Preprint Article Version 1 This version is not peer-reviewed

Relationship between Response to PDE5 Inhibitors and Penil Duplex Doppler Ultrasound in Erectile Dysfunction

Version 1 : Received: 13 January 2018 / Approved: 22 January 2018 / Online: 22 January 2018 (09:03:17 CET)

How to cite: Ogreden, E.; Oğuz, U.; Demirelli, E.; Tosun, A.; Yalçın, O. Relationship between Response to PDE5 Inhibitors and Penil Duplex Doppler Ultrasound in Erectile Dysfunction. Preprints 2018, 2018010196 (doi: 10.20944/preprints201801.0196.v1). Ogreden, E.; Oğuz, U.; Demirelli, E.; Tosun, A.; Yalçın, O. Relationship between Response to PDE5 Inhibitors and Penil Duplex Doppler Ultrasound in Erectile Dysfunction. Preprints 2018, 2018010196 (doi: 10.20944/preprints201801.0196.v1).

Abstract

Relationship between the results of penile duplex doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data of 148 patients with ED were analysed retrospectively. Patients who did not respond to therapy were classified as Group I (n = 32), those responded partially were classified as Group II (n = 40) and complete responders were classified as Group III (n = 76). Age, comorbid diseases, vascular and penile pathology were compared among the three groups. While diabetes mellitus (DM) and dyslipedimia positivity adversely affect the response to treatment, the presence of hypertension (HT), peyronie's disease and priapism increase the therapeutic response to the treatment (p < 0.05). Arterial insufficiency was present in 20(30.3%), 25(37,9%) and 21(31.8%) of the patients in Group I, Group II and Group III, respectively (p = 0.001). Venous insufficiency was observed in 3(14.3%) patients in Group I and in 8(85.7%) patients in Group III (p = 0.001). Arterial/venous insufficiency was seen in 9(30%), 14(46.7%) and 7(23.3%) of the patients in Group I, Group II and Group III, respectively (p = 0.001). Response rate to treatment was highest in normal patients according to PDDU, followed by patients with venous insuffiency. Besides, it was found that DM decreased the response to treatment, whereas response was increased in cases with HT, priapism and Peyronie’s disease.

Subject Areas

comorbid diseases; erectile dysfunction; penile duplex doppler ultrasound; penile pathology; phosphodiesterase type 5 inhibitors

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