Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202407.1705.v1

MixDeR: A SNP Mixture Deconvolution Workflow for Forensic Genetic Genealogy

Rebecca Mitchell, Michelle Peck, Erin Gorden, Rebecca Just

Subject: Biology And Life Sciences, Other Keywords: mixtures; SNPs; forensic genetic genealogy (FGG); investigative genetic genealogy (IGG); Kintelligence; software

Online: 24 July 2024 (14:45:02 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1346.v1

Bibliometric Analysis on Genetic Factors of Osteoarthritis Pathogenesis: Characteristics and Trends from 2014 to 2023

Yangguang Lu, Feitian Ni, Yiran Bu, Jialing Lou, Bohuai Yu, Hongzhi Zhang, Haoyang Li, Yige Zhang, Hantao Hu, Di Lu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: bibliometrics; genetic factors; Osteoarthritis

Online: 18 December 2023 (13:42:11 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0697.v1

Selection of Short-Day Strawberry Genotypes through Multivariate Analysis

Thiago Rutz, Juliano Tadeu Vilela de Resende, Keny Henrique Mariguele, Ricardo Antônio Zeist, Andre Luiz Biscaia Ribeiro da Silva

Subject: Biology And Life Sciences, Horticulture Keywords: Fragaria × ananassa; genetic parameters; selection index; clusterin

Online: 11 July 2023 (08:40:08 CEST)

Show abstract| Download PDF| Share

Strawberry is produced in tropical regions using imported cultivars adapted to temperate and subtropical climates. These cultivars, under tropical conditions, produce below their genetic potential. Through multivariate analyses, the objective was to evaluate and select short-day strawberry genotypes based on intraspecific crosses, product characteristics, and fruit quality. The genotypes were obtained from the cross between 'Camino Real' (female parent) and the first-generation genotypes RVCA16, RVCS44, RVFS06, RVFS07, and RVDA11 (male parent), obtained in previous selections. The experimental design consisted of augmented blocks with standard controls, consisting of first-generation genotypes and commercial cultivars. The fruits were harvested and evaluated for productivity and post-harvest characteristics: Total Fruit Mass (MTF); Total Number of Fruits (TFN); Average Fruit Mass (AFM); Commercial Fruit Mass (CFM); Fruit Commercial Number (CFN); Average Commercial Mass of Fruits (ACFM); Total Soluble Solids (TSS); Firmness (F); Brightness (L); Hue Angle (°Hue); Chroma (C). The selection index of Mulamba and Mock (1978) was used with an intensity of 3% to obtain superior genotypes and submitted to multivariate analysis for comparative purposes. Of the 1500 genotypes evaluated, it was possible to select 44 genotypes with characteristics superior to the 13 controls. The RVDA11CR59 genotype showed better values for the attributes of interest, but the RVCS44CR population, from the cross between 'Camino Real' × RVCS44 ('Camarosa' × 'Sweet Charlie'), obtained the highest number (16) of individuals among those selected. Significant traits had high heritability but were not necessarily reflected in high selection gain. Coefficients of genetic variation were high, indicating sufficient genetic variability to select genotypes for these traits. When multivariate analyses were used, it was possible to group the selected genotypes into the same cluster according to the similarity and balance in the responses to the evaluated variables, demonstrating that these analyses help other parameters choose superior genotypes. The multivariate analysis allowed the selection of more balanced genotypes for production and post-harvest traits for tropical climates.

Preprint ARTICLE | doi:10.20944/preprints201908.0010.v1

Kalina-Flash Cycle Performance Analysis and Parametric Optimization

Raveendra Nath R, C. Vijaya Bhaskar Reddy, K.Hemachandra Reddy

Subject: Engineering, Mechanical Engineering Keywords: genetic algorithm; Kalina cycle; energy efficiency; Exergy efficiency;

Online: 1 August 2019 (06:13:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0083.v1

Resolving Relationships of Bolbitis sinensis Species Complex Using RAD Sequencing

Liyun Nie, Yuhan Fang, Zengqiang Xia, Xueying Wei, Zhiqiang Wu, Yuehong Yan, Faguo Wang

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Bolbitis; Species delimitation; Phylogenetic analysis; Genetic diversity and differentiation; RAD sequencing

Online: 3 June 2024 (12:10:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202305.1454.v1

Relevance of Genetic Identification and Kinship Analysis in Human and Natural Catastrophes – A Review

Alejandra Real-Picado, Luis Diaz, Cláudia Gomes

Subject: Medicine And Pharmacology, Other Keywords: Catastrophes; Genetic identification; Kinship analysis; DNA degradation

Online: 22 May 2023 (03:01:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0666.v1

Correlational Analysis of Genetic Mutations and Galectin Levels in Breast Cancer Patients

Ella G. Markalunas, David H. Arnold, Avery T. Funkhouser, Julie C. Martin, Michael Shtutman, William J. Edenfield, Anna V. Blenda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast Cancer; Genomics; Genetic Mutation; Biomarker; Galectins; Metastasis

Online: 10 May 2024 (11:30:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Background: Galectins are innate immune system regulators, associated with disease progression in cancer. This paper aims to investigate the correlation between mutated cancer-critical genes and galectin levels in breast cancer patients to determine whether galectins and genetic profiles can be used as biomarkers for disease and potential therapy targets. Materials and Methodology: Prisma Health Cancer Institute’s Biorepository provided seventy-one breast cancer patient samples, including all four stages as well as major molecular subtypes and histologies of breast cancer. Hotspot mutation statuses of cancer-critical genes were determined using multiplex PCR in tumor samples from the same patients by Precision Genetics and the University of South Carolina Functional Genomics Core Facility. The galectin levels of patients’ sera were analyzed using enzyme-linked immunosorbent assay (ELISA) to measure the concentrations of galectins-1, -3, and -9. Analysis was performed using JMP software to compare mean and median serum galectin levels between samples with and without specific cancer-critical genes including pooled t-test, Wilcoxon test, ANOVA, Tukey’s range test, and Steel Dwass Method (α=0.05). Results: Our analysis indicates that KIT mutations correlate with elevated serum levels of galectin-1 and -9 in patients with breast cancer. In patients with Luminal A subtype, FLT3 mutation correlates with lower serum galectin-1 and -9 levels and TP53 mutations correlate with higher serum galectin-3 levels. Patients with invasive ductal carcinoma had significantly higher serum galectin-3 levels than patients with ductal carcinoma in situ. Patients with both TP53 and PIK3CA mutations exhibit elevated serum galectin-3 levels, while patients with one or neither mutation show no significant difference in serum galectin-3 levels. In addition, metastatic breast cancer samples were more likely to have KIT or PIK3CA mutation compared to primary breast cancer samples. Conclusion: The relationship between genetic mutations and galectin levels has the potential to identify appropriate candidates for combined therapy, targeting genetic mutations and galectins. Further understanding of the effect of genetic mutations and galectin levels on cancer progression and metastasis could aid in the search for biomarkers for breast cancer diagnosis, disease progression, and prognosis.

Preprint REVIEW | doi:10.20944/preprints202407.2564.v1

The Genetic Analysis and Clinical Therapy in Lung Cancer: Current Advances and Future Directions

Angela Rina, Debora Maffeo, Francesca Minnai, Martina Esposito, Maria Palmieri, Viola Bianca Serio, Diletta Rosati, Francesca Mari, Elisa Frullanti, Francesca Colombo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung cancer; genetic discoveries; target therapy; personalized treatments

Online: 31 July 2024 (14:29:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1482.v1

Comparative Proteomic Analysis of Toxoplasma gondii RH Wild-Type and Four SRS29B (SAG1) Knock-Out Clones Reveals Significant Differences between Individual Strains

Kai Pascal Alexander Hänggeli, Andrew Hemphill, Norbert Müller, Manfred Heller, Uldry Anne-Christine, Sophie Braga-Lagache, Joachim Müller, Ghalia Boubaker

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic manipulation; pleiotropic effects; systems biology

Online: 22 May 2023 (09:03:52 CEST)

Show abstract| Download PDF| Supplementary Files| Share

In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a suitable tool to identify the role of specific genes. The general consensus implies that only the gene of interest is affected by the knock-out. Is this really the case? In a previous study, we have generated knock-out (KO) clones of TgRH88_077450 (SRS29B; SAG1) which differed in the numbers of integrated dihydrofolate-reductase-thymidylate-synthase (MDHFR-TS) drug-selectable marker. Clones 18 and 33 had a single insertion of MDHFR-TS within SRS29B. Clone 6 was disrupted by the insertion of a short unrelated DNA-sequence, but the marker was integrated elsewhere. In clone 30, the marker was inserted into SRS29B and several other MDHFR-TS copies were found in the genome. KO and wild-type (WT) tachyzoites had similar shape, dimensions and vitality. This prompted us to investigate the impact of the genetic engineering as such on the overall proteome patterns of the four clones as compared to the respective WT. Comparative shotgun proteomics of the five strains was performed. Overall, 3236 proteins were identified. Principal component analysis of the proteomes revealed five distinct clusters corresponding to the five strains by both iTop3 and iLFQ algorithms. Detailed analysis of the differentially expressed proteins revealed that the target of the KO, srs29B, was lacking in all KO clones. Besides this protein, twenty other proteins were differentially expressed between KO clones and WT or between different KO clones. The protein exhibiting the highest variation between the five strains was srs36D encoded by TgRH_016110. The deregulated expression of SRS36D was further validated by quantitative PCR. Moreover, the transcript levels of three other selected SRS genes, namely SRS36B, SRS46, and SRS57 exhibited significant differences between individual strains. These results indicate that knocking out a given gene may affect the expression of other genes. Therefore, care must be taken when specific phenotypes are regarded as a direct consequence of the KO of a given gene.

Preprint ARTICLE | doi:10.20944/preprints201607.0015.v1

Design and analysis of the redundancy allocation problem using a greedy technique

Souradeep Nanda, SIDDHARTH SHARMA, Kundnani Piyush, ANAND SHANKER DEB, C. Vijayalakshmi

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Redundancy Allocation Problem, Genetic Algorithm, Simulated Annealing, Greedy Algorithm

Online: 9 July 2016 (05:13:42 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1578.v1

Genetic Diversity Analysis of Guangxi Kumquat (Fortunella Swing) Germplasm Using SRAP Molecular Markers

Binghao Liu, Ping Ding, Rongchun Ye, Yi Li, Shanhan Ou, Alessandra Gentile, Xianfeng Ma, Ziiu Deng

Subject: Biology And Life Sciences, Horticulture Keywords: Guangxi kumquat; Germplasm resources; Diversity; SRAP markers; Genetic analysis

Online: 23 May 2023 (05:06:39 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202111.0533.v1

Unlocking the Complete Chloroplast Genome of a Native Tree Species from the Amazon Basin, Capirona (Calycophyllum spruceanum Benth., Rubiaceae), and Its Comparative Analysis with Other Ixoroideae Species

Carla L. Saldaña, Pedro Rodriguez-Grados, Julio C. Chávez-Galarza, Shefferson Feijoo, Juan Carlos Guerrero Abad, Héctor V. Vásquez, Jorge L. Maicelo, Jorge H. Jhoncon, Carlos I. Arbizu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chloroplast; genetic resources; genomics capirona; phylogenomics

Online: 29 November 2021 (12:32:24 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202408.2221.v1

Human-Activity-Mediated Gene Flows Are Involved in the Establishment of Magnaporthe oryzae Population Structures: A Population Genomic Analysis

Guohua Duan, Yuchan Liu, Cheng Zheng, Kaihui Yu, Jiahui Xie, Baohua Wang, Huakun Zheng, Wei Tang, Jiandong Bao, Zonghua Wang, Meilian Chen

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Magnaporthe oryzae; population structure; genetic diversity; gene flow

Online: 30 August 2024 (08:36:22 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0568.v1

Risk Factor Analysis and Genetic Parameter Estimation for Pre-weaning Mortality Traits in Boer, Spanish, and Crossbred Goat Kids

Liuhong Chen, William Foxworth, Scott Horner, Mustafa Hitit, Negusse Kidane, Erdogan Memili

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: pre-weaning mortality; risk factors; goat; genetic parameter

Online: 11 March 2024 (17:44:10 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0826.v1

SSR Based Genetic Diversity Analysis and Population Structure of Proso millet (Panicum miliaceum L.) in Kazakhstan

Meisam Zargar, Elmira Dyussibayeva, Aidyn Orazov, Aiym Zeinullina, Irina Zhirnova, Gulzat Yessenbekova, Aiman Rysbekova

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: proso millet collection; genetic diversity; SSR markers; agronomic traits

Online: 13 September 2023 (10:37:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1721.v1

Deciphering Double-Walled Corrugated Board Geometry Using Image Analysis and Genetic Algorithm

Maciej Rogalka, Jakub Krzysztof Grabski, Tomasz Garbowski

Subject: Engineering, Mechanical Engineering Keywords: corrugated board; double-walled; flute parameters; cross-section image; genetic algorithm

Online: 24 January 2024 (09:29:32 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201807.0443.v1

Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis

Joel Ferreira Santiago Junior, Claudia Cristina Biguetti, Mariza Akemi Matsumoto, Guilherme Abu Halawa Kudo, Raquel Barroso Parra da Silva, Patrícia Pinto Saraiva, Walid D. Fakhouri

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: genetic factors; dental implants; bone quality; bone regeneration; success rate

Online: 24 July 2018 (06:01:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0712.v1

Prevalence and Genetic Analysis of Porcine Circovirus Type 2 That Circulated between 2014 and 2021 in Jiangsu, China

Qi Xiao, Meng Qu, Jianping Xie, Cigen Zhu, Yuping Shan, Aihua Mao, Wenxian Qian, Jiaping Zhu, Jiahui Guo, Dong Lang, Jiaqiang Niu, Libin Wen, Kongwang He

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: porcine circovirus type 2; Jiangsu Province; genetic analysis; genotype

Online: 9 September 2024 (23:42:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201904.0321.v1

Whole Genome Diversity, Population Structure and Linkage Disequilibrium Analysis of Chickpea (Cicer arietinum L.) Genotypes Using Genome-Wide DArTseq-Based SNP Markers

Somayeh Farahani, Mojdeh Maleki, Rahim Mehrabi, Homayoun Kanouni, Reza Talebi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chickpea; genetic diversity; linkage disequilibrium; DArTseq-SNP markers

Online: 29 April 2019 (07:56:52 CEST)

Show abstract| Download PDF| Share

Characterization of genetic diversity, population structure and linkage disequilibrium is prerequisite for proper management of breeding programs and conservation of genetic resources. In this study, 186 chickpea genotypes including advanced “Kabuli” breeding lines and Iranian landrace “Desi” chickpea genotypes were genotyped using DArTseq-Based SNP markers. Out of 3339 SNPs, 1152 markers with known chromosomal position were selected for genome diversity analysis. The number of mapped SNP markers varied from 52 (LG8) to 378 (LG4), with an average of 144 SNPs per linkage group. The chromosome size that covered by SNPs varied from 16236.36 kbp (LG8) to 67923.99 kbp (LG5), while LG4 showed higher number of SNPs, with an average of 6.56 SNPs per Mbp. Polymorphism information content (PIC) value of SNP markers ranged from 0.05 to 0.50, with an average of 0.32, while the markers on LG4, LG6 and LG8 showed higher mean PIC value than average. Un-weighted Neighbor Joining cluster analysis and Bayesian-based model population structure grouped chickpea genotypes into four distinct clusters. Principal component analysis (PCoA) and Discriminant Analysis of Principal Component (DAPC) results were consistent with that of the cluster and population structure analysis. Linkage disequilibrium (LD) was extensive and LD decay in chickpea germplasm was relatively low. A few markers showed r²≥0.8, while 2961 pairs of markers showed complete LD (r²=1) and a huge LD block was observed on LG4. High genetic diversity and low kinship value between pairs of genotypes suggesting the presence of a high genetic diversity among studied chickpea genotypes. This study also demonstrated the efficiency of DArTseq-based SNP genotyping for large scale genome analysis in chickpea. The genotypic markers provided in this study are useful for various association mapping studies when combined with phenotypic data of different traits such as seed yield, abiotic and biotic stresses and therefore can be efficiently used in breeding programs to improve chickpea.

Preprint COMMUNICATION | doi:10.20944/preprints202403.0549.v1

Preliminary Analysis of the Development of the Breeding Program of Peruvian Paso Horse under Field Conditions

Jorge Luis Vilela, Paola Quintana, María Lourdes Velarde, Rosario Gonzales, Teresa Vargas, José Dextre

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Peruvian paso horse; heritability; genetic correlations; repeatability; overreach; term; acuteness

Online: 11 March 2024 (09:47:24 CET)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202401.1175.v1

The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics

Laynie Dratch, Tanya M Bardakjian, Kelsey Johnson, Nareen Babaian, Pedro Gonzalez-Alegre, Lauren Elman, Colin Quinn, Michael H Guo, Steven S Scherer, Defne A Amado

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurogenetics; genetic testing; genetic counseling; neuromuscular

Online: 16 January 2024 (06:25:11 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202209.0263.v1

Phenotypic Variations, Environmental Effects and Genetic Basis Analysis of Grain Elemental Concentrations in Rice (Oryza sativa L.) for Improving Human Nutrition

Yheni Dwiningsih, Jawaher Alkahtani

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: rice; nutrient elements; toxic elements; phenotypic variance; genetic basis

Online: 19 September 2022 (05:31:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0671.v1

Long-Term Pedigree Analysis: An Effective Tool for Managing Congenital Malformations in Cattle

Jindřich Čítek, Libor Večerek, Soňa Šlosárková, Petr Fleischer, Daniela Schröffelová, Josef Kučera

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic health; surveillance program; aplasia genitalis; atresia ani et recti; hernia cerebralis

Online: 26 March 2021 (15:09:33 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0571.v1

Streamlined Two-Step Fragment Analysis PCR and Exome Sequencing of RFC1 for Diagnostic Testing of Suspected CANVAS Patients

Helena Jaklič, Ivana Babič Božović, Borut Peterlin, Anja Kovanda

Subject: Medicine And Pharmacology, Other Keywords: Cerebellar ataxia neuronopathy and vestibular areflexia syndrome (CANVAS); RFC1; genetic testing; genetic diagnostics, ; fluorescent PCR; repeat-primed PCR; repeat-expansion; fragment length analysis

Online: 11 March 2024 (05:36:41 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0749.v1

Path Analysis of Agro Technological Traits Associated with Sugar Yield in Different Sugar Beet (Beta vulgaris L.) Monogerm Cultivars

Farhang Movloudi, Esmail Nabizadeh, Heydar Azizi, Reza Afshar, Saman Yazdanseta, Masoud Hashemi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Cause and effect relationships; Genetic correlation; Sugar Beet Final yield

Online: 10 September 2024 (12:06:55 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0577.v1

Admixture Analysis Using Genotyping-by-Sequencing Reveals Genetic Relatedness and Parental Lineage Distribution in Highbush Blueberry Genotypes and Cross Derivatives

Krishnanand P. Kulkarni, Nicholi Vorsa, Purushothaman Natarajan, Sathya Elavarthi, Massimo Iorizzo, Umesh K. Reddy, Kalpalatha Melmaiee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: vaccinium; admixture analysis; genotyping-by-sequencing; genetic relatedness; Blueberry germplasm

Online: 23 November 2020 (09:48:11 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0481.v1

IRAPs in Combination with Highly Informative ISSRs Confer Effective Potentials for Genetic Diversity and Fidelity Assessment in Rhododendron

Sulin Wen, Hong Zhao, Manying Zhang, Guang Qiao, Xiaohui Shen

Subject: Biology And Life Sciences, Plant Sciences Keywords: genetic fidelity; genetic diversity; IRAP; ISSR; Rhododendron

Online: 28 March 2023 (09:56:04 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202407.1531.v1

Pregnancy Planning and Genetic Testing: Exploring Advantages, and Challenges

Ulf Kristoffersson, Maria Johansson-Soller

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Pregnancy planning and genetic testing; preconception genetic testing; genetic disorders; reproductive healthcare; genetic counselling; ethical and societal considerations

Online: 18 July 2024 (16:48:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0351.v2

Analysis of the Infiltration Complex System Using a Novel GSA-Hybrid for Automatic Calibration Focused at Civil Construction

Domingo_Stalin Aguero_Martinez, Thiago Murari, Marceelo Moret

Subject: Environmental And Earth Sciences, Soil Science Keywords: Infiltration; GSA-HYBRID Algorithm; GSA Algorithm; Genetic Algorithms; Calibration; Characteristic Curve

Online: 27 June 2022 (11:18:05 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.2266.v1

Inherited Metabolic Diseases From Past to Present: A Bibliometric Analysis (1968-2023)

Banu Kadıoğlu Yılmaz, Ayşe Hümeyra Akgül

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Inherited metabolic disease; bibliometric study; newborn screening; gene therapy; metabolomics; molecular genetic analysis; phenylketonuria

Online: 30 June 2023 (14:24:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1357.v1

Revisiting Classical Controllers Design and Tuning with Genetic Programming

Carlos A. García, Manel Velasco, Cecilio Angulo, Pau Marti, Antonio Camacho

Subject: Engineering, Control And Systems Engineering Keywords: genetic algorithm; genetic programming; control design; control tuning

Online: 22 November 2023 (07:49:09 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1532.v1

Adapt the Parameters of RBF Networks Using Grammatical Evolution

Ioannis G. Tsoulos, Alexandros Tzallas, Evangelos Karvounis

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Neural networks; Genetic algorithms; Genetic programming; Grammatical evolution

Online: 22 September 2023 (08:37:54 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202007.0583.v1

A Systematic Review on Extreme Phenotype Strategies to Search for Rare Variants in Genetic Studies of Complex Disorders

Sana Amanat, Teresa Requena, Jose Antonio Lopez-Escamez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic association studies; extreme phenotype; genetic epidemiology; tinnitus

Online: 24 July 2020 (13:43:00 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1687.v1

Virulence of Circulating Marek’s Disease Virus Strains in Vaccinated Chicken Flocks in Taiwan: Data on Genetic Analysis of the meq Oncogene

Ming-Chu Cheng, Guan-Hua Lai, Yi-Lun Tsai, Yi-Yang Lien

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Marek’s disease virus; vaccinated chicken flocks; meq oncogene; genetic characteristics; virulence

Online: 25 September 2023 (11:24:28 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202403.0614.v1

Population Structure and Genetic Diversity of Ajuga Arabica in Saudi Arabia: A Comparative Analysis of DNA and Gene Sequences

Mohammad Odah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Ajuga arabica, Genetic Diversity, Population Structure, DNA Sequence, Gene Sequence.

Online: 11 March 2024 (11:02:33 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.1729.v1

Assessment of Diversity and Genetic Variability of Guava (Psidium guajava) by Means of Microsatellite Markers in Montería, Córdoba-Colombia

Enrique Pardo-Perez, Elizabeth Ramos-Rivero, Luis Causil-Vargas

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic diversity; genetic variability; microsatellites; allele frequencies; population structure

Online: 28 November 2023 (08:08:48 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Operationalising Forensic Genetic Genealogy in an Australian Context

Nathan Scudder, Runa Daniel, Jennifer Raymond, Alison Sears

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: forensic genetic genealogy; investigative genetic genealogy; DNA; forensic DNA

Online: 1 August 2020 (16:29:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0139.v1

Spatial Transcriptomic Analysis of Focal and Normal Areas of Myocyte Disarray in Human Hypertrophic Cardiomyopathy

Jason Laird, Gayani Perera, Rebecca Batorsky, Hongjie Wang, Knarik Arkun, Michael T. Chin

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Hypertrophic Cardiomyopathy; spatial transcriptomics; single nucleus RNA-sequencing; gene expression; bioinformatics; cardiovascular disorder; genetic disorder

Online: 4 July 2023 (05:18:51 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Hypertrophic Cardiomyopathy (HCM) is a common inherited disorder that can lead to heart failure and sudden cardiac death, characterized at the histological level by focal areas of myocyte disarray, hypertrophy and fibrosis, and few disease-targeted therapies exist. To identify, focal, spatially restricted alterations in transcriptional pathways and reveal novel therapeutic targets, we performed a spatial transcriptomic analysis of areas of focal myocyte disarray compared to areas of normal tissue, using a commercially available platform (GeoMx, nanoString). We analyzed surgical myectomy tissue from four patients with HCM and control interventricular septum tissue from two unused organ donor hearts that were free of cardiovascular disease. Histological sections were reviewed by an expert pathologist and 72 focal areas with varying degrees of myocyte disarray (normal, mild, moderate, severe) were chosen for analysis. Areas of interest were interrogated with the Human Cancer Transcriptome Atlas designed to profile 1800 transcripts. Differential expression analysis revealed significant changes in gene expression between HCM and Control tissue, and functional enrichment analysis indicated these genes were primarily involved in interferon production and mitochondrial energetics. Within HCM tissue, differentially expressed genes between areas of mild and moderate disarray were enriched for genes related to mitochondrial energetics (moderate disarray) and response to oxygen/cytokine levels (mild disarray). The comparison between areas of moderate and severe disarray were enriched for genes related to the c-Jun N-terminal kinase (JNK) cascade in severe disarray. Analysis of ligand-receptor pair gene expression revealed that HCM tissue exhibited downregulation of platelet-derived growth factor (PDGF), NOTCH, junctional adhesion molecule, and CD46 signaling, while showing upregulation of fibronectin, CD99, cadherin, and amyloid precursor protein signaling. A deconvolution analysis utilizing the matched single nuclei RNA-sequencing (snRNA-seq) data to determine cell type composition in areas of interest revealed significant differences in fibroblast and vascular cell composition in areas of severe disarray when compared to normal areas in HCM samples. Cell composition in normal areas from control tissue was also divergent from normal areas in HCM samples, which was consistent with the differential expression results. Overall, our data identify novel and potential disease-modifying targets for therapy in HCM.

Preprint ARTICLE | doi:10.20944/preprints202205.0292.v1

Meier-Gorlin Syndrome: Clinical Misdiagnosis as Jeune Syndrome, Genetic Testing and Functional Analysis of ORC6 Mutations and the Development of a Prenatal Test

Maria S. Nazarenko, Iuliia V. Viakhireva, Mikhail Y. Skoblov, Elena V. Soloveva, Aleksei A. Sleptcov, Ludmila P. Nazarenko

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Meier-Gorlin syndrome; Jeune syndrome; ORC6; exon skipping variant; prenatal genetic testing

Online: 23 May 2022 (10:18:24 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0010.v1

Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso

Nouhoun Traoré, Mahamadi Kientega, Hamidou Maïga, Karim Nebié, Issaka Zida, Roberto Galizi, Emmanuel Kiendrebeogo, Bazoumana BD Sow, Adrien M. G. Belem, Remy A. Dabiré, Abdoulaye Diabaté

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: genetic diversity; genetic structure; microsatellite markers; Bactrocera dorsalis; Burkina Faso

Online: 1 March 2024 (07:57:48 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1083.v1

Prevalence of Genetic Variants and Deep Phenotyping of Patients with Thoracic Aortic Aneurysm and Dissection: A Cross-Sectional Single Centre Cohort Study

Adrian Mahlmann, Nesma Elzanaty, Mai Saleh, Marc Irqsusi, Ardawan Rastan, Jennifer Lynne Leip, Christian-Alexander Behrendt, Tamer Ghazy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: thoracic aortic disease; phenotype; genetic mutation; genetic variant; aneurysm; dissection

Online: 14 December 2023 (12:14:50 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint CONCEPT PAPER | doi:10.20944/preprints202011.0387.v1

Genetic Music: When Genes Code for Melodies Instead of Proteins

Marga Consortium, Blanca A. Gutierrez, Iván Aitor Lucas del-Amo, Beatriz Alejos Bermudez, Cristina Gonzalez Moran, Veronica Noval Gutierrez, Borja Sanchez

Subject: Social Sciences, Anthropology Keywords: genetic music; genetic code; music composition; steam disciplines; notch1 gene

Online: 13 November 2020 (15:34:47 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201707.0047.v1

Genetic Structure and Eco-Geographical Differentiation of Wild Sheep Fescue (Festuca ovina L.) in Xinjiang, Northwest China

Chenglin Zhang, Jianbo Zhang, Yan Fan, Ming Sun, Wendan Wu, Wenda Zhao, Xiaopeng Yang, Linkai Huang, Yan Peng, Xiao Ma, Xinquan Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Festuca ovina L.; AFLP, genetic diversity; genetic barriers; environmental factors

Online: 18 July 2017 (10:05:56 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.0711.v1

Unlocking glioblastoma vulnerabilities with CRISPR-based genetic screening

Yitong Fang, Xing Li, Ruilin Tian

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: glioblastoma; CRISPR-based genetic screening; therapy resistance; genetic determinants; therapeutic targets

Online: 10 April 2024 (08:14:36 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202012.0738.v1

Utility of Whole-Exome Sequencing in Pediatric and Medical Diagnosis

Mohd Fareed, Varun Sharma, Hemender Singh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Next generation sequencing; Genetic disorders; Genomic medicine; Genetic counseling; Rare diseases

Online: 29 December 2020 (16:47:01 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202012.0144.v1

Genetic Environments of Plasmid-Mediated bla_CTXM-15beta-lactamase gene in Enterobacteriaceae from Africa

Babafela Awosile, Michael Agbaje

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Antimicrobial resistance; blaCTX-M-15; genetic environment; mobile genetic elements; Africa

Online: 7 December 2020 (12:49:16 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0065.v1

Comparative Genetic Association Analysis of Human Genetic Susceptibility to Pulmonary and Lymph Node Tuberculosis

Abhimanyu -, Mridula Bose, Astha Giri, Mandira Varma-Basil

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pulmonary tuberculosis; lymph node tuberculosis; extra-pulmonary tuberculosis; single nucleotide polymorphisms; cytokine; innate immunity; genetic association; genotype; serum

Online: 5 December 2022 (08:00:15 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1185.v1

Genetic regulation of human isomiR biogenesis

Guanglong Jiang, Jill L. Reiter, Chuanpeng Dong, Yue Wang, Fang Fang, Zhaoyang Jiang, Yunlong Liu

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: microRNA; isomiR; genetic association

Online: 18 July 2023 (07:52:22 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0710.v1

Genetic Algorithm Based Feature Selection Technique for Optimal Intrusion Detection

Sydney Mambwe Kasongo

Subject: Engineering, Automotive Engineering Keywords: Intrusion Detection; Genetic Algorithm

Online: 29 June 2021 (13:30:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0618.v1

Functional Analysis of Genetic Tests in Neurological Diagnostics: Advances and Future Prospects

Richard Murdoch Montgomery

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Neurological diagnostics; Genetic technologies; Microarray analysis Variant sequencing; Exome sequencing; RNA sequencing; Whole genome sequencing; Functional analysis; Personalized medicine; Neurological disorders

Online: 9 September 2024 (09:21:13 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202001.0276.v1

Genetic Variation of Traits in Natural Enemies Relevant for Biological Control: A Systematic Review

Kim B. Ferguson, Sophie R. Chattington, Wouter N. Plouvier, Bart A. Pannebakker

Subject: Biology And Life Sciences, Insect Science Keywords: genetic improvement; genetic variation; heritability; systematic review; biocontrol agent; life history traits

Online: 24 January 2020 (10:39:55 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201804.0157.v1

Topological Information Data Analysis: Poincare-Shannon Machine and Statistical Physic of Finite Heterogeneous Systems

Pierre Baudot, Monica Tapia, Jean-Marc Goaillard

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: information theory; cohomology; algebraic topology; topological data analysis; genetic expression; epigenetics; machine learning; statistical physic; multivariate mutual-information; complex systems; biodiversity

Online: 12 April 2018 (05:35:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

This paper establishes methods that quantify the structure of statistical interactions within a given data set using the characterization of information theory in cohomology by finite methods, and provides their expression in terms of statistical physic and machine learning. Following [1–3], we show directly that k multivariate mutual-informations (I_k) are k-coboundaries. The k-cocycles are given by I_k = 0, which generalize statistical independence to arbitrary dimension k. The topological approach allows to investigate Shannon’s information in the multivariate case without the assumptions of independent identically distributed variables. We develop the computationally tractable subcase of simplicial information cohomology represented by entropy H_k and information I_k landscapes. The I₁ component defines a self-internal energy functional U_k, and (−1)^k I_k_,k≥2 components define the contribution to a free energy functional G_k of the k-body interactions. The set of information paths in simplicial structures is in bijection with the symmetric group and random processes, provides a topological expression of the 2nd law and points toward a discrete Noether theorem (1st law). The local minima of free-energy, related to conditional information negativity and the non-Shannonian cone of Yeung [4], characterize a minimum free energy complex. This complex formalizes the minimum free-energy principle in topology, provides a definition of a complex system, and characterizes a multiplicity of local minima that quantifies the diversity observed in biology. Finite data size effects and estimation bias severely constrain the effective computation of the information topology on data, and we provide simple statistical tests for the undersampling bias and for the k-dependences following [5]. We give an example of application of these methods to genetic expression and cell-type classification. The maximal positive I_k identifies the variables that co-vary the most in the population, whereas the minimal negative I_k identifies clusters and the variables that differentiate-segregate the most. The methods unravel biologically relevant I₁₀ with a sample size of 41. It establishes generic methods to quantify the epigenetic information storage and a unified epigenetic unsupervised learning formalism.

Preprint CASE REPORT | doi:10.20944/preprints202312.0328.v1

The Effect of Pathogenic Tumor Suppressor Gene Variants on COVID-19: A Report of Three Cases with Varied Severity and Outcomes

Rostislav K. Skitchenko, Yury A. Barbitoff, Mikhail A. Fedyakov, Anna Yu. Anisenkova, Sergei V. Mosenko, Svetlana V. Apalko, Andrey S. Glotov, Oleg S. Glotov, Sergey G. Shcherbak

Subject: Biology And Life Sciences, Other Keywords: COVID-19; SARS-CoV-2; oncology; genetic variants; NGS; severity; genetic associations; exome

Online: 6 December 2023 (08:52:54 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0099.v1

Genetic Parameters of Growth Traits and Quantitative Genetic Metrics for Selection and Conservation of Mecheri Sheep of Tamil Nadu

B. Balasundaram, A.K. Thiruvenkadan, N. Murali, J. Muralidharan, D. Cauveri, Sunday O. Peters

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Genetic parameters, (Co)variance components, Mecheri sheep, Animal models, Maternal genetic influence, Inbreeding

Online: 6 December 2022 (10:03:11 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202107.0509.v1

Genetic Variation of Native Perilla Germplasms Collected from South Korea Using SSR Markers and Morphological Characteristics

Jun Seok Oh, Kyu Jin Sa, Hyeon Park, Do Yoon Hyun, Sookyeong Lee, Ju-Hee Rhee, Ju Kyong Lee

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Perilla crop; genetic resources; morphological traits; principal component analysis; SSR marker; genetic variation

Online: 22 July 2021 (08:04:28 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0299.v1

Comparative Genomic Analysis Reveals Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with High Transmissibility of blaKPC Plasmids

Muna ALMuzahmi, Meher Rizvi, Manawr AL-Quraini, Zakariya AL-Muharrami, Zaaima AL-Jabri

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: mobile genetic elements; Anti-microbial resistance; Klebsiella pneumoniae; Whole genome sequencing; integrons; plasmids; sequence types; phylogenetic analysis

Online: 6 September 2023 (04:28:45 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0042.v1

Serological and Oncoinformatic Analysis of HbA1c as a Prognostic Biomarker in Screening the Risks of Different Cancers among the Male T2D Patients of Bangladesh

Md. Al Hasibuzzaman, Salauddin Al Azad, Md. Abdur Rashid Mia, Samarth Islam, Sharmin Ahmed, Afsana Masud, Samiur Rahman, Arysha Alif Khan, Fahmida Hoque Rimti, Ashrak Shad Pyash, Partha Biswas, Homayra Rahman Shoshi, Fariha Hoque Rimu, Ramiza Nausheen Zaman, Md. Ataur Rahman, Bonglee Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HbA1c biomarker; type 2 diabetes; cancer risk profiling; serological diagnosis; oncoinformatic screening; genetic overexpression; promoter methylation

Online: 2 August 2022 (06:04:42 CEST)

Show abstract| Download PDF| Share

This research aimed to figure out the applications of HbA1c protein and HbA1 gene as the prognostic biomarkers for assessing the risks of different cancers among male T2D patients in Bangladesh considering their serological and oncoinformatic parameters. Depending on the concentrations of HbA1c (%) of the T2D patients (n=300), their individual FBS (mmol/L); THABF (mmol/L); creatinine (mg/dl); SC (mg/dl); STGs (mg/dl); HDLC (mg/dl); and LDLC (mg/dl) were estimated. The values of the patients were compared with the control (n=60) group as the serological analysis. Besides, HbA1 gene (encoding hBA1c protein) overexpression and promotor methylation responsible for BLCA, BRCA, CHOL, COAD, LUAD, LUSC, PAAD, and PRAD cancers in the male T2D patients were profiled as the oncoinformatic parameters based on the sample types; caner stages; racial footprints; gender; age; nodal metastasis; p53 methylations; pancreatitis; diabetes status; smoking behaviors; and overall/disease-free survivability. Finally, the ‘HbA1 gene strings’ responsible for genetic coexpression; endophytic vesicle regulation; antioxidant regulation; oxygen species metabolic regulation; and gene-mediated response to the reactive oxygen molecules were studied comprehensively. A strong correlation between BMI and FBS was observed in both the patients and the control (P<0.0001). Similarly, the values of FBS, THABF, and creatinine resulted in equal significance (P<0.0001) as compared to the HbA1c concentrations of all the T2D and control individuals. The SC, STGs, HDLC, and LDLC concentrations regulated ardently in both the control (P<0.0001), and patients group (P<0.0001), while HbA1c ranged from 3.8-5.8%, and 5.11-15.8% respectively. HbA1 gene is found downregulating with cancer progressed in most of the oncoinformatic parameters. According to the DA, CS, EI, CE, PC, NC, GF, H, and AT profiles; the HbA1 gene interacts with 8 other genes responsible for creating a protein cluster comprising- AHSP, HBA1, HBA2, HBB, HBD, HBE1, HBG2, RPS12, and RPS19 proteins for cancer formation. To recapitulate, HbA1c protein and HbA1 gene can be used as the prognostic serological and molecular biomarkers respectively for determining the risks of cancers among male chronic T2D patients.

Preprint CASE REPORT | doi:10.20944/preprints202403.1661.v2

A Case Report of Acute Lymphoblastic Leukaemia (ALL)/Lymphoblastic Lymphoma (LBL) Following the Second Dose of Comirnaty®: An Analysis of the Potential Pathogenic Mechanism Based on of the Existing Literature

Patrizia Gentilini, Janci C. Lindsay, Nafuko Konishi, Masanori Fukushima, Panagis Polykretis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19 genetic vaccines; mRNA vaccines; adverse effects; lymphoblastic leukemia; lymphoblastic lymphoma

Online: 1 April 2024 (13:21:50 CEST)

Show abstract| Download PDF| Share

In this report we describe the case of a healthy, young, athletic woman who developed acute lymphoblastic leukaemia (ALL)/lymphoblastic lymphoma (LBL) after receiving the second dose of the Pfizer/BioNTech modified mRNA (modRNA) COVID-19 genetic vaccine (marketed as Comirnaty^®). The first dose of the genetic vaccine did not appear to illicit any noticeable side effects, but within 24 hours of the second dose the patient suffered widespread and intensifying bone pain, fever, vomiting, and general malaise. Due to the persistence of the symptoms, the patient underwent a series of tests and examinations including a full laboratory workup, a consult with a clinical immunologist and rheumatologist, a Positron Emission Tomography (PET) imaging, as well as an osteomedullary biopsy. These together led to a definitive diagnosis of ALL. A time interval of 16 weeks from the second vaccination to the diagnosis of cancer was noted. Several similar cases with identical pathology which developed after the modRNA COVID-19 vaccination, are described in case reports in the scientific literature. The massive and indiscriminate use of genetic vaccines to fight COVID-19 is raising serious concerns about their safety and about the technology platform as a whole for this purpose. Growing evidence is accumulating regarding the biodistribution and persistence of the modRNA which can reach, thanks to the lipid nanoparticles, a multitude of tissues and organs of the body, including the bone marrow and other blood-forming organs and tissues. Moreover, there is evidence that the modRNA vaccines display a particular tropism for the bone marrow, influencing the immune system at multiple levels and being able to trigger not only autoimmune-based pathologies, but also neoplastic mechanisms. The aim of this article is to assess, on the basis of the available scientific literature, the risk of developing haematopoietic cancers after modRNA vaccination, and to investigate the potential genetic mechanisms involved in the pathogenesis of disease.

Preprint ARTICLE | doi:10.20944/preprints202405.1663.v1

Genetic Algorithm based optimization of Clustering Algorithms for the Healthy Aging Dataset

Kahkashan Kouser, Amrita Priyam, Mansi Gupta, Sanjay Kumar, VANDANA BHATTACHARJEE

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Genetic Algorithms; Clustering; KMeans++; optimization

Online: 27 May 2024 (10:05:29 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1730.v1

Genetic Diversity of Human Norovirus in Children Less Than 5 Years of Age With Acute Gastroenteritis in Rural Communities in the Gambia

Sheriffo Jagne, M. Jahangir Hossain, Martin Antoni, Abdul Karim Sesay, Muhammed Khalie Abdul, Nuredin I. Mohammed, Madikay Senghore, Alansana Darboe, Jarra Manneh, Abdoulie Kanteh, Dam Khan, Saikou Y Bah, Ndaw Sylvanus Peter, Osbourne Quaye, George Enyimah Armah

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Norovirus genetic diversity genogroups genotypes

Online: 24 January 2024 (10:15:24 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202308.0706.v2

Dr Jekyll and Mr Hyde: From Two Branches of Immune Response to Three Types of Interferon Response

Brent Brown, Chinua Imarogbe, Ingo Fricke, Pascal Mensah

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Interferon; Innate; Adaptive; Genetic; Molecular

Online: 26 September 2023 (11:35:53 CEST)

Show abstract| Download PDF| Share

Interferons were the original prototype cytokine system discovered in 20th-century research. As the name implies, they were originally thought to be synthesised and secreted between cells. Thanks to technological advances, the processes involved in protein secretion can be explained comparatively more clearly at both the genetic and biochemical levels. The discovery of interferon (IFN) occurred when genetic research was still in its infancy. Franklin and Wilkins discovered the structure and function of deoxyribonucleic acid (DNA) at the same time as Crick and Watson; however, Isaacs and Lindemann, two scientists, described the first IFN in 1957. Mutations can be caused by inherent genetic protein synthesis and during infection as well as within IFN regulation pathways affecting cell proliferation. This remains central to host cell IFN synthesis and effects through IFN protein receptor subunits defined by 6 protein domains. Type II IFN is key to immune cell function secreted by a variety of immune cells, mainly natural killer (NK) as well as T cells. Single–stranded and/or double–stranded RNA/DNA viruses, as well as bacterial infections (e.g., Escherichia coli) and fungal infections (e.g., Aspergillus), also affect IFN regulation. Pathogenic proteins utilise intra/extracellular proteins that sense foreign antigens like Toll–like Receptors (TLRs), affected by mutations within the human cellular IFN transduction pathways. Since the discovery of the third IFN type in 2003, when immune cell phenotypes were further characterised, questions remain about the immunological mechanisms contributing to the regulation of the innate and adaptive host immune system. Alterations in the synthesis of type I/II/III host IFNs can differentially and beneficially alter homeostatic cellular pathways in pathological disease, with type I IFN being synthesised in cancer as well as by homeostatic cells. Therefore, considered here are the overall IFN molecular, cell regulatory mechanisms in the context of immune cell research developments.

Preprint CASE REPORT | doi:10.20944/preprints202306.0239.v1

Optimal Evaluation of Left Ventricular Hypertrophic Phenotype Using Parametric CMR Mapping and Genetic Testing

Andrés Felipe Barragán-Amado, Jaime A Parra, María C Manzur, Julian A Gelves-Meza, Claudia P Jaimes, María F Tamayo, Héctor M Medina, María Juliana Rodríguez-González

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiomyopathy; Genetic disorders; Cardiovascular Imagen

Online: 5 June 2023 (05:02:25 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0114.v1

Genetic Determinants of Atherogenic Indexes

Tomas Texis, Susana Rivera-Mancia, Eloisa Colin-Ramirez, Raul Cartas-Rosado, David Koepsell, Kenneth Rubio-Carrasco, Mauricio Rodriguez-Dorantes, Vanessa Gonzalez-Covarrubias

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Dyslipidemia; atherogenic indexes; genetic associations

Online: 7 April 2023 (05:24:09 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1960.v1

Directional Breeding Generates Distinct Genetic Diversity in Hybrid Turf Bermudagrass as Probed with SSR Markers

Desalegn D. Serba, Tilin Fang, Yanqi Wu

Subject: Biology And Life Sciences, Plant Sciences Keywords: C. dactylon; C. transvaalensis; interspecific hybrids; cluster analysis; genetic similarity; genetic diversity; directional breeding

Online: 29 May 2023 (08:55:06 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201912.0021.v1

Protein 0^th-Order Structure: The Key for Creating Entirely New Gene/Protein

Kenji Ikehara

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein 0th-order structure; origin of gene; origin of protein; origin of genetic code; GNC primeval genetic code hypothesis; SNS primitive genetic code hypothesis

Online: 3 December 2019 (11:10:12 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0169.v1

The Supersymmetry Genetic Code Table and Quadruplet Symmetries of DNA Molecule Are the Unchangeable and Synchronized with the Codon Free Energy Mapping during Evolution

Marija Rosandic, Vladimir Paar

Subject: Biology And Life Sciences, Other Keywords: genetic code symmetry, mitochondrial genetic code, energy code, DNA quadruplet symmetry, classification of trinucleotides/codons

Online: 4 October 2023 (07:43:22 CEST)

Show abstract| Download PDF| Share

The Supersymmetry Genetic code (SSyGC) table is based on five physicochemical symmetries: 1) double mirror symmetry on the principle of the horizontal and vertical mirror symmetry axis between all bases (purines [A, G) and pyrimidines (U, C)], and 2) of bases in form of codons 3) direct – complement like codon/anticodon symmetry in the sixteen alternating boxes of the genetic code columns, 4) A+T rich and C+G rich alternate codons in the same row between both columns of the genetic code, 5) the same position between divided and undivided codon boxes in relation to horizontal mirror symmetry axes. The SSyGC table has a unique physicochemical purine – pyrimidine symmetry net which is as the core symmetry common for all, more than thirty different nuclear and mitochondrial genetic codes. This net is present in the SSyGC table of all RNA and DNA living species. None of these symmetries is present in the Standard Genetic Code (SGC) table which is constructed on the alphabetic horizontal and vertical U-C-A-G order of bases. Here we show that the free energy value of each codon incorporated as fundamentally mapping the “energy code” in the SSyGC table is compatible with mirror symmetry. On the other hand, in the SGC table the same free energy values of codons are dispersed and a mirror symmetry between them is not recognizable. At the same time the mirror symmetry of the SSyGC table and the DNA quadruplets together with our classification of codons/trinucleotides are perfectly imbedded in the mirror symmetry energy mapping of codons/trinucleotides and point out in favor of maintaining the integrity of the genetic code and DNA genome. We also argue that physicochemical symmetries of the SSyGC table in the manner of the purine – pyrimidine symmetry net, the quadruplet symmetry of DNA molecule and the free energy of codons have remined unchanged during all of evolution. The unchangeable and universal symmetry properties of the genetic code, DNA molecule and energy code are decreasing disorder between codons/trinucleotides and shed a new light on evolution. Diversity in all living species on Earth is broad, but the symmetries of the Supersymmetry Genetic Code as the code of life and the DNA quadruplets related to the” energy code” are unique, unchangeable and have the power of natural laws.

Preprint ARTICLE | doi:10.20944/preprints202212.0234.v1

History of Advances in Genetic Engineering of Viruses Prior to COVID-19 Pandemic

Mikhail Teppone

Subject: Biology And Life Sciences, Virology Keywords: reassortant virus; recombinant virus; chimeric virus; genetic engineering; reverse genetic; SARS-CoV-2; COVID-19

Online: 13 December 2022 (08:47:51 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0205.v1

Genetic Characterization of Some Accessions of Barley in Algeria with Microsatellites (SSR) Markers

Warda Taibi, Fatima Henkrar, Sripada Mahabala Udupa, Suheil bechir semir Gaouar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Genetic diversity; SSR markers; barley; Algeria

Online: 2 July 2024 (14:49:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0870.v1

Selection of Improved Banana Diploid Resistant to Fusarium oxysporum f. sp. cubense Races 1 and Subtropical 4

Welly Sacramento Santana, Anelita de Jesus Rocha, Wesley Barreto da Silva, Vanusia B. Oliveira Amorim, Andresa Priscila de Souza Ramos, Fernando Haddad, Edson Perito Amorim

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Musa spp; genetic resistance; Fusarium wilt

Online: 15 April 2024 (04:25:42 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0274.v1

Constructing the Bounds for Neural Network Training Using Grammatical Evolution

Ioannis G. Tsoulos, Alexandros Tzallas, Evangelos Karvounis

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Neural networks; Genetic algorithms; Grammatical Evolution

Online: 5 October 2023 (10:59:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0075.v1

Deep Network Optimization Using a Genetic Algorithm for Recognizing Hand Gestures via EMG Signals

Kasra Sehat, Seyed Mohammadreza Shokouhyan, Nada K. Abdallah, Kinda Khalaf

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: EMG; optimization; genetic algorithm; deep learning

Online: 4 January 2023 (09:21:39 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202201.0414.v1

Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions

Deiviane Calegar, Beatriz Nunes, Kerla Monteiro, Polyanna Bacelar, Brenda Evangelista, Mayron Moraes, Jurecir Silva, Jéssica Santos, Márcio Bóia, Lauren Jaeger, Filipe Anibal Carvalho-Costa

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Giardia duodenalis; Assemblages; Epidemiology; Genetic diversity

Online: 27 January 2022 (11:18:33 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0692.v1

Use of Genetic Algorithms to Optimize Efficiency in Small-Scale Structures

Aaron Chew

Subject: Engineering, Civil Engineering Keywords: Genetic algorithms, structures, algorithms, generative design

Online: 29 March 2021 (12:50:16 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Evaluation of the Gene Flow From East to West among Various Populations of Rajasthan, India

R.K. Kumawat, Pankaj Shrivastava, Shivani Dixit, Divya Shrivastava, G.K. Mathur, Gyaneshwer Chaubey

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Genetic affinity; STR; Rajasthan; Heterozygosity; Polymorphic

Online: 21 June 2020 (14:12:03 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper REVIEW

Physicochemical Foundations of Life that Direct Evolution. Why Chance and Natural Selection cannot Explain Evolution

Didier Auboeuf

Subject: Biology And Life Sciences, Biophysics Keywords: evolution; genetic code; RNA; protein; physicochemistry

Online: 28 November 2019 (09:38:55 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201911.0349.v1

Genetic Diversity of Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae) Colonizing Sweet Potato and Cassava in South Sudan

Beatrice Clarence Misaka, Everlyne N. Wosula, Philip W. Marchelo-d'Ragga, Trine Hvoslef-Eide, James Peter Legg

Subject: Biology And Life Sciences, Forestry Keywords: Bemisia tabaci; genetic diversity; distribution; haplotype

Online: 28 November 2019 (03:24:39 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201806.0201.v1

The Critical Needs and Challenges for Genetic Architecture Studies in Africa

Alicia R. Martin, Solomon Teferra, Marlo Möller, Eileen G. Hoal, Mark J. Daly

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic architecture; Africa; GWAS; health disparities

Online: 13 June 2018 (11:17:04 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202211.0264.v1

Analysis of Charging Infrastructure for Private, Battery-electric Passenger Cars: Optimizing Spatial Distribution using a Genetic Algorithm

Diego Fadranski, Anne Magdalene Syré, Alexander Grahle, Dietmar Göhlich

Subject: Engineering, Automotive Engineering Keywords: charging infrastructure; e-mobility; electric vehicle; optimization; private electric car; transport simulation; distribution of charging Infrastructure; battery electric; genetic optimization; high-power charging

Online: 15 November 2022 (01:15:14 CET)

Show abstract| Download PDF| Share

To enable the deployment of battery-electric vehicles (BEV) as passenger cars in the private transport sector, a suitable charging infrastructure is crucial. In this paper a methodology for efficient spatial distribution of charging infrastructure is evaluated by investigating a scenario with a market penetration of BEVs of 100 percent (around 1.3 million vehicles). It aims towards the development of various charging infrastructure scenarios - including public and private charging - which are suitable to cover the charging demand. Therefore, these scenarios are investigated in detail with focus on number of public charging points, their spatial distribution, the available charging power and the necessary capital costs. For the creation of those charging infrastructure scenarios a placement model is developed. It uses the data of a MATSim (Multi-Agent Transport Simulation) traffic simulation of the metropolitan area of Berlin to evaluate and optimize different distributions of charging infrastructure. The model uses a genetic algorithm and the principle of multi-objective optimization. The capital cost of the charging points and the mean detour car drivers must cover additionally are used as optimization criteria. Using these criteria should lead to cost efficient infrastructure solutions which provide high usability at the same time. The main advantage of the method selected is that multiple optimal solutions with different characteristics can be found and suitable solutions can be selected by using other criteria subsequently. The optimized charging infrastructure solutions show capital costs between 624 and 2950 million euro. Users must cover an additionally mean detour of 254m to 590m per charging process to reach an available charging point. According to the results a suitable ratio between charging points and vehicles is between 11:1 and 5:1. A share of fast charging infrastructure (>50kW) of less than ten percent seems to be sufficient, if it is situated at main traffic routes and highly frequented places.

Preprint ARTICLE | doi:10.20944/preprints202402.0713.v1

Cyclic Gray Codes in Modeling Inherited Cyclic Biostructures and Analysis of Statistical Rules of Genomic DNAs

Sergey Petoukhov

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic code; cycles; Gray codes; genomic DNAs; binary oppositions; binary-genomic numbers; complementarity operation; statistical analysis; Karnaugh maps; Hilbert curve; Walsh functions

Online: 13 February 2024 (08:15:44 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1951.v1

Groups of Symmetries of the Two Classes of Synthetases in the Four-Dimensional Hypercubes of the Extended Code Type II

Marco V. José, Eberto R. Morgado, Juan R. Bobadilla

Subject: Biology And Life Sciences, Life Sciences Keywords: Aminoacyl-tRNA synthetases; Standard Genetic Code; Symmetry groups; Origin and evolution of the genetic code; Group Theory

Online: 29 August 2023 (08:34:06 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202410.1114.v1

Application of CRISPR/Cas9 Technology in Rice Germplasm Innovation and Genetic Improvement

Jijin Chen, Zhening Miao, Deyan Kong, Anning Zhang, Feiming Wang, Guolan Liu, Xinqiao Yu, Lijun Luo, Yi Liu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Gene editing; CRISPR/Cas9; Rice; Genetic improvement

Online: 15 October 2024 (15:26:46 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202410.0665.v1

An All-in-One Device for a Rapid and Simple Genetic Detection

Lilas Pommiès, Hervé Boutal, David Fras, Karim Boudergui, Stéphanie Simon, Hervé Volland

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: All-in-one device; POCT; Genetic detection

Online: 9 October 2024 (12:21:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202410.0259.v1

Evaluation of Cell-free DNA Long Fragments in the Triage of FIT+ Patients Enrolled in a Colorectal Cancer Screening Program: An Italian Prospective, Cross-Sectional Study

Mauro Scimia, Francesco Pepe, Gianluca Russo, Umberto Malapelle, Simone Scimia, Annalaura Alfieri, Valentina Olivieri, Rachel Chuang, Hiromi Tanaka, Michael Sha, David Chen, Shuo Shen, Claudia Scimone, Lucia Palumbo, Yulia Gavrilov, Stav Edelstein, Maria Antonia Bianco, Giancarlo Troncone

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: colorectal cancer screning; colorectal cancer; genetic testing

Online: 3 October 2024 (12:30:08 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202409.1958.v1

Genetic Engineering in Bacteria, Fungi, and Oomycetes

Piao Yang, Abraham Condrich, Ling Lu, Sean Scranton, Camina Hebner, Mohsen Sheykhhasan, Muhammad Azam Ali

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Genetic engineering; CRISPR; Bacteria; Fungi; Oomycetes; GEMs

Online: 25 September 2024 (08:56:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.1280.v1

Enhancing Drought and Arsenic Resistance in Oryza sativa by Hyperexpression of Aquaporin Genes

Prisha Bhat

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Arsenic contamination; Rice arsenic; genetic augmentation; bioremediation

Online: 20 May 2024 (12:53:55 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0592.v1

Progress and Application of Genomic Selection in Sheep and Goat

Linyun Zhang, Yixin Duan, Naiyi Xu, Yongju Zhao

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Goat; Sheep; Genomic Selection; Genetic Evaluation; Accuracy

Online: 9 May 2024 (11:57:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1144.v1

Linking Wetland Ecosystem Services to Fish Genetic Resources with Special Reference to Hilsa Shad (Tenualosa ilisha): A Novel Study from Northeastern Bangladesh

Atiqur Rahman Sunny, Md. Arifur Rahman, Md. Nazmul Hasan, Jeba Faizah Rahman, Sharif Ahmed Sazzad, Md. Faruque Miah, Md. Ashrafuzzaman, Shamsul Haque Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Wetland; Ecosystem services; Genetic diversity; Hilsa; Bangladesh

Online: 20 February 2024 (12:44:47 CET)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202312.1693.v2

Creutzfeldt -Jakob Disease Associated with E200K Mutation and SARS-Cov2 Infection, Pure Coincidence or Neurodegenerative Acceleration?

Elisa Colaizzo, Luca Prosperini, Antonio Petrucci, Alessia Perna

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: genetic CJD; mutation E200K; COVID-19; prion

Online: 27 December 2023 (05:21:05 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.2104.v1

Optimization of Dual-Design Operation Ventilation System Network Based on Improved Genetic Algorithm

Yanbo Feng, Han Zhu, Xiwen Feng, Qianru Chen, Xiangyu Sun, Zhengrong Li

Subject: Engineering, Architecture, Building And Construction Keywords: ventilation system networks; design optimization; genetic algorithm

Online: 1 November 2023 (03:55:34 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0827.v1

AI-Based Procedure for the Assessment of Voice Characteristics in Genetic Syndromes

Federico Calà, Lorenzo Frassineti, Elisabetta Sforza, Roberta Onesimo, Lucia D’Alatri, Claudia Manfredi, Antonio Lanata, Giuseppe Zampino

Subject: Engineering, Bioengineering Keywords: Genetic syndrome; Acoustical analysis; Artificial Intelligence; Classification

Online: 12 October 2023 (12:03:32 CEST)

Show abstract| Download PDF| Share

Preprint INTERESTING IMAGES | doi:10.20944/preprints202309.1918.v1

Isoniazid-Resistant Tuberculosis—A Series of Clinical Cases

Teodora Butnaru, Florin Dumitru Mihaltan, Ancuta Alina Constantin

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: multidrug-resistant tuberculosis; genetic mutations; clinical cases.

Online: 28 September 2023 (08:02:58 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202309.1060.v1

Rare and Complex Cardiac Anomalies Associated with 22q11.2 Deletion: An Ultrasonographic Visual Trip from Diagnosis until Delivery

Radu Vlădăreanu, Călina Maier, Raluca Tocariu, Marcela Șerban, Elvira Brătilă

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: interrupted aortic arch; 22q11.2DS; ultrasound; genetic tests

Online: 18 September 2023 (05:41:23 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0114.v1

Design and Multi-Objective Optimization of a Photovoltaic System by a Genetic Algorithm

Khadidjatou Thiaw, Amadou Diao, Amy Sadio, Senghane Mboji

Subject: Physical Sciences, Applied Physics Keywords: photovoltaic system; LPSP; TLCC; optimization; genetic algorithm

Online: 4 September 2023 (03:50:12 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0020.v1

Genetic Drift and Alphapapillomavirus Evolution

Robert D. Burk, Lisa Mirabello, Robert DeSalle

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: molecular evolution; genetic drift; human papillomavirus (HPV)

Online: 1 June 2023 (03:52:59 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1634.v1

Genotypic and Sanitary Characterization of Minority Grapevine Varieties Prospected in Andalusia, Spain

Inmaculada Rodríguez-Torres, Ana Martín Carrillo, María del Pilar Ramírez, Francisco Jesus Gómez Gálvez, Leonardo Velasco Arjona, Carlos Padilla, Enrico Cretazzo

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: genetic resources; molecular markers; local cultivar; certification

Online: 23 May 2023 (09:55:00 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202305.0087.v1

Recent Population Dynamics of Japanese Encephalitis Virus

Jinpeng Xu, Abdul Wahaab, Sawar Khan, Mohsin Nawaz, Muhammad Naveed Anwar, Ke Liu, Jianchao Wei, Muddassar Hameed, Zhiyong Ma

Subject: Biology And Life Sciences, Virology Keywords: Japanese encephalitis virus; Population dynamic; Genetic diversity

Online: 2 May 2023 (11:02:54 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0505.v1

Tomato Defence Suppression is a Common Trait in Tetranychus urticae Collected from Field-Grown Tomatoes

Jéssica Teodoro-Paulo, Carlos Fernandes, Lin Dong, Sara Magalhães, Alison B. Duncan, Juan M. Alba, Merijn R. Kant

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: phylogeny; salivary effectors; effector 84; genetic diversity

Online: 28 February 2023 (04:44:34 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202302.0305.v1

National and Ethnic Mutation Frequency Databases: Cross Comparison and Future Direction

Shumaila Khan, Mehmood Alam, Shahnaz Khan, Wahab Khan, Ihsan Rabbi, Iqbal Qasim

Subject: Computer Science And Mathematics, Information Systems Keywords: genetic databases; mutation disorders; ethnic specific databases

Online: 17 February 2023 (07:59:08 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202301.0197.v1

Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review

Juan Angel Garcia-Quiñones, Celia Nohemi Sanchez-Dominguez, María Fernanda Serna-Rodríguez, Ivan Alberto Marino-Martinez, Ana María Rivas-Estilla, Antonio Alí Pérez-Maya

Subject: Social Sciences, Behavior Sciences Keywords: Biomarkers; Genetic; Suicidal behavior; Suicide; Mexican; Genomic.

Online: 11 January 2023 (10:34:57 CET)

Show abstract| Download PDF| Share

Search Results

625 articles found