Effect of Dietary Soybean Oil Inclusion on Liver-Related Transcription Factors in a Pig Model for Metabolic Diseases

Simara Larissa Fanalli; Bruna Pereira Martins da Silva; Julia Dezen Gomes; Fernanda Nery Ciconello; Vivian Vezzoni de Almeida; Felipe André Oliveira Freitas; Gabriel Costa Monteiro Moreira; Bárbara Silva-Vignato; Juliana Afonso; James Reecy; James Koltes; Dawn Koltes; Luciana Correia de Almeida Regitano; Julio Cesar de Carvalho Baileiro; Luciana Freitas; Luiz Lehmann Coutinho; Heidge Fukumasu; Severino Matias de Alencar; Albino Luchiari Filho; Aline Silva Mello Cesar

doi:10.20944/preprints202202.0149.v1

How to cite: Fanalli, S.L.; da Silva, B.P.M.; Gomes, J.D.; Ciconello, F.N.; de Almeida, V.V.; Freitas, F.A.O.; Moreira, G.C.M.; Silva-Vignato, B.; Afonso, J.; Reecy, J.; Koltes, J.; Koltes, D.; Regitano, L.C.D.A.; Baileiro, J.C.D.C.; Freitas, L.; Coutinho, L.L.; Fukumasu, H.; de Alencar, S.M.; Luchiari Filho, A.; Cesar, A.S.M. Effect of Dietary Soybean Oil Inclusion on Liver-Related Transcription Factors in a Pig Model for Metabolic Diseases. Preprints 2022, 2022020149. https://doi.org/10.20944/preprints202202.0149.v1 Fanalli, S.L.; da Silva, B.P.M.; Gomes, J.D.; Ciconello, F.N.; de Almeida, V.V.; Freitas, F.A.O.; Moreira, G.C.M.; Silva-Vignato, B.; Afonso, J.; Reecy, J.; Koltes, J.; Koltes, D.; Regitano, L.C.D.A.; Baileiro, J.C.D.C.; Freitas, L.; Coutinho, L.L.; Fukumasu, H.; de Alencar, S.M.; Luchiari Filho, A.; Cesar, A.S.M. Effect of Dietary Soybean Oil Inclusion on Liver-Related Transcription Factors in a Pig Model for Metabolic Diseases. Preprints 2022, 2022020149. https://doi.org/10.20944/preprints202202.0149.v1

Abstract

The objective of this study was to identify key transcription factors involved in lipid metabolism and immune response related to the differentially expressed genes (DEG) from the liver samples of 35 pig model for metabolic diseases fed diets containing either 1.5 or 3.0% soybean oil (SOY1.5 or SOY3.0). A total of 281 DEG between SOY1.5 and SOY3.0 diets (log2fold-change ≥ 1 or ≤ −1; FDR-corrected p-value < 0.1) were identified, in which 129 were down-regulated and 152 were up-regulated in SOY1.5 group. The functional annotation analysis detected transcription factors linked to lipid homeostasis and immune response, such as RXRA, EGFR, and SREBP2 precursor. These findings demonstrated that key transcription factors related to lipid metabolism could be modulated by dietary inclusion of soybean oil. It could contribute to nutrigenomics research field that aims to elucidate dietary interventions in animal and human health, as well as to drive the food technology and science.

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Effect of Dietary Soybean Oil Inclusion on Liver-Related Transcription Factors in a Pig Model for Metabolic Diseases

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