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Preprint REVIEW | doi:10.20944/preprints202004.0204.v1

Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence

Celestino Sardu, Jessica Gambardella, Marco Bruno Morelli, Xujun Wang, Raffaele Marfella, Gaetano Santulli

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Covid-19; coronavirus; cardiovascular disease; thrombosis; hypertension; endothelial dysfunction

Online: 13 April 2020 (02:23:33 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201912.0264.v2

4-Year Long Progression-Free and Symptom-Free Survival of a Patient with Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used as a Stand-Alone Treatment After Failed Standard Oncotherapy

Csaba Tóth, Andrea Dabóczi, Madhvi Chanrai, Mária Schimmer, Katalin Horváth, Zsófia Clemens

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: glioblastoma; brain tumor; paleolithic diet; ketogenic diet; paleolithic ketogenic diet; metabolic therapy; intestinal permeability; cancer treatment

Online: 9 November 2020 (11:25:35 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0101.v1

The Powerful Immune System Against Powerful COVID-19: A Hypothesis

Farzad Taghizadeh-Hesary, Hassan Akbari

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; ATP; Immune dysfunction

Online: 7 April 2020 (12:07:22 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202312.0791.v1

Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in ME/CFS Evolving from the Post COVID-19 Syndrome

Klaus Josef Wirth, Matthias Löhn

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Post-COVID Syndrome, Long-COVID; Long-COVID; Precapillary cardiovascular disturbances; Capillary disturbances; ß2AdR dysfunction; Mitochondrial dysfunction; Post-Exertional Malaise; Exercise intolerance

Online: 13 December 2023 (03:40:03 CET)

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID Syndrome (PCS). A fraction of the PCS patients develops the full clinical picture of ME/CFS. New observations in microvessels and blood from patients suffering from PCS have appeared and include microclots and malformed pathological blood cells. Capillary blood flow is impaired not only by pathological blood components but also by prothrombotic changes in the vascular wall, endothelial dysfunction, and expression of adhesion molecules in the capillaries. These disturbances can finally cause a low capillary flow and even capillary stasis. A low cardiac stroke volume due to hypovolemia and the inability of the capacitance vessels to adequately constrict to deliver the necessary cardiac preload generate an unfavorable low precapillary perfusion pressure. Furthermore, a predominance of vasoconstrictor over vasodilator influences exists, in which sympathetic hyperactivity and endothelial dysfunction play a strong role, causing constriction of resistance vessels and of precapillary sphincters which leads to a fall in capillary pressure behind the sphincters. The interaction of these two precapillary cardiovascular mechanisms causing a low capillary perfusion pressure is hemodynamically highly unfavorable in the presence of a primary capillary stasis already caused by the pathological blood components and their interaction with the capillary wall, to severely impair organ perfusion. The detrimental coincidence of the microcirculatory with the precapillary cardiovascular disturbances may constitute the key disturbance of the Post-COVID-19 syndrome and finally lead to ME/CFS in pre-disposed patients because the interaction causes a particular kind of perfusion disturbance - capillary ischemia-reperfusion - which has a high potential of causing mitochondrial dysfunction by inducing sodium- and calcium-overload in skeletal muscles. The latter in turns worsens the vascular situation by the generation of reactive oxygen species to close a vicious cycle from which the patient can hardly escape.

Preprint ARTICLE | doi:10.20944/preprints201808.0169.v1

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

Liudmyla Lazarenko, O. Melnikova, Lidiia Babenko, Rostyslav Bubnov, Tetiana Beregova, Tetiana Falalyeyeva, Mykola Spivak

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: metabolic syndrome; diabetes mellitus; obesity, lactobacilli; bifidobacteria; glucose; macrophages; inflammation; mouse model

Online: 8 August 2018 (14:27:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0425.v1

Obstructive Sleep Apnea as a Cause of Gout

Burton Abrams, Peter Delannoy, Richard Johnson

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: sleep apnea; hypoxia; gout; hyperuricemia; urate; metabolic comorbidities

Online: 24 February 2023 (09:31:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0142.v1

Relationship between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients

Rand Farag, Dujana Alayobi, Khalid Alsaleh, Ehab Serour, Hye-Joo Kwon, Afaf El-ansary

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aflatoxin B1; transaminases; hepatocellular carcinoma; Saudi patients; liver dysfunction

Online: 29 December 2016 (10:59:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0019.v1

“NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic Profiling

Marietta Kokla, Anton Klåvus, Stefania Noerman, Ville M. Koistinen, Marjo Tuomainen, Iman Zarei, Topi Meuronen, Merja R. Häkkinen, Soile Rummukainen, Ambrin Farizah Babu, Taisa Sallinen, Olli Kärkkäinen, Jussi Paananen, David Broadhurst, Carl Brunius, Kati Hanhineva

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; LC-MS; mass spectrometry; metabolic profiling; computational; statistical; unsupervised learning; supervised learning; pathway analysis

Online: 3 February 2020 (05:54:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0132.v1

Geography of Food Consumption Patterns between South and North China

Fangfang Song, Mi Sook Cho

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chinese adults; north region; south region; dietary pattern; metabolic syndrome

Online: 31 October 2016 (02:51:27 CET)

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Preprint REVIEW | doi:10.20944/preprints201702.0047.v1

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

Manuela Aragno, Raffaella Mastrocola

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: advanced glycation end products; fructose; glucose; lipogenesis; sphingolipids; NLRP3; Nrf2; mitochondrial dysfunction; oxidative stress

Online: 14 February 2017 (08:38:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201706.0121.v1

Molecular interactions of autophagy with the immune system and cancer

Yonggeun Hong, Yunho Jin, Yunkyung Hong, Chanyoung Park

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: autophagy； immune system； cancer；cell death；metabolic homeostasis

Online: 27 June 2017 (06:30:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint REVIEW | doi:10.20944/preprints201704.0171.v1

Peroxiredoxin 4 (PRDX4): Its Critical In Vivo Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic Mice

Sohsuke Yamada, Xin Guo, Akihide Tanimoto

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Peroxiredoxin (PRDX) 4, chronic inflammatory disease, metabolic syndrome, human PRDX4 transgenic mice (Tg), animal model.

Online: 26 April 2017 (17:57:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0124.v1

Assessing and Resolving Model Misspecifications in Metabolic Flux Analysis

Rudiyanto Gunawan, Sandro Hutter

Subject: Engineering, Bioengineering Keywords: metabolic flux analysis, model misspecification, constraint-based model, stoichiometric model, Chinese hamster ovary cell culture

Online: 16 March 2017 (17:38:36 CET)

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Preprint REVIEW | doi:10.20944/preprints201804.0260.v1

What Is the Heart? Anatomy, Form, Function, and Misconceptions

Gerald D. Buckberg, Navin C. Nanda, Christopher Nguyen, Mladen J. Kocica

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: conventional heart anatomy; helical ventricular myocardial band; mitral valve opening; isovolumic relaxation time; RV function; diastolic dysfunction

Online: 20 April 2018 (08:10:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201803.0064.v2

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease

Marit K. Zinöcker, Inge A. Lindseth

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: western diet; microbiome; food processing; inflammation; metabolic diasease

Online: 19 March 2018 (07:31:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.0170.v1

Vascular Dysfunctions Contribute to the Long-term Cognitive Deficits Following COVID-19

zahra shabani, Jialing Liu, hua su

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Long-COVID-19; SARS-CoV-2; Endothelial cells; Cognitive dysfunction; Blood Brain Barrier; Neuro-inflammation

Online: 2 June 2023 (09:38:56 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201905.0078.v1

Derivations of the Core Functions of the Maximum Entropy Theory of Ecology

Alexander Brummer, Erica Newman

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: information entropy, information theoretics, macroecology, metabolic theory, scaling, species abundance distribution, species-area relationship

Online: 7 May 2019 (11:24:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0185.v1

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Rostyslav Bubnov, Mykola Spivak

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: predictive preventive personalized medicine; Lactobacillus; Bifidobacterium; probiotics, gut microbiota; patient phenotype, individualized medicine; metabolic syndrome

Online: 11 September 2018 (06:00:03 CEST)

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The modification the gut microbiota in metabolic syndrome and associated chronic diseases is among leading tasks of microbiome research and needs for clinical use of probiotics. Evidence lack for the implications for microbiome modification to improve metabolic health in particular when applied impersonalized. Probiotics have tremendous potential in personalized nutrition and medicine to develop healthy diets. The aim was to to conduct comprehensive overview of recent updates of role of microbiota on human health and development of metabolic syndrome and efficacy of microbiota modulation considering specific properties of probiotic strain and particular aspects of metabolic syndrome and patient`s phenotype to fill the gap between probiotic product and individual to facilitate development of individualized / personalized probiotic and prebiotic treatments. We discuss the relevance of using host phenotype-associated biomarkers, those based on imaging and molecular and patrient`s history, reliable and accessible to facilitate person-specific appication of probiotics and prebiotic substances. Microbiome phenotypes can be parameters of predictive medicine to recognize patient`s predispositions and evaluate treatment responses; the number of phenotype markers can be effectively involved to monitor microbiome modulation. The studied strain-dependent properties of probiotic strains are potentially relevant for individualized treatment for gut and distant sites microbiome modulation. The evidence regarding probiotic strains properties can be taken to account via pathophysiology-based approach for most effective individualized treatment via gut, oral and vaginal and other sites microbiome modulation according to phenotype of the patient providing individualized and personalized medical approaches. Preventive potential of probiotics is strong and well-documented. Recommendations for individualized clinical use of probiotics, and for probiotic studies design have been suggested.

Preprint REVIEW | doi:10.20944/preprints202105.0257.v1

Recent Developments in Treating Cognitive Impairment Associated with Schizophrenia

Robert A Bittner, Catherine V Barnes-Scheufler, Meike D Hettwer, Andreas Reif, Mishal Qubad

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Schizophrenia, cognitive dysfunction, neural plasticity, inflammation, cognitive biomarker, pharmacological treatment, cognitive remediation, aerobic exercise, brain stimulation

Online: 12 May 2021 (07:26:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0049.v1

Mangosteen Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study

Mikiko Watanabe, Elena Gangitano, Davide Francomano, Eliana Addessi, Raffaella Toscano, Daniela Costantini, Dario Tuccinardi, Stefania Mariani, Sabrina Basciani, Giovanni Spera, Lucio Gnessi, Carla Lubrano

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: garcinia mangostana; inflammation; insulin resistance; metabolic syndrome; diabetes; xanthones; mangostin; phytotherapy; dietary supplements

Online: 4 April 2018 (06:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0078.v1

Factors Influencing the Production of Different Types of Fatty Acid and Staphyloxanthin in the Staphylococcus aureus Membrane

Kiran Tiwari, Craig Gatto, Brian J. Wilkinson

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: membrane fatty acids composition; Staphylococcus aureus; staphyloxanthin; membrane fluidity; metabolic regulation

Online: 6 April 2018 (11:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0210.v1

Intestinal Microbial and Metabolite Profiling of Mice Fed with Dietary Glucose and Fructose

João C. P. Silva, Marta Mota, Fátima O. Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S. Barros, John G. Jones, Ana M. Gil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: fructose; intestinal microbiota; short-chain fatty acids; metabolic profiling

Online: 23 January 2018 (05:31:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0136.v1

One Week Feeding of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver

Takehito Sugasawa, Seiko Ono, Masato Yonanine, Shin-ichiro Fujita, Yuki Matsumoto, Kai Aoki, Takuro Nakano, Shinsuke Tami, Yasuko Yoshida, Yasushi Kawakami, Kazuhiro Takekoshi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: CDAHFD; NASH; Mitochondrial dysfunction; Liver; Oxidative stress

Online: 7 May 2021 (09:47:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0732.v1

Cognition Enhancing Effect of Rosemary Plant (Rosmarinus officinalis, L) in Preclinical Studies: A Systematic Review and Meta-Analysis

Shalam Mohamed Hussain, Ayesha Farhana Syeda, Mohammad Alshammari, Sulaiman Alnasser, Naif Alenzi, Samyah Alanazi, Nandakumar Krishnadas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Rosemary; Alzheimer’s disease; cognition; meta-analysis; preclinical study; mild cognitive dysfunction; herbal drugs; rosmarinic acid

Online: 30 September 2020 (10:04:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0081.v1

Insulin Resistance Syndrome- the Sensitive IRS

Eleni Pellazgu

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: insulin resistance; diet; exercise; microbiome; metabolic disorders

Online: 9 January 2018 (10:05:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0551.v1

Serum Magnesium Levels in Patients with Obstructive Sleep Apnoea: A Systematic Review and Meta-Analysis

Zahraa Al Wadee, Soo Liang Ooi, Sok Cheon Pak

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Obstructive sleep apnoea; intermittent airway obstruction; sleep disorder; magnesium; micronutrient deficiency; metabolic risk factor

Online: 30 August 2021 (15:47:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0055.v1

The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST)

Lisa Te Morenga, Paul Docherty, Sheila Williams, Jim Mann

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: diet; dietary protein; dietary fibre; insulin sensitivity assessment; insulin sensitivity; insulin resistance; metabolic syndrome

Online: 8 November 2017 (16:20:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0064.v1

Metabolic Reprogramming and Its Role in Plant Cold Acclimation

Lisa Fürtauer, Jakob Weiszmann, Wolfram Weckwerth, Thomas Nägele

Subject: Biology And Life Sciences, Plant Sciences Keywords: cold acclimation; metabolic reprogramming; carbohydrates; subcellular metabolism; sucrose cycling; enzyme activity; arrhenius equation; kinetic modelling; arabidopsis thaliana

Online: 7 October 2019 (11:19:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0059.v1

Data Normalization in NMR-based Metabolomics

Helena Zacharias, Michael Altenbuchinger, Wolfram Gronwald

Subject: Biology And Life Sciences, Biophysics Keywords: data normalization; data scaling; zero-sum; metabolic fingerprinting; NMR; statistical data analysis

Online: 3 July 2018 (16:22:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0265.v2

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

Melvin Hayden

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Aging; Alzheimer’s disease; brain insulin resistance; db/db diabetic mouse model; diabetic cognopathy; insulin resistance; metabolic syndrome; mixed dementia; obesity; type 2 diabetes mellitus

Online: 9 September 2019 (06:12:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0342.v1

Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis

Ifan Ali Wafa, Nando Reza Pratama, Nurizzah Farahiyah Sofia, Elsha Stephanie Anastasia, Tiffany Konstantin, Maharani Ayuputeri Wijaya, M. Rifqi Wiyono, Lilik Djuari, Hermina Novida

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 lockdown; diabetes mellitus; meta-analysis; metabolic control; systematic review

Online: 14 June 2021 (09:44:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0245.v1

COVID-19 Comorbidity and Metabolic Syndrome: Is There a Molecular Basis?

Madhurima Basu, Chinmay Saha, Kamalika Roy Choudhury, Susmita Dutta, Sujoy Ghosh, Subhankar Chowdhury, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: COVID-19; Metabolic syndrome; Comorbidity; Enrichment analysis; biological processes and pathways

Online: 21 June 2020 (09:52:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0177.v1

Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice

Gábor Somlyai, Lajos I. Nagy, László G. Puskás, András Papp, Beáta Zs. Kovács, István Fórizs, György Czuppon, Ildikó Somlyai

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Deuterium-depleted water (DDW); deuterium-depleted organic compounds (DDOC); anticancer drug development; D/H ratio; production of metabolic water; ketogenic diet

Online: 13 June 2022 (09:49:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0220.v1

Genetic Optimization Algorithm for Metabolic Engineering Revisited

Tobias B. Alter, Lars M. Blank, Birgitta E. Ebert

Subject: Engineering, Bioengineering Keywords: metabolic strain design; heuristic optimization; constraint-based modeling

Online: 27 March 2018 (05:55:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0663.v1

Ciliary Dysfunction Secondary to COVID-19. Explanation of the Pathogenesis From Analysis of Human Interactome With Sars-Cov-2 Proteome

Alejandro Jesús Bermejo-Valdés, Alexander Ariel Padrón-González, Jessica Archer-Jiménez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; interactome; ciliary-flagellar dysfunction; infertility; pathogenicity

Online: 25 December 2020 (13:18:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0196.v1

Relationship between Response to PDE5 Inhibitors and Penil Duplex Doppler Ultrasound in Erectile Dysfunction

Ercan Ogreden, Ural Oğuz, Erhan Demirelli, Alptekin Tosun, Orhan Yalçın

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: comorbid diseases; erectile dysfunction; penile duplex doppler ultrasound; penile pathology; phosphodiesterase type 5 inhibitors

Online: 22 January 2018 (09:03:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0124.v1

Development of a Food-Based Index of Dietary Inflammatory Potential for Koreans and Its Relationship with Metabolic Syndrome

Woori Na, Tae Yang Yu, Cheongmin Sohn

Subject: Biology And Life Sciences, Food Science And Technology Keywords: metabolic syndrome; inflammation; index; Korea

Online: 10 April 2018 (09:50:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0164.v1

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome

Pedram Shokouh, Per Bendix Jeppesen, Kjeld Hermansen, Natalja Nørskov, Christoffer Laustsen, Stephen Jacques Hamilton-Dutoit, Haiyun Qi, Hans Stødkilde-Jørgensen, Søren Gregersen

Subject: Biology And Life Sciences, Food Science And Technology Keywords: coffee; dietary supplements; metabolic syndrome X; non-alcoholic fatty liver disease; adiponectin; hyperpolarized magnetic resonance spectroscopy

Online: 27 October 2017 (02:32:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0272.v1

Metabolic Reprogramming, Meaning and Implications

Pierre Jacquet, Angélique Stéphanou

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Metabolic reprogramming; Warburg effect; Cancer metabolism

Online: 14 January 2021 (13:30:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0163.v1

Yarrowia lipolytica strains and their biotechnological applications: how natural biodiversity and metabolic engineering could contribute to cell factories improvement

Catherine Madzak

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: white biotechnology; metabolic engineering; non-conventional yeast; oleaginous yeast; cell factory; heterologous expression; biodiversity; Yarrowia lipolytica; Yarrowia clade; GMO

Online: 7 June 2021 (10:50:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1554.v1

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

David Mantle, Iain Parry Hargreaves, Joan Carles Domingo, Jesus Castro-Marrero

Subject: Biology And Life Sciences, Life Sciences Keywords: chronic fatigue syndrome; coenzyme Q10; fibromyalgia; Long COVID; mitochondrial dysfunction; myalgic encephalomyelitis; post-viral fatigue syndrome

Online: 24 November 2023 (11:27:34 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202003.0338.v3

Yin-Yang Balance of ACE/ACE2 Pathways: The Rational for Administration of ACE2 Pathway Inhibitors in Patients Infected by SARS-CoV-2

Loris Zamai

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Severe Acute Respiratory Syndrome Coronavirus-2; (soluble) ACE2; eosinophil; asthma; IL-10; Lung fibrosis; hypercapnic acidosis; hypoxia; infarction; hypertension; cardiac dysfunction; respiratory distress; coagulopathy; Angiotensin; renin; Ang (1-7); Ang (1-9); Mas receptor; AT2 receptor

Online: 6 May 2020 (04:40:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0444.v1

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach

Aileen Hill, Sebastian Borosch, Carina Benstöm, Christina Neubauer, Patrick Meybohm, Pascal Langlois, Neill KJ Adhikari, Daren K Heyland, Christian Stoppe

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: vitamin C; ascorbic acid; cardiac surgery; antioxidant therapy; nutrient; oxidative stress; organ dysfunction; multi organ failure

Online: 27 June 2018 (12:29:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0548.v1

Metabolic Modelling Approaches for Describing and Engineering Microbial Communities

Beatriz García-Jiménez, Jesús Torres, Juan Nogales

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: genome-scale metabolic model; microbial community; optimization; design; engineering; computational methods; synthetic microbial consortia

Online: 23 September 2020 (09:52:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201712.0186.v1

Growth Hormone (GH) and Cardiovascular system

Diego Caicedo, Oscar Díaz, Pablo Devesa, Jesús Devesa

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiovascular diseases; atherosclerosis; oxidative stress; angiogenesis and arteriogenesis; endothelial dysfunction; growth hormone; IGF-I; wound healing

Online: 26 December 2017 (10:30:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0324.v1

Exposure to Environmental Factor Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, And Future Directions

Md. Ataur Rahman, Md. Abdul Hannan, Md Jamal Uddin, Md Saidur Rahman, Md Mamunur Rashid, Bonglee Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Toxic heavy metal; neurological conditions; mitochondrial dysfunction; proteostasis; environmental chemicals; phytochemicals.

Online: 14 July 2021 (11:26:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0110.v1

An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga Chlamydomonas reinhardtii

Ashok Aspatwar, Susanna Haapanen, Seppo Parkkila

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: carbonic anhydrases; CA gene family; Chlamydomonas reinhardtii; model alga; metabolic role; photosynthesis

Online: 12 January 2018 (07:21:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0185.v1

Early Detection and Diagnosis of Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency Missed by Newborn Screening Using Tandem Mass Spectrometry

Hiroko Shigetomi, Toju Tanaka, Masayoshi Nagao, Hiroyuki Tsutsumi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: SLC25A13; amino acid ratio; citrullinemia; latent liver dysfunction; mitochondrial aspartate-glutamate carrier

Online: 26 December 2017 (10:18:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0187.v1

Endothelial Dysfunction in SARS CoV-2 Infection

Francesco Nappi, Sanjeet Singh Avtaar Singh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endothelial dysfunction; SARS-CoV-2 infection; thrombosis, angiotensin-converting enzyme-2; angiogenesis

Online: 15 February 2022 (11:05:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0205.v1

Incorporating an Increase in Plant-Based Food Choices into a model of Culturally Responsive Care for Obesity in Hispanic/Latino Adults and Children

Pramil Singh, Jessica Steinbach, Anna Nelson, Wendy Shih, Mary D'Avila, Selene Castilla, Michael Jordan, William McCarthy, David Hayes Bautista, Hector Flores

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: diabetes; vegetarian; diet; nutrition; metabolic syndrome; disparity; child

Online: 17 October 2019 (15:24:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0073.v1

Mitochondrial Dysfunction: a Notable Contributor to the Progression of Alzheimer’s & Parkinson’s Disease

Abolaji Samson Olagunju, Abiola Adeyanju Alagbe, Titilayomi Ayomide Otenaike, Babatunde Oladayo Fabiyi, John Oluwafemi Teibo, Naeem Qusty, Safaa Qusti, Eida Mohammed Alshammari, Gaber El-Saber Batiha, Olabode Omotoso

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Mitochondrial dysfunction; Alzheimer's disease; Parkinson's disease; Neurodegeneration; Amyloid beta; Parkin

Online: 3 September 2021 (16:01:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0059.v1

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Hytham Al-Gethmy, Usama Fahmy, Nabil Alhakamy, Osama Ahmed, Khalid El-Say

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Bioavailability; Box-Behnken design; β-cyclodextrin; erectile dysfunction; taste masking; vardenafil.

Online: 4 December 2018 (16:39:51 CET)

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Preprint ESSAY | doi:10.20944/preprints202007.0440.v1

Application of Metabolic Engineering Approaches in Enhancing Biological Hydrogen Production

Wenfa Ng

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: metabolic engineering; biohydrogen production; microbes; co-culture; metabolic network analysis

Online: 19 July 2020 (20:43:36 CEST)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0244.v1

Curating and Comparing 114 Strain-Specific Genome-Scale Metabolic Models of Staphylococcus aureus

Alina Renz, Andreas Dräger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; MRSA; genome-scale metabolic models; model-driven discovery; strain-specific models

Online: 8 April 2021 (14:25:31 CEST)

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Working Paper ARTICLE

Promoting Exercise in Urban Area: Importance of Green Space and Facility Accessibility

John W.M. Yuen, Katherine K.P. Chang, Frances K.Y. Wong, Fiona Y. Wong, Judy J. Siu, H.C. Ho, M.S. Wong, Janice Y.S. Ho, K.L. Chan, Lin Yang

Subject: Environmental And Earth Sciences, Environmental Science Keywords: physical activity; exercise; green cover; open space; Metabolic Equivalent of Task; International Physical Activity Questionnaire; health promotion

Online: 20 March 2019 (10:46:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0280.v1

A Mechanistic Model for Genome-Scale Estimations of Metabolic Activity

Cankut Cubuk, Carlos Loucera, Marta Hidalgo, Alicia Amadoz, Jose Carbonell-Caballero, María Peña-Chilet, Joaquin Dopazo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: metabolic pathways; mechanistic model; Transcriptomic

Online: 14 January 2021 (18:01:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0248.v1

Joint Transcriptome and Metabolome Analysis Prevails Biological Mechanisms Underlying the Prosurvival Fight in Heat Stressed Granulosa Cells

Abdul Sammad Sammad, Hanpeng Luo, Lirong Hu, Adnan Khan, Huabin Zhu, Yachun Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: granulosa cells; heat stress; integrated analysis; transcriptomics; metabolomics; differentially ex-pressed genes; metabolites; signaling pathways; metabolic pathways; cancer pathways

Online: 27 April 2022 (05:08:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0198.v1

Sudden Onset, Acute Loss of Taste and Smell in Coronavirus Disease 2019 (COVID-19): A Systematic Review

Lakshman SAMARANAYAKE, Kausar Fakhruddin, Chamila Panduwawala

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: loss of taste and smell; dysgeusia; anosmia; chemosensory dysfunction; SARS-CoV-2; COVID-19

Online: 16 June 2020 (07:46:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0139.v1

A High-throughput Method for Fingerprinting of Rhizobial Free Fatty Acids by the Combination of a Thin Film Chemical Deposition Technique and Matrix-assisted Laser Desorption/ionization Time-of Flight Mass Spectrometry

Alexsey Gladchuk, Julia Schumilina, Alena Kusnetsova, Ksenia Bureiko, Alexander Tsarev, Irina Alexandrova, Larisa Leonova, Vladimir A. Zhukov, Igor A. Tikhonovich, Claudia Birkemeyer, Ekaterina Podolskaya, Andrej Frolov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bacteria; barium monocarboxylates; chemical deposition techniques; free fatty acids (FFAs); Langmuir film technology; matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS); metabolic fingerprinting; rhizobia

Online: 13 January 2020 (13:25:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0315.v1

Prevalence of Metabolic Syndrome and Its Associated Factors among Vegetarians in Malaysia

Yuan Kei Ching, Yit Siew Chin, Mahenderan Appukutty, Wan Ying Gan, Vasudevan Ramanchadran, Yoke Mun Chan

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: metabolic syndrome; vegetarian; vegetarianism practices; overweight; lifestyle behaviors

Online: 20 June 2018 (08:49:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0014.v1

Microbial Degradation of Pharmaceuticals

Swathi Kandhasamy, Sudha Balraj, Suganya Kanagaraj, Sumathi Sundaravadivelu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pharmaceutical toxicants; recalcitrant pollutants; co-metabolic pathways; biostimulation; bioaug-mentation

Online: 1 June 2022 (10:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0290.v3

New Workflow Predicts Drug Targets Against SARS-CoV-2 via Metabolic Changes in Infected Cells

Nantia Leonidou, Alina Renz, Reihaneh Mostolizadeh, Andreas Dräger

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: host-virus interactions; tissue-specific model; COVID-19; SARS-CoV-2; antiviral targets; flux balance analysis; flux variability analysis; reaction knockout; host-derived enforcement; metabolic modeling; virus mutations; software engineering; Python

Online: 17 January 2023 (01:50:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0087.v1

Nutritional Quality during Development Alters Insulin-Like Peptides Expression and Physiology of the Adult Yellow Fever Mosquito, Aedes aegypti

Rana Pooriirouby, Arvind Sharma, Joshua Beard, Jeremiah Reyes, Andrew Nuss, Monika Gulia-Nuss

Subject: Biology And Life Sciences, Insect Science Keywords: insulin-signaling; insulin receptor; Aedes aegypti; mosquitoes; insulin; insulin-like peptides; nutrition; hyperinsulinemia; larval-diet; metabolic reserves

Online: 6 June 2018 (11:55:53 CEST)

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Working Paper ARTICLE

Obesity and Telomere Length: Does the Obesity Paradox Exist?

Jin-Hee Kim, Hae-Jin Ko, A-Sol Kim, Ha-Na Moon, Hye-In Choi, Ji-Yeon Park, Sung-Kook Lee, Hee-Jung Yoon

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Body mass index, Metabolic syndrome, Obesity, Obesity paradox, Telomere, Waist circumference, Waist-to-hip ratio, Waist-to-height ratio

Online: 4 September 2019 (14:20:32 CEST)

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Background Telomere shortening is related to aging and unfavourable health outcomes. Obesity and metabolic diseases are important factors for accelerating aging. This study aimed to find out the association between obesity, metabolic disease, and telomere length in metabolically healthy adults. Methods 237 adults were enrolled with written consents at a health promotion centre of a tertiary hospital from February 2014 to March 2015. After excluding 99 subjects who met the exclusion criterion, a total of 130 metabolically healthy subjects were selected for final analysis. The subjects were divided into quartile groups according to the telomere lengths of their oral mucosal cells. Results The subjects consisted of 66 (50.8%) males with a mean age of 58.59 years. The body mass index (BMI, kg/m2) increased significantly along with the quartile groups (Q1, 23.00; Q2, 23.96; Q3, 23.70; Q4, 25.20; P-for trend=0.008). Waist circumference (WC, P-for trend=0.022), waist-to-hip ratio (WHR, P-for trend=0.005), and waist-to-height ratio (WHtR, P=0.001) also increased along with the quartile groups. Obesity prevalence (BMI ≥25 kg/m2), abdominal obesity (WC ≥90 cm for men, ≥85 cm for women), WHR 〉1.0 for men or 〉0.85 for women, and WHtR ≥0.5 increased significantly as the telomere length increased (P-for trend <0.05). After adjusting for covariates, the ORs for each obesity markers increased as the telomere length increased (P-for trend <0.05); and the ORs of WHtR were especially meaningful (Q1, 1.00; Q2, 2.53; Q3, 2.97; Q4, 7.81; P-for trend = 0.001). There were no significant trends for metabolic syndrome and its components along with the prevalence of fatty liver disease. Conclusion Obesity markers and telomere length had significant positive correlation despite the established theory. The obesity paradox may exist in metabolically healthy adults with regard to telomere length, However, further studies with larger sample sizes for the association between obesity and telomere length are needed.

Preprint ARTICLE | doi:10.20944/preprints201906.0086.v1

Hyperglycemia: The Metabolic Syndrome Component That Aggravates Erectile Dysfunction in Mexican Patients

Alan Espinosa-Marrón, Christian A. Quiñones-Capistrán, Aquiles Rubio-Blancas, María del Pilar Milke-García, Ricardo A. Castillejos-Molina

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: erectile dysfunction; metabolic syndrome; risk factors; hyperglycaemia

Online: 11 June 2019 (08:04:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0334.v1

Pathophysiological Aspects of Vascular Remodeling in Cardiopulmonary Lesions: Influence of ID3 & Estrogenic Endocrine Disruptors

Vincent Avecilla, Mayur Doke

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiopulmonary lesions, endocrine disruptors, ID3, vascular dysfunction, vascular remodeling

Online: 19 July 2018 (12:57:32 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201910.0020.v1

Rapid Efficacy of Gemtuzumab Ozogamicin in Refractory AML Patients with Organ Dysfunctions

Daniil Zaytsev, Larisa Girshova, Vladimir Ivanov, Irina Budaeva, Dmitri Motorin, Renat Badaev, Julia Mirolubova, Tamara Chitanava, Ekaterina Zaykova, Julia Alexeeva, Andrey Zaritskey

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: acute myeloid leukemia; patients with organ dysfunction; gemtuzumab ozogamicin

Online: 2 October 2019 (06:19:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0014.v2

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Bipradas Roy, Sadia Afrin Runa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; Diabetes; Neurological dysfunction; Cardiovascular complications; Pulmonary dysfunction; Renal dysfunction; bone loss; Eye disease; Gastrointestinal complications

Online: 23 May 2022 (11:00:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0302.v1

Methanolic Extract of Maytenus Procumbens Roots Ameliorates Erectile Dysfunction in Fructose-Streptozotocin Induced Type 2 Diabetic in Rats

Nkosinathi Cele, Sihle Ephraim Mabhida, Thembeka Nyawo, Khanyisani Ziqubu, Sthandiwe Mazibuko-Mbeje, Mosa Rehamang, Andy Opoku

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Maytenus procumbens; Erectile dysfunction; Phosphodiesterase-5; cyclic guanosine monophos-phate

Online: 12 February 2021 (12:15:08 CET)

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Preprint REVIEW | doi:10.20944/preprints201805.0264.v1

Endoplasmic Reticulum Stress in Metabolic Disorders

Rose Ghemrawi, Shyue-Fang Battaglia-Hsu, Carole Arnold

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: endoplasmic reticulum stress; metabolic disorders; unfolded protein response; inflammation; lipotoxicity; glucotoxicity; therapy

Online: 21 May 2018 (08:09:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0524.v1

From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID

Pablo Gonzalez-Garcia, Ornella Fiorillo Moreno, Eloina Zarate Peñate, Alejandro Calderón-Villalba, Lisandro Pacheco Lugo, Antonio Acosta Hoyos, Jose Luis Villarreal Camacho, Roberto Navarro Quiroz, Leonardo Pacheco Londoño, Gustavo Aroca Martinez, Noelia Moares, Antonio Gabucio, Cecilia Fernandez-Ponce, Francisco Garcia-Cozar, Elkin Navarro Quiroz

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; SARS-CoV-2; Long COVID; Cytopathy; cytokine storm; sequelae; PASC; coronavirus; angiotensin-converting enzyme 2; cell dysfunction

Online: 30 March 2023 (05:09:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0325.v1

Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young “Healthy” Smokers Measured by Heart Rate Variability

Zdravko Taralov, Peter Dimov, Kiril Terziyski, Blagoi Marinov, Mariyan Topolov, Stefan Kostianev

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability, smoking, hypoxia, autonomic dysfunction

Online: 20 June 2018 (15:38:52 CEST)

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Background and objectives: Smoking leads to autonomic dysfunction. However, the clinical methods for diagnosing this dysfunction are not sufficient. Since exogenous hypoxia leads to changes in the autonomic cardiac control, the aim of our study was to compare the activity of the autonomic nervous system via heart rate variability (HRV) in young “healthy” smokers and non-smokers before, during and after a short-term exogenous hypoxic exposure. Methods: Twenty-one healthy non-smoking males aged 28.0±7.4 (mean±SD) and fourteen healthy smoking males aged 28.1±4.3 with 9.2±5.6 pack-years were subjected to one-hour hypoxic exposure (FiО2=12.3±1.5%) via hypoxicator (AltiPro 8850 Summit+, Altitude Tech, Canada) with simultaneous recording of electrocardiography and pulse oximetry. HRV data was derived via specific software (Kubios HRV, Finland) by analyzing the pre-hypoxic, hypoxic and post-hypoxic periods. Results: Standard deviation of the intervals between normal beats (SDNN) was higher in non-smokers in the pre-hypoxic period (62.0±32.1 vs 40.3±16.2, p=0.013) but not in hypoxia (75.7±34.8 vs 57.9±18.3, p=0.167). When comparing intragroup HRV changes of shifting from hypoxic to post-hypoxic (normoxic) conditions we found that there is a significant increase in the root mean square of successive RR interval differences (RMSSD) (65.9±40.2 vs 75.1±45.9, p=0.011) and in the high frequency (lnHF) (6.8±1.4 vs 7.2±1.3, p=0.014) and a decrease in LF/HF (3.0±2.3 vs 1.9±1.5, p<0.001), but these changes were observed only in the group of non-smokers. Conclusions: Smoking likely impairs autonomic regulation in young healthy males and may lead to a decreased HRV even before subjective clinical signs and symptoms. Hypoxic exposure test could be applied in clinical practice for early detection of autonomic dysfunction in smokers, because their parasympathetic reactivation is blunted when shifting from hypoxic to normoxic ambient conditions measured by HRV.

Preprint ARTICLE | doi:10.20944/preprints202101.0209.v1

Utilizing the Food-Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach

Snehal R. Jadhav, Rohan M. Shah, Avinash V. Karpe, Robert Barlow, Kate McMillan, Michelle L. Colgrave, David J. Beale

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: leafy greens; spinach; metabolomics; metabolic profiling; food pathogens; biomarker discovery

Online: 12 January 2021 (08:20:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0027.v1

Determination of Phenolic Composition and Antioxidant Activity in Flowers and Stems of Rumex Tunetanus Using RP-UHPLC-ESI-QTOF-MS

Jouda Abidi, Sonda Ammar, Mohamed Bouaziz

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Rumex tunetanus; Phenolic compounds; Metabolic profiling; Antioxidant activity; RP-UHPLC-ESI-QTOF-MS

Online: 3 December 2018 (13:58:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0040.v1

Advanced Microsamples: Current Applications and Considerations for Mass Spectrometry-Based Metabolic Phenotyping Pipelines

Jayden Lee Roberts, Luke Whiley, Nicola Gray, Melvin Gay, Nathan G. Lawler

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Microsampling; sample miniaturisation; dried blood spot (DBS); dried plasma spot (DPS); dried serum spot (DSS); metabolic phenotyping; gas chromatography-mass spectrometry (GC-MS); liquid chromatog-raphy-mass spectrometry (LC-MS)

Online: 3 June 2022 (09:53:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0009.v1

How Smell Regulates Metabolism: The Role Of Ectopically Expressed Olfactory Receptors In Lipid and Glucose Homeostasis

Ginevra Urbani, Eleonora Distrutti, Michele Biagioli, Silvia Marchianò, Stefano Fiorucci

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: olfactory receptors; glucose metabolism; type 2 diabetes mellitus; lipid metabolism; NAFLD; metabolic syndrome

Online: 2 April 2022 (09:00:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0788.v1

Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target

Alina Renz, Lina Widerspick, Andreas Dräger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; COVID-19; Flux Balance Analysis (FBA); Genome-Scale Metabolic Models; Target Identification; Reaction Knock-Out; Structural Proteins; Purine Metabolism; Pyrimidine Metabolism; B.1.1.7; B.1.351

Online: 30 April 2021 (15:14:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0201.v1

An ultradian feeding schedule in rats affects metabolic gene expression in liver, brown adipose tissue and skeletal muscle with only mild effects on circadian clocks

Paul de Goede, Satish Sen, Yan Su, Ewout Foppen, Vincet-Joseph Poirel, Etienne Challet, Andries Kalsbeek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Suprachiasmatic nucleus (SCN); Circadian clock; Soleus Muscle (SM); Brown adipose tissue (BAT); liver; 6-meal feeding; Respiratory exchange ratio (RER); Clock genes; metabolic genes; Shift work.

Online: 11 September 2018 (14:21:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0382.v1

E/e’ ratio Predicts the Atrial Pacing-induced Left atrial Pressure Response in Patients with Preserved Ejection Fraction

Seung-Young Roh, Kwang-No Lee, Yong-soo Baek, Mohammad Iqbal, Anupam Jena, Saruul Tseveendee, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: diastolic dysfunction; heart failure; atrial fibrillation; atrial hypertension; left atrial pressure

Online: 15 March 2021 (13:02:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0334.v1

The Role of Alpha-Synuclein And Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders

C. Alejandra Morato Torres, Zinah Wassouf, Faria Zafar, Danuta Sastre, Tiago Fleming Outeiro, Birgitt Schüle

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alpha-synuclein; SNCA; PARK2; 22q11.2 deletion syndrome; autism spectrum disorders; neuronal development; Parkinson’s disease; neurodegeneration; synaptic dysfunction

Online: 15 July 2020 (11:36:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0613.v1

Effects of Tempeh Fermentation with Lactobacillus Plantarum and Rhizopus Oligosporus on Streptozotocin-Induced Type II Diabetes Mellitus in Rats

Ying Che Huang, Bo-Hua Wu, Yung-Lin Chu, Wen-Chang Chang, Ming-Chang Wu

Subject: Biology And Life Sciences, Food Science And Technology Keywords: tempeh; lactic acid bacteria; short chain fatty acids; metabolic syndrome; high fat diet; feces

Online: 31 July 2018 (09:37:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0305.v1

Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns

Johra Khan, Prashanta Kumar Deb, Somi Priya, Karla Damiàn Medina, Rajlakshmi Devi, Sanjay G. Walode, Mithun Rudrapal

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dietary flavonoids; cardioprotective effects; ROS scavenging; myocardial dysfunction; bioavailability and drug metabolism; toxicity; drug discovery

Online: 11 June 2021 (08:44:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0069.v1

Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms using Computational Systems Biology Approaches

Sahar Aghakhani, Naouel Zerrouk, Anna Niarakis

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Fibroblasts; Rheumatoid Arthritis; Cancer; Metabolic Reprogramming; Glycolytic Switch; Systems Biology; Computational Modelling

Online: 2 November 2020 (19:28:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202204.0202.v1

SGLT2 Inhibitors and Potential Applications in Treating Metabolic Syndrome

Clayton Goddard, Karin Allenspach, Audrey Deflandre, Claudine Zemirline, Emilie Guillot, Jonathan P. Mochel

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Metabolic syndrome; SGLT2 inhibitors; Dapagliflozin; Empagliflozin; Canagliflozin; Translational modeling

Online: 21 April 2022 (10:12:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0329.v1

Transpiration Responses of Herbicide-Resistant and -Susceptible Palmer amaranth [Amaranthus palmeri (S.) Wats.] to Progressively Drying Soil

Koffi Badou-Jeremie Kouame, Mary C. Savin, Gulab Rangani, Thomas R. Butts, Matthew B. Bertucci, Nilda Roma-Burgos

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: metabolic resistance; drought tolerance; threshold FTSW; stomatal closure; EPSPS gene amplification; S-metolachlor resistance; glyphosate resistance

Online: 21 January 2022 (13:37:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0304.v1

Predictors of Spontaneous Remodelling of Angular Knee Deformities in Children with Healed Nutritional Rickets: A Prospective Cohort Study Protocol

Mostafa M. Baraka, Shady Samir, Shady Mahmoud, Heba Elsedfy, Rana A. Mahmoud, Tamer A. El-Sobky

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Child nutrition disorders; Vitamin D deficiency rickets; Metabolic bone diseases; Genu valgum; Genu varum; Bone remodelling.

Online: 13 August 2021 (22:44:42 CEST)

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Background: Nutritional rickets is still considered as a global health problem especially in low-resource countries and immigrant societies of developed countries. Generalized skeletal deformities including angular knee deformities as genu varum and genu valgum are prominent features of nutritional rickets. Angular knee deformities can cause gait difficulties. However, the true remodelling potential of the healed knee deformities is largely unknown to the pediatric and orthopedic community. Aims: The primary objective of this study protocol is to investigate the natural history of disease in regard to the remodelling potential of angular knee deformities in children and adolescents with healed nutritional rickets. And determine the potential patient- and deformity-related factors that are associated with a favorable deformity remodelling as age and sex of patients and type, severity, laterality of deformities etc. Methods: This will be a prospective observational analytical cohort natural history of disease study. A minimum of at least 140 knees with healed nutritional rickets and angular knee deformities will be observed at regular three-monthly intervals over a period of at least one year. We will report two outcome variables namely; clinical and radiological tibio-femoral angle. And independent patient and deformity-related variables as age, sex, deformity type, severity and laterality. Inferential statistics namely bivariate and multivariate analysis will be employed accordingly to identify the relation between outcome variables and the different independent variables. Ethics and dissemination: This protocol study has been approved by the institutional research ethics committee. Results will be presented at conferences and submitted to relevant international and society publications. Authors will also communicate the results to their scholarly networks and post them on scholarly networking sites. Conclusions: This study has the potential for improving the decision-making process as to which patients deserve conservative treatment and which deserve surgical deformity correction. Results are expected to have an impact on the clinical practice of pediatricians, orthopedic surgeons and family physicians alike.

Preprint REVIEW | doi:10.20944/preprints202311.0461.v1

Ten Quick Tips for Accurate Reconstruction of Prokaryotic and Eukaryotic Genome-Scale Metabolic Models

Gabriela Canto-Encalada, Jenna Armstrong, Carlos Focil-Espinosa4, Ademikanra Adekunle-Fiyin, Ila Peeler, William R. Gebbie, Julio Nunez-Garcia, Alexis Saldivar, Diego Martinez, Cristal Zuniga

Subject: Biology And Life Sciences, Other Keywords: Genome-scale metabolic model reconstruction; manual curation; quick tips; systems biology

Online: 7 November 2023 (14:59:34 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0143.v1

Linking Aromatic Hydroxy Metabolic Functionalization of Drug Molecules to Structure and Pharmacologic Activity

Babiker M. El-Haj, Samrein B.M. Ahmed, Mousa A. Qarawi, Heyam S. Ali

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Aromatic hydroxy metabolites; arenolic drug metabolites; metabolic O-dealkylation; metabolic aromatic ring hydroxylation; primary and auxiliary pharmacophores; auxophores; metabolic modification of drug activity

Online: 9 July 2018 (13:28:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0517.v1

Metabolite Transporter and Its Impact on Metabolic Engineering Approaches

Mostafa Gomaa FADL

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gram-negative bacterial; Metabolite transporter; pathways; metabolic engineering approaches

Online: 25 January 2021 (15:49:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0123.v1

Effects of Caffeinated and Decaffeinated Coffee Consumption on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis of Data from Randomised Controlled Trials

Nur Nadiah Syuhada Ramli, Areej A Alkhaldy, Abbe Maleyki Mhd Jalil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolic syndrome; caffeinated coffee; decaffeinated coffee; green coffee extract; chlorogenic acid

Online: 4 August 2021 (22:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0467.v1

Nicotine Changes Airway Epithelial Phenotype and May Increase the SARS-COV2 Infection Severity

Leonardo Lupacchini, Fabrizio Maggi, Carlo Tomino, Chiara De Dominicis, Cristiana Mollinari, Massimo Fini, Stefano Bonassi, Daniela Merlo, Patrizia Russo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cell Proliferation; EMT; Mitochondrial Dysfunction; nAChR; Nicotine; SARS-CoV-2

Online: 18 December 2020 (13:24:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0280.v1

Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase

Colbie Reed, Geoffrey Hutinet, Valérie de Crécy-Lagard

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: comparative genomics; metabolic reconstruction; bioinformatics; conserved unknowns; function prediction; functional annotation; orthology

Online: 13 July 2021 (08:58:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0543.v1

The Influence of Probiotic Supplementation on Depressive Symptoms, Inflammation and Oxidative Stress Parameters and Faecal Microbiota in Patients with Depression Depending on Metabolic Syndrome Comorbidity – PRO-DEMET Randomised Study Protocol

Oliwia Gawlik-Kotelnicka, Anna Skowrońska, Aleksandra Margulska, Karolina H. Czarnecka-Chrebelska, Igor Łoniewski, Karolina Skonieczna-Żydecka, Dominik Strzelecki

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; metabolic syndrome; probiotics; microbiota; inflammation; oxidative stress

Online: 24 February 2021 (11:20:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0404.v1

A Historical Perspective on Sacral Nerve Stimulation (SNS) for Bowel Dysfunction

Elroy Patrick Weledji

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: pelvic floor; bowel; dysfunction; sacral nerve; stimulation

Online: 19 August 2021 (12:19:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0017.v1

Inclusion and Withdrawal Criteria for Growth Hormone (GH) Therapy in Children with Idiopathic GH Deficiency—Towards Following the Evidence but Still with Unresolved Problems

Joanna Smyczyńska

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: short stature; growth hormone deficiency; insulin-like growth factor-1; growth hormone stimulation tests; neurosecretory dysfunction; final height; retesting

Online: 4 January 2022 (18:05:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0241.v1

Diabetes Mellitus: A path to Amnesia, Personality and Behavior Change.

Rahnuma Ahmad, Kona Chowdhury, Santosh Kumar, Mohammed Irfan, Govindool Sharaschandra Reddy, Farhana Akter, Dilshad Jahan, Mainul Haque

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Diabetes Mellitus; Vascular Dementia; Alzheimer’s Disease; Inflammation; Atherosclerosis; Mitochondrial dysfunction; Cognitive dysfunction

Online: 17 January 2022 (15:46:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0223.v1

The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell to Cell Connections

Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Miriam Scicchitano, Cristina Carresi, Federica Scarano, Francesca Bosco, Saverio Nucera, Stefano Ruga, Maria Caterina Zito, Rocco Mollace, Ernesto Palma, Massimo Fini, Carolina Muscoli, Vincenzo Mollace

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: brain blood barrier; endothelial dysfunction; neurodegeneration

Online: 13 August 2018 (08:59:21 CEST)

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