Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence

Celestino Sardu; Jessica Gambardella; Marco Bruno Morelli; Xujun Wang; Raffaele Marfella; Gaetano Santulli

doi:10.20944/preprints202004.0204.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 9 April 2020 / Approved: 13 April 2020 / Online: 13 April 2020 (02:23:33 CEST)

The symptoms most commonly reported by patients affected by coronavirus disease 2019 (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g. high blood pressure, thrombosis, pulmonary embolism) seem to suggest that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ of COVID-19.

Covid-19; coronavirus; cardiovascular disease; thrombosis; hypertension; endothelial dysfunction

Comment 1

Received: 21 April 2020
Commenter: Fabio Strelo
The commenter has declared there is no conflict of interests.

Comment: Yes, I think this is the key to find a better treatment and a vaccin.

Please, check the results from Swiss study :
http://www.en.usz.ch/media/press-releases/pages/covid-19-endotheliitis.aspx

+ Respond to this comment

Comment 2

Received: 7 May 2020
The commenter has declared there is no conflict of interests.

Comment: See the peer-reviewed version here: https://tinyurl.com/ybd95wo2

+ Respond to this comment

Your full name

Your affiliation information (e.g., name of your university/institution/organization)

Not displayed online.

Your Email address (not made public)

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website I want to get recognition for my comment on Publons

[what’s this?]. Link your accounts here

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

Notify me about updates to this article or when a peer-reviewed version is published.

Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence

Abstract

Subject Areas

Comments (2)