Acinetobacter lwoffii. Among the gram-positive pathogens of UTI, Staphylococcus spp prevailed - 411 (59.57%), followed by Enterococcus spp 197 (28.55%) and Streptococcus spp 81 (11.73%). Coagulase-negative staphylococci 381 (92,7%) isolates out of total 411 staphylococcal isolates. Staphylococcus epidermidis 245 (59,61%) and Staphylococcus haemolyticus 81 (21,17%) were the most frequent isolated coagulase-negative staphylococci. Of 411 staphylococcal isolates, 182 (44.28%) were MRS Conclusion: We found that UTIs among our study population were predominantly caused by ten opportunistic pathogens. The most common uropathogens with a frequency of 66.9% were E. coli- 30.53%, S. epidermidis -20.16%, and Enterococcus spp. -16.21%. Frequently isolated pathogens included Klebsiella, S. haemolyticus spp., and Streptococcus spp. which amounted to 21.98%. The distribution within the patient group was equable and ranged from 6,67% to 8,15%. Etiologically significant pathogens included Enterobacter spp., Proteus spp., Acinetobacter spp., Pseudomonas spp. These bacteria accounted for 11.11%. The distribution within the group was again equable and ranged within 2,55% to 2,96%.

Preprint ARTICLE | doi:10.20944/preprints202201.0476.v1

Opportunistic Pathogens in Patients with Urinary Tract Infection

ANTONELLA CHESCA, AIGUL MEDETOVA, GALIYA ABDULINA, Aliya Kabduova, Gulnara Beysembayeva, Dan Moraru, Tim Sandle

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Urinary tract infections (UTIs); opportunistic pathogens

Online: 31 January 2022 (21:38:17 CET)

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Introduction: Urinary tract infections (UTIs) remain one of the most important problems of modern urology and medicine. Infections bring great discomfort and significantly reduce the quality of life. UTIs rank second after respiratory tract infections in outpatients. The most common pathogen of UTI are E.coli. The study of the etiology of UTI has great clinical and epidemiological importance in routine practice.Objective: To assess the etiological significance of pathogens in the occurrence of urinary tract infections in the Karaganda region of Kazakhstan.Methods: A total of 2378 patients presenting UTIs were enrolled and each provided a urine sample. The study was carried out in the Clinical Microbiology Laboratory MediTEC-NS between 2 January and 29 December 2018. Identification of isolated microorganisms was carried out on a WalkAway 96 Plus microbiological analyzer, Microscan model manufactured by Beckman Coulter (USA). Statistical Analysis was performed using the STATISTICA-6 package.Results: Out of 2378 patients a total of 1177 (49,5%) urine samples tested positive by culture test. From these samples, 1356 strains of microorganisms were isolated, of which 84.79% were monoculture and 21% were of a mixed culture. Gram-positive bacteria 690 (50, 88%), Gram-negative bacteria 630 (46, 46%), and Candida 36 (2.65%) were identified. Gram-negative rods were represented by Enterobacterales 557 (88.41%) and non-fermenting bacteria 73 (11.59%). In the Enterobacterales group included Escherichia coli 371 (66.61%) of which 108 (29,1%) ESBL strains. The next etiologically significant uropathogens were Klebsiella- 99 (17, 77%), Enterobacter-36 (6,46%) and Proteus-32 (8,09). K.pneumoniae prevailed in comparison with other Klebsiella spp. ESBL producing was 34 (57, 6%) out of 59 K.pneumoniae isolates. Gram-negative non-fermenting rod were represented by Acinetobacter spp-34 (46.57%) and Pseudomonas spp 31 (42.47%). Of 34 Acinetobacter spp. isolates 22 (64.7%) were identified as Acinetobacter lwoffii. Among the gram-positive pathogens of UTI, Staphylococcus spp prevailed - 411 (59.57%), followed by Enterococcus spp 197 (28.55%) and Streptococcus spp 81 (11.73%). Coagulase-negative staphylococci 381 (92,7%) isolates out of total 411 staphylococcal isolates. Staphylococcus epidermidis 245 (59,61%) and Staphylococcus haemolyticus 81 (21,17%) were the most frequent isolated coagulase-negative staphylococci. Of 411 staphylococcal isolates, 182 (44.28%) were MRSConclusion: We found that UTIs among our study population were predominantly caused by ten opportunistic pathogens. The most common uropathogens with a frequency of 66.9% were E. coli- 30.53%, S. epidermidis -20.16%, and Enterococcus spp. -16.21%. Frequently isolated pathogens included Klebsiella, S. haemolyticus spp., and Streptococcus spp. which amounted to 21.98%. The distribution within the patient group was equable and ranged from 6,67% to 8,15%. Etiologically significant pathogens included Enterobacter spp., Proteus spp., Acinetobacter spp., Pseudomonas spp. These bacteria accounted for 11.11%. The distribution within the group was again equable and ranged within 2,55% to 2,96%.

Preprint ARTICLE | doi:10.20944/preprints202201.0473.v1

Opportunistic Pathogens in Patients with Urinary Tract Infection

Antonella Elisa Chesca, Galiya G Abdulina, Aigul A. Medetova, Aliya Kabduova Kabduova, Gulnara Gulnara Beysembayeva, Dan Dan Moraru, Tim Sandle Sandle

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Urinary tract infections (UTIs); opportunistic pathogens

Online: 31 January 2022 (21:18:06 CET)

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Abstract Introduction: Urinary tract infections (UTIs) remain one of the most important problems of modern urology and medicine. Infections bring great discomfort and significantly reduce the quality of life. UTIs rank second after respiratory tract infections in outpatients. The most common pathogen of UTI are E.coli. The study of the etiology of UTI has great clinical and epidemiological importance in routine practice. Objective: To assess the etiological significance of pathogens in the occurrence of urinary tract infections in the Karaganda region of Kazakhstan. Methods: A total of 2378 patients presenting UTIs were enrolled and each provided a urine sample. The study was carried out in the Clinical Microbiology Laboratory MediTEC-NS between 2 January and 29 December 2018. Identification of isolated microorganisms was carried out on a WalkAway 96 Plus microbiological analyzer, Microscan model manufactured by Beckman Coulter (USA). Statistical Analysis was performed using the STATISTICA-6 package. Results: Out of 2378 patients a total of 1177 (49,5%) urine samples tested positive by culture test. From these samples, 1356 strains of microorganisms were isolated, of which 84.79% were monoculture and 21% were of a mixed culture. Gram-positive bacteria 690 (50, 88%), Gram-negative bacteria 630 (46, 46%), and Candida 36 (2.65%) were identified. Gram-negative rods were represented by Enterobacterales 557 (88.41%) and non-fermenting bacteria 73 (11.59%). In the Enterobacterales group included Escherichia coli 371 (66.61%) of which 108 (29,1%) ESBL strains. The next etiologically significant uropathogens were Klebsiella- 99 (17, 77%), Enterobacter-36 (6,46%) and Proteus-32 (8,09). K.pneumoniae prevailed in comparison with other Klebsiella spp. ESBL producing was 34 (57, 6%) out of 59 K.pneumoniae isolates. Gram-negative non-fermenting rod were represented by Acinetobacter spp-34 (46.57%) and Pseudomonas spp 31 (42.47%). Of 34 Acinetobacter spp. isolates 22 (64.7%) were identified as Acinetobacter lwoffii. Among the gram-positive pathogens of UTI, Staphylococcus spp prevailed - 411 (59.57%), followed by Enterococcus spp 197 (28.55%) and Streptococcus spp 81 (11.73%). Coagulase-negative staphylococci 381 (92,7%) isolates out of total 411 staphylococcal isolates. Staphylococcus epidermidis 245 (59,61%) and Staphylococcus haemolyticus 81 (21,17%) were the most frequent isolated coagulase-negative staphylococci. Of 411 staphylococcal isolates, 182 (44.28%) were MRS Conclusion: We found that UTIs among our study population were predominantly caused by ten opportunistic pathogens. The most common uropathogens with a frequency of 66.9% were E. coli- 30.53%, S. epidermidis -20.16%, and Enterococcus spp. -16.21%. Frequently isolated pathogens included Klebsiella, S. haemolyticus spp., and Streptococcus spp. which amounted to 21.98%. The distribution within the patient group was equable and ranged from 6,67% to 8,15%. Etiologically significant pathogens included Enterobacter spp., Proteus spp., Acinetobacter spp., Pseudomonas spp. These bacteria accounted for 11.11%. The distribution within the group was again equable and ranged within 2,55% to 2,96%.

Preprint ARTICLE | doi:10.20944/preprints202201.0291.v1

Does Far-Infrared Therapy Improve Peritoneal Function and Reduce Peritonitis Recurrent in Peritoneal Dialysis Patients?

Yuanmay Chang, Jui-Ting Chang, Mei Yee Lee, Mei-Zen Huang, Yann-Fen C. C. Chao, Yung-Luen Shih, Yao-Rong Hwang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: end-stage renal disease; peritoneal dialysis; far-infrared therapy (FIR)

Online: 20 January 2022 (09:05:44 CET)

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Introduction: The treatment of peritoneal dialysis in end-stage renal disease is increasing in clinical practice. The main purpose of this study was to evaluate the effect of far-infrared radiation therapy on inflammation and the cellular immunity of patients undergoing peritoneal dialysis. Materials and Methods: We recruited 56 patients undergoing peritoneal dialysis, and we included 32 patients from the experimental group and 24 patients from the control group in the final analysis. The experimental evaluation in our study was as follows: (1) We used abdominal computed tomography to measure the diameter and degree of hardening of the abdominal veins and large blood vessels to explore the changes in abdominal blood vessels. (2) The study compared the effects of peritoneal dialysis using albumin, blood urea nitrogen, creatinine, white blood cell, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, erythrocyte sedimentation rate, Hs-CRP clearance rate, and HBAlC. (3) We compared the cytokine concentration of blood between the two groups while controlling for GM-CSF, IL-2, IFN-γ, IL-6, IL-18, IL-4, IL-5, IL-13, IL-12p70, TNF-α, and IL-1β. Results and Discussion: (1) There was no significant difference in the abdominal blood vessels of the experimental group relative to the control group according to abdominal CT measured over 6 months. (2) Our study demonstrates the statistically significant effect of FIR therapy on the following parameters: albumin (p = 0.048*), creatinine (p = 0.039*), and Hs-CRP (p < 0.001**) decreased significantly, and glomerular filtration rate (eGFR, p = 0.043*) and glucose (p < 0.001**) increased significantly. Our study found that, in the experimental group, albumin and creatinine decreased significantly due to FIR therapy for 6 months. However, our study also found that, in the experimental group, glucose (p < 0.001**) increased significantly due to FIR therapy for 6 months. Peritoneal dialysis combined with FIR can reduce the side effects of glucose in dialysis buffer, which interferes with peritoneal inflammation and peritoneal mesothelial cell fibrosis. In addition, we also found that, in the experimental group, Hs-CRP (p < 0.001**) decreased significantly due to FIR therapy for 6 months. (3) No statistical significance in the inflammatory cytokines related to FIR therapy differences was observed in our study. IFN-γ (p = 0.124), IL-12p70 (p = 0.093), IL-18 (p = 0.213), and TNF-α (p = 0.254) did not exhibit significant improvements in peritoneal dialysis with FIR treatment over 6 months. IFN-γ and IL-18 in the plasma of patients in the experimental group and the control group were higher in the third month than in the first month. Conclusion: We found that the effect of peritoneal dialysis improved significantly with FIR therapy, and significant improvements in the peritoneal permeability and inflammatory response were observed. end-stage renal disease; peritoneal dialysis; far-infrared therapy (FIR)

Preprint CASE REPORT | doi:10.20944/preprints202201.0190.v1

Imaging of Type I Retroaortic Left Renal Vein & Nutcracker Syndrome

Giovanni Fontanella, Simona Borrelli, Umberto Dello Iacono, Barbara Brogna

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: left renal vein; urology; radiology

Online: 13 January 2022 (13:19:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0182.v1

Urinary Incontinence and Its Association with Physical and Psycho-Cognitive Factors: A Cross-Sectional Study in Older People Living in Nursing Homes

Pau Farrés-Godayol, Javier Jerez-Roig, Eduard Minobes-Molina, Meltem Yildirim, Miriam Molas-Tuneu, Anna Escribà-Salvans, Sandra Rierola-Folchs, Montse Romero-Mas, Miriam Torres-Moreno, Laura Coll-Planas, Joanne Booth, Maria Giné-Garriga

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: older people; nursing home; incontinence; urinary incontinence; pelvic health; sedentary behaviour; physical health; faecal incontinence; low urinary tract symptoms

Online: 12 January 2022 (18:41:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0060.v1

Negative mpMRI Rules Out Extra-Prostatic Extension in Prostate Cancer Before Robot-Assisted Radical Prostatectomy

Eoin Dinneen, Clare Allen, Tom Strange, Daniel Heffernan-Ho, Jelena Banjeglav, Jamie Lindsay, John-Patrick Mulligan, Tim Briggs, Senthil Nathan, Ashwin Sridhar, Jack Grierson, Aiman Haider, Christos Panayi, Dominic Patel, Alex Freemna, Jonathan Aning, Rajendra Persad, Imran Ahmad, Lornezo Dutto, Neil Oakley, Alessandro Ambrosi, Tom Parry, Veeru Kasivisvanathan, Francesco Giganti, Greg Shaw, Shonit Punwani

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: extra-prostatic extension; magnetic resonance imaging; radical prostatectomy; nerve-sparing; prostate cancer; staging; diagnostic accuracy

Online: 6 January 2022 (10:05:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0289.v1

BRD9 Expression, Alteration, Survival And Pathway Analysis In 11 Independent Prostate Cancer Cohorts

Nafisa Barma, Timothy C Stone, Lina Maria Carmona Echeverria, Susan Heavey

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: BRD9; Prostate Cancer; SWI/SNF; Survival; pathways; signal transduction; human cohorts; targeted therapy

Online: 16 September 2021 (13:51:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0335.v2

Gender Differences in Urothelial Bladder Cancer. Effects of Natural Killer Lymphocyte Immunity

Charles T. Lutz, Lydia Livas, Steven R Presnell, Morgan Sexton, Peng Wang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Urothelial bladder cancer; Natural Killer Cells; Androgens; Immunosuppression; X Chromosome

Online: 15 September 2021 (12:21:27 CEST)

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Working Paper REVIEW

M2 Macrophage in Fibrosis and Kidney Graft Rejection

Reza Jafari, Motahareh Dargahi, Niloufar Taheri

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: M2 macrophages; Fibrosis; kidney; Graft rejection

Online: 8 September 2021 (11:24:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0108.v1

Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS). Part II

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Adrian M. E. Pilatz, Kurt G. Naber, Florian M. E. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women

Online: 6 September 2021 (17:02:05 CEST)

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Working Paper ARTICLE

External validation of the Briganti nomogram to predict lymph node invasion in prostate cancer - setting a new threshold value.

Bartosz Małkiewicz, Kuba Ptaszkowski, Klaudia Knecht, Adam Gurwin, Karol Wilk, Paweł Kiełb, Krzysztof Dudek, Romuald Zdrojowy

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; radical prostatectomy; pelvic lymph node dissection; lymph node invasion; preoperative nomogram

Online: 11 May 2021 (10:39:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0472.v1

Exosomes Derived from SIRT6 Transfected Urine-Derived Stem Cells Improves Renal Fibrosis

Rui Wang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: renal fibrosis; USCs; exosome; SIRT6

Online: 18 March 2021 (10:57:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0735.v1

Greek Version of the Acute Cystitis Symptom Score. Part I: Linguistic Validation

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Kurt G. Naber, Adrian Pilatz, Florian M. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Greek language; translation; acute cystitis symptom score; ACSS; cystitis; urinary tract infection; female pa-tients; diagnosis; patient-reported outcome

Online: 29 December 2020 (15:40:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0560.v1

Effects of Integrated Indirect Forest Therapy on Emotion, Fatigue, Stress, and Immune Function in Hemodialysis Patients

Hyoyoung Kang, Youngran Chae

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: hemodialysis; indirect forest therapy; emotion; fatigue; stress; heart rate variability; natural killer cells

Online: 22 December 2020 (12:42:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0484.v1

Validation of the American English Version of The Acute Cystitis Symptom Score

Jakhongir F. Alidjanov, Kurt G. Naber, Adrian Pilatz, Florian M. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; ACSS; cystitis; urinary tract infection; female patients; diagnosis; patient-reported outcome

Online: 18 November 2020 (16:35:23 CET)

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Working Paper ARTICLE

Methylation‐Based Reclassification of Bladder Cancer Based on Immune Cell Genes

Qizhan Luo, Thomas-Alexander Vögeli

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Immune cell; DNA CpGs; Bladder cancer; Subtype; mutation; CNV; Immune score; Immune Checkpoints

Online: 5 September 2020 (06:00:06 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202008.0292.v1

Granulomatosis with Polyangiitis Restricted to The Back Muscle: The First Case Report

Yu-Mi Lee, Sang Wan Chung

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ANCA-associated vasculitis; organ limited vasculitis; GPA

Online: 13 August 2020 (06:59:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0261.v1

Impact of COVID-19 on Urology Practice in Saudi Arabia

Meshari Alzahrani, Mohammad Alkhamees, Sulaiman Almutairi, Ahmed Aljuhayman, Sultan Alkhateeb

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Saudi Arabia; Urology; COVID-19; Telemedicine; Residency

Online: 11 August 2020 (09:47:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0104.v1

Trends in Antibiotic Resistance of Major Uropathogens

Falah Hasan Obayes AL-Khikani

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Urinary tract infection; antimicrobial agents; antibiotic resistance; E. coli; uropathogens; aminoglycosides

Online: 6 July 2020 (10:30:47 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202006.0314.v2

Semen Quality as a Potential Susceptibility Indicator to SARS-CoV-2 Insults in Polluted Areas

Luigi Montano, Ian Marc Bonapace, Francesco Donato, Pietro Massimiliano Bianco, Antonino Guglielmino, Marina Piscopo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: air pollution; COVID-19; semen quality; environmental marker; health marker; oxidative stress

Online: 6 July 2020 (09:48:39 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202006.0314.v1

Semen Quality as a Potential Susceptibility Indicator to SARS-CoV-2 Insults in Polluted Areas

Luigi Montano, Ian Marc Bonapace, Francesco Donato, Pietro Massimiliano Bianco, Antonino Guglielmino, Marina Piscopo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: air pollution; COVID-19; semen quality; environmental marker; health marker; oxidative stress

Online: 26 June 2020 (12:37:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0003.v1

Lower Thiol, Glutathione, and Glutathione Peroxidase Levels in Prostate Cancer: A Meta-Analysis Study

Nattanan Sajjaboontawee

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: antioxidants; oxidative stress; prostate cancer; benign prostatic hyperplasia; biomarkers; pathways

Online: 2 June 2020 (09:27:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0339.v1

Surgical Outcomes of Transvaginal Neobladder-Vaginal Fistula Repair after Radical Cystectomy with Ileal Orthotopic Neobladder

Wan Song, Dong Hyeon Lee

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Neobladder-vaginal fistula; Orthotopic urinary diversion; Radical cystectomy; Surgical outcomes; Vaginal approach

Online: 21 May 2020 (09:32:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0301.v2

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmed, Meng Tang, Junaid Wazir, Xiaohui Zhou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 24 April 2020 (04:30:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0301.v1

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Kashif Dar, Ziwei Liu, Junaid Zwzir, Meng Tang, Bilal Ahmed, Xiaohui Zhou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 17 April 2020 (13:50:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0280.v1

Effects of 2019 Novel Coronavirus on Male Reproductive System: A Retrospective Study

Jinzhuo Ning, Wei Li, Yuan Ruan, Yuqi Xia, Xiongfei Wu, Ke Hu, Xuhong Ding, Xiaojun Wu, Lilei Yu, Jianlin Zhou, Zhangfan Mao, Wanzhou Xu, Weimin Yu, Fan Cheng

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: COVID-19; 2019-nCoV; male reproductive system; a retrospective study

Online: 16 April 2020 (13:50:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0472.v1

Tratment With Folic Acid Increases Paraoxonase 1 Activity Thereby Improving Chronic Kidney Disease

Andressa Matsumoto, Michael Maes, Ana Paula Michelin, Kamila Bonifácio, Laura Semeão, Rafael Martins, João Pedrão, Estefânia Moreira, Vinicius Delfino, Décio Barbosa

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; folic acid; inflammation; oxidative stress; antioxidants; biomarkers

Online: 31 March 2020 (23:32:43 CEST)

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Working Paper CASE REPORT

Novel Coronavirus Infection and Acute Kidney Injury in Two Renal Transplant Recipients: Case Report

Qiuyu Li, Qin Cheng, Zhiling Zhao, Lin Zeng, Lan Zhu, Wei Guo, Chao Li, Junhong Wang, Shu Li, Ning Shen, Qinggang Ge

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: novel coronavirus infection; renal transplant; acute kidney injury

Online: 12 March 2020 (03:02:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0362.v1

Six-Month Physical Activity Versus Sclerostin and Interleukin 6 Concentration in Patients Receiving Renal Replacement Therapy by Hemodialysis – Pilot Study

Agnieszka Turoń-Skrzypińska, Grazyna Dutkiewicz, Malgorzata Marchelek-Mysliwiec, Violetta Dziedziejko, Krzysztof Safranow, Aleksandra Ryl, Kazimierz Ciechanowski, Iwona Rotter

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: physical activity; hemodialysis; sclerostin; interleukin 6

Online: 25 February 2020 (06:18:45 CET)

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Background: Chronic kidney disease and renal replacement therapy are associated with reduced physical activity, which may result in the presence of mineral-bone disorders and an increase in inflammation markers. The aim of the study was to assess the relationship between the performance of daily physical activity, expressed in the number of steps performed by patients undergoing hemodialysis and the concentration of selected biochemical parameters (SCL, IL-6). Materials and Methods: The study involved 33 patients aged 59.8 ± 9.8 years from the dialysis station at the Department of Nephrology, Transplantology and Internal Medicine PUM. Group C consisted of 30 people aged 54.9 (9.37), with GFR over 60 mL/min/1.73m. The study group was divided into S-N and N-S. Participants of the S-N group were assigned the task of performing the appropriate daily number of steps, and the N-S group was to perform spontaneous physical activity. The tasks were replaced after the third month of the research project. Physical activity was measured with pedometers. Anthropometric and biochemical parameters were assessed at baseline, after the third and sixth month of the study. Descriptive statistics, intergroup comparisons using Mann-Whitney U or Kruskal-Wallis tests and Spearman correlation analysis were performed. The level of significance was set at p≤0.005. Results: Patients from the S-N and N-S groups compared to group C performed significantly fewer steps in the 0-3 month and 4-6 month periods. In the S-N group, with an increase in steps performed in the period of 4-6 months, sclerostin levels dropped in the 6th month. In group C, the concentration of SCL and IL-6 decreased with the increase in the number of steps taken. Only in group C the waist circumference decreased with the increase of the number of steps performed. Conclusions: Patients receiving renal replacement therapy by hemodialysis showed significantly lower physical activity compared to people without kidney disease. Performing bigger number of steps can lower sclerostin levels in hemodialysis patients.

Preprint ARTICLE | doi:10.20944/preprints202002.0286.v1

AR-V7 Positivity Varies with Circulating Tumor Cell (CTC) Enrichment and Novel CTC Enrichment Is Able to Reduce AR-V7 False Positivity

Takehiko Nakasato, Chiho Kusaka, Mika Ota, Yuki Hasebe, Kumiko Ueda, Tsutomu Unoki, Kazuhiko Oshinomi, Jun Morita, Yoshiko Maeda, Takeshi Shichijo, Michio Naoe, Yoshio Ogawa

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: AR-V7; Androgen receptors; Docetaxel; Cabazitaxel; Abiraterone; Enzalutamide

Online: 20 February 2020 (06:45:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0380.v1

Physical Activity in Elderly Kidney Transplant Patients with Multiple Renal Arteries

Armando Calogero, Caterina Sagnelli, Gaia Peluso, Antonello Sica, Maria Candida, Silvia Campanile, Gianluca Minieri, Paola Incollingo, Massimiliano Creta, Luigi Pelosio, Vincenzo Tammaro, Alessandro Scotti, Akbar Jamshidi, Marcello Caggiano, Evangelista Sagnelli, Concetta Anna Dodaro, Nicola Carlomagno, Michele Santangelo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: physical activity; kidney transplantation; elder age; vascular anomalies; marginal kidneys

Online: 29 December 2019 (11:06:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0030.v1

A Pilot Randomized Crossover Trial Assessing the Safety and Short-Term Effects of Walnut Consumption by Patients with Chronic Kidney Disease

Pilar Sanchis, Marilisa Molina, Francisco Berga, Elena Muñoz, Regina Fortuny, Antonia Costa-Bauza, Felix Grases, Juan Manuel Buades

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: walnuts; kidney disease; phytate; dietary intervention; phosphorous

Online: 4 November 2019 (02:59:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0017.v1

Accuracy of Magnetometer-Guided Sentinel Lymphadenectomy after Intraprostatic Injection of Superparamagnetic Iron Oxide Nanoparticles in Prostate Cancer: The SentiMag Pro II Study

Alexander Winter, Svenja Engels, Philipp Goos, Marie-Christin Süykers, Stefan Gudenkauf, Rolf-Peter Henke, Friedhelm Wawroschek

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: lymphadenectomy; magnetometer; prostate cancer; sentinel lymph node dissection; spion; superparamagnetic iron oxide nanoparticles

Online: 3 November 2019 (15:38:28 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0218.v1

Membranous Glomerulonephritis: Overview of the Role of Serum and Urine Biomarkers in the Management

Sadiq Mu'azu Maifata, Rafidah Hod, Nor Fadhina Zakaria, Fauzah Abd Ghani

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: M-type phospholipase A2; Thrombospondin type containing domain A7; Retinol-binding protein; Beta-2 microglobulin; membranous glomerulonephritis; neutral endopeptidase

Online: 19 September 2019 (04:59:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0142.v1

Chronic Kidney Disease–Associated Pruritus is Caused by Dysregulated Ion Channels in Sensory Neurons

Akishi Momose, Michihiko Yabe, Shigetoshi Chiba, Kenjirou Kumakawa, Yasuo Shiraiwa, Hiroki Mizukami

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: uremic pruritus; ion channels; cell signaling; Cav3.2 calcium channel; RT-PCR; skin

Online: 14 September 2019 (19:00:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0191.v1

General Anesthetic Agents and Renal Function after Nephrectomy

Ho-Jin Lee, Jinyoung Bae, Yongsuk Kwon, Hwan Suk Jang, Seokha Yoo, Chang Wook Jeong, Jin-Tae Kim, Won Ho Kim

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: nephrectomy; acute kidney injury; chronic kidney disease; sevoflurane; desflurane; propofol

Online: 19 August 2019 (03:47:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0090.v1

Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset

Masari Otsuki, Noboru Fukuda, Takashi Inoue, Takayuki Mineshige, Tomoyasu Otsuki, Shu Horikoshi , Morito Endo, Masanori Abe

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: human; TGF-β1; pyrrole-imidazole polyamide; renal disease; marmoset

Online: 7 August 2019 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0059.v1

Predicting Residual Function in Hemodialysis and Hemodiafiltration – A Population Kinetic, Decision Analytic Approach

Mohammad Achakzai, Christos Argyropoulos, Maria Eleni Roumelioti

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Residual Renal Function, Middle Molecules, Beta 2 Microglobulin, Cystatin C, Population Kinetic Model, Dialysis, Simulator Calibration Framework, Equation, Biomarkers, Urea Clearance

Online: 3 July 2019 (09:42:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0271.v1

The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Nationwide Population-Based Study

Yookyung Lee, SuYeon Kwon, JongJoo Moon, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; disease progression; end stage renal disease; mortality; health-related behaviors; physical activity; smoking; alcohol

Online: 26 June 2019 (15:38:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0142.v1

NGF Induces Proliferation and Aggressiveness In Prostate Cancer Cells.

Marzia Di Donato, Gustavo Cernera, Antimo Migliaccio, Gabriella Castoria

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: NGF/TrkA signaling; mitogenesis; invasiveness; EMT; 3D models; castrate-resistant prostate cancers

Online: 11 April 2019 (12:55:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0143.v1

The Impact of Tumor Eco-Evolution in Tumor Sampling

Estibaliz Lopez-Fernandez, Jose I. Lopez

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: clear cell renal cell carcinoma; tumor evolution; tumor ecology; intratumor heterogeneity; multisite tumor sampling; targeted therapy

Online: 6 November 2018 (13:30:54 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201810.0472.v1

The Role of Vitamin D and Oxidative Stress in Chronic Kidney Disease

Keith C. Norris, Opeyemi Olabisi, M. Edwina Barnett, Yuan-Xiang Meng, David Martins, Chamberlain Obialo, Jae Eun Lee, Susanne B. Nicholas

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: vitamin D; oxidative stress; kidney disease, disparities

Online: 22 October 2018 (05:42:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0077.v1

Impact of Sarcopenia as a Prognostic Biomarker of Bladder Cancer

Hiroshi Fukushima, Kosuke Takemura, Hiroaki Suzuki, Fumitaka Koga

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: sarcopenia; prognosis; biomarker; bladder cancer; urothelial carcinoma

Online: 3 August 2018 (16:05:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0424.v1

The endoscopic Botulinum toxin-A injections in equally efficient in the treatment of neurogenic bladder dysfunctions in children in different age groups. Single centre experience after more than 550 procedures.

Paweł Kroll, Ewa Gajewska, Beata Kasprowicz, Jerzy Harasymczuk, Magdalena Sobieska

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: neurogenic bladder, botulinum toxin, bladder overactivity, urodynamics, child

Online: 23 July 2018 (12:48:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0384.v1

Moderate Effect of Flavonoids on Vascular and Renal Function In Spontaneously Hypertensive Rats

María Dolores Paredes, Paola Romecín, Noemi Atucha, Francisco O’Valle, Julian Castillo, M. Clara Ortiz, Joaquin Garcia-Estañ

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Flavonoids, nitric oxide, heart, kidney, sodium balance, phenylephrine, acetylcholine

Online: 20 July 2018 (12:57:00 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201801.0227.v1

An Ambiguous Case of Abdominal Pain involving Renal Artery Thrombosis with Renal Infarction

Muhammad Shohel Almamun, Abrar Munir, Ali Reza Raza, Sakina Koubeh, Abu zour Hassan, Hesham Kaawan, Sarah Moore, Ramneet Khurana

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Lactate dehydrogenase (LDH), Computed Tomography (CT), Glomerular filtration rate (GFR), C reactive protein (CRP), Angiotensin converting enzyme inhibitor (ACEI) Angiotensin receptor blocker (ARB), Kidney Urinary bladder ( KUB), Dimercapto Succinic Acid (DMSA)

Online: 24 January 2018 (11:41:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0196.v1

Relationship between Response to PDE5 Inhibitors and Penil Duplex Doppler Ultrasound in Erectile Dysfunction

Ercan Ogreden, Ural Oğuz, Erhan Demirelli, Alptekin Tosun, Orhan Yalçın

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: comorbid diseases; erectile dysfunction; penile duplex doppler ultrasound; penile pathology; phosphodiesterase type 5 inhibitors

Online: 22 January 2018 (09:03:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0043.v1

Magnetic Marking and Intraoperative Detection of Primary Draining Lymph Nodes in High-Risk Prostate Cancer Using Superparamagnetic Iron Oxide Nanoparticles: Additional Diagnostic Value?

Alexander Winter, Svenja Engels, Lena Reinhardt, Clara Wasylow, Holger Gerullis, Friedhelm Wawroschek

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: superparamagnetic iron oxide nanoparticles (SPION); prostate cancer; sentinel node; magnetometer; lymphadenectomy

Online: 7 November 2017 (02:50:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0097.v1

The Impact of Pelvic Floor Muscles Exercises with and without Synergistic Muscles on Quality of Life of Women with Stage I Stress Urinary Incontinence

Magdalena Ptak, Agnieszka Brodowska, Sylwester Ciećwież, Iwona Rotter

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: LUTS; stress urinary incontinence; perimenopause; pelvic floor

Online: 27 February 2017 (17:41:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0089.v1

Estimation of the Daily Salt Intake by 24-Hour Urinary Sodium Excretion in Morocco: A Pilot Study

Abdelfettah Derouiche, Younes El-Kardi, Karima Mohtadi, Ali Jafri

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: hypertension; salt intake; urinary excretion; Morocco

Online: 17 November 2016 (10:49:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0027.v1

Vitamin C Supplementation and Hyperuricemia: Fact or Hoax?

Firas S. Azzeh, Abrar H. Al-Hebshi, Haya D. Al-Essimii, Mohammed A. Alarjah

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: vitamin C; hyperuricemia; gout; glomerular filtration rate

Online: 3 November 2016 (10:49:06 CET)

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Medicine and Pharmacology