Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Nano-lipids based on Ginger Oil and Lecithin as A Potential Drug Delivery System

Version 1 : Received: 29 June 2022 / Approved: 30 June 2022 / Online: 30 June 2022 (08:00:31 CEST)

A peer-reviewed article of this Preprint also exists.

Quach, H.; Le, T.-V.; Nguyen, T.-T.; Nguyen, P.; Nguyen, C.K.; Dang, L.H. Nano-Lipids Based on Ginger Oil and Lecithin as a Potential Drug Delivery System. Pharmaceutics 2022, 14, 1654. Quach, H.; Le, T.-V.; Nguyen, T.-T.; Nguyen, P.; Nguyen, C.K.; Dang, L.H. Nano-Lipids Based on Ginger Oil and Lecithin as a Potential Drug Delivery System. Pharmaceutics 2022, 14, 1654.

Journal reference: Pharmaceutics 2022, 14, 1654
DOI: 10.3390/pharmaceutics14081654

Abstract

Lipid nanoparticles have an interesting part of drug delivery system. In this study, the modification of the convention nano-lipid based soybean lecithin was demonstrated. Ginger oil derived Zingiber officinale was used along with lecithin, cholesterol and span 80 to fabricate nano-lipid (GL nano-lipid) using thin-film method. Through TEM and confocal microscope, GL nano-lipid exposes the liposome- like morphology. The average size of the resultant nanoparticles was 249.1nm with monodistribution (PDI= 0.021). The ζ-potential of GL nano-lipid was negative as similar to as prepared nano-lipid based lecithin. GL nano-lipid express the highly stable over 60 days of storage at room temperature in term of size, ζ-potential. A shift of pH value from alkaline to acid was detected in lecithin nano-lipid, while with the incorporation of ginger oil, pH value of nano-lipid dispersion was around 7.0. Furthermore, due to the rich of shogaol-6 and other active compounds in ginger oil, the GL nano-lipid is endowed with intrinsic antibacterial feature. In addition, the sulforhodamine B (SRB) assay and live/dead imaging revealed the excellent biocompatibility of GL nano-lipid. Notably, GL nano-lipid was capable to carry the hydrophobic agents as curcumin and perform a pH-dependent release profile. A subsequent characterization are a suitable potential for drug delivery system.

Keywords

lecithin; ginger oil; essential oil; nano-lipid; drug delivery system

Subject

MATERIALS SCIENCE, Nanotechnology

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