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Preprint ARTICLE | doi:10.20944/preprints201812.0137.v2

Applications, Promises, and Pitfalls of Deep Learning for Fluorescence Image Reconstruction

Chinmay Belthangady, Loic A. Royer

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: microscopy, fluorescence, machine learning, deep learning, inverse problems, image reconstruction, image restoration, super-resolution, deconvolution, spectral unmixing

Online: 5 February 2019 (10:30:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0004.v2

Artificial Intelligence for Microscopy: What You Should Know

Lucas von Chamier, Romain F. Laine, Ricardo Henriques

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: artificial intelligence; machine learning; live-cell imaging; super-resolution microscopy; classification; segmentation

Online: 19 February 2019 (12:20:04 CET)

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Working Paper BRIEF REPORT

Exploring Potential Super Infection in SARS-CoV2 by Genome-Wide Analysis and Receptor–Ligand Docking

Chuanjun Shu, Xuan Huang, Juergen Brosius, Cheng Deng

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: SARS-CoV2; spike; receptor–ligand docking; super infection

Online: 20 March 2020 (08:30:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0352.v1

The Field Guide to 3D Printing in Microscopy

Mario Del Rosario, Hannah S. Heil, Afonso Mendes, Vittorio Saggiomo, Ricardo Henriques

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: 3d printing; microscopy; open-source; optics; super-resolution

Online: 14 May 2021 (16:10:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0726.v1

Big Bang Process, Magnetic Monopoles and Super Unification Theory of All Forces Using the GEM Wave

Jae-Kwang Hwang

Subject: Physical Sciences, Particle And Field Physics Keywords: Big bang; Super unification theory; 4-D Euclidean space; CPT symmetric universe; Origins of the energy (mass); charge and time; Magnetic monopoles

Online: 31 August 2020 (16:28:30 CEST)

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Working Paper COMMUNICATION

Mid-Low Resolution Remote Sensing Ship Detection Using Super-Resolved Feature Representation

Shitian He, Huanxin Zou, Yingqian Wang, Runlin Li, Fei Cheng, Xu Cao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Ship detection; image super-resolution; mid-low resolution remote sensing images

Online: 16 August 2021 (12:51:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0173.v1

At the molecular resolution with MINFLUX?

Kirti Prakash

Subject: Biology And Life Sciences, Biophysics Keywords: MINFLUX, STED, SMLM, localisation precision, image resolution, super-resolution imaging

Online: 8 February 2021 (07:50:16 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202201.0364.v2

Storage of Biochemical Information as the Start of Life: A Hypothetical Model for the Development of the First Cell

Ulrich Schreiber

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: origin of life; hydrothermal biochemistry; information storage; continental crust model; super-critical fluids; proto-tRNA; hydrophobicity of anti-codon

Online: 13 January 2023 (08:40:36 CET)

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The storage of biochemical information, which is a prerequisite for the development of the first cell, is an unsolved problem affecting all concepts of the origin of life. However, if the protected environment in the continental crust is taken into account, completely new possibilities emerge for identifying processes that may have been crucial for the formation of the first cell. Under this background, we can hypothesize that cellular life began, with a self-sustaining cycle of molecular reaction steps and information storage of peptide sequences in RNA in a crustal depth of approximately 1000 m. This cycle was made possible in an open system bound to gas-permeable tectonic fracture zones with a high proportion of CO₂ and/or N₂. It can be assumed that a large number of RNA-like molecular strands formed in the crustal environment, from which a special RNA was selected by flotation processes, which formed the basis of a proto-tRNA. The formation of peptides and vesicles in supercritical CO₂ and the chemical evolution of peptides have already been proven at conditions of the upper continental crust. The behavior of individual amino acids in connection with vesicle formation deserves special interest. Hydrophobic amino acids accumulate in the vesicle membrane, with their position in the membrane depending on the degree of hydrophobicity. Selection of a proto-tRNA with an acceptor arm ending with the bases CCA resulted in a distinctive property. The position of adenine at the tip of the acceptor arm permitted it to penetrate the membrane, allowing it to be linked to an amino acid at the 3'-OH position of the terminal ribose. The penetration depth was controlled by the hydrophobicity of the opposite anti-codon, with adenine always occupying the middle position for the hydrothermally formed hydrophobic amino acids. When the vesicle membrane was closely occupied by proto-tRNAs, the anti-codons acted as templates and stored the sequence of the peptides that form. In the cases of hydrophilic anti-codons, the acceptor arm does not reach far enough into the membrane. This allowed hydrophilic amino acids to be linked to 2´-OH.

Preprint ARTICLE | doi:10.20944/preprints202109.0467.v2

Unified Explanation of Big Bang, Inflation, Charged Black Hole Decay, Galaxy Formation, Proton Spin Crisis and Elementary Particle Masses

Jae-Kwang Hwang

Subject: Physical Sciences, Particle And Field Physics Keywords: Elementary particles; Galaxy structures; Charged black hole decay; Big bang and inflation; Super-massive black holes; Coulomb forces; Proton spin crisis; Dark matters; 4-D Euclidean space.

Online: 11 October 2021 (11:46:24 CEST)

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Space-time evolution is briefly explained by using the 3-dimensional quantized space model (TQSM) based on the 4-dimensional (4-D) Euclidean space. The energy (E=cDtDV), charges (|q|= cDt) and absolute time (ct) are newly defined based on the 4-D Euclidean space. The big bang is understood by the space-time evolution of the 4-D Euclidean space but not by the sudden 4-D Minkowski space-time creation. The big bang process created the matter universe with the positive energy and the partner anti-matter universe with the negative energy from the CPT symmetry. Our universe is the matter universe with the negative charges of electric charge (EC), lepton charge (LC) and color charge (CC). This first universe is made of three dark matter -, lepton -, and quark - primary black holes with the huge negative charges which cause the Coulomb repulsive forces much bigger than the gravitational forces. The huge Coulomb forces induce the inflation of the primary black holes, that decay to the super-massive black holes. The dark matter super-massive black holes surrounded by the normal matters and dark matters make the galaxies and galaxy clusters. The spiral arms of galaxies are closely related to the decay of the 3-D charged normal matter black holes to the 1-D charged normal matter black holes. The elementary leptons and quarks are created by the decay of the normal matter charged black holes, that is caused by the Coulomb forces much stronger than the gravitational forces. The Coulomb forces are very weak with the very small Coulomb constants (k₁(EC) = k_dd(EC) ) for the dark matters and very strong with the very big Coulomb constants (k₂(EC) = k_nn(EC)) for the normal matters because of the non-communication of the photons between the dark matters and normal matters. The photons are charge dependent and mass independent. But the dark matters and normal matters have the similar and very weak gravitational forces because of the communication of the gravitons between the dark matters and normal matters. The gravitons are charge independent and mass dependent. Note that the three kinds of charges (EC, LC and CC) and one kind of mass (m) exist in our matter universe. The dark matters, leptons and quarks have the charge configurations of (EC), (EC,LC) and (EC,LC,CC), respectively. Partial masses of elementary fermions are calculated, and the proton spin crisis is explained. The charged black holes are not the singularities.

Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0144.v1

Pyridoxal 5'-phosphate to mitigate immune dysregulation and coagulopathy in COVID-19

Julie Desbarats

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19, SARS-CoV-2, pyridoxal 5'-phosphate, pyridoxine, vitamin B6, immune response, IL-6, TNF, type I interferon, lymphopenia, blood clotting, coagulopathy, cytokine storm, sphingosine-1-phosphate, kynurenine, inflammasome, serine hydroxymethyltransferase 2 (SHMT2), hypertension, angiotensin

Online: 8 May 2020 (12:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0319.v1

Between Life and Death: Reducing Phototoxicity in Super-Resolution Microscopy

Kalina L. Tosheva, Yue Yuan, Pedro M. Pereira, Siân Culley, Ricardo Henriques

Subject: Biology And Life Sciences, Other Keywords: Phototoxicity, Photodamage, Super-Resolution Microscopy, Fluorescence

Online: 30 August 2019 (08:22:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0055.v1

Numerical Simulation of Hypervelocity Impact FEM-SPH Algorithm Based on Large Deformation of Material

Aimin Yang, Jinze Li, Hengheng Qu, Yuhang Pan, Yanhong Kang, Yuzhu Zhang

Subject: Computer Science And Mathematics, Analysis Keywords: finite element method; smoothed particle method; fem-sph algorithm; large deformation; super high speed collision

Online: 14 October 2016 (11:05:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201609.0096.v2

Quantum Cosmology vs. Observational Cosmology (A Simple, Curious and Advanced Approach)

U. V. S. Seshavatharam, S. Lakshminarayana

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: big bang; planck scale Hubble parameter; quantum cosmology; Mach’s principle; holographic principle; observational cosmology; super luminal expansion speed; super luminal rotation speed; dark energy; cosmic rotational kinetic energy; cosmic microwave back

Online: 8 October 2016 (10:26:06 CEST)

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Working Paper ARTICLE

Design Of a Dynamic and Self-Adapting System, Supported With Artificial Intelligence, Machine Learning and Real-Time Intelligence For Predictive Cyber Risk Analytics in Extreme Environments- Cyber Risk in the Colonisation of Mars

Petar Radanliev

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial intelligence; machine learning; real-time probabilistic data; for cyber risk; super forecasting; red teaming;

Online: 12 April 2021 (12:18:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0556.v1

Super-Resolution of Sentinel-2 Images at 10m Resolution without Reference Images

Yunhe Li, Bo Li

Subject: Engineering, Automotive Engineering Keywords: super-resolution; generative adversarial network; Sentinel-2

Online: 21 April 2021 (08:25:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0224.v2

Pseudopterosin Inhibits Proliferation and 3D Invasion in Triple Negative Breast Cancer by Agonizing Glucocorticoid Receptor Alpha

Julia Sperlich, Nicole Teusch

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: pseudopterosin; triple negative breast cancer; glucocorticoid receptor alpha; dexamethasone; cell proliferation; 3D invasion; tumor spheroid; co-culture; interleukin 6; interleukin 8

Online: 2 August 2018 (06:08:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0209.v1

Making Low-Resolution Satellite Images Reborn: A Deep Learning Approach for Super-Resolution Building Extraction

Lixian Zhang, Runmin Dong, Shuai Yuan, Weijia Li, Juepeng Zheng, Haohuan Fu

Subject: Environmental And Earth Sciences, Environmental Science Keywords: remote sensing imagery; building extraction; super-resolution; deep learning.

Online: 29 July 2021 (11:08:09 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201612.0111.v2

Nano Metal Dioxide Incorporated Conversion Phosphate Coatings—A Chemical Approach

Nilesh S. Bagal, Vaibhav S. Kathavate, Pravin P. Deshpande

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: chemical phosphate coating; EIS; nano TiO2; TAFEL

Online: 23 December 2016 (10:23:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0614.v1

Mixed Effects and Mechanisms of Cannabinoids for Triple-Negative Breast Cancer Treatment

Khanh Tran

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Triple-negative breast cancer; cannabinoid; marijuana; cell signalling; medicinal plants

Online: 28 July 2021 (08:56:32 CEST)

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Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the lack of estrogen receptors (ER), progesterone receptors, and HER-2 receptors. Thus, TNBC tumours do not benefit from the current therapies targeting ER or HER-2. Therefore, there is an urgent need to develop novel treatment for this subtype of breast cancer. Marijuana is a common name given to Cannabis plants, a group of plants in the Cannabis genus of the Cannabaceae family. Cannabis plants are among the oldest cultivated crops, traced back at least 12,000 years and are well known for their multi-purpose usage, including medicinal purposes. The main active compounds extracted from Cannabis plants are 21-carbon-containing terpenophenolics, which are referred to as phytocannabinoids. Of these, the tetrahydrocannabinol (THC) group contains highly potent cannabinoids, including delta-9-tetrahydrocannabinol (∆9-THC) and delta-8-tetrahydrocannabinol (∆8-THC), which are the most abundant THCs and are largely responsible for psychological and physiological effects of marijuana. The use of Cannabis plants for medicinal purposes was first recorded in 2337 BC in China, where Cannabis plants were used to treat pains, rheumatism, and gout. Recently, several cannabinoids have been approved for a number of treatments, one of which is the treatment of nausea and vomiting caused by chemotherapy in cancer patients. Furthermore, increasing evidence shows that cannabinoids not only attenuate side effects due to cancer treatment, but might also potentially possess direct antitumor effects in several cancer types, including breast cancer. However, anti-tumour activity of marijuana has been variable in different studies and even promoted tumour growth in some cases. In addition, the mechanisms of cannabinoid action in cancer remain unclear. This review summarizes evidence about the mixed actions of cannabinoids in cancer in general and triple-negative breast cancer in particular.

Preprint ARTICLE | doi:10.20944/preprints201706.0106.v1

Effect of a Particulate and a Putty-Like Tricalcium Phosphate-Based Bone Grafting Material on Bone Formation, Volume Stability and Osteogenic Marker Expression after Bilateral Sinus Floor Augmentation in Humans

Christine Knabe, Doaa Adel-Khattab, Esther Kluk, Rainer Struck, Michael Stiller

Subject: Chemistry And Materials Science, Biomaterials Keywords: Tricalcium phosphate putty scaffold; bioactive ceramics; bone formation, osteogenesis, osteogenic markers, hard tissue histology; immunohistochemical analysis; split-mouth design; sinus floor augmentation; bone grafting materials

Online: 22 June 2017 (18:33:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2246.v3

Rlc Electrical Modelling of Black Hole and Early Universe. Generalization of Boltzmann’s Constant in Curved Space-Time

Hector Gerardo Flores

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: RLC electrical model; RC electrical model; cosmology; astronomy; astrophysics; background radiation; Hubble’s law; Boltzmann´s constant; dark energy; dark matter; black hole; Big Bang; cosmic inflation; early universe; quantum gravity; CERN; LHC; Fermilab; general relativity; particle physics; condensed matter physics; M theory; super string theory; extra dimensions

Online: 8 August 2023 (13:53:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0108.v1

Neuropsychological Findings in Adults with Triple X Syndrome

Maarten Otter, Bea Campforts, Connie TRM Stumpel, Thérèse Van Amelsvoort, Claudia Vingerhoets, Marjan Drukker

Subject: Social Sciences, Cognitive Science Keywords: Triple X syndrome; Adults; Neurocognitive functioning; Sex Chromosomal Disorders; Attention; Psychomotor speed; Executive functioning

Online: 7 June 2022 (11:26:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0342.v1

Economic Potential of Rare Earth Elements in the Philippine Phosphogypsum

Jennyvi D. Ramirez, Reymar R. Diwa, Botvinnik L. Palattao, Estrellita U. Tabora, Angel T. Bautista VII, Rolando Y. Reyes

Subject: Chemistry And Materials Science, Biomaterials Keywords: phosphogypsum; REE; tailings pond; phosphate industry

Online: 15 July 2021 (09:10:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0705.v1

Generalization of the Standard Model. Theory of Everything (T.O.E.)

Hector Gerardo Flores, Maria Isabel Gonçalves de Souza, Harshit Jain

Subject: Physical Sciences, Particle And Field Physics Keywords: RLC electrical model; RC electrical model; cosmology; astronomy; astrophysics; background radiation; Hubble’ s law; Boltzmann´; s constant; dark energy; dark matter; black hole; Big Bang; cosmic inflation; early universe; quantum gravity; CERN; LHC; Fermilab; general relativity; particle physics; condensed matter physics; M theory; super string theory; extra dimensions.

Online: 9 January 2024 (10:21:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2076.v2

Electrical-Quantum Modelling of the Neutron and Proton as a Three-Phase Alternating Current Electrical Generator. Determination of the Number of Quarks-Antiquarks-Gluons and Gravitons, Inside a Neutron

Hector Gerardo Flores, Maria Isabel Gonçalves de Souza

Subject: Physical Sciences, Theoretical Physics Keywords: RLC electrical model; RC electrical model; cosmology; astronomy; astrophysics; background radiation; Hubble’ s law; Boltzmann´; s constant; dark energy; dark matter; black hole; Big Bang; cosmic inflation; early universe; quantum gravity; CERN; LHC; Fermilab; general relativity; particle physics; condensed matter physics; M theory; super string theory; extra dimensions

Online: 1 April 2024 (13:28:53 CEST)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202205.0230.v1

SEN2VENµS, a Dataset for the Training of Sentinel-2 Super-Resolution Algorithms

Julien Michel, Juan Vinasco-Salinas, Jordi Inglada, Olivier Hagolle

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Single Image Super-Resolution; Sentinel-2; VENµS; remote sening

Online: 17 May 2022 (11:13:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0323.v1

Triple Langmuir Probe for Diagnosis of Plasma Produced by Dielectric Barrier Discharge of Parallel Plates in Atmospheric Pressure

Ivan Alves de Souza, João Freire de Medeiros Neto, Antônia Karla Paixão Silveira, Thércio Henrique de carvalho Costa, Efrain Pantaleon Matamoros, Michelle Cequeira Feitor, Rômulo Ribeiro Magalhães Sousa

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: optical emission spectroscopy; Lissajous figures; triple Langmuir probe

Online: 31 January 2019 (07:36:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0546.v1

Atezolizumab and Pembrolizumab in Triple-Negative Breast Cancer: A Meta-Analysis

Mahwish Amin, Shaiza Sharif, Waleed Asghar, Humaira Sadaf, Azza Sarfraz, Zouina Sarfraz, Ivan Cherrez-Ojeda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; Pembrolizumab; Atezolizumab; chemotherapy; anti-PD-L1; biomarkers; targeted therapies; development of novel drugs

Online: 24 May 2021 (09:23:50 CEST)

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Working Paper REVIEW

Structural Changes of Hydroxylapatite During Plasma Spraying: Raman and NMR Spectroscopy Results

Robert Bertram Heimann

Subject: Chemistry And Materials Science, Biomaterials Keywords: hydroxylapatite, oxyhydroxylapatite, oxyapatite, tricalcium phosphate, tetracalcium phosphate, Raman spectroscopy, MAS-CP NMR spectroscopy, 2D-HETCOR NMR spectroscopy.

Online: 5 August 2021 (11:06:47 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202203.0146.v1

Expansion Microscopy on Saccharomyces cerevisiae

Artemis G. Korovesi, Leonor Morgado, Marco Fumasoni, Ricardo Henriques, Hannah Heil, Mario Del Rosario

Subject: Biology And Life Sciences, Biophysics Keywords: expansion microscopy; yeast; Saccharomyces cerevisiae; super-resolution

Online: 10 March 2022 (10:51:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0603.v1

nanoPaint: Dynamic Imaging of Nanoscopic Structural Plasticity of the Plasma Membrane

Mariana Tasso, Thomas Pons, Nicolas Lequeux, Julie Nguyen, Zsolt Lenkei, Diana Zala

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: super-resolution microscopy; quantum dots; cannabinoid receptor type 1; neuronal plasticity; synapses

Online: 25 October 2018 (11:19:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0002.v1

Combining Blockchain Technology and the Physical Internet to Achieve Triple Bottom Line Sustainability: A Comprehensive Research Agenda for Modern Logistics and Supply Chain Management

Horst Treiblmaier

Subject: Computer Science And Mathematics, Computer Science Keywords: blockchain; distributed ledger technology; physical internet; logistics; supply chain management; research framework; innovation; information technology; triple bottom line; sustainability

Online: 1 February 2019 (04:00:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0129.v1

A Phase-Field Perspective on Mereotopology

Georg J. Schmitz

Subject: Physical Sciences, Mathematical Physics Keywords: Region based theory of space; RBTS; Contact algebra; Dyadic and Triadic relations; sequent algebra; boundaries; triple junctions; mereotopology; 4D mereotopology; mereophysics; Region Connect Calculus RCC; invariant spacetime interval; Falaco solitons; phase-field method; intuitionistic logic

Online: 5 August 2021 (08:39:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0054.v1

Phosphate Detection in Hydroponics using Molecularly Imprinted Polymer Sensors

Christopher S. Storer, Zachary Coldrick, Daniel Tate, Jack Marsden Donoghue, Bruce Grieve

Subject: Engineering, Electrical And Electronic Engineering Keywords: hydroponics; interdigitated electrodes; molecularly imprinted polymer; nutrient monitoring; phosphate; polymer sensor; precision agriculture

Online: 8 January 2018 (09:22:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0349.v1

Ethical Regulators and Super-Ethical Systems

Mick Ashby

Subject: Engineering, Control And Systems Engineering Keywords: ethics; regulator; superintelligence; super-ethical systems; requisite variety; cybernetics; third-order cybernetics; cyberanthropic utopia; grand challenge

Online: 31 July 2019 (10:40:58 CEST)

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Working Paper REVIEW

Application of Super-Resolution and Advanced Quantitative Microscopy to the Spatio-Temporal Analysis of Influenza Virus Replication

Emma Touizer, Christian Sieben, Ricardo Henriques, Mark Marsh, Romain F. Laine

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: super-resolution microscopy; advanced light microscopy; quantitative microscopy; live-cell microscopy; SMLM; STORM; SIM; STED; expansion microscopy; influenza virus; viral replication

Online: 6 January 2021 (10:40:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0062.v1

Histological Assessment of Bone Regeneration by Octacalcium Phosphate and Bone Matrix Gelatin Composites in a Rat Mandibular Defect Model

Fereydoon Sargolzaei Aval, Eshaghali Saberi, Mohammad Reza Arab, Narjes Sargolzaei, Esmaeel Zare, Heshmatallah Shahraki, Forough Sargolzaeiaval, Maryam Arab

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: octacalcium phosphate; bone matrix gelatin; osteogenesis

Online: 9 January 2018 (03:14:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0216.v1

Developing Green Super Rice Varieties with High Nutrient Use Efficiency by Phenotypic Selection Under Varied Nutrient Conditions

Zilhas Jewel, Jauhar Ali, Yunlong Pang, Mahender Anumalla, Bart Acero, Jose Hernandez, Jianlong Xu, Zhikang Li

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: nutrient use efficiency; grain yield; nitrogen, phosphorus; potassium; green super rice; BC breeding

Online: 12 July 2018 (11:05:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0302.v2

Gravitational Field and Mass

Yin Zhu

Subject: Physical Sciences, Particle And Field Physics Keywords: Super strong gravitational field; Mass-Gravitational field conversion; Graviton-photon conversion; Graviton-photon to electron-proton conversion; Vacuum fluctuation; Vacuum polarization

Online: 1 December 2021 (12:49:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0132.v1

Concentrated Phosphorus Recovery from Food Grade Animal Bones for Agronomical Efficient Innovative Fertiliser Applications in the Organic and Low Input Farming Sectors

Edward Someus

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: bio-phosphate; ABC Animal-Bone-Char; 3R pyrolysis; phosphorus recovery; animal by-products; apatite

Online: 10 April 2018 (16:28:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0288.v1

A Methylcellulose Hydrogel as Support for 3D Plotting of Complex Shaped Calcium Phosphate Scaffolds

Tilman Ahlfeld, Tino Köhler, Charis Czichy, Anja Lode, Michael Gelinsky

Subject: Chemistry And Materials Science, Biomaterials Keywords: calcium phosphate cement; methylcellulose; 3D plotting; support; hydroxyapatite

Online: 16 July 2018 (12:55:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0010.v1

Revolution in Gene Medicine Therapy and Genome Therapy

David Jiang, Christine L. Xu, Stephen H. Tsang

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Gene therapy, gene editing, CRISPR/Cas9, Cas12a, dual AAV, triple AAV, clinical trials, retina, hereditary retinal dystrophies

Online: 1 October 2018 (13:52:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0291.v1

Standardized in vivo Evaluation of Biocompatibility and Bioresorption of a New Synthetic Membrane for Guided Bone Regeneration

Lívia da Costa Pereira, Carlos Fernando de Almeida Barros Mourão, Adriana Terezinha Neves Novellino Alves, Rodrigo Figueiredo de Brito Resende, Marcelo José Pinheiro Guedes de Uzeda, Rafael Seabra Louro, Mônica Diuana Calasans-Maia

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Membranes; Polymer; Biocompatibility; Inflammatory cells; Calcium Phosphate

Online: 29 January 2019 (09:38:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0092.v1

Principal Mismatch Patterns across a Simplified Highly Renewable European Electricity Network

Mads Raunbak, Timo Zeyer, Kun Zhu, Martin Greiner

Subject: Engineering, Energy And Fuel Technology Keywords: renewable energy networks; principal component analysis; large-scale integration of renewables; wind power; solar power; super grid; energy system design

Online: 20 September 2017 (04:44:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0619.v1

Gas Hydrate Estimate in an Area of Deformation and High Heat Flow at the Chile Triple Junction

Lucía Villar-Muñoz, Iván Vargas-Cordero, Joaquim P. Bento, Umberta Tinivella, Francisco Fernandoy, Michela Giustiniani, Jan H. Behrmann, Sergio Calderon-Diaz

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: BSR; gas hydrate; methane; seepage; active margin; Chile Triple Junction

Online: 26 October 2018 (06:18:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0009.v1

Grain Refinement Kinetics in a Low Alloyed Cu-Cr-Zr Alloy Subjected to Large Strain Deformation

Anna Morozova, Elijah Borodin, Vladimir Bratov, Sergey Zherebtsov, Andrey Belyakov, Rustam Kaibyshev

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Cu-Cr-Zr alloy; grain refinement; severe plastic deformation; triple junctions; grain refinement kinetics

Online: 1 December 2017 (16:05:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0313.v3

Small-Object Detection in Remote Sensing Images with End-to-End Edge-Enhanced GAN and Object Detector Network

Jakaria Rabbi, Nilanjan Ray, Matthias Schubert, Subir Chowdhury, Dennis Chao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: object detection; faster region-based convolutional neural network (FRCNN); single-shot multibox detector (SSD); super-resolution; remote sensing imagery; edge enhancement; satellites

Online: 29 April 2020 (13:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0777.v1

Prediction of Response to Atezolizumab Plus Nab-Paclitaxel in Unresectable Locally Advanced Triple Negative Breast Cancer (TNBC): the ClinicalUsefulness of PD-L1 mRNA Expression in Plasma-Derived Exosomes

Lucrezia Raimondi, Gian Paolo Spinelli, Paolo Ciracì, Filippo Maria Raimondi, Rachele Lazzeroni, Laura Di Benedetto, Stefano Valabrega, Laura Giaconi, Luigi Rossi, Giuseppe Naso

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Exosomal PD-L1 mRNA; extracellular vesicles; Triple Negative Breast Cancer; Immunotherapy; PD-L1 axis; Atezolizumab – nab-paclitaxel; Predictive biomarkers; Liquid biopsy

Online: 31 March 2021 (15:27:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0095.v1

EP4 as a Therapeutic Target for Aggressive Human Breast Cancer

Mousumi Majumder, Pinki Nandi, Ahmed Omar, Kingsley Chukwunonso Ugwuagbo, Peeyush K. Lala

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: COX-2; breast cancer; PGE2; EP receptors; stem-like cells; metastasis; angiogenesis; lymphangiogenesis; MicroRNAs; triple negative breast cancer

Online: 13 February 2018 (09:16:54 CET)

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G protein-coupled receptors (GPCRs, also called seven-transmembrane or heptahelical receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular ligands and transmit signals to an intracellular guanine nucleotide-binding protein (G protein). When a ligand binds, the receptor activates the attached G-protein by causing the exchange of Guanosine-5'-triphosphate (GTP) for guanosine diphosphate (GDP). They play a major role in many physiological functions as well as in the pathology of many diseases including cancer progression and metastasis. Only a few GPCR members have been exploited as targets for developing drugs with therapeutic benefit in cancer. Present review deals with the Prostaglandin E receptor EP4, a member of the EP family of GPCR, as a promising newer therapeutic target for treating breast cancer. We show that aberrant over-expression of cyclooxygenase (COX)-2, an inflammation-associated enzyme, occurring in 40-50% of breast cancer patients leads to tumor progression and metastasis due to multiple cellular events resulting from an increased prostaglandin (PG) E2 production in the tumor milieu. They include inactivation of host anti-tumor immune (NK and T) cells, increased immuno-suppressor function of tumor-associated macrophages, promotion of tumor cell migration, invasiveness and tumor-associated angiogenesis (due to upregulation of VEGF-A), lymphangiogenesis (due to upregulation of VEGF-C/D) and a stimulation of stem-like cell (SLC) phenotype in cancer cells. All these events were primarily mediated by activation of the PGE receptor EP4 on tumor or host cells. We show that selective EP4 antagonists (EP4A) could mitigate all these events tested with cells in vitro as well as in vivo in syngeneic COX-2 expressing mammary cancer bearing mice or immune-deficient mice bearing COX-2 over-expressing human breast cancer xenografts. We suggest that EP4A can avoid thrombo-embolic side effects of long term use of COX-2 inhibitors by sparing cardio-protective roles of PGI2 via IP receptor activation or PGE2 via EP3 receptor activation. Furthermore, we identified two COX-2/EP4 induced oncogenic and SLC-stimulating microRNAs - miR526b and miR655, one of which (miR655) appears to be a potential blood biomarker in breast cancer patients, for monitoring SLC-ablative therapies such as with EP4A. We suggest that EP4A will likely produce the highest benefit in aggressive breast cancers such as COX-2 expressing triple-negative breast cancers, when combined with other newer agents such as PD-1 or PD-L1 inhibitors.

Preprint ARTICLE | doi:10.20944/preprints201803.0174.v1

Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women

Tarun Mamidi, Jiande Wu, Paul B. Tchounwou, Lucio Miele, Chindo Hicks

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: gene expression obesity triple negative breast cancer

Online: 20 March 2018 (07:56:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0344.v1

Vitamin D Content of Australian Native Food Plants and Australian-Grown Edible Seaweed

Laura J. Hughes, Lucinda J. Black, Jill L. Sherriff, Eleanor Dunlop, Norbert Strobel, Robyn M. Lucas, Janet F. Bornman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: LC-QQQ; liquid chromatography; triple quadrupole; vitamin D; 25(OH)D; plants; algae

Online: 24 May 2018 (09:27:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0085.v1

Chick Embryo Experimental Platform for 3D Tissue Engineering Modelling of Cancer Micrometastases for Tumor Biology, Drug Development and Nanomaterials Testing

Anna Guller, Inga Kuschnerus, Vlada Rozova, Annemarie Nadort, Yin Yao, Zahra Khabir, Alfonso Garcia-Bennett, Liuen (Olivia) Liang, Aleksandra Polikarpova, Yi Qian, Ewa M. Goldys, Andrei Zvyagin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chick embryo; 3D culture; tumor models in vitro; tissue engineering; metastasis; triple-negative breast cancer; liver; mesoporous silica nanoparticles; doxorubicin; micrometastasis

Online: 6 September 2021 (11:46:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0178.v1

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Melissa Davis, Rachel Martini, Lisa Newman, Olivier Elemento, Jason White, Akanksha Verma, Indrani Datta, Indra Adrianto, Kevin Gardner, Hyung-Gyoon Kim, Windy Dean-Colomb, Isam Eldin Eltoum, Andra R Frost, William E. Grizzle, Andrea Sboner, Upender Manne, Clayton Yates

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; African Ancestry; RNAseq analysis; oncologic pathways

Online: 12 April 2020 (04:22:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0138.v1

Who is the Muslim? Discursive Representations of the Muslims and Islam in Indian Prime Time News

Onaiza Drabu

Subject: Social Sciences, Political Science Keywords: politics of representation; media; Islam; media representation; Muslims; Islamophobia.; racism; anti-Muslim racism; love jihad; triple talaq; Muslims in India

Online: 7 August 2018 (08:27:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0140.v1

Pathway-Focused Gene Interaction Analysis Reveals the Regulation of TGFβ, Pentose Phosphate and Antioxidant Defense System by Placental Growth Factor in Retinal Endothelial Cell Functions: Implication in Diabetic Retinopathy

Hu Huang, Madhu Sudhana Saddala, Anton Lennikov, Anthony Mukwaya, Lijuan Fan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: PlGF; PGF; blood-retinal barrier; RNA Seq; HREC; gene ontology; fastQC; Trimmomatic; KEGG; pentose phosphate pathway; TGF-β

Online: 10 July 2019 (07:48:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0284.v1

Roles of Arbuscular Mycorrhizal Fungi on Soil Fertility and Its Importance in Phytoremediation of Polluted Soil

Abdoulaye Fofana Fall, Grace Nakabonge, Joseph Ssekandi, Hassna Founoune-Mboup, Samuel Obeng Apori, Abibatou Ndiaye, Arfang Badji, Khady Ngom

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Microorganisms; Macro-aggregation; Rock phosphate; Glomalin

Online: 16 September 2021 (13:29:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0255.v1

Magnesium Potassium Phosphate Compound for Immobilization of Radioactive Waste Containing Actinide and Rare Earth Elements

Sergey E. Vinokurov, Svetlana A. Kulikova, Boris F. Myasoedov

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: magnesium potassium phosphate compound; actinides; rare earth elements; uranium; plutonium; americium; lanthanum; neodymium; immobilization; leaching

Online: 18 May 2018 (06:13:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0007.v1

Conversion of Bivalve Shells to Advanced Calcium Phosphate Materials: A Simple, Rapid, Environmentally Benign, and Cost-effective Approach to Recycle Seafood Wastes

Somkiat Seesanong, Banjong Boonchom, Kittichai Chaiseeda, Wimonmat Boonmee, Nongnuch Laohavisuti

Subject: Chemistry And Materials Science, Biomaterials Keywords: calcium phosphate; monocalcium phosphate; tricalcium phosphate; calcium carbonate; seashell; bivalve shells

Online: 1 July 2021 (10:48:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0121.v1

Project Management’s Triple Constraints Mapping on Augmented Reality based Learning System for Improved Quality

Mehreen Sirshar, Syeda Hafsa Ali, Haleema Sadia Baig

Subject: Engineering, Control And Systems Engineering Keywords: triple constraints; augmented reality; Augmented reality-based learning systems; time; cost; scope; artificial intelligence; education

Online: 9 December 2019 (09:17:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0329.v1

From Shipbreaking Literature to Sustainability Framework for Developing Country Recycling: a Review (Part 2)

Sm Rahman

Subject: Engineering, Automotive Engineering Keywords: shipbreaking; triple bottom line sustainability; strange alliance; organizational learning

Online: 18 January 2021 (12:09:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0166.v1

Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone

Jooseong Kim, Sukyoung Kim, In-Hwan Song

Subject: Chemistry And Materials Science, Biomaterials Keywords: Octacalcium phosphate (OCP); Hydroxyapatite (HA); Biphasic calcium phosphate (BCP); Xeno-genic bone; Synthetic bone; Bone Regeneration; Phase conversion; Mineralization

Online: 9 September 2021 (08:23:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0252.v1

Synergy in Knowledge-Based Innovation Systems at National and Regional Levels: The Triple Helix Model and the Fourth Industrial Revolution

Loet Leydesdorff

Subject: Social Sciences, Library And Information Sciences Keywords: triple helix; innovation systems; reflexive turn; expectation; synergy

Online: 19 April 2018 (11:28:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0632.v1

Mathematical Blockchain Modeling of Peer-to-Peer Networks for Gene Expression in Cell Population

Jung In Choi

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Blockchain; P2P Networks; Nucleobase DNA/RNA sequence; Gene Expression; Cell Population; Epigenetics; Methylation; Consensus; Hash Algorithm; Triple Codons; Protein Synthesis; Cryptocurrency

Online: 28 August 2020 (10:33:42 CEST)

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The study presents a mathematical modeling for supporting the premise that our body is composed of blockchain systems. A cell population is considered a space with peer-to-peer communication networks for applying blockchain protocol. Transaction is defined as gene expression that constantly occurs for protein synthesis in each cell. The transaction process proceeds according to the blockchain protocol with sharing and recording the data on the blockchain ledger. The premise comes from the clues of the previous research such that the cell population is a complex structured network system having cell-to-cell connections. Although individual cells exhibit stochastic nonlinear dynamic behavior, cell population shows consensus behavior that reaches to ensemble through interaction among cells. It is inferred that gene expression is not regulated by the corresponding cell only nor determined by external intelligence such as the brain. This is achieved through a consensus through stochastic interactions between cells over the whole cell population. These findings imply that mathematical blockchain modeling is a suitable for gene expression process. The original contribution of the study is a methodology for applying mathematically the blockchain protocol to the real biological gene expression process. In other words, the DNA sequence is converted into a numeral bit sequence that makes it possible to implement the blockchain protocol. A new DNA sequence scheme is proposed with adding methylated cytosine and adenine as the 5th and 6th bases for including epigenetic information which has profound effect on gene expression and regulation. The methodology was applied to the real biological synthesis process of protein samples. The protein is composed of amino acids that are encoded by triplet codons of 216 kinds with 6 base RNA sequence. The gene expression information is traced backward from a synthesized protein sample, amino acids of codons, RNA transcript up to DNA sequence. One of the results is a numeric value in the form of a bit sequence with which mathematical blockchain modeling is applicable. The cryptographic authentication and the consensus process are mathematically proven to work properly by the blockchain protocol. It implies that the same protein is synthesized, but with different epigenetic data, then protein's latent material properties will certainly be different. Although the result has not been justified by the biologic experiment yet, it is sure that the biological hidden algorithm inside DNA sequence will be revealed by the binary bit-logic with physical on/off states which is mathematically proven. The research will greatly contribute to disease treatment and medicine development as well as epigenetics in the future.

Preprint REVIEW | doi:10.20944/preprints201912.0165.v2

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Andriy Cherkas, Serhii Holota, Tamaz Mdzinarashvili, Rosita Gabbianelli, Neven Zarkovic

Subject: Biology And Life Sciences, Food Science And Technology Keywords: glucose; pentose phosphate pathway; NADPH; redox balance; glycogen; glycolysis; stress resistance; insulin resistance

Online: 30 January 2020 (12:49:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0206.v1

The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis

Askhat Myngbay, Limara Manarbek, Steve B. Ludbrook, Jeannette Kunz

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Collagen triple helix repeat containing 1; CTHRC1; rheumatoid arthritis; biomarker; bone erosion; cartilage destruction; fibroblast-like synoviocytes; Wnt signaling

Online: 10 July 2020 (07:51:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0133.v1

Phenotypic Heterogeneity Drives Differential Disease Outcome in Triple Negative Breast Cancer

Archana P. Thankamony, Reshma Murali, Priyanka Chakraborty, Nitheesh Karthikeyan, Binitha Anu Varghese, Vishnu Sunil Jaikumar, Mohit Kumar Jolly, Radhika Nair

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Intratumoral heterogeneity; Triple negative breast cancer (TNBC); Macc1; Phenotypic heteroge-neity

Online: 9 February 2022 (10:40:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0327.v1

Truncations of W∞ Algebras

Mohammed Akram Fellah

Subject: Physical Sciences, Mathematical Physics Keywords: Vertex Algebras on the corner; the GL-twisted N=4 Super Yang Mills gauge theory; W∞ Algebras

Online: 23 March 2020 (01:45:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0423.v1

Multi-Scale Computational Simulation of Amorphous Silicates. Structural, Dielectric and Vibrational Spectroscopic Properties

José Ángel Martínez-González, Javier Navarro-Ruiz, Albert Rimola

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: DFT; periodic simulations; amorphous minerals; physico-chemical properties; super-cell

Online: 26 June 2018 (13:10:49 CEST)

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Silicates are among the most abundant and important inorganic materials, not only in the Earth’s crust but also in the interstellar medium in the form of micro-/nano-particles or embedded in the matrices of comets, meteorites and other asteroidal bodies. Although the crystalline phases of silicates are indeed present in Nature, amorphous forms are also highly abundant. Here we report a theoretical investigation of the structural, dielectric and vibrational properties of the amorphous bulk for forsterite (Mg₂SiO₄) as a silicate test case by a combined approach of classical molecular dynamics (MD) simulations for structure evolution, and periodic quantum mechanical DFT calculations for electronic structure analysis. Using classical MD based on an empirical partial charge rigid ionic model within a melt-quenching scheme at different temperatures performed with the GULP 4.0 code amorphous bulk structures for Mg₂SiO₄ were generated using as initial guess the crystalline phase. This has been done for bulks with three different unit cell sizes adopting a super-cell approach; i.e., 1×1×2, 2×1×2 and 2×2×2. The radial distribution functions indicated a good degree of amorphisation of the structures. Periodic B3LYP-geometry optimizations performed with the CRYSTAL14 code on the generated amorphous systems were used to analyze their structure, to calculate their high frequency dielectric constants (ε_∞), and to simulate the IR, Raman and reflectance spectra, which were compared with the experimental and theoretical crystalline Mg₂SiO₄. The most significant changes of the physico-chemical properties of the amorphous systems compared to the crystalline ones are presented and discussed (e.g., larger deviations in the bond distances and angles, broadening of the IR bands, etc.), which are consistent with their disordered nature. It is also shown that by increasing the unit cell size the bulk structures present larger degree of amorphisation.

Preprint REVIEW | doi:10.20944/preprints202004.0139.v1

Potential Super Spreading’s of SARS-2 Pandemic. A Short Review

Anthony Kyriakopoulos

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS epidemiology; super spread events; efficient diagnosis to contain magnitude of SARS-2 outbreaks

Online: 9 April 2020 (07:48:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0081.v1

Recrystallization of Triple Superphosphate Produced From Oyster Shell Waste for Agronomic Performance and Environmental Issue

Somkiat Seesanong, Chaowared Seangarun, Banjong Boonchom, Chuchai Sronsri, Nongnuch Laohavisuti, Kittichai Chaiseeda, Wimonmat Boonmee

Subject: Chemistry And Materials Science, Biomaterials Keywords: Ca(H2PO4)2·H2O; Triple superphosphate; Fertilizer; Recrystallization; Oyster shell; Thermal decomposition

Online: 6 January 2022 (11:48:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0235.v1

Improvement of Cadmium Detoxification Potential and Plant Growth Promotion by Bacterial Endophytes

Ihsan Ullah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: endophytic bacteria; indole-3-acetic acid; cadmium accumulation; phosphate solubilization; reduced glutathione

Online: 23 August 2019 (04:06:54 CEST)

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Working Paper COMMUNICATION

Doubly-Charged Negative Ions of Triple-Hybrid Atomic-Metal, Super-benzene, Fullerene, and Nanotube as Novel Catalysts for Clean Air through SO₂ Reduction by CO

Kelvin Suggs, Alfred Z Msezane

Subject: Physical Sciences, Acoustics Keywords: Sulfur dioxide reduction; doubly-charged anions; triple-hybrid catalyst; super-benzene; fullerene; atomic metals; tunable catalysts; carbon nanotube

Online: 9 June 2021 (11:52:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0508.v1

Finite Element Modeling of A phenomenological Constitutive Model for Super-elastic Shape Memory Alloy and its Application for Preload Process Analysis of Bolted Joint

Xiangjun Jiang, Jin Huang, Yongkun Wang, Fengqun Pan, Baotong Li, Peng Hao

Subject: Engineering, Mechanical Engineering Keywords: SMAs; Super-elasticity; FE implementation; Phase transformation ratcheting; Preload process analysis of bolt

Online: 26 July 2018 (09:45:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0263.v1

Isolation and Characterization of Phosphate Solubilizing Streptomyces Endemic From Sugar Beet Fields Of the Beni-Mellal Region In Morocco

Yassine Aallam, Driss Dhiba, Sanaâ Lemriss, Amal Souiri, Fatma Karray, Taoufik El Rasafi, Nezha Saïdi, Abdelmajid Haddioui, Saâd El Kabbaj, Marie Joëlle Virolle, Hamdali Hanane

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Insoluble phosphate; Biosolubilizing; Biofertilizer; Actinobacteria; Sugar beet

Online: 9 April 2021 (13:34:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0266.v1

Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs as Novel Tools for Non-Invasive cell Assays

Alexandra Ruthenbeck, Elisa Marangoni, Björn-Ph. Diercks, Aileen Krüger, Viacheslav O. Nikolaev, Andreas H. Guse, Chris Meier

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: cyclic nucleotide monophosphate; bio-reversible protection; acyloxybenzyl phosphate ester

Online: 12 October 2018 (11:32:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0408.v1

Effect of Cavity Vacuum Pressure Diminution on Thermal Performance of Triple Vacuum Glazing

Saim Memon, Farukh Farukh, Karthikeyan Kandan

Subject: Physical Sciences, Applied Physics Keywords: vacuum pressure; triple vacuum glazing; finite element modelling; thermal performance; towards zero-energy buildings

Online: 23 August 2018 (06:35:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0317.v1

Potential of Advanced Consolidants for the Application on Sandstone Rocks: A Comparative Study

Monika Remzova, Radek Zouzelka, Jaroslav Lukes, Jiri Rathousky

Subject: Chemistry And Materials Science, Nanotechnology Keywords: consolidation; sandstone; alkoxide consolidants; diammonium hydrogen phosphate; accelerated weathering; durability

Online: 28 September 2019 (15:12:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0177.v1

The Akimotoite--Majorite--Bridgmanite Triple Point Determined in Large Volume Press and Laser-Heated Diamond Anvil Cell

Britany Kulka, Jonathan Dolinschi, Kurt Leinenweber, Vitali Prakapenka, Sang-Heon Shim

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: triple point; bridgmanite; akimotoite; majorite; large-volume press; laser-heated diamond anvil cell

Online: 12 December 2019 (12:47:47 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202008.0665.v1

Evolutionary Insights into the Envelope Protein of SARS-CoV-2

M. Shaminur Rahman, M. Nazmul Hoque, M. Rafiul Islam, Israt Islam, Israt Dilruba Mishu, Md. Mizanur Rahaman, Munawar Sultana, M. Anwar Hossain

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; envelop protein; mutations; transmembrane domain; triple cysteine motif

Online: 30 August 2020 (11:50:59 CEST)

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Working Paper ARTICLE

Effect of W on the Evolution of Precipitates in Ni-Co-Cr-W-Mo Super-Alloys

Hansheng Bao, Zhihua Gong, Zhengzong Chen, Gang Yang, Zhengdong Liu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: nickel-based super-alloys; M6C; u phase; long time exposure; M12C

Online: 16 September 2019 (01:22:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0530.v1

Supervised Strategies of Multiblock Data Analysis: A Unified Approach and Extension

Essomanda Tchandao Mangamana, Romain Lucas Glele Kakai, El Mostafa Qannari

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Multiblock data analysis; redundancy analysis; PLS regression; super- vised methods; multicolinearity

Online: 22 March 2021 (12:25:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0194.v1

Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass

Ana S. Neto, Daniela Brazete, José M.F. Ferreira

Subject: Chemistry And Materials Science, Biomaterials Keywords: Cuttlefish bone; Biphasic calcium phosphate; Porous scaffolds; Sol-gel coatings; Bioactivity; Tissue engineering

Online: 16 July 2019 (12:32:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0333.v1

Enhanced lycopene Production in Escherichia coli by Expression of Two MEP Pathway Enzymes from Vibrio sp. dhg

Min Jae Kim, Myung Hyun Noh, Sunghwa Woo, Hyun Gyu Lim, Gyoo Yeol Jung

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: metabolic engineering; lycopene; MEP pathway; 1-deoxy-D-xylulose-5-phosphate synthase; farnesyl diphosphate synthase; Vibrio sp. dhg

Online: 29 October 2019 (10:40:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0355.v2

Understanding Nuclear Binding Energy with Nucleon Mass Difference via Strong Coupling Constant and Strong Nuclear Gravity

Satya Seshavatharam U.V, S. Lakshminarayana

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: strong (nuclear) gravity; nuclear elementary charge; strong coupling constant; nuclear charge radius; beta stability line; nuclear binding energy; nucleon mass difference; Fermi’s weak coupling constant; Newtonian gravitational constant; deuteron; interaction range; super heavy elements

Online: 8 January 2019 (10:57:41 CET)

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With reference to electromagnetic interaction and Abdus Salam’s strong (nuclear) gravity, 1) Square root of ‘reciprocal’ of the strong coupling constant can be considered as the strength of nuclear elementary charge. 2) ‘Reciprocal’ of the strong coupling constant can be considered as the maximum strength of nuclear binding energy. 3) In deuteron, strength of nuclear binding energy is around unity and there exists no strong interaction in between neutron and proton.

G_{s} ≅ 3.32688 \times 10^{28} m^{3} {kg}^{- 1} \sec^{- 2}

being the nuclear gravitational constant, nuclear charge radius can be shown to be,

R_{0} ≅ \frac{2 G_{s} m_{p}}{c^{2}} ≅ 1.24 fm .

e_{s} ≅ (\frac{G_{s} m_{p}^{2}}{ℏ c}) e ≅ 4.716785 \times 10^{- 19} C

being the nuclear elementary charge, proton magnetic moment can be shown to be,

μ_{p} ≅ \frac{e_{s} ℏ}{2 m_{p}} ≅ \frac{e G_{s} m_{p}}{2 c} ≅ 1.48694 \times 10^{- 26} J {. T}^{- 1} .

α_{s} ≅ {(\frac{ℏ c}{G_{s} m_{p}^{2}})}^{2} ≅ 0.1153795

being the strong coupling constant, strong interaction range can be shown to be proportional to

\exp (\frac{1}{α_{s}^{2}}) .

Interesting points to be noted are: An increase in the value of

α_{s}

helps in decreasing the interaction range indicating a more strongly bound nuclear system. A decrease in the value of

α_{s}

helps in increasing the interaction range indicating a more weakly bound nuclear system. From

Z ≅ 30

onwards, close to stable mass numbers, nuclear binding energy can be addressed with,

{(B)}_{A_{s}} ≅ Z \times {(\frac{1}{α_{s}} + 1) + \sqrt{\sqrt{30 \times 31}}} (m_{n} - m_{p}) c^{2} \approx Z \times 19.66 MeV .

With further study, magnitude of the Newtonian gravitational constant can be estimated with nuclear elementary physical constants. One sample relation is,

(\frac{G_{N}}{G_{s}}) ≅ \frac{1}{2} {(\frac{m_{e}}{m_{p}})}^{10} [\sqrt{\frac{G_{F}}{ℏ c}} / (\frac{ℏ}{m_{e} c})]

where

G_{N}

represents the Newtonian gravitational constant and

G_{F}

represents the Fermi’s weak coupling constant. Two interesting coincidences are,

{(m_{p} / m_{e})}^{10} ≅ \exp (1 / α_{s}^{2})

and

2 G_{s} m_{e} / c^{2} ≅ \sqrt{G_{F} / ℏ c} .

Preprint ARTICLE | doi:10.20944/preprints202104.0158.v1

Thickness Optimization of Thin-Film Tandem Organic Solar Cell

Kamran Ali Bangash, Syed Asfandyar Ali Kazmi, Waqas Farooq, Saba Ayub, Muhammad Ali Musarat, Wesam Salah Alaloul, Muhammad Faisal Javed, Amir Mosavi

Subject: Computer Science And Mathematics, Computer Science Keywords: Organic Solar Cells; Triple Junction; Tandem, Energy Harvesting; Temperature.

Online: 6 April 2021 (09:21:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0444.v1

Changes in Cell Morphology and Actin Organization in Embryonic Stem Cells Cultured Under Different Conditions

Kasper Graves Hvid, Irene Istúriz Petitjean, Younes Farhangi Barooji, Joshua M Brickman, Lene Broeng Oddershede, Poul Martin Bendix

Subject: Physical Sciences, Biophysics Keywords: actin cytoskeleton; super-resolution microscopy; embryonic stem cells; primed embryonic stem cells; micro-rheology; cell culturing; optical tweezers

Online: 23 August 2021 (13:31:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0730.v1

Strategic Actors and their Scenarios in the Extraction of Phosphates from the Mantaro Valley

Israel Mallma, Lita Salazar Vásquez

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Prospective analysis; strategic actors; scenarios; objectives; policies; phosphate extraction; mining project; rural communities

Online: 28 April 2021 (07:47:34 CEST)

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Followed by the aspect of respect for rights 20, the social and environmental issue has a score of 19.9, the dialogue issue is 19. In short, the proximity plan indicates that the policies used regarding the issue of generating employment and economic growth (Empresa Mantaro Perú SAC), continue to be the strategic variables in the first instance, but they are far from the social actors (rural communities of Aco, Vico, Cruz Pampa and others) and environmental (Junín environmental dialogue table) and Ombudsman's Office (rights) that are currently closer together. The actor from the Archbishop of Huancayo referred to communication is one of the driving variables of power. The proximity plan shows us that the policies used regarding the issue of generating employment and economic growth (Empresa Mantaro Perú SAC), continue to be the strategic variables in the first instance, but that they are far from the social actors (Rural Communities of Aco , Vico, Cruz Pampa and others) and environmental (Junín Environmental Dialogue Table) and Ombudsman's Office (rights) that are currently closer together. The actor from the Archbishop of Huancayo referred to communication is one of the driving variables of power. The proximity plan shows us that the policies used regarding the issue of generating employment and economic growth (Empresa Mantaro Perú SAC), continue to be the strategic variables in the first instance, but that they are far from the social actors (Rural Communities of Aco , Vico, Cruz Pampa and others) and environmental (Junín Environmental Dialogue Table) and Ombudsman's Office (rights) that are currently closer together. The actor from the Archbishop of Huancayo referred to communication is one of the driving variables of power. but they are far from the social actors (rural communities of Aco, Vico, Cruz Pampa and others) and environmental (Junín Environmental Dialogue Table) and the Ombudsman's Office (rights) that are closer together today. The actor from the Archbishopric of Huancayo referred to communication, is within the driving variables of power. but they are far from the social actors (rural communities of Aco, Vico, Cruz Pampa and others) and environmental (Junín Environmental Dialogue Table) and the Ombudsman's Office (rights) that are currently closer together. The actor of the Archbishopric of Huancayo referred to communication, is within the driving variables of power.

Preprint REVIEW | doi:10.20944/preprints202109.0047.v2

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC

Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; TGF-β

Online: 8 September 2021 (20:53:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0595.v1

Nanoemulsion-Enabled Oral Delivery of Novel Anticancer ω-3 Fatty Acid Derivatives

Gabriela Garrastazu Pereira, Tristan Rawling, Michele Pozzoli, Curtis Pazderka, Yongjuan Chen, Colin R. Dunstan, Michael Murray, Fabio Sonvico

Subject: Chemistry And Materials Science, Nanotechnology Keywords: nanoemulsion; oral delivery; ω-3 polyunsaturated fatty acid derivative; MDA-MB-231; triple-negative breast cancer

Online: 30 September 2018 (05:14:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0363.v1

Experimental Dental Composites Containing a Novel Methacrylate-Functionalized Calcium Phosphate Component: Evaluation of Bioactivity and Physical Properties

SUNNY SKARIA, KENNETH J BERK

Subject: Chemistry And Materials Science, Biomaterials Keywords: Dental composite, Methacrylated calcium phosphate, translucency, Biomineralization

Online: 16 May 2021 (22:39:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0175.v1

Non-Equilibrium Quantum Brain Dynamics: Super-radiance and Equilibration in 2+1 Dimensions

Akihiro Nishiyama, Shigenori Tanaka, Jack A. Tuszynski

Subject: Physical Sciences, Quantum Science And Technology Keywords: non-equilibrium quantum field theory; quantum brain dynamics; kadanoff–baym equation; entropy; super-radiance

Online: 16 October 2019 (04:47:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0512.v1

Compatibility of Maximum Inorganic and Organic Calcium and Phosphate Content in Neonatal Parenteral Solutions

Dorota Watrobska-Swietlikowska

Subject: Biology And Life Sciences, Food Science And Technology Keywords: parenteral nutrition, neonatal solution; calcium; phosphate; organic; inorganic; precipitation;

Online: 26 September 2018 (13:57:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0290.v1

Bioceramics Based on Calcium Pyrophosphate

Tatiana V. Safronova, Andrey S. Kiselev, Irina I. Selezneva, Tatiana B. Shatalova, Yulia S. Lukina, Yaroslav Yu Filippov, Otabek U. Toshev, Snezhana A. Tikhonova, Olga S. Antonova, Alexander V. Knotko

Subject: Chemistry And Materials Science, Biomaterials Keywords: calcium lactate pentahydrate; monocalcium phosphate monohydrate; mechanical activation; powder; brushite; monetite; calcium pyrophosphate; ceramics; biocompatibility

Online: 23 February 2022 (12:07:43 CET)

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Working Paper ARTICLE

Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer

Alyssa Vito, Stephanie Rathmann, Natalie Mercanti, Nader El-Sayes, Karen Mossman, John Valliant

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; immunotherapy; immune checkpoint therapy; radionuclide therapy

Online: 9 April 2021 (13:26:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0651.v1

Durum Wheat Yield and N Uptake as Affected by N Rate, Timing and Source in Two Mediterranean Environments

Silvia Pampana, Marco Mariotti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: 3,4-Dimethylpyrazole phosphate; Durum Wheat; Environmental impact; Methylene Urea; Nitrogen Management; Nitrate-Vulnerable zones; Sustainable Agriculture; Urea

Online: 27 May 2021 (07:43:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0250.v1

How Single-Molecule Localization Microscopy Expanded Our Mechanistic Understanding of RNA Polymerase II Transcription

Peter Hoboth, Ondřej Šebesta, Pavel Hozak

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell nucleus; gene expression; transcription foci; transcription factors; super-resolution microscopy; structured illumination; stimulated emission depletion; stochastic optical reconstruction; photoactivation

Online: 9 June 2021 (10:29:32 CEST)

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Working Paper ARTICLE

Influence of Incidental Application of Sulfur Impurity in Triple-Super Phosphate Fertilizer on Wheat Yield

Assefa Menna, Jemanesh Haile

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Wheat; yield; triple-super-phosphate; sulfur; nitrogen; micro-dosing, precision-farming

Online: 21 July 2021 (08:22:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0297.v1

The Effect of Vanadate, Phosphate, Fluoride Compounds and Their Effect on the Aqueous Corrosion of Magnesium Alloy AZ31 in Dilute Chloride Solutions

Zhiyuan Feng, Jichao Li, Zi Yang, Rudolph Buchheit

Subject: Chemistry And Materials Science, Electrochemistry Keywords: light alloys; magnesium; corrosion; vanadate; phosphate; fluoride; inhibition; conversion coating

Online: 21 February 2020 (02:21:19 CET)

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Working Paper ARTICLE

Prognostic Impact of Immunoglobulin Kappa C (IGKC) In Early Breast Cancer

Marcus Schmidt, Karolina Edlund, Jan G Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Slavomir Krajnak, Marco J. Battista, Walburgis Brenner, Annette Hasenburg, Jörg Rahnenführer, Mathias Gehrmann, Pirkko-Liisa Kellokumpu-Lehtinen, Ralph M Wirtz, Heikki Joensuu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: triple-negative breast cancer; prognosis; immune system; immunoglobulin kappa C

Online: 31 May 2021 (12:27:49 CEST)

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