Preprint Case Report Version 2 Preserved in Portico This version is not peer-reviewed

4-Year Long Progression-Free and Symptom-Free Survival of a Patient with Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used as a Stand-Alone Treatment After Failed Standard Oncotherapy

Version 1 : Received: 7 December 2019 / Approved: 20 December 2019 / Online: 20 December 2019 (06:36:16 CET)
Version 2 : Received: 8 November 2020 / Approved: 9 November 2020 / Online: 9 November 2020 (11:25:35 CET)

How to cite: Tóth, C.; Dabóczi, A.; Chanrai, M.; Schimmer, M.; Horváth, K.; Clemens, Z. 4-Year Long Progression-Free and Symptom-Free Survival of a Patient with Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used as a Stand-Alone Treatment After Failed Standard Oncotherapy. Preprints 2019, 2019120264 (doi: 10.20944/preprints201912.0264.v2). Tóth, C.; Dabóczi, A.; Chanrai, M.; Schimmer, M.; Horváth, K.; Clemens, Z. 4-Year Long Progression-Free and Symptom-Free Survival of a Patient with Recurrent Glioblastoma Multiforme: A Case Report of the Paleolithic Ketogenic Diet (PKD) Used as a Stand-Alone Treatment After Failed Standard Oncotherapy. Preprints 2019, 2019120264 (doi: 10.20944/preprints201912.0264.v2).

Abstract

Studies in animal models have suggested that the ketogenic diet may be effective in the treatment of cancer. However, human cohort studies on the ketogenic diet have, thus far, failed to show benefits in cancer survival or in any other hard clinical endpoints of the disease. This paper presents a case report of a patient with glioblastoma multiforme. The patient had initially been treated with standard oncotherapy including surgery, radiotherapy and chemotherapy. Despite standard treatment, the patient experienced a recurrence of the glioblastoma seven months later. Subsequently, the patient refused radiotherapy and chemotherapy and opted to use the paleolithic ketogenic diet (PKD) as a stand-alone therapy. Following the adoption of the PKD, progression of the disease has been completely halted. At the time of writing, the patient has remained in remission for 48 months, is without side-effects and experiences an excellent quality of life without the use of any drugs.

Subject Areas

glioblastoma; brain tumor; paleolithic diet; ketogenic diet; paleolithic ketogenic diet; metabolic therapy; intestinal permeability; cancer treatment

Comments (1)

Comment 1
Received: 9 November 2020
Commenter: Zsófia Clemens
Commenter's Conflict of Interests: Author
Comment: Since 10 months have passed since the initial submission, reviewers suggested to update the manuscript wit follow-up data. Therefore we updated the manusript.
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