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Preprint ARTICLE | doi:10.20944/preprints202309.0858.v1

Comparative Analysis of Phospholipase D (PLD) Gene Family in Camelina sativa and Brassica napus and Its Responses in Camelina Seedlings under Salt Stress

Parviz Heidari, Fatemeh Puresmaeli, Yavar Vafaee, Mostafa Ahmadizadeh, Mohammadreza Ensani, Haniyeh Ahmadinia

Subject: Biology And Life Sciences, Plant Sciences Keywords: evolution analysis; oilseeds; regulatory system; sequence analysis; lipid signaling

Online: 13 September 2023 (10:34:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0286.v1

Melatonin Enhanced Drought Stress Tolerance and Productivity of Pelargonium graveolens L. (Herit) by Regulating Physiological and Biochemical Responses

Ragia Mazrou, Fahmy A. S. Hassan, Mohamed Magdy F Mansour, Mohamed M Mousa

Subject: Biology And Life Sciences, Horticulture Keywords: essential oil; enzymatic antioxidants; drought; glutathione; lipid peroxidation; proline

Online: 6 September 2023 (04:25:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1166.v1

Review on Smart Nanocarrier Bilayer Lipid-Coated graphene@MSN Nanocomposites

Ketan B. Patil, Jayvadan K. Patel

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Mesoporous materials; lipid bilayer; graphene oxide; graphene@MSN nanocomposites

Online: 16 August 2023 (20:23:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0920.v1

Agaricus bisporus Extract (H2Oslim^®) Exerts an Anti-obesity Effect in High-Fat Diet-Induced Obese C57BL/6N Mice by Inhibiting Pancreatic Lipase-Mediated Fat Absorption

Hyungkeun Kim, Young Eun Jeon, So Mi Kim, Jae In Jung, Donghyeon Ko, Eun Ji Kim

Subject: Biology And Life Sciences, Food Science And Technology Keywords: agaricus bisporus; chitosan; polysaccharide; lipid absorption; pancreatic lipase; obesity

Online: 11 August 2023 (09:36:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1446.v1

Leptospira Lipid a Is a Potent Adjuvant Capable of Inducing Antigen-Specific Sterilizing Immunity Against Leptospirosis

Vivek Varma, Mohammad Kadivella, Sridhar Kavela, Syed Faisal

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Lig A; Lipid A; Adjuvant; Vaccine; MPLA; Alum; Leptospirosis

Online: 20 July 2023 (15:02:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0234.v1

Review of Lipid Metabolic Pathways and Calcium Signaling in the Apicomplexan Families and their Importance in Drug Discovery

Joseph A. Ayariga, Iddrisu Ibrahim, Soumyakrishnan Syamala, Daniel Abugri, James Abugri

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: lipid metabolism; Apicomplexa; drug discovery; calcium signaling; acidocalcisomes; parasite

Online: 14 February 2023 (04:42:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0243.v1

Antioxidant and Antidiabetic Activity of Algae

Atef Mohamed Abo-Shady, Saly Farouk Gheda, Gehan Ahmed Ismail, João Cotas, Leonel Pereira, Omnia Hamdy Abdel-Karim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: diabetes; antioxidant; antihyperglycemic; lipid profile; body weight; algal treatments

Online: 14 December 2022 (03:17:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0069.v1

Cell/Tissue based Reconstituted Lipid Nanoparticles as Versatile Drug Delivery Carrier

Cheng Wang

Subject: Chemistry And Materials Science, Biomaterials Keywords: reconstituted lipid nanoparticles; drug delivery systems; solvent diffusion method

Online: 3 November 2022 (03:57:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0149.v1

Effect of Dietary Soybean Oil Inclusion on Liver-Related Transcription Factors in a Pig Model for Metabolic Diseases

Simara Larissa Fanalli, Bruna Pereira Martins da Silva, Julia Dezen Gomes, Fernanda Nery Ciconello, Vivian Vezzoni de Almeida, Felipe André Oliveira Freitas, Gabriel Costa Monteiro Moreira, Bárbara Silva-Vignato, Juliana Afonso, James Reecy, James Koltes, Dawn Koltes, Luciana Correia de Almeida Regitano, Julio Cesar de Carvalho Baileiro, Luciana Freitas, Luiz Lehmann Coutinho, Heidge Fukumasu, Severino Matias de Alencar, Albino Luchiari Filho, Aline Silva Mello Cesar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: immune response; fatty acid; lipid metabolism; RNA-Seq; transcriptome

Online: 10 February 2022 (10:57:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0066.v1

In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels

Maegan E. Boutot, Brian W. Whitcomb, Nadia Abdelouahab, Andrea A. Baccarelli, Amélie Boivin, Artuela Caku, Virginie Gillet, Guillaume Martinez, Jean-Charles Pasquier, Jiping Zhu, Larissa Takser, Lindsay St-Cyr, Alexander Suvorov

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: dyslipidemia; fetal programing; lipid metabolism; NAFLD; persistent organic pollutants

Online: 3 September 2021 (13:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0385.v1

Milk Fermented with Lactobacillus casei Strain AP Improves Lipid Profiles in Obese Indonesian Adults

Widodo Widodo, Anggeria Oktavisa Denta, Sunarti Sunarti, Dietmar Haltrich

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Obesity; Lactobacillus casei AP; probiotic; fermented milk; lipid profiles

Online: 18 August 2021 (14:15:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0419.v1

Biomass and Lipid Productivity by Two Algal Strains of Chlorella Sorokiniana Grown in Hydrolysate of Water Hyacinth

Swati Dahiya, Raja Chowdhury, Wendong Tao, Pradeep Kumar

Subject: Engineering, Automotive Engineering Keywords: Hydrolysate; Chlorella sorokiniana; lipid; biomass productivity; nutrient amended media.

Online: 21 January 2021 (12:39:53 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202003.0401.v1

Roles for the SNAP25 Linker Domain in the Fusion Pore and a Dynamic Plasma Membrane SNARE Acceptor Complex

Ronald Holz, Mary Bittner

Subject: Biology And Life Sciences, Biophysics Keywords: SNAP25; linker; protein lipid interaction; acceptor complex; exocytosis; fusion

Online: 27 March 2020 (02:56:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0368.v1

Liquid-Liquid Equilibrium Behavior and In Vitro Digestion Simulation of Medium Chain Fatty Acids

Ericsem Pereira, Antonio J. A. Meirelles, Guilherme J. Maximo

Subject: Chemistry And Materials Science, Food Chemistry Keywords: phase equilibrium; in vitro lipid digestion; fats and oils

Online: 25 March 2020 (04:14:17 CET)

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Working Paper ARTICLE

Myelin Disturbances Produced by Sub-Toxic Concentration of Heavy Metals: Role of Oligodendrocyte Dysfunction

Jessica Maiuolo, Roberta Macrì, Irene Bava, Micaela Gliozzi, Vincenzo Musolino, Saverio Nucera, Cristina Carresi, Miriam Scicchitano, Francesca Bosco, Federica Scarano, Ernesto Palma, Santo Gratteri, Vincenzo Mollace

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: heavy metals; oligodendrocytes; myelination; lipid formation; intracellular calcium regulation

Online: 1 August 2019 (04:47:18 CEST)

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Evidence has been accumulated demonstrating that heavy metals may accumulate in various organs leading to tissue damage and toxic effects in mammals. In particular, the Central Nervous System (CNS) seems to be particularly vulnerable to cumulative concentrations of heavy metals, though the pathophysiological mechanisms is still to be clarified. In particular the potential role of oligodendrocyte dysfunction and myelin production after exposure to subtoxic concentration of heavy metals is to be better assessed. Here we investigated on the effect of sub-toxic concentration of several essential (Cu^{2 +}, Cr³⁺, Ni²⁺, Co²⁺) and non-essential (Pb²⁺, Cd²⁺, Al³⁺) heavy metals on MO3.13 and SHSY5Y human oligodendrocyte and neuronal cell lines (grown individually or in co-culture). In particular, exposure of both cell lines to heavy metals produced a reduced cell viability of co-cultured cell lines compared to cells grown separately. This effect was more pronounced in neurons which were more sensitive to metals than oligodendrocytes when the cells were grown in co-culture. On the other hand, a significant reduction of lipid component in cells occurred after their exposure to heavy metals, an effect accompanied by substantial reduction of the main protein that makes up myelin (MBP) in co-cultured cells. Finally, the effect of heavy metals in oligodendrocytes were associated to imbalanced intracellular calcium ion concentration as measured through the fluorescent Rhod-2 probe, thus confirming that heavy metals, even used at subtoxic concentrations, lead to dysfunctional oligodendrocytes. In conclusion, our data show, for the first time, that sub-toxic concentrations of several heavy metals lead to dysfunctional oligodendrocytes, an effect highlighted when these cells are co-cultured with neurons. The pathophysiological mechanism(s) underlying this effect is to be better clarified. However, imbalanced intracellular calcium ion regulation, altered lipid formation and, finally, imbalanced myelin formation seem to play a major role in early stages of heavy metal-related oligodendrocyte dysfunction.

Preprint ARTICLE | doi:10.20944/preprints201809.0421.v1

Nanoparticle-Lipid Interaction: Job Scattering Plots to Differentiate Vesicle Aggregationfrom Supported Lipid Bilayer Formation

Fanny Mousseau, Evdokia Oikonomou, Victor Baldim, Stéphane Mornet, Jean-François Berret

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Nanoparticles – Bio-nano interfaces – Electrostatic interactions – Supported Lipid Bilayers

Online: 20 September 2018 (16:29:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0026.v1

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation in Vivo

Marc Foretz, Patrick Even, Benoit Viollet

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: AMPK; liver; lipid metabolism; fatty acid oxidation; indirect calorimetry

Online: 1 August 2018 (16:06:39 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.0870.v1

When Congenital Heart Repair Is Good but Vision Is Not –a Rare Occurrence of Cortical Visual Impairment Due to Unilateral Subdural Hematoma

Abhavya Shree, Rajat Kalra

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: congenital heart repair, cortical blindness, subdural hematoma

Online: 13 May 2024 (13:08:31 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.0301.v1

Congenital Complete Heart Block—To Stimulate (When?) or Not to Stimulate?

Piotr Kukla, Beata Podlejska, Jerzy Wiliński

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: congenital heart block; cardiac pacemaker; atropine; salbutamol

Online: 6 May 2024 (12:36:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0020.v1

Tachycardia-Induced Cardiomyopathy in an Infant with Atrial Flutter and Prolonged Recovery of Cardiac Function

Tomohide Sakai, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka W Ozawa, Yukiko Hata, Shojiro Ichimata, Naoki Nishida, Keiichi Hirono

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: tachycardia-induced cardiomyopathy; atrial flutter; heart failure

Online: 1 May 2024 (04:30:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0901.v1

Impact of Withdrawal of SGLT2 Inhibitors on Clinical Outcomes in Patients with Heart Failure

Masaki Nakagaito, Teruhiko Imamura, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; SGLT2 inhibitor; hospitalization; medical cost

Online: 15 April 2024 (11:36:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0029.v1

Apolipoprotein E Gene Variation in Pakistani Type 2 Diabetic Subjects with and without Cardiovascular Complications

Shehwar Nadeem, Tahir Maqbool, Javed Anver Qureshi, Awais Altaf, Sadia Naz, Muzmmal Mateen Azhar, Inam Ullah

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Apolipoprotein E; polymorphisms; Ischemic heart disease; stroke

Online: 1 April 2024 (10:26:55 CEST)

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Background Apolipoprotein E (APOE) gene polymorphism has been implicated in the pathogenesis of various metabolic disorders, including type 2 diabetes mellitus (T2DM). Type 2 diabetes mellitus (T2DM) is a major public health concern worldwide, including in Pakistan. Cardiovascular problems linked with T2DM have a significant impact on people and society. The study's goal is to investigate the relationship between Apolipoprotein E (ApoE) genotypes, lipid profiles, and cardiovascular complications such as ischemic heart disease (IHD) and stroke. Methods: This study was carried out on 260 subjects, divided into control D1: Diabetics without cardiovascular issues. D2: Diabetics with heart disease. D3: Diabetics with stroke. D4: Diabetics with both heart disease and stroke. Anthropometric parameters (age, BMI) and risk factors (smoking, diabetes duration, hypertension) were assessed in all groups. Serum levels of TC, TG, LDL, HDL, VLDL, creatinine, BSF, and HbA1c were measured. Apolipoprotein E gene polymorphism was determined using PCR-RFLP. Results: Hypertension, BMI, and dyslipidemia, defined as elevated levels of total cholesterol, triglycerides, LDL, HDL, and VLDL, as well as uncontrolled hyperglycemia (elevated fasting blood sugar and glycated hemoglobin) in T2DM, were linked to vascular complications such as IHD and stroke. Hypertension was prevalent in 75.4% of the population, with greater rates among the elderly. Stage 2 hypertension was more prevalent in all age groups. Apolipoprotein E gene polymorphism was discovered, with genotypes 3/3, 4/4, 2/3, and 3/4 being the most prevalent. Genotype 3/4 was more common in diabetics who had IHD/stroke or both problems, whereas genotype 2/3 was linked to DM and stroke. Conclusion: It is concluded that BMI, hypertension, hyperglycemia, atherosclerosis, and dyslipidemia are linked with cardiovascular complications of type 2 diabetes. Apolipoprotein E gene polymorphism is associated with cardiovascular disease in diabetic patients by affecting the lipid profile.

Preprint REVIEW | doi:10.20944/preprints202403.0531.v1

Challenges in Echocardiography for the Diagnosis and Prognosis of Non-ischemic Hypertensive Heart Disease

Nikolaos PE Kadoglou, Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Ioannis Korakianitis, Michael Myrianthefs

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Hypertensive heart disease; echocardiography; prognosis; speckle tracking

Online: 8 March 2024 (16:49:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0391.v1

Carbohydrate Antigen 125 (CA 125): Novel Biomarker in Acute Heart Failure

Mihai Cristian Marinescu, Violeta Diana Oprea, Sorina Nicoleta Munteanu, Aurel Nechita, Dana Tutunaru, Luiza-Camelia Nechita, Aurelia Romila

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: acute heart failure; CA 125; NTpro BNP

Online: 8 March 2024 (01:55:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2153.v1

Different Mechanisms in Doxorubicin-induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations

Hien C. Nguyen, Jefferson C. Frisbee, Krishna K. Singh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: BRCA2; BRCA1; doxorubicin; breast cancer; heart failure

Online: 28 December 2023 (05:10:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1483.v1

Radiation Exposure Assessment in Coronary Angiography CT Scan: Establishing Diagnostic Reference Level for Northeast Assam Population

Arnabjyoti Deva Sarma, Jibon Sharma, Manash Pratim Sarma, Mrinal Kanti Singha

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: radiology; computed tomography; coronary angiography; phantom; heart

Online: 22 September 2023 (05:16:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1359.v1

Acute changes on atrial function during progressive exercise in patients with heart failure with mildly-reduced ejection fraction. A case-control study

Ferdinando Iellamo, Giuseppe Caminiti, Marco Alfonso Perrone, Valentino D'Antoni, Alessandro Gismondi, Deborah Di Biasio, Sara Vadala, Giuseppe Marazzi, Valentina Morsella, Maurizio Volterrani

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: left atrial function, heart failure; stepwise exercise

Online: 19 June 2023 (12:59:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0014.v1

Empagliflozin Reduces Interleukin-6 Levels in Patients With Heart Failure

Michael Gotzmann, Pauline Henk, Ulrik Stervbo, Arturo Blázquez-Navarro, Andreas Mügge, Nina Babel, Timm H. Westhoff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: SGLT2 inhibition; empagliflozin; heart failure; interleukin 6

Online: 1 June 2023 (03:33:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1473.v1

Characterization of a Decellularized Sheep Pulmonary Heart Valves and Analysis of their Capability as a Xenograft Initial Matrix Material in Heart Valve Tissue Engineering

Müslüm Süleyman İNAL, Cihan DARCAN, Ali AKPEK

Subject: Engineering, Bioengineering Keywords: Decellularization; heart valve; tissue engineering; xenograft; biomaterial

Online: 22 May 2023 (08:26:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1056.v1

Impact on Accessibility to Care and Outcomes of a Clinician-to-Clinician Electronic Consultation Program in Heart Failure Patients with Previous Hospital Admissions: Implications for Heart Failure Care

David García-Vega, Pilar Mazon-Ramos, Manuel Portela-Romero, Moisés Rodríguez-Mañero, Daniel Rey-Aldana, Manuela Sestayo-Fernandez, Sergio Cinza-Sanjurjo, Jose Ramon González-Juanatey

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; hospitalization; cardiovascular outcomes; electronic consultation

Online: 15 May 2023 (15:30:16 CEST)

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(1) Objectives. Patients with heart failure (HF) who experience hospitalizations for worsening HF (HFH) are at high risk of subsequent events. We aimed to evaluate the impact of an outpatient care management program that includes a clinician-to-clinician e-consultation using an integrated electronic medical record in a healthcare area with a widely dispersed population on delay time in care, hospital admissions, and mortality in a high-risk group of patients with HF and previous episodes of HFH. (2) Methods. We selected 6,444 HF patients who visited the cardiology service at least once between 2010 and 2021. Of these, 4,851 were attended in e-consult, and 2,008 in one-time in-person consultations. In 2,230 HF patients, there was documentation of a previous episode of HFH. Using an interrupted time series regression model, we analysed the impact of incorporating e-consult into the health care model in the group of patients with HFH and evaluated the elapsed time to cardiology care, heart failure (HF), cardiovascular (CV), and all-cause hospital admissions and mortality, calculating the incidence relative risk (iRR). (3) Results. In the group of patients with previous HF hospitalizations, the introduction of e-consult substantially decreased waiting times to cardiology care. The time elapsed to care after e-consult implementation was significantly reduced compared with the previous in-person period (8.6 [8.7] vs 55.4 [79.9] days, p<0.001). In that group of patients, after e-consult implantation, hospital admissions for HF were reduced (iRR [CI95%]: 0,837 [0,840-0,833]), 0,900 [0,862-0,949] for CV and 0,699 [0,678-0,726] for all-cause hospitalizations. There was also lower mortality (iRR [CI95%]: 0.715 [0.657-0.798] due to HF, 0,737 [0.764-0.706] for CV and 0,687 [0.652-0,718] for all-cause). The improved outcomes after e-consultation implementation were significantly higher in the group of patients with previous HFH and were independent of the patient’s clinical characteristics managed during the in-person or e-consultation periods. (4) Conclusions. In HF patients with previous HFH, an outpatient care program that includes an e-consult significantly reduced waiting times to cardiology care and was safe, with a lower rate of hospital admissions and mortality in the first year.

Preprint ARTICLE | doi:10.20944/preprints202305.0387.v1

Improvement of Left Atrial Function after Twelve-Weeks of Supervised Concurrent Training in Patients with Heart Failure with Mid-Range Ejection Fraction: A Pilot Study

Giuseppe Caminiti, Ferdinando Iellamo, Marco Alfonso Perrone, Valentino D'Antoni, Alessandro Gismondi, Giuseppe Marazzi, Sara Vadala, Deborah Di Biasio, Vincenzo Manzi, Maurizio Volterrani

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: concurrent training; heart failure; left atrial dysfunction

Online: 6 May 2023 (07:51:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0185.v1

Role of Chest Radiographs and Electrocardiograms in Predicting the Hemodynamics of Congenital Heart Disease

Romila Chimoriya, Gaurav Kumar, Kritika Rana, Ritesh Chimoriya, Reena Anand, Kulbhusan S. Dagar, Neeraj Awasthy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; chest radiograph; electrocardiogram; echocardiography

Online: 14 September 2022 (02:55:41 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202206.0258.v1

Comparison of the Use of Desflurane vs. Propofol in Aortic Valve Replacement Surgery: Differences in Nephroprotection

Jose Luis Guerrero Orriach, Alfredo Malo-Manso, Mercedes Nuñez Galo, Inmaculada Bellido Estevez, Amalio Ruiz Salas, Jose Cruz Mañas, Lourdes Garrido Sanchez, Laura Gonzalez-Alvarez

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: desflurane; cardiac surgery; halogenated; kidney; heart; preconditioning

Online: 20 June 2022 (04:52:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0116.v1

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and EPAC : A Role for the Mitochondrial Permeability Transition Pore

Martin John Lewis, Igor Khaliulin, Katie Hall, M.Saadeh Suleiman

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Ischaemia/reperfusion injury; Development; Mitochondria; Immature Heart

Online: 10 January 2022 (13:38:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0172.v1

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients

Aušra Mongirdienė, Julius Liobikas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: monocyte subset; heart failure; inflammation; cytokine; macrophage

Online: 10 December 2021 (11:54:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0185.v1

Prognostic Value of the Six-Minute Walk Test in Heart Failure

Vinicius Astolpho, Roberto Barbosa, Gabriela Devens, Leticia Louzada, Pietro Lima, Rodolfo Sylvestre, Renato Serpa, Osmar Calil, Luiz Fernando Barbosa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: heart failure; 6-minute walk test; prognosis

Online: 4 November 2020 (10:08:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0003.v1

Prognostic Impact of Acute Kidney Injury on Decompensated Heart Failure

Layane Batista, Roberto Barbosa, Caroline Carrera, Gabriella Curcio, Pietro Lima, Vinicius Astolpho, Rodolfo Sylvestre, Lucas De Barros, Renato Serpa, Osmar Calil, Luiz Fernando Barbosa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Heart Failure; Acute Kidney Injury; Prognosis; Mortality.

Online: 2 November 2020 (08:09:49 CET)

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Introduction: Decompensated heart failure (HF) is a complex and debilitating syndrome, which constitutes a severe emergency condition with high morbidity and mortality. The kidneys play fundamental roles in the pathophysiology of HF and, in the context of decompensations, acute kidney injury (AKI) has a bilateral cause-and-effect relationship, which can significantly worsen prognosis. However, the interaction between AKI and decompensated HF is poorly understood. Objective: This study aimed to assess the occurrence of AKI in patients hospitalized due to decompensated HF and to analyze its prognostic impact during hospitalization. Methods: Prospective single-center observational study that included patients hospitalized due to decompensated HF in a tertiary-level teaching hospital, conducted between July 2017 and January 2020. Patients who developed AKI during hospitalization were compared with those who did not develop it, until hospital discharge or death. AKI was defined as a serum creatinine increase greater than or equal to 0.3 mg/dl in 48 hours, a 1.5-fold increase in baseline creatinine in seven days or urinary volume <0.5 ml/kg/h during six hours, according to the Acute Kidney Injury Network (AKIN) criteria. The endpoints analyzed were death, need for invasive mechanical ventilation (IMV) and length of hospital stay. The Wilcoxon, Mann-Whitney and unpaired student t tests were used. Results: Ninety-nine patients were included, with a mean age of 65.4 ± 14 years, of which 47 (47.5%) were male and 52 (52.5%) were female. Reduced ejection fraction was observed in 77.8% of patients, whilst 22.2% had a diagnosis of HF with preserved EF. The decompensation clinical classifications were: dry and warm = 7 (7.1%), wet and warm = 72 (72.7%), wet and cold = 15 (15.1%) and dry and cold = 5 (5.1%). The average left ventricular ejection fraction was 38.3% ± 15. AKI ocurred in 22 patients (22.2%). Comparison between patients who evolved with and without AKI showed higher mortality (36.4% vs 10.4%, p = 0.004) and the need for IMV (54.5% vs 13%, p = 0.0001) in the first group. There was no significant difference regarding the length of in-hospital stay (22.9 ± 19 vs 18.8 ± 16 days, p = 0.26). Conclusions: The occurrence of AKI was frequent in patients with decompensated HF requiring hospitalization, affecting approximately one out of five patients. This complication was significantly associated with increased mortality and the need for IMV during hospitalization.

Preprint REVIEW | doi:10.20944/preprints202010.0493.v1

Obesity and COVID-19 Infection Severity: From Pathophysiology to Clinical Implications

Abdallah Fayssoil, Marie Charlotte De Carne De Carnavalet, Nicolas Mansencal, Frédéric Lofaso, Benjamin Davido

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; Obesity; BMI; heart; lung; severity

Online: 23 October 2020 (13:28:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0034.v1

Acupuncture on Lactate, Perceived Exertion in Recreational Athletes Submitted to HIIT

Carlos Soares Pernambuco, Rodrigo Gomes de Souza Vale, João Rafael Valentim-Silva, Carlos Alberto de Souza Filho, Vinicius do Espirito Santo de Jesus, Eliane da Silva Borges, Leandra Silva Cardoso, Isabel Cristina Regazzi, Estelio Henrique Martin Dantas

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Acupuncture; lactate; heart rate; physical performance; sustainability

Online: 2 August 2020 (14:46:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0039.v1

Fetal Heart Rate Signal Dataset for Training Morphological Analysis Methods and Evaluating them Against an Expert Consensus

Samuel Boudet, Agathe Houze de l'Aulnoit, Romain Demailly, Aline Delgranche, Laurent Peyrodie, Régis Beuscart, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Other Keywords: fetal heart rate, baseline, acceleration, deceleration, dataset

Online: 2 July 2019 (11:17:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0139.v1

A Fetal Heart Rate Morphological Analysis Toolbox for MATLAB

Samuel Boudet, Agathe Houzé de l'Aulnoit, Romain Demailly, Aline Delgranche, Laurent Peyrodie, Régis Beuscart, Denis Houzé de l'Aulnoit

Subject: Computer Science And Mathematics, Other Keywords: fetal heart rate; baseline; acceleration; deceleration; MATLAB

Online: 15 June 2019 (03:39:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0325.v1

Effects of Acute Hypoxic Provocation on Autonomic Nervous System in Young “Healthy” Smokers Measured by Heart Rate Variability

Zdravko Taralov, Peter Dimov, Kiril Terziyski, Blagoi Marinov, Mariyan Topolov, Stefan Kostianev

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability, smoking, hypoxia, autonomic dysfunction

Online: 20 June 2018 (15:38:52 CEST)

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Background and objectives: Smoking leads to autonomic dysfunction. However, the clinical methods for diagnosing this dysfunction are not sufficient. Since exogenous hypoxia leads to changes in the autonomic cardiac control, the aim of our study was to compare the activity of the autonomic nervous system via heart rate variability (HRV) in young “healthy” smokers and non-smokers before, during and after a short-term exogenous hypoxic exposure. Methods: Twenty-one healthy non-smoking males aged 28.0±7.4 (mean±SD) and fourteen healthy smoking males aged 28.1±4.3 with 9.2±5.6 pack-years were subjected to one-hour hypoxic exposure (FiО2=12.3±1.5%) via hypoxicator (AltiPro 8850 Summit+, Altitude Tech, Canada) with simultaneous recording of electrocardiography and pulse oximetry. HRV data was derived via specific software (Kubios HRV, Finland) by analyzing the pre-hypoxic, hypoxic and post-hypoxic periods. Results: Standard deviation of the intervals between normal beats (SDNN) was higher in non-smokers in the pre-hypoxic period (62.0±32.1 vs 40.3±16.2, p=0.013) but not in hypoxia (75.7±34.8 vs 57.9±18.3, p=0.167). When comparing intragroup HRV changes of shifting from hypoxic to post-hypoxic (normoxic) conditions we found that there is a significant increase in the root mean square of successive RR interval differences (RMSSD) (65.9±40.2 vs 75.1±45.9, p=0.011) and in the high frequency (lnHF) (6.8±1.4 vs 7.2±1.3, p=0.014) and a decrease in LF/HF (3.0±2.3 vs 1.9±1.5, p<0.001), but these changes were observed only in the group of non-smokers. Conclusions: Smoking likely impairs autonomic regulation in young healthy males and may lead to a decreased HRV even before subjective clinical signs and symptoms. Hypoxic exposure test could be applied in clinical practice for early detection of autonomic dysfunction in smokers, because their parasympathetic reactivation is blunted when shifting from hypoxic to normoxic ambient conditions measured by HRV.

Preprint ARTICLE | doi:10.20944/preprints202308.0249.v1

Ultra-High Resolution Electrocardiography Enables Earlier Detection of Transmural and Subendocardial Myocardial Ischemia Compared to Conventional Electrocardiography

Kirill V. Zaichenko, Anna A. Kordyukova, Dmitry L. Sonin, Michael M. Galagudza

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart; ischemia; reperfusion; electrocardiography; ultra-high resolution electrocardiography; power spectral density; ischemic heart disease; subclinical atherosclerosis; sensitivity; risk stratification

Online: 3 August 2023 (05:17:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0508.v1

Is Continuous ECG Recording on Heart Rate Monitors the Most Expected Function by Endurance Athletes, Coaches, and Doctors?

Robert Gajda

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: heart rate monitor; ECG; portable/wearable monitoring system; heart rate variability; long-term assessment; arrhythmia; QARDIO MD VSI system

Online: 24 August 2020 (07:45:40 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.0336.v1

Nano(bio)materials Do Not Affect Macrophage Phenotype – A Study Conducted by the REFINE Project

Christopher A.W. David, Jolanda P. Vermeulen, Sabrina Gioria, Rob J. Vandebriel, Neill J. Liptrott

Subject: Immunology And Allergy, Medicine And Pharmacology Keywords: Monocyte-derived macrophages; Nanostructured lipid carrier; Polymeric nanomedicine; Immunotoxicity assessment

Online: 7 May 2024 (08:17:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1536.v1

The Effectiveness of Nutritional Interventions Implemented Through Lady Health Workers on the Reduction of Stunting in Children under 5 in Pakistan; The Difference‐in‐Difference Analysis

Khizar Ashraf, Tanvir M. Huda, Javeria Ikram, Shabina Ariff, Muhammad Sajid, Gul Nawaz Khan, Muhammad Umer, Imran Ahmed, Michael John Dibley, Sajid Bashir Soofi

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: nutrition; Pakistan; Stunting prevention; Lipid based nutrient supplements; programmatic review

Online: 23 April 2024 (17:51:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1170.v1

Effects of Salmonella Typhimurium Infection on Intestinal Flora and Arachidonic Acid Metabolism in Wenchang Chickens

Shenghong Chen, Yaochen Xie, Dingqian Guo, Tiansen Li, Zhen Tan, Xuhua Ran, Xiaobo Wen

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella Typhimurium; gut microbiota; lipid oxidation; arachidonic acid; Wenchang chicken

Online: 17 April 2024 (14:51:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0509.v1

The Influence of a High-Cholesterol Diet and Forced Training on Lipid Metabolism and Intestinal Microbiota in Male Wistar Rats

Yuliya S. Sidorova, Nikita A. Petrov, Yuliya M. Markova, Alexey I. Kolobanov, Sergey N. Zorin

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: cholesterol; hypercholesterolemia; physical activity; lipid metabolism; liver; intestinal microbiota; rats

Online: 8 April 2024 (07:01:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1161.v1

Cellular Response of Adapted and Non-Adapted Tetrahymena thermophila Strains to Europium Eu(III) Compounds

Patricia Alonso, Javier Blas, Francisco Amaro, Patricia De Francisco, Ana Martin-Gonzalez, Juan Carlos Gutiérrez

Subject: Biology And Life Sciences, Toxicology Keywords: Europium; lipid metabolism; bioaccumulation; oxidative stress; gene expression; Tetrahymena thermophila

Online: 19 March 2024 (14:48:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1253.v1

Development of Glycyrrhizinic Acid-Based Lipid Nanoparticle (LNP-GA) as an Adjuvant That Improves the Immune Response to Porcine Epidemic Diarrhea Virus Spike Recombinant Protein

José Bryan García-Cambrón, José Luis Cerriteño-Sánchez, Rocío Lara-Romero, David Quintanar-Guerrero, Gerardo Blancas-Flores, Brenda L. Sánchez-Gaytán, Irma Herrera-Camacho, Julieta Sandra Cuevas-Romero

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Porcine epidemic diarrhea virus; lipid nanoparticle; recombinant protein; immune response

Online: 17 January 2024 (11:11:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0843.v1

Lipid Nanoparticle (LNP) Delivery Vector-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

Liusheng Wu, Xiaoqiang Li, Xinye Qian, Shuang Wang, Jixian Liu, Jun Yan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Lipid nanoparticles (LNPs); mRNA vaccine; Tumor immunity; Delivery vector; Review

Online: 13 December 2023 (03:35:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0766.v1

Effect of a Multi-Strain Probiotic on Growth Performance, Lipid Profile, Antioxidant Status and Immune Response in Piglets at Weaning

Gopal Sarkar, Samiran Mondal, Debasis Bhattacharya, Perumal Ponraj, Sneha Sawhney, Arun Kumar De

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Probiotics; pigs; growth performance; lipid profile; oxidative stress; cytokines; immunity

Online: 13 September 2023 (02:27:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1863.v1

Update on Biomarkers Associated with Large Artery Atherosclerosis Stroke

Madalena Rosário, Ana Catarina Fonseca

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: atherosclerosis; stroke; carotid; stenosis; biomarker; plaque; lipid; inflammation; IL-6

Online: 27 June 2023 (11:00:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2011.v1

Effects of Different Freezing Rate and Frozen Storage Temperature on the Quality of Large-mouth Bass (Micropterus salmoides)

Yulong Bao, Yaqi Zhang, Wanjun Xu

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Freezing; protein oxidation; lipid oxidation; water-holding; GC×GC-TOFMS

Online: 29 May 2023 (12:40:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0214.v1

Natural Compounds: Co-Delivery Strategies with Chemotherapeutic Agents or Nucleic Acids using Lipid-Based Nanocarriers

Patrícia V. Teixeira, Eduarda Fernandes, Telma B. Soares, Filomena Adega, Carla M. Lopes, Marlene Lúcio

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: cancer; conventional therapy; combined therapy; lipid-based nanocarriers; natural compounds

Online: 13 March 2023 (04:32:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0183.v1

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Javad Alizadeh, Mahboubeh Kavoosi, Navjit Singh, Shahrokh Lorzadeh, Amir Ravandi, Biniam Kidane, Naseer Ahmed, Fatima Mraiche, Michael R Mowat, Saeid Ghavami

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: lung cancer; Lipid Metabolism; Glucose Metabolism; Krebs Cycle; Cholesterol Metabolism

Online: 10 January 2023 (10:39:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202208.0248.v1

Additional Proposed Tests of the Soliton/Wave-Action Potential Model, and How the Thermodynamic/Theory-Based Philosophical Approach Abandons the Scientific Method

Scott Meissner

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: action potential; soliton/wave; lipid phase transition; scientific method; membrane

Online: 15 August 2022 (04:27:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0417.v1

Nano-lipids based on Ginger Oil and Lecithin as A Potential Drug Delivery System

Hung Quach, Tuong-Vi Le, Thanh-Thuy Nguyen, Phuong Nguyen, Cuu Khoa Nguyen, Le Hang Dang

Subject: Chemistry And Materials Science, Nanotechnology Keywords: lecithin; ginger oil; essential oil; nano-lipid; drug delivery system

Online: 30 June 2022 (08:00:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0531.v1

Extracellular Vesicles Trigger Atp Release and Promote Migration of Human Microglia through the p2x4 Receptor / Mfg-e8 – Dependent Mechanisms

Ugnė Jonavičė, Diana Romenskaja, Karolina Kriaučiūnaitė, Akvilė Jarmalavičiūtė, Justina Pajarskienė, Vytautas Kašėta, Virginijus Tunaitis, Tarja Malm, Rashid Giniatulin, Augustas Pivoriūnas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Microglia; Extracellular vesicles; migration; P2X4 receptor; MFG-E8; lipid rafts

Online: 22 June 2021 (08:26:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0276.v1

LRH-1 Ameliorates Hepatic Triglyceride Accumulation via Regulation of Perilipin 5 in the Liver

Rubee Pantha, Jae-Ho Lee, Jae-Hoon Bae, Eun Hee Koh, Dae-Kyu Song, Seung-Soon Im

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: liver receptor homolog-1; perilipin 5; triglyceride; fasting; lipid droplet

Online: 11 February 2021 (10:36:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0150.v2

Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-Kda Heat-Shock Protein, HspA1A

Larissa Smulders, Amanda J. Daniels, Caroline P. Plescia, Devon Berger, Robert V. Stahelin, Nikolas Nikolaidis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chaperone function; heat-shock proteins; lipid binding; phosphatidylserine; protein refolding

Online: 29 July 2020 (12:18:02 CEST)

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Working Paper REVIEW

Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update

David Balgoma, Luis Gil-de-Gómez, Olimpio Montero

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Lipidomics; ssRNA+ virus; membrane fusion; lipid metabolism; cholesterol; sphingolipids; phosphatidylinositol

Online: 17 July 2020 (14:01:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0320.v1

Antiproliferation Activity and Mechanism of c9, t11, c15-CLNA and t9, t11, c15-CLNA from Lactobacillus plantarum ZS2058 on Colon Cancer Cells

Qing Ren, Bo Yang, Guangzhen Zhu, Shunyu Wang, Chengli Fu, Hao Zhang, Paul Ross, Catherine Stanton, Haiqin Chen, Wei Chen

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: conjugated linolenic acid; Caco-2 cell; lipid peroxidation; apoptosis; pyroptosis

Online: 27 January 2020 (02:03:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0193.v1

Sodium Chloride-Induced Salt Stress Responses of Antioxidative Activities in Leaves and Roots of Pistachio Rootstock

Mohammad Akbari, Ramesh katam, Rabab Husain, Mostafa Farajpour, Silvia Mazzuca, Nasser Mahna

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: antioxidant enzymes; lipid peroxidation; NaCl; Pistacia vera; rootstock; salinity stress

Online: 17 October 2019 (11:53:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0120.v1

The potential of different Autotaxin inhibitor types regulating catalysis-dependent and -independent signalling

Fernando Salgado Polo, Anastassis Perrakis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Lysophosphatidic acid; Autotaxin; inhibitor; allosteric; orthosteric; lipid chaperone; signalling, GPCR

Online: 11 September 2019 (13:18:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0492.v1

A rationale for mesoscopic domain formation in biomembranes

Nicolas Destainville, Manoel Manghi, Julie Cornet

Subject: Physical Sciences, Biophysics Keywords: membranes; vesicles; lipids; proteins; mesophase separation; domains; lipid rafts; clusters

Online: 25 July 2018 (15:50:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0098.v1

Margarines and fast-food French fries: low content of trans fatty acids

Iciar Astiasarán, Elena Abella, Giulia Gatta, Diana Ansorena

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: food composition tables; lipid profile; trans fat; fast food; spreads

Online: 20 June 2017 (11:34:57 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1689.v1

Nephrotic Range Proteinuria and Restrictive Heart Failure in a Patient with Secondary Amyloidosis: A Case Report

Simoni Shah, Hetansh Shah, Manas Parikh, Dev Desai, Vismit Gami

Subject: Other, Medicine And Pharmacology Keywords: amyloidosis; Congo red stain; nephrotic syndrome; heart failure

Online: 25 April 2024 (16:11:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1054.v1

Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management

Diana-Aurora Arnautu, Octavian-Marius Cretu, Daniel Florin Lighezan, Minodora Andor, Ioana Citu, Dragoș Cozma, Brenda-Cristiana Bernad, Adrian-Pavel Trifa, Diana Lighezan, Elena-Silvia Bernad, Dragos Catalin Jianu, Cristian Oancea, Ioan-Radu Lala, Sergiu-Florin Arnautu, Mirela-Cleopatra Tomescu

Subject: Biology And Life Sciences, Life Sciences Keywords: dilated cardiomyopathy; genetics; heart failure; genotype - specific therapy

Online: 16 April 2024 (15:53:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0573.v1

Within-week variation of training load in Turkish elite soccer players by players positions (a GPS technology study)

Hakan BAYRAKTAR, Erkan GÜNAY, Erhan Çene, Egemen Mancı, Zeki Akyıldız

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Soccer; TRIMP; Workload; Players; Heart Rate; GPS; Microcycles.

Online: 8 April 2024 (15:01:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1997.v2

The congestion “Pandemic” in Acute Heart Failure Patients

Daniela Mocan, Radu Ioan Lala, Maria Puschita, Luminita Pilat, Dan Alexandru Darabantiu, Adina Pop Moldovan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; congestion; volume overload; volume redistribution; biomarkers

Online: 5 March 2024 (05:55:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1313.v1

Hearables: In-ear Multimodal Data Fusion for Robust Heart Rate Estimation

Marek Zylinski, Amir Nassibi, Edoardo Occhipinti, Adil Malik, Matteo Bermond, Harry J. Davies, Danilo P. Mandic

Subject: Engineering, Bioengineering Keywords: Data fusion method; Heart rate tracing; Hearables; Wearables

Online: 22 February 2024 (12:21:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0619.v1

Embodimetrics: A Principal Component Analysis of the Combined Assessment of Cardiac, Cognitive and Mobility Parameters

Andrea Chellini, Katia Salmaso, Michele Di Domenico, Nicola Gerbi, Marco Donati, Marco Iosa

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: embodiment; heart rate variability; stroop task; motor control

Online: 12 February 2024 (13:19:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1671.v1

Predictive Analytics in Heart Failure Prediction: A Systematic Review

Qisthi Alhazmi Hidayaturrohman, Eisuke Hanada

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: heart failure; predictive analytics; machine learning; readmission; mortality

Online: 24 January 2024 (02:47:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1004.v1

Predicting Long-Term Childhood Survival of Newborns with Congenital Heart Defects: A Population-Based, Prospective Cohort Study (EPICARD)

Makan Rahshenas, Nathalie Lelong, Damien BONNET, Lucile Houyel, Babak Choodari-Oskooei, Mithat Gonen, Francois Goffinet, Babak KHOSHNOOD

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: congenital heart defects; mortality; prediction; long-term; childhood

Online: 12 January 2024 (11:37:40 CET)

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Introduction: Congenital heart defects (CHD) are the most frequent group of major congenital anomalies, accounting for almost 1% of all births. They comprise a very heterogeneous group of birth defects in terms of their severity, clinical management, epidemiology and embryologic origins. Taking this heterogeneity into account is an important imperative to provide reliable prognostic information to patients and their caregivers, as well as to compare results between centers or to assess alternative diagnostic and treatment strategies. The Anatomic and Clinical Classification of CHD (ACC-CHD) aims to facilitate both the CHD coding process and data analysis in clinical and epidemiological studies. Objectives: 1) To describe the long-term childhood survival of newborns with CHD and 2) To develop and validate predictive models of infant mortality based on the ACC-CHD. Materials and Methods: This study is based on data from a population-based, prospective cohort study: Epidemiological Study of Children with Congenital Heart Defects (EPICARD). The final study population comprised 1881 newborns with CHD after excluding cases that were associated with chromosomal and other anomalies. Statistical analysis included non-parametric survival analysis and flexible parametric survival models. The predictive performance of models was assessed by Harrell’s C index and the Royston-Sauerbrei R2 with internal validation by bootstrap. Results: The overall 8-year survival rate for newborns with isolated CHD was 0.96 [0.93- 0.95]. There was a substantial difference between the survival rate of the categories of ACC-CHD. The highest and lowest 8-year survival rates were 0.995 [0.989-0.997] and 0.34 [0.21-0.50] for “interatrial communication abnormalities and ventricular septal defects” and "functionally univentricular heart", respectively. Model discrimination as measured by Harrell’s C was 87% and 89% for the model with ACC-CHD alone and the full model, which included other known predictors of infant mortality, respectively. The predictive performance as measured by R2 was 45% and 50%, for the ACC-CHD alone and the full model. These measures were essentially the same after internal validation by bootstrap. Conclusion: The ACC-CHD classification provided the basis of a highly discriminant survival model with good predictive ability for the 8-year survival of newborns with CHD. Prediction of individual outcomes remains an important clinical and statistical challenge.

Preprint REVIEW | doi:10.20944/preprints202312.0329.v1

Clinical Review of Hypertensive Acute Heart Failure

Ratko Lasica, Lazar Djukanovic, Jovanka Vukmirovic, Marija Zdravkovic, Arsen Ristic, Milika Asanin, Dragan Simic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hypertension; acute heart failure; congestion; diagnosis; modern therapy

Online: 6 December 2023 (07:06:50 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.1692.v1

One-Year Real-World Experience with Mavacamten and its Physiologic Effects on Obstructive Hypertrophic Cardiomyopathy

Daniel Kim, Emily Chu, Emily Keamy-Minor, Ishan Paranjpe, Wilson Tang, Jack O'Sullivan, Yaanik Desai, Michael Liu, Elise Munsey, Kimberly Hecker, Isabella Cuenco, Beth Kao, Ellen Bacolor, Colleen Bonnett, Andrea Linder, Kathleen Lacar, Nancy Robles, Cynthia Lamendola, Allysonne Smith, Joshua Knowles, Marco Perez, Masataka Kawana, Karim Sallam, Chad Weldy, Matthew Wheeler, Victoria Parikh, Heidi Salisbury, Euan Ashley

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: mavacamten; cardiac myosin inhibitor; hypertrophic cardiomyopathy; heart failure

Online: 27 November 2023 (11:50:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0159.v1

Utility of Point-of-Care Ultrasound in Predicting Acute Heart Failure In-Hospital Worsening in Acutely Decompensated Oldest-Old Patients

Tessa Mazzarone, Virginia Morelli, Andrea Giusti, Maria Giovanna Bianco, Lorenzo Maccioni, Cristina Cargiolli, Daniela Guarino, Agostino Virdis, Chukwuma Okoye

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Heart Failure; older adults; ultrasound; outcomes; pleural effusion

Online: 2 November 2023 (10:31:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0293.v1

A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis

Faizus Sazzad, KR Ramanathan, Irwan Shah Moideen, Abdulrahman El Gohary, John C Stevens, Theo Kofidis

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: personalized; individualized; open heart surgery; implantation; systematic review

Online: 5 October 2023 (13:45:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1262.v1

Gender-Based Clinical, Therapeutic Strategies and Prognosis Differences in Atrial Fibrillation

Aurelio Quesada, Javier Quesada-Ocete, Blanca Quesada-Ocete, Victor Del Moral-Ronda, Javier Jiménez-Bello, Ricardo Rubini-Costa, Carl J. Lavie, Daniel P. Morin, Fernando De la Guía-Galipienso, Ricardo Rubini-Puig, Fabian Sanchis-Gomar

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atrial fibrillation; gender; electrical cardioversion; heart failure; mortality

Online: 17 August 2023 (07:15:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1285.v1

Extracellular Vesicle microRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets

Changhai Tian, Jessica N. Ziegler, Irving Zucker

Subject: Biology And Life Sciences, Life Sciences Keywords: Extracellular vesicles; MicroRNAs; Sorting mechanism; Biomarkers; Heart failure

Online: 20 July 2023 (02:49:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1254.v1

Parkinson's Disease and the Heart: Studying Cardiac Metabolism in the 6-Hydroxydopamine model

Victor Silva da Fonsêca, Valeria de Cassia Gonçalves, Mario Augusto Izidoro, Antônio-Carlos G. de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; cardiac metabolism; heart; 6-hydroxydopamine; metabolites

Online: 16 June 2023 (14:16:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0991.v1

Exercise Effects on Left Ventricular Remodeling in Patients With Cardiometabolic Risk Factors

Evanthia Bletsa, Evangelos Oikonomou, Kyriakos Dimitriadis, Panagiota K. Stampouloglou, Christos Fragoulis, Stavroula P. Lontou, Emmanouil Korakas, Eirini Beneki, Konstantinos Kalogeras, Vaia Lampadiari, Konstantinos Tsioufis, Manolis Vavouranakis, Gerasimos Siasos

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: exercise; diabetes; obesity; hypertension; ventricular remodeling; heart failure

Online: 14 June 2023 (05:34:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0731.v1

The Effect of Drotaverine on Gastrointestinal Motility and Heart Rate Variability in Normal, Resting Horses

Alina Anton

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: antispasmodic; heart rate variability; intestinal function; parasympathetic activity

Online: 9 June 2023 (15:50:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0797.v1

Nutritional Supplementation and Exercise – Essential Allies in the Treatment of Chronic Heart Failure: The Metabolic and Molecular Bases.

Evasio Pasini, Giovanni Corsetti, Francesco Saverio Dioguardi

Subject: Biology And Life Sciences, Life Sciences Keywords: Heart failure; Malnutrition; Exercise; Amino-acids; mTOR; Deptor

Online: 23 April 2023 (08:45:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0422.v1

Assessment and management of Heart Failure in Patients with Chronic Kidney Disease

Andrea Igoren Guaricci, Francesca Sturdà, Roberto Russo, Paolo Basile, Andrea Baggiano, Saima Mushtaq, Laura Fusini, Fabio Fazzari, Fulvio Bertrandino, Francesco Monitillo, Maria Cristina Carella, Marco Simonini, Gianluca Pontone, Marco Matteo Ciccone, Giuseppe Grandaliano, Giuseppe Vezzoli, Francesco Pesce

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; kidney disease; multidisciplinary assessment; personalized treatment

Online: 17 April 2023 (07:27:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0415.v1

Heart Rate Estimation by Video-Based Reflec-tance Photoplethysmography

Ozzy King

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: reflectance PPG; reflectance photoplethysmography; heart rate estimation; video

Online: 24 February 2023 (02:52:59 CET)

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Non-invasive heart rate (HR) monitoring is important in clinical settings as it plays a critical role in diagnosing a range of health conditions and assessing well-being. Presently, the gold standards for HR measurement are all based on sensors which require skin contact. Apart from inconvenience, contact sensors have proven problematic in certain scenarios – they cannot be used when mechanical isolation of the patient is imperative (burn victims, patients with shaky hands and feet), cause skin damage to premature babies in the ICU and increase the risk of spreading infections. Non-contact HR monitoring using a camera has been recently shown to be a viable alternative. It is now possible to record cardiac-synchronous blood volume variations from facial videos of human subjects under ambient lighting. These variations produce corresponding changes in skin reflectance which can be extracted as a raw reflectance photoplethysmography (rPPG) signal and processed to reveal HR. In this project, an algorithmic framework for webcam-based HR detection was successfully implemented in MATLAB. The investigation was based on 100 self-captured videos (dark-skinned subject) and 48 videos (from 12 subjects, all but one fair-skinned) obtained from COHFACE – an online database of facial videos and corresponding physiological signals. While the performance metrics (mean error, SNR) of the rPPG signals obtained from the self-captured videos were poor (best case mean error of 22%), they were good enough to demonstrate the success of the implementation. The poor results were primarily imputed to skin tone as rPPG SNR is known to be particularly low for dark tones. The results of the COHFACE videos were far superior, with mean error ranging from 3% to 15% (among 8 different rPPG signals) and 0% to 9% under ambient and dedicated lighting, respectively. This investigation sets the foundation for future research directed at optimizing rPPG performance metrics for dark-skinned subjects.

Preprint ARTICLE | doi:10.20944/preprints202212.0376.v2

A Fresh View at Sports PSM-Systems

Vladimir Savostyanov, Alexander Kobelev

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Sport; Heart Rate; Breathe Rate; Monitoring; Functional Athlete Readiness; Impedance; Rheography

Online: 6 January 2023 (02:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0250.v1

Folic Acid Exerts Dose-Dependent Biphasic Effects on Cardiac Development of Zebrafish Embryos

Xuhui Han, Bingqi Wang, Hongjie Wang, Yao Zu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: mthfr; folic acid; heart development; zebrafish; CRISPR/Cas9

Online: 15 September 2021 (09:16:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0110.v1

Effects of Sex and 17β-Estradiol on Cardiac Fibroblast Morphology and Signaling Activities in vitro

Kelsey Watts, Will Richardson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac fibroblasts; sex-specific; estrogen; fibrosis; heart failure

Online: 6 September 2021 (17:24:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0655.v1

ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ

Mario Pavez-Giani, Pablo Sanchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Paula Giraldo, Silke Oberdorf-Maass, Kirsten Nijholt, Salva Yurista, Hendrik Milting, Joan Heller Brown, Peter Van Der Meer, Rudolf A. de Boer, Herman H.W. Silljé, B. Daan Westenbrink

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mitochondria; Ca2+ handling; heart failure; CaMKII; cardiomyocyte hypertrophy

Online: 26 March 2021 (10:41:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0291.v1

Heart Diseases Diagnose via Artificial Intelligence-Powered Mobile Application

Mesut Guven, Firat Hardalac, Kanat Ozisik, Funda Tuna

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Heart diseases; Auscultation; Machine learning; Telemedicine; Digital Stethoscope

Online: 15 January 2021 (12:45:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0278.v1

Perinatal Cardiovascular Evaluation in Dorper Sheep: Echocardiographic Description and Behavior of the Heart Rate Variability on the Field

Amanda Sarita Cruz Aleixo, Mayra de Castro Ferreira Lima, Ana Luisa Holanda de Albuquerque, Raphael Tortorelli Teixeira, Renata Alves de Paula, Marina Cecília Grandi, Danilo Otávio Laurenti Ferreira, Lukas Garrido Albertino, Miriam Harumi Tsunemi, Simone Biagio Chiacchio, Maria Lucia G. Lourenço

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: sheep; gestation; hemodinamycs; heart rate variability; cardiac output

Online: 13 October 2020 (12:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0483.v1

Comparing Lung CT in COVID-19 Pneumonia and Acute Heart Failure: An Imaging Conundrum

Leonardo Paskah Suciadi, Yonathan William, Patricia Jorizal, Vera Nevyta Tarigan, Andreas Hartanto Santoso, Joshua Henrina, Firman Tedjasukmana, Nathania Marliani Kristanti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Lung CT; imaging; COVID-19; Pneumonia; Heart Failure

Online: 31 May 2020 (16:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0174.v1

Strangers, Friends, and Lovers Show Specific Physiological Synchronies In Different Emotional Contexts

Andrea Bizzego, Atiqah Azhari, Nicola Campostrini, Anna Truzzi, Li Ying Ng, Giulio Gabrieli, Marc H. Bornstein, Peipei Setoh, Gianluca Esposito

Subject: Social Sciences, Behavior Sciences Keywords: heart rate variability; dyads; physiological synchrony; relationship; emotion

Online: 15 November 2019 (06:09:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201901.0312.v1

Functional Morphology of the Cardiac Jelly in the Tubular Heart of Vertebrate Embryos

Jörg Männer, Talat Mesud Yelbuz

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: embryonic heart tube; extracellular matrix; cardiac jelly; hydraulic skeleton; heart skeleton; valveless pumping; blood flow; non-circular cross sections; ballooning; trabeculation

Online: 30 January 2019 (11:16:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202405.0738.v1

An Overview of Nanoparticle-Based Delivery Platforms for Vaccines

Yang Lin, Xuehua Chen, Ke Wang, Li Liang, Hongxia Zhang

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: Vaccine platform; Nanoparticles; mRNA vaccine; Lipid-based nanoparticles; Anti-tumor immunity

Online: 13 May 2024 (12:14:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1166.v1

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Debora Santonocito, Carmelo Puglia, Lucia Montenegro

Subject: Public Health And Healthcare, Other Keywords: bemotrizinol; emulsions; sensory evaluation; UV-filters; lipid nanoparticles; in vitro SPF

Online: 17 April 2024 (13:05:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1026.v1

The Impact of Magnesium on the Growth, Physiology and Quality of Tea Plants under Acid Stress

XinHang LV, Haimin Kong, Yubo Luo, Dubi Dong, Wenbin Liu, Dongtao Wu, Zhengqian Ye, Jiawei Ma, Dan Liu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: magnesium; tea plant; acid stress; antioxidant enzymes; lipid peroxidation; tea quality

Online: 18 March 2024 (12:18:49 CET)

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