Preprint Review Version 1 This version is not peer-reviewed

Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis

Version 1 : Received: 23 July 2018 / Approved: 24 July 2018 / Online: 24 July 2018 (06:01:10 CEST)

A peer-reviewed article of this Preprint also exists.

Santiago Junior, J.F.; Biguetti, C.C.; Matsumoto, M.A.; Abu Halawa Kudo, G.; Parra da Silva, R.B.; Pinto Saraiva, P.; Fakhouri, W.D. Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis. Genes 2018, 9, 444. Santiago Junior, J.F.; Biguetti, C.C.; Matsumoto, M.A.; Abu Halawa Kudo, G.; Parra da Silva, R.B.; Pinto Saraiva, P.; Fakhouri, W.D. Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis. Genes 2018, 9, 444.

Journal reference: Genes 2018, 9, 444
DOI: 10.3390/genes9090444

Abstract

Dental implants provide a predictable treatment option for partial and complete edentulism via the placement of fixed permanent artificial root to support prosthetic dental crowns. Despite the high survival rates, long-term implant failures are still reported leading to implant removal and additional financial and health burdens. While extrinsic factors that improve survival rate of implants have been well explored, the impact of genetic factors on this matter is poorly understood. A systematic review and meta-analysis study was conducted to determine whether genetic factors contribute to increase the risk of dental implant failure. A comprehensive search for peer-reviewed articles on dental implants and genetics was performed using various literature database libraries. The study design was conducted according to PRISMA guidelines, and the obtained records were registered in PROSPERO database. According to the exclusion/inclusion criteria, 11 studies were eligible for this study out of 808 articles. The meta-analysis of the combined association studies of DNA variations and dental implants did not indicate an increase risk for implant failure due to DNA variations in IL-1B, IL-10 and TNF-α. This study emphasizes the need for larger randomized controlled clinical trails to inform clinicians and patients about the role of genetic factors on dental implant survival and success rate in healthy and compromised patients.

Subject Areas

genetic factors; dental implants; bone quality; bone regeneration; success rate

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