Preprint Article Version 1 This version is not peer-reviewed

Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass

Version 1 : Received: 15 July 2019 / Approved: 16 July 2019 / Online: 16 July 2019 (12:32:14 CEST)

How to cite: Neto, A.S.; Brazete, D.; Ferreira, J.M. Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass. Preprints 2019, 2019070194 (doi: 10.20944/preprints201907.0194.v1). Neto, A.S.; Brazete, D.; Ferreira, J.M. Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass. Preprints 2019, 2019070194 (doi: 10.20944/preprints201907.0194.v1).

Abstract

The combination of calcium phosphates (CaP) with bioactive glasses (BG) has received an increased interest in the field of bone tissue engineering. In the present work, biphasic calcium phosphates (BCP) obtained by hydrothermal transformation (HT) of cuttlefish bone (CB) were coated with a Sr-, Mg- and Zn-doped sol-gel derived BG. The scaffolds were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The initial CB structure was maintained after HT and the scaffold functionalization did not jeopardize the internal structure. The results of in vitro bio-mineralization after immersing the BG coated scaffolds in simulated body fluid (SBF) showed extensive formation of bone-like apatite onto the surface of the scaffolds. Overall, the functionalized CB derived BCP scaffolds revealed promising properties for their use in bone tissue engineering field.

Subject Areas

Cuttlefish bone; Biphasic calcium phosphate; Porous scaffolds; Sol-gel coatings; Bioactivity; Tissue engineering

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