Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management

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Version 1 : Received: 31 May 2023 / Approved: 1 June 2023 / Online: 1 June 2023 (08:13:11 CEST)

How to cite: Shetty, A.; Delanerolle, G.; Cavalini, H.; Qui, Y.; Boyd, A.; Bouchareb, Y.; Thillainathan, A.; Kim, S.; Phiri, P.; Shi, J. A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management. Preprints 2023, 2023060063. https://doi.org/10.20944/preprints202306.0063.v1 Shetty, A.; Delanerolle, G.; Cavalini, H.; Qui, Y.; Boyd, A.; Bouchareb, Y.; Thillainathan, A.; Kim, S.; Phiri, P.; Shi, J. A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management. Preprints 2023, 2023060063. https://doi.org/10.20944/preprints202306.0063.v1

Abstract

Background: Chronic, non-cancer pain represents a serious public health and economic issue affecting approximately 20% of the global population. Chronic pain can affect many aspects of patient’s lives, including mental health, employment, and relationships. Current medical management is largely focussed on investigating and managing acute pain. Patients and clinicians are now increasingly aware of the potential benefits of combined treatments or complex interventions in alleviating chronic pain. These approaches include both physical interventions, such as exercise or yoga, as well as psychological support including cognitive behavioural therapy (CBT) and talking therapies. Methods: This study used network meta-analyses to explore the prevalence of complex interventions in pain management, and the effects of these interventions on quality of life, using outcome measures including intensity of chronic pain, assessment of functional disability and participant’s psychological state. Results: Psychological interventions were associated with improvements in pain intensity and depression. Exercise and manipulation technique-based treatments provided a statistically significant reduction in pain intensity. This effect was enhanced when exercise and CBT were combined. Mensendieck somatocognitive therapy (MSCT) plus standard gynaecological treatment (STGT) treatments appeared to have a better effect on chronic pain than multimodal exercise plus CBT treatment. Combined MSCT and STGT treatment, and multimodal exercise plus CBT treatments, reduced pain intensity, whilst MSCT+STGT treatments had a slightly better effect than exercise plus CBT treatment.Conclusions: Complex interventions have become more popular with patients as the risks associated with other interventions including surgery and pharmacological management have become better understood. These interventions can have a significant positive effect both on the physical and psychological health of patients. The analysis presented in this study suggests that further work is warranted in this area and that additional studies are required, both in more geographically diverse locations, and with larger cohorts.

Keywords

chronic pain; non-pharmaceutical pain management; interventions

Subject

Medicine and Pharmacology, Anesthesiology and Pain Medicine

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