Version 1
: Received: 18 July 2018 / Approved: 19 July 2018 / Online: 19 July 2018 (12:57:32 CEST)
How to cite:
Avecilla, V.; Doke, M. Pathophysiological Aspects of Vascular Remodeling in Cardiopulmonary Lesions: Influence of ID3 & Estrogenic Endocrine Disruptors. Preprints2018, 2018070334. https://doi.org/10.20944/preprints201807.0334.v1
Avecilla, V.; Doke, M. Pathophysiological Aspects of Vascular Remodeling in Cardiopulmonary Lesions: Influence of ID3 & Estrogenic Endocrine Disruptors. Preprints 2018, 2018070334. https://doi.org/10.20944/preprints201807.0334.v1
Avecilla, V.; Doke, M. Pathophysiological Aspects of Vascular Remodeling in Cardiopulmonary Lesions: Influence of ID3 & Estrogenic Endocrine Disruptors. Preprints2018, 2018070334. https://doi.org/10.20944/preprints201807.0334.v1
APA Style
Avecilla, V., & Doke, M. (2018). Pathophysiological Aspects of Vascular Remodeling in Cardiopulmonary Lesions: Influence of ID3 & Estrogenic Endocrine Disruptors. Preprints. https://doi.org/10.20944/preprints201807.0334.v1
Chicago/Turabian Style
Avecilla, V. and Mayur Doke. 2018 "Pathophysiological Aspects of Vascular Remodeling in Cardiopulmonary Lesions: Influence of ID3 & Estrogenic Endocrine Disruptors" Preprints. https://doi.org/10.20944/preprints201807.0334.v1
Abstract
Cardiopulmonary lesions, which manifest from various types of diseases such as pulmonary arterial hypertension, atherosclerosis, pulmonary arteriovenous malformations, lymphangioleiomyomatosis, and peripheral arterial disease, pose a public health problem. Vascular remodeling, which refers to alternations to the structure of the vessel is an important pathophysiological feature of these diseases. The Inhibitor of DNA-binding/Differentiation-3 (ID3), which is part of the ID family of transcriptional regulators, has been demonstrated to contribute to an essential role in the vasculature and therefore may influence the alterations of these lesions. This review will cover the existing understanding of how ID3 may contribute to cardiopulmonary lesion perturbations via involvement in vascular remodeling. Furthermore, based on the accumulative quantity of reports that indicate oxidative stress plays a essential function in the pathophysiology of vascular remodeling, we will also consider the impact of exposure to estrogenic endocrine disruptors (EEDs) such as polychlorinated biphenyls (PCBs) and bisphenol A (BPA) on ID3 & cardiopulmonary disease. Improved understanding of how ID3 pathways contributes to these molecular mechanisms in the lesion will prospectively deliver beneficial information in the mediation of vascular remodeling associated with ID3 & EED exposure, which may play an essential role in cardiopulmonary disease prevalence.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
