Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence

Celestino Sardu; Jessica Gambardella; Marco Bruno Morelli; Xujun Wang; Raffaele Marfella; Gaetano Santulli

doi:10.20944/preprints202004.0204.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 9 April 2020 / Approved: 13 April 2020 / Online: 13 April 2020 (02:23:33 CEST)

The symptoms most commonly reported by patients affected by coronavirus disease 2019 (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g. high blood pressure, thrombosis, pulmonary embolism) seem to suggest that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ of COVID-19.

Covid-19; coronavirus; cardiovascular disease; thrombosis; hypertension; endothelial dysfunction

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Comment 1

Received: 21 April 2020
Commenter: Fabio Strelo
The commenter has declared there is no conflict of interests.

Comment: Yes, I think this is the key to find a better treatment and a vaccin.

Please, check the results from Swiss study :
http://www.en.usz.ch/media/press-releases/pages/covid-19-endotheliitis.aspx

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Comment 2

Received: 7 May 2020
The commenter has declared there is no conflict of interests.

Comment: See the peer-reviewed version here: https://tinyurl.com/ybd95wo2

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Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence

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