Preprint Article Version 1 This version is not peer-reviewed

Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women

Version 1 : Received: 19 March 2018 / Approved: 20 March 2018 / Online: 20 March 2018 (07:56:33 CET)

How to cite: Mamidi, T.; Wu, J.; Tchounwou, P.B.; Miele, L.; Hicks, C. Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women. Preprints 2018, 2018030174 (doi: 10.20944/preprints201803.0174.v1). Mamidi, T.; Wu, J.; Tchounwou, P.B.; Miele, L.; Hicks, C. Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women. Preprints 2018, 2018030174 (doi: 10.20944/preprints201803.0174.v1).

Abstract

Background: Triple negative breast cancer (TNBC) is the most aggressive form of breast cancer with poor outcomes. The molecular basis of TNBC remains poorly understood. The objective of this study was to explore the relationship between obesity and TNBC in premenopausal and postmenopausal Caucasian women using whole genome transcription profiling. Methods: We compared gene expression levels of tumor samples drawn from normal weight, overweight and obese in pre and postmenopausal women diagnosed with TNBC. We performed hierarchical clustering to assess similarity in patterns of gene expression profiles, and conducted network and pathway analysis to identify molecular networks and biological pathways. Results: We discovered gene signatures distinguishing normal weight from obese, normal weight from overweight and overweight from obese individuals in both premenopausal and postmenopausal women. The analysis revealed molecular networks and biological pathways dysregulated in response to obesity. Among the discovered pathways included the unfolded protein response, endoplasmatic reticulum stress, B cell receptor and the autophagy signaling pathways in obese premenopausal women and the integrin, axonal guidance, ERK/MAPK and Glutathione biosynthesis signaling pathways obese postmenopausal women. Conclusions: The results suggest that both overweight and obesity are associated with TNBC, highlighting the need for conformation of these results in independent studies.

Subject Areas

gene expression obesity triple negative breast cancer

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