Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients

Version 1 : Received: 9 December 2021 / Approved: 10 December 2021 / Online: 10 December 2021 (11:54:31 CET)

How to cite: Mongirdienė, A.; Liobikas, J. Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients. Preprints 2021, 2021120172 (doi: 10.20944/preprints202112.0172.v1). Mongirdienė, A.; Liobikas, J. Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients. Preprints 2021, 2021120172 (doi: 10.20944/preprints202112.0172.v1).

Abstract

Chronic heart failure (CHF) results when heart cannot constantly supply the body tissues with oxygen and required nutrients, and it can be categorized as heart failure (HF) with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). There are different causes and mechanisms of the HF pathogenesis; however, the inflammation can be regarded as one of the factors promoting both HFrEF and HFpEF. Monocytes, a subgroup of leucocytes, are known as cellular mediators in response to cardiovascular injury and are closely related to inflammatory reactions. These cells are a vital component of the immune system and are the source of macrophages, which participate in cardiac tissue repair after injury. However, the monocytes are not homogenous as thought, and thus can present different functions under different cardiovascular disease conditions. In addition, there is still an open question whether the functions of monocytes and macrophages should be regarded as a cause or a consequence in CHF development. Therefore, our aim was to summarize the current studies on the function of various monocyte subsets in CHF with a focus on the role of a certain monocyte subset in HFpEF and HFrEF patients, and the relation to inflammatory markers.

Keywords

monocyte subset; heart failure; inflammation; cytokine; macrophage

Subject

MEDICINE & PHARMACOLOGY, Cardiology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.