Working Paper Review Version 1 This version is not peer-reviewed

Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update

Version 1 : Received: 16 July 2020 / Approved: 17 July 2020 / Online: 17 July 2020 (14:01:21 CEST)

A peer-reviewed article of this Preprint also exists.

Balgoma, D.; Gil-de-Gómez, L.; Montero, O. Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update. Metabolites 2020, 10, 356. Balgoma, D.; Gil-de-Gómez, L.; Montero, O. Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update. Metabolites 2020, 10, 356.

Journal reference: Metabolites 2020, 10, 356
DOI: 10.3390/metabo10090356

Abstract

Recent COVID-19 outbreak has come into prominence the pathogenetic mechanisms underlying the Biology and Biochemistry of viral infections. COVID-19 illness is brought about by infection with the severe acute respiratory syndrome coronavirus SARS-CoV-2 [1,2], an enveloped positive single stranded RNA virus (ssRNA+). From a lipidomics viewpoint, there is a variety of mechanisms involving virus infection that encompass virus entry, disturbance of host cell lipid metabolism, and the role played by diverse lipids in regard to the infection effectiveness. All these aspects have currently been tackled separately as independent issues and focusing on the function of proteins. Here we review the role of cholesterol and other lipids in in ssRNA+ and SARS-COV-2 infection.

Subject Areas

Lipidomics; ssRNA+ virus; membrane fusion; lipid metabolism; cholesterol; sphingolipids; phosphatidylinositol

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.