Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

The Powerful Immune System Against Powerful COVID-19: A Hypothesis

Version 1 : Received: 6 April 2020 / Approved: 7 April 2020 / Online: 7 April 2020 (12:07:22 CEST)

A peer-reviewed article of this Preprint also exists.


On March 11, 2020, the World Health Organization declared the coronavirus outbreak a pandemic. Since December 2019, the world has experienced an outbreak of coronavirus disease 2019 (COVID-19). Epidemiology, risk factors, and clinical characteristics of patients with COVID-19 have been reported but the factors affecting the immune system against COVID-19 have not been well described. In this article, we provide a novel hypothesis to describe how an increase in cellular adenosine triphosphate (c-ATP) can potentially improve the efficiency of innate and adaptive immune systems to either prevent and fight off COVID-19.


COVID-19; ATP; Immune dysfunction


Biology and Life Sciences, Immunology and Microbiology

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