Preprint Article Version 1 This version is not peer-reviewed

A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome

Version 1 : Received: 26 October 2017 / Approved: 27 October 2017 / Online: 27 October 2017 (02:32:43 CEST)

How to cite: Shokouh, P.; Jeppesen, P.B..; Hermansen, K.; Nørskov, N.; Laustsen, C.; Hamilton-Dutoit, S.J.; Qi, H.; Stødkilde-Jørgensen, H.; Gregersen, S. A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome. Preprints 2017, 2017100164 (doi: 10.20944/preprints201710.0164.v1). Shokouh, P.; Jeppesen, P.B..; Hermansen, K.; Nørskov, N.; Laustsen, C.; Hamilton-Dutoit, S.J.; Qi, H.; Stødkilde-Jørgensen, H.; Gregersen, S. A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome. Preprints 2017, 2017100164 (doi: 10.20944/preprints201710.0164.v1).

Abstract

Since coffee has been shown to influence positively the metabolism of subjects with metabolic syndrome (MetS), we aimed to evaluate the short- and long-term effects of a coffee-based supplement on different features of diet-induced MetS. 24 Sprague Dawley rats were divided into control or nutraceuticals groups to receive a high-fat/high fructose diet with or without a mixture of caffeic acid (30 mg/day), trigonelline (20 mg/day), and cafestol (1 mg/day) for 12 weeks. An additional 11 rats were assigned to an acute crossover study. In the chronic experiment, nutraceuticals did not alter body weight or glycemic control but improved fed hyperinsulinemia and HOMA-IR, and plasma adiponectin levels. The impact of nutraceuticals on post-prandial glycemia tended to be more pronounced after acute administration than at the end of the chronic study. Circulating and intrahepatocellular alanine transaminase activity, assessed by hyperpolarized-13C NMR spectroscopy, were reduced by coffee nutraceuticals at endpoint. There was also a tendency towards lower liver triglyceride content and histological steatosis score in the intervention group. In conclusion, a mixture of coffee nutraceuticals improved insulin sensitivity and exhibited hepatoprotective effects in a rat model of MetS. Higher dosages with or without caffeine deserve to be studied in the future.

Subject Areas

coffee; dietary supplements; metabolic syndrome X; non-alcoholic fatty liver disease; adiponectin; hyperpolarized magnetic resonance spectroscopy

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