Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Javad Alizadeh
ORCID logo ,
Mahboubeh Kavoosi
,
Navjit Singh
ORCID logo ,
Shahrokh Lorzadeh
,
Amir Ravandi
,
Biniam Kidane
ORCID logo ,
Naseer Ahmed
ORCID logo ,
Fatima Mraiche
,
Michael R Mowat
,
Saeid Ghavami
* ORCID logo
Version 1 : Received: 4 January 2023 / Approved: 10 January 2023 / Online: 10 January 2023 (10:39:28 CET)

A peer-reviewed article of this Preprint also exists.

Alizadeh, J.; Kavoosi, M.; Singh, N.; Lorzadeh, S.; Ravandi, A.; Kidane, B.; Ahmed, N.; Mraiche, F.; Mowat, M.R.; Ghavami, S. Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer. Cancers 2023, 15, 2195. Alizadeh, J.; Kavoosi, M.; Singh, N.; Lorzadeh, S.; Ravandi, A.; Kidane, B.; Ahmed, N.; Mraiche, F.; Mowat, M.R.; Ghavami, S. Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer. Cancers 2023, 15, 2195.

Abstract

Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation is closely associated with metabolism in mammalian cells acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. Also, we discuss the impact of these metabolic pathways on autophagy in lung cancer.

Keywords

lung cancer; Lipid Metabolism; Glucose Metabolism; Krebs Cycle; Cholesterol Metabolism

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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