Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mitochondrial Dysfunction: a Notable Contributor to the Progression of Alzheimer’s & Parkinson’s Disease

Version 1 : Received: 1 September 2021 / Approved: 3 September 2021 / Online: 3 September 2021 (16:01:26 CEST)

How to cite: Olagunju, A.S.; Alagbe, A.A.; Otenaike, T.A.; Fabiyi, B.O.; Teibo, J.O.; Qusty, N.; Qusti, S.; Alshammari, E.M.; Batiha, G.E.; Omotoso, O. Mitochondrial Dysfunction: a Notable Contributor to the Progression of Alzheimer’s & Parkinson’s Disease. Preprints 2021, 2021090073 (doi: 10.20944/preprints202109.0073.v1). Olagunju, A.S.; Alagbe, A.A.; Otenaike, T.A.; Fabiyi, B.O.; Teibo, J.O.; Qusty, N.; Qusti, S.; Alshammari, E.M.; Batiha, G.E.; Omotoso, O. Mitochondrial Dysfunction: a Notable Contributor to the Progression of Alzheimer’s & Parkinson’s Disease. Preprints 2021, 2021090073 (doi: 10.20944/preprints202109.0073.v1).

Abstract

Mitochondrial dysfunctions remained a pivotal mechanism in manifold neurodegenerative diseases. Mitochondrial homeostasis within the cell is an essential aspect of cell biology. Mitochondria which is also known as the power-generating set of the cell, have a dominant role in several processes associated with the genomic integrity and cellular equilibrium maintenance. They are involved in maintaining optimal cells functioning and guidance from possible DNA damage which could lead to mutations and onset of diseases. Conversely, system perturbations which could be due to environmental factors or senescence induce changes in the physiological balance and result in the mitochondrial functions impairment. The focal point of this review focuses on mitochondrial dysfunction as a significant condition in the onset of neuronal disintegration. We explain the pathways associated with the dysfunction of the mitochondria which are common amongst the most recurring neurodegenerative diseases including Alzheimers and Parkinsons disease. Do mitochondrial dysfunctions represent an early event in causing a shift towards neuropathological processes?

Keywords

Mitochondrial dysfunction; Alzheimer's disease; Parkinson's disease; Neurodegeneration; Amyloid beta; Parkin

Subject

LIFE SCIENCES, Molecular Biology

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