Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Milk Fermented with Lactobacillus casei Strain AP Improves Lipid Profiles in Obese Indonesian Adults

Version 1 : Received: 17 August 2021 / Approved: 18 August 2021 / Online: 18 August 2021 (14:15:22 CEST)

How to cite: Widodo, W.; Denta, A.O.; Sunarti, S.; Haltrich, D. Milk Fermented with Lactobacillus casei Strain AP Improves Lipid Profiles in Obese Indonesian Adults. Preprints 2021, 2021080385 (doi: 10.20944/preprints202108.0385.v1). Widodo, W.; Denta, A.O.; Sunarti, S.; Haltrich, D. Milk Fermented with Lactobacillus casei Strain AP Improves Lipid Profiles in Obese Indonesian Adults. Preprints 2021, 2021080385 (doi: 10.20944/preprints202108.0385.v1).

Abstract

Obesity and hyperglycemia can trigger various diseases, including diabetes mellitus and cardiovascular ailments. Health-promoting fermented milk products can be useful in tackling these issues. One such product is the fermented milk developed using Lactobacillus casei AP, a probiotic strain from Indonesia that has not been tested in humans thus far. Our objective was to examine the effects of L. casei AP-fermented milk products on lipid profiles, blood glucose levels and monocyte chemoattractant protein-1 (MCP-1) levels in obese adults. A total of 29 obese subjects were given L. casei AP-fermented milk products, and their fasting blood glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels were measured using diagnostic system kits. MCP-1 levels were measured using enzyme-linked immunosorbent assay. It was determined that the administration of L. casei AP-fermented milk products significantly reduced total cholesterol, LDL and triglyceride levels (p < 0.05); however, it did not increase HDL (p > 0.05), MCP-1 or fasting blood glucose levels (p ≥ 0.05). In conclusion, in obese Indonesian adults, L. casei AP-fermented milk might reduce total cholesterol, LDL and triglyceride levels but may not affect HDL, MCP-1 or fasting blood glucose levels.

Keywords

Obesity; Lactobacillus casei AP; probiotic; fermented milk; lipid profiles

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