Working Paper Brief Report Version 1 This version is not peer-reviewed

Exploring Potential Super Infection in SARS-CoV2 by Genome-Wide Analysis and Receptor–Ligand Docking

Version 1 : Received: 19 March 2020 / Approved: 20 March 2020 / Online: 20 March 2020 (08:30:40 CET)

How to cite: Shu, C.; Huang, X.; Brosius, J.; Deng, C. Exploring Potential Super Infection in SARS-CoV2 by Genome-Wide Analysis and Receptor–Ligand Docking. Preprints 2020, 2020030310 Shu, C.; Huang, X.; Brosius, J.; Deng, C. Exploring Potential Super Infection in SARS-CoV2 by Genome-Wide Analysis and Receptor–Ligand Docking. Preprints 2020, 2020030310

Abstract

SARS-CoV2 (corona virus) has spread globally at an unprecedented rate; so far, increasing SARS-CoV2-infected individuals have been identified. Although the situation in China is improving and is currently under control, the outbreak in other countries and its pandemic management is only beginning to develop. Based on 154 SARS-CoV2 genome sequence analyses, we used receptor–ligand docking to identify one potential point mutation (V354F) on the spike structure which enhances spike binding to ACE2 receptors underlying potential super infection. Importantly, the V354F site on spike S1 had been identified in 5/10 infected French patients living in Paris, who sharing 100% identical SARS-CoV2 genomes. With Covid-19 cases increasing rapidly in France that could lead to a new explosion, we suggest that the French government should identify all potential super spreaders and treat them accordingly. In summary, our study provides on of the measures to avoid the potential second worldwide explosion of SARS-CoV2.

Subject Areas

SARS-CoV2; spike; receptor–ligand docking; super infection

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