Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Additional Proposed Tests of the Soliton/Wave-Action Potential Model, and How the Thermodynamic/Theory-Based Philosophical Approach Abandons the Scientific Method

Version 1 : Received: 11 August 2022 / Approved: 15 August 2022 / Online: 15 August 2022 (04:27:26 CEST)

How to cite: Meissner, S. Additional Proposed Tests of the Soliton/Wave-Action Potential Model, and How the Thermodynamic/Theory-Based Philosophical Approach Abandons the Scientific Method. Preprints 2022, 2022080248. https://doi.org/10.20944/preprints202208.0248.v1 Meissner, S. Additional Proposed Tests of the Soliton/Wave-Action Potential Model, and How the Thermodynamic/Theory-Based Philosophical Approach Abandons the Scientific Method. Preprints 2022, 2022080248. https://doi.org/10.20944/preprints202208.0248.v1

Abstract

This article is a followup to an earlier review which outlined some of the interesting features of the soliton/wave-action potential (AP) model, and noted the need to test its key aspects; including the need to test if its presumed lipid phase transition is actually happening during AP firings in excitable cells. The intent here is to point out the sort of tests, and evidence from them, that might be needed if the soliton/wave-AP model is to be accepted broadly by biologists. Here, after an overview of the modern electrophysiological-AP model and of the soliton/wave-AP model, there are three areas considered. First, possible compositional influences on membrane properties relative to the soliton/wave-AP model are presented. Including questions with regard to the soliton/wave-AP model’s assumption that changes in surface potentials influence the transmembrane potential. Second, some recent work from the good folks who advocate for the soliton/wave-AP model concerning the occurrence of lipid phase transitions in neurons or in extracts from nervous tissues are examined. Here it is noted that there is a need to consider whether these lipid phase transitions happen within normal physiological conditions or not. Third, and finally, the advocates for the soliton/wave-AP model have adopted a thermodynamic/theory-based philosophical approach in their studies. It is argued that this philosophical approach is a radical departure from the philosophical approach used under the scientific method. The features of this new approach, and implications its use, are examined.

Keywords

action potential; soliton/wave; lipid phase transition; scientific method; membrane

Subject

Biology and Life Sciences, Anatomy and Physiology

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