Version 1
: Received: 7 August 2018 / Approved: 8 August 2018 / Online: 8 August 2018 (14:27:20 CEST)
How to cite:
Lazarenko, L.; Melnikova, O.; Babenko, L.; Bubnov, R.; Beregova, T.; Falalyeyeva, T.; Spivak, M. Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice. Preprints2018, 2018080169. https://doi.org/10.20944/preprints201808.0169.v1
Lazarenko, L.; Melnikova, O.; Babenko, L.; Bubnov, R.; Beregova, T.; Falalyeyeva, T.; Spivak, M. Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice. Preprints 2018, 2018080169. https://doi.org/10.20944/preprints201808.0169.v1
Lazarenko, L.; Melnikova, O.; Babenko, L.; Bubnov, R.; Beregova, T.; Falalyeyeva, T.; Spivak, M. Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice. Preprints2018, 2018080169. https://doi.org/10.20944/preprints201808.0169.v1
APA Style
Lazarenko, L., Melnikova, O., Babenko, L., Bubnov, R., Beregova, T., Falalyeyeva, T., & Spivak, M. (2018). Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice. Preprints. https://doi.org/10.20944/preprints201808.0169.v1
Chicago/Turabian Style
Lazarenko, L., Tetiana Falalyeyeva and Mykola Spivak. 2018 "Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice" Preprints. https://doi.org/10.20944/preprints201808.0169.v1
Abstract
Introduction. The use of probiotics demonstrate efficacy against obesity and metabolic syndrome (MetS). Detection effective probiotic strains for hyperglycemia and immunity associated with is important task. The aim of the study was to evaluate an influence of Lactobacillus casei IMV B-7280 separately and composition L. casei IMV B-7280 / Bifidobacterium animalis VKB / B. animalis VKL on the levels of blood glucose and immunity in obese mice. Meterials and methods. Obesity was induced by fat-enriched diet (FED) in male BALB/c mice. Obese mice were transferred to standard diet and received per os probiotic strains daily during 10 days. We measured tumor necrosis factor-a (TNF-a) in blood serum using enzyme-linked immunosorbent assay and functional activity of peritoneal exudate macrophages (PEMs). Glucose levels in blood was defined with glucometer. Results. We ascertained that all probiotic strains induced reducing mice weight and visceral fat, normalization of TNF-a production and functional activity of PEMs. Treatment with L. casei IMV B-7280 was associated with decreasing blood glucose levels. No normalization of glucose and TNF-a levels in obese mice, transferred to standard diet without probiotic treatment, although we revealed decreasing their weight and visceral fat and partial recover of functional activity of PEMs. Conclusions. Probiotic strain L. casei IMV B-7280 (separately) and composition L. casei IMV B-7280 / B. animalis VKB / B. animalis VKL can re-equilibrate metabolic and inflammation indices in mouse obesity model. L. casei IMV B-7280 alone was more efficient in decreasing glucose levels than composition of strains.
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
