Version 1
: Received: 8 September 2021 / Approved: 9 September 2021 / Online: 9 September 2021 (08:23:32 CEST)
How to cite:
Kim, J.; Kim, S.; Song, I. Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone. Preprints2021, 2021090166. https://doi.org/10.20944/preprints202109.0166.v1
Kim, J.; Kim, S.; Song, I. Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone. Preprints 2021, 2021090166. https://doi.org/10.20944/preprints202109.0166.v1
Kim, J.; Kim, S.; Song, I. Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone. Preprints2021, 2021090166. https://doi.org/10.20944/preprints202109.0166.v1
APA Style
Kim, J., Kim, S., & Song, I. (2021). Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone. Preprints. https://doi.org/10.20944/preprints202109.0166.v1
Chicago/Turabian Style
Kim, J., Sukyoung Kim and In-Hwan Song. 2021 "Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone" Preprints. https://doi.org/10.20944/preprints202109.0166.v1
Abstract
Octacalcium phosphate (OCP) is a precursor of biological apatite crystals that has attracted attention as a possible bone substitute. On the other hand, few studies have examined this material at the experimental level due to the limitations of OCP mass production. Recently, mass production technology of OCP was developed, and the launch of OCP bone substitutes is occurring. In this study, the bone regeneration capacity of OCP products was compared with two of the most clinically used materials: heat-treated bovine bone (BHA) and sintered biphasic calcium phosphate (BCP). Twelve rabbits were used, and defects in each tibia were filled with OCP, BHA, BCP, and left unfilled as control (CON). The tibias were harvested at 4 and 12 weeks, and 15 μm slides were prepared using the diamond grinding method after being embedded in resin. Histological and histomorphometric analyses were performed to evaluate the bone regeneration ability and mechanism. The OCP showed significantly higher resorption and new bone formation in both periods analysed (p<0.05). Overall, OCP bone substitutes can enhance bone regeneration significantly by activating osteoblasts and a rapid phase transition of OCP crystals to biological apatite crystals (mineralisation), as well as providing additional space for new bone formation by rapid resorption.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
