Version 1
: Received: 25 September 2023 / Approved: 25 September 2023 / Online: 25 September 2023 (11:24:28 CEST)
How to cite:
Cheng, M.; Lai, G.; Tsai, Y.; Lien, Y. Virulence of Circulating Marek’s Disease Virus Strains in Vaccinated Chicken Flocks in Taiwan: Data on Genetic Analysis of the meq Oncogene. Preprints2023, 2023091687. https://doi.org/10.20944/preprints202309.1687.v1
Cheng, M.; Lai, G.; Tsai, Y.; Lien, Y. Virulence of Circulating Marek’s Disease Virus Strains in Vaccinated Chicken Flocks in Taiwan: Data on Genetic Analysis of the meq Oncogene. Preprints 2023, 2023091687. https://doi.org/10.20944/preprints202309.1687.v1
Cheng, M.; Lai, G.; Tsai, Y.; Lien, Y. Virulence of Circulating Marek’s Disease Virus Strains in Vaccinated Chicken Flocks in Taiwan: Data on Genetic Analysis of the meq Oncogene. Preprints2023, 2023091687. https://doi.org/10.20944/preprints202309.1687.v1
APA Style
Cheng, M., Lai, G., Tsai, Y., & Lien, Y. (2023). Virulence of Circulating Marek’s Disease Virus Strains in Vaccinated Chicken Flocks in Taiwan: Data on Genetic Analysis of the meq Oncogene. Preprints. https://doi.org/10.20944/preprints202309.1687.v1
Chicago/Turabian Style
Cheng, M., Yi-Lun Tsai and Yi-Yang Lien. 2023 "Virulence of Circulating Marek’s Disease Virus Strains in Vaccinated Chicken Flocks in Taiwan: Data on Genetic Analysis of the meq Oncogene" Preprints. https://doi.org/10.20944/preprints202309.1687.v1
Abstract
Marek’s disease (MD) is an important neoplastic disease caused by serotype 1 Marek's disease virus (MDV-1), which results in severe economic losses worldwide. Despite vaccination practices that have controlled the MD epidemic, current increasing MD-suspected cases indicate the persistent viral infections circulating among vaccinated chicken farms in many countries. However, the lack of available information about phylogeny and molecular characterization of circulating MDV-1 field strains in Taiwan reveals a potential risk in MD outbreaks. This study investigated the genetic characteristics of 18 MDV-1 isolates obtained from 17 vaccinated chicken flocks in Taiwan between 2018 and 2020. Based on the sequences of the meq oncogene, phylogenetic analysis demonstrated that the circulating Taiwanese MDV-1 field strains were predominantly in a single cluster that showed high similarity with strains/isolates from countries of East Asian region. Because the isolated strains were obtained from CVI988/Rispens vaccinated chicken flocks and the molecular characteristics of the Meq oncoprotein showed the features like vvMDV and vv+MDV strains, the circulating Taiwanese MDV-1 field strains may have higher virulence compared with vvMDV pathotype. In conclusion, the presented data demonstrate the circulation of hypervirulent MDV-1 strains in Taiwan and highlight the importance of routine surveillance and precaution strategies in response to the emergence of enhanced virulent MDV-1.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
