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Preprint ARTICLE | doi:10.20944/preprints201707.0050.v1

Airflow sensitivity assessment based on the underground mine ventilation systems modeling

Wacław Dziurzyński, Andrzej Krach, Teresa Pałka

Subject: Engineering, Control And Systems Engineering Keywords: ventilation process prediction; safety of mine ventilation system; sensitivity of the main air flows in ventilation subnetworks

Online: 18 July 2017 (12:27:46 CEST)

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This paper presents a methodology for determining the sensitivity of the main air flow directions in ventilation subnetworks to changes of aerodynamic resistance and of air density in mine workings. Formulae for determination of the sensitivity of the main subnetwork air flows by establishing the degree of dependency of the air volume stream in a given working on the variations in resistance or air density of other workings of the network have been developed. They have been implemented in the VentGraph mine ventilation network simulator. This software, widely used in Polish collieries provides an extended possibility to predict the process of ventilation, air distribution and, in the case of underground fire, also the spread of combustion gasses. The new method facilitates assessment by mine ventilation services of the stability of ventilation systems in exploitation areas and determine of the sensitivity of the main subnetwork air flow directions to changes of aerodynamic resistance and air density. Recently in some Polish collieries new longwalls are developed in seams located deeper then the bottom of the intake shaft. Such solution is called “exploitation below the level of access” or “sublevel”. The new approach may be applied to such developments to assess the potential of changes of direction and air flow rates. In addition, interpretation of the developed sensitivity indicator is presented. While analyzing air distributions for sublevel exploitation, application of current numerical models for calculations of the distribution results in tangible benefits, such as the evaluation of the safety or risk levels for such exploitation. Application of the VentGraph computer program, and particularly the module POŻAR (fire) with the newly developed options, enables an additional approach to the sensitivity indicator in evaluating air flow safety levels for the risks present during exploitation below the level of the intake shaft. The analyses performed and examples presented enabled useful conclusions in mining practice to be drawn.

Preprint ARTICLE | doi:10.20944/preprints201703.0185.v1

Design, Fabrication and Analysis of Threshold-Value Judging Mechanism in MEMS Safety and Arming Device

Dakui Wang, Wenzhong Lou, Yue Feng, Fufu Wang

Subject: Engineering, Mechanical Engineering Keywords: MEMS S&A device; threshold-value judging mechanism; fabrication process; tensile test; theoretical, simulationand experimentalanalysis; parametric design method

Online: 24 March 2017 (10:12:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0212.v1

Taxonomy and Species Delimitation in Cyanobacteria

Alessio Papini, Sara Falsini, Tiruha Habte Karssa

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Cyanobacteria; Arthrospira; species concept; typus; species concept in prokaryotes

Online: 8 March 2021 (11:18:31 CET)

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Cyanobacteria are prokaryotes whose taxonomy follows the same rules of a code (the International Botanical Nomenclature Code, IBNC) built for eukaryotic photosynthetic organisms. Hence, names of cyanobacteria follow the same rules and are assigned to biological entities (species) that should correspond to eukaryotic species. The main difficulty in the current situation is that the species concept in eukaryotes is based theoretically mainly on the biological species concept, that is centered on genetic exchange through sexual reproduction or lack of them. However, as shown, this difference is important from a theoretical point of view, but also in eukaryotes, the boundaries between different species are very rarely checked experimentally by direct observation of sexual barriers and hybridization events. The main concept for species delimitation is hence that related to morphology and, more recently and always in relation to morphology, DNA sequences. The introduction of distances obtained from matrixes of aligned sequences in the framework of a barcoding project provides a quantitative interpretation of species delimitation in relation to genetic distance that can be used both in eukaryotes and prokaryotes. However, the introduction of quantitative criteria needs the definition of distance thresholds to identify the boundaries between different species and, for doing that, it is necessary to test the distance thresholds in models of traditionally defined and recognized species. An alternative approach may be the comparison of the molecular distance (quantitative approach) to data about the capability of strains/species to exchange genetic information. Unfortunately data about this last question is still scarce. The adoption of molecular criteria to check species boundaries based on morphological characters has proved particularly challenging in cyanobacteria: a known example is provided. In conclusion, the only possible approach appears to be the association of molecular data to the increase of available data about the cell structure and the variation thereof in different physiological situations, particularly at the ultrastructural level. A further necessity is the check of the typus for a large number of cyanobacteria species, often based on old basionyms. In many of these cases the typus is often a drawing and more rarely a herbarium specimen or a microscope slide. In many cases an epitypification or a neotypification appears to be necessary.

Preprint TECHNICAL NOTE | doi:10.20944/preprints201908.0295.v2

Detecting IoT Devices and How They Put Large Heterogeneous Networks at Security Risk

Sharad Agarwal, Pascal Oser, Stefan Lüders

Subject: Computer Science And Mathematics, Security Systems Keywords: Internet of Things; security; vulnerabilities and protective measures; control network security; operation in multi-user environments; risk assessment

Online: 15 September 2019 (02:55:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0035.v1

Use of the QuantiFERON-TB Gold In-Tube Test in the Diagnosis and Monitoring of Treatment Efficacy in Active Pulmonary Tuberculosis

Ping-Chin Chang, Pin-Hui Wang, Kow-Tong Chen

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: QuantiFERON-TB Gold In-Tube test; pulmonary tuberculosis; sensitivity; specificity

Online: 9 January 2017 (03:58:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0411.v2

Estimation of Flexible Pavement Structural Capacity Using Machine Learning Techniques

Nader Karballaeezadeh, Hosein Ghasemzadeh Tehrani, Danial Mohammadzadeh S., Shahaboddin Shamshirband

Subject: Engineering, Civil Engineering Keywords: transportation infrastructure; flexible pavement; structural number prediction; Gaussian process regression; m5p model tree; random forest

Online: 9 June 2020 (11:35:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0117.v1

Mining Productive-associated Periodic Frequent Pattern in Body Sensor Data for Smart Home Care

Wala Ismail , Mohammad Mehedi Hassan

Subject: Computer Science And Mathematics, Information Systems Keywords: Body sensor network; Smart home, knowledge discovery in BSN data; frequent patterns; periodic patterns and productive pattern.

Online: 18 April 2017 (18:15:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0137.v1

Opportunities and Challenges in Data-Driven Healthcare Research

You Chen

Subject: Medicine And Pharmacology, Other Keywords: opportunity; challenge; perspective; health data; disease prediction; clinical outcome prediction; healthcare process; data quality; quantity and quality analysis; artificial intelligence

Online: 8 June 2018 (13:22:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0067.v1

Transition from Pediatric Care to Adult Care in Headache Patients

Allyson Bazarsky , Shalonda K. Slater , Hope L. O’Brien

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Transition Medicine; Pediatric migraine; Pediatric; Migraine; Migraine in young adults

Online: 14 June 2017 (09:26:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0140.v1

Influence of Alkali Metal Substitution on the Phase Transition Behavior of CsGaQ2 (Q = S, Se)

Daniel Friedrich, Marc Schlosser, Martin Etter, Arno Pfitzner

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: chalcogenogallates; polymorphism; solid solutions; in situ X-ray diffraction; synchrotron radiation; rietveld refinement

Online: 20 October 2017 (12:53:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0189.v1

Progress of In-Situ Study on Mechanical Properties for Micro/Nano-Structured Alloy

Jie Sheng, Peiqing La, Junqiang Ren, Jiqiang Ma, Yu Shi, Zhengning Li, Fuan Wei, Keliang Wang, Yi Song

Subject: Chemistry And Materials Science, Nanotechnology Keywords: micro/nano-structured alloy; mechanical properties; in-situ tensile; deformation mechanism; research progress

Online: 27 December 2017 (06:39:22 CET)

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Working Paper ARTICLE

Evaluation of a Learning Tool for In-Situ Monitoring of Metal Additive Manufacturing

Brent Valle, Karel Lietaert, Natania Antler, John Newman, Erik Xiao, Sam Coeck

Subject: Computer Science And Mathematics, Software Keywords: laser powder bed fusion; process monitoring; defect detection; coaxial

Online: 19 April 2019 (11:18:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0115.v1

Bivariate Kumaraswamy Models via Modified Symmetric FGM Copulas: Properties and Applications in Insurance Modeling

Indranil Ghosh

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: Bivariate Kumaraswamy distribution; copula based construction; Kendall'stau; dependence structures; application in insurance risk modeling

Online: 25 September 2017 (06:55:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0251.v2

“All That Matter ... in One Big Bang ...,” & Other Cosmological Singularities

Emilio Elizalde

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: The Big Bang concept; history of modern cosmology; singularity theorems; cosmological singularities in modified gravity models

Online: 8 February 2018 (08:54:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0109.v1

Novel Supervisory Control Algorithm to Improve the Performance of a Real-Time PV Power-Hardware-In-Loop Simulator with Non-RTDS

Dae-Jin Kim, Byungki Kim, Hee-Sang Ko, Moon-Seok Jang, Kyung-Sang Ryu

Subject: Engineering, Electrical And Electronic Engineering Keywords: Photovoltaic; Power-Hardware-In-Loop-Simulator; Supervisory control algorithm; Real-time processing;

Online: 22 September 2017 (16:13:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0035.v1

Application of Coupled-Wave Wentzel-Kramers-Brillouin Approximation to Ground Penetrating Radar

Igor Prokopovich, Alexei Popov, Lara Pajewski, Marian Marciniak

Subject: Physical Sciences, Applied Physics Keywords: ground penetrating radar; electromagnetic propagation in nonhomogeneous media; time-domain analysis

Online: 6 December 2017 (09:00:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0016.v1

Chance-Constrained Optimization Dispatch and Demand Response Control of Thermostatically Controlled Loads and Plug-in Electric Vehicles

Jianqiang Hu, Jinde Cao

Subject: Engineering, Electrical And Electronic Engineering Keywords: Chance constraint programming; Source-load systems; Demand response control; Thermostatically controlled loads (TCLs); Plug-in electric vehicles (PEVs).

Online: 1 September 2021 (12:25:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0714.v1

Towards a Biomanufactory on Mars

Aaron Berliner, Jacob M. Hilzinger, Anthony J. Abel, Matthew McNulty, George Makrygiorgos, Nils J.H. Averesch, Soumyajit Sen Gupta, Alexander Benvenuti, Daniel Caddell, Stefano Cestellos-Blanco, Anna Doloman, Skyler Friedline, Desiree Ho, Wenyu Gu, Avery Hill, Paul Kusuma, Isaac Lipsky, Mia Mirkovic, Jorge Meraz, Vince Pane, Kyle B. Sander, Fengzhe Shi, Jeffrey M. Skerker, Alexander Styer, Kyle Valgardson, Kelly Wetmore, Sung-Geun Woo, Yongao Xiong, Kevin Yates, Cindy Zhang, Shuyang Zhen, Bruce Bugbee, Devin Coleman-Derr, Ali Mesbah, Somen Nandi, Robert W. Waymouth, Peidong Yang, Craig S. Criddle, Karen A. McDonald, Amor A. Menezes, Lance C. Seefeldt, Douglas S. Clark, Adam P. Arkin

Subject: Engineering, Automotive Engineering Keywords: space systems bioengineering; human exploration; mars; in situ resource utilization; life support systems; biomanufacturing

Online: 29 December 2020 (07:57:37 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202301.0049.v1

Quality Assurance in Higher Education and its Implications on Higher Education Institutions and Challenges in Zambia

Tuesday Bwalya

Subject: Social Sciences, Education Keywords: Quality Assurance in Higher Education in Zambia; Higher Education and Quality Assurance; Zambia’s Higher Education

Online: 4 January 2023 (02:58:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0138.v1

Who is the Muslim? Discursive Representations of the Muslims and Islam in Indian Prime Time News

Onaiza Drabu

Subject: Social Sciences, Political Science Keywords: politics of representation; media; Islam; media representation; Muslims; Islamophobia.; racism; anti-Muslim racism; love jihad; triple talaq; Muslims in India

Online: 7 August 2018 (08:27:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0017.v1

The Relationship between Consuming Fashion and Self-Confidence on the Buying Behaviour in the Clothing Market as a Mediator

Milad Zam, Mohammadhosein Tavakoli, Hasan Ramezanian, Amin Rezasoltani

Subject: Business, Economics And Management, Marketing Keywords: Interest in modem personal taste; utilitarianism; new fashion products; self-confidence; fashion buying behaviour

Online: 1 August 2022 (09:40:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0280.v1

Serious Games and Gamification: A Systematic Literature Review

Akif Quddus Khan, Salman Khan, Utkurbek Safaev

Subject: Social Sciences, Education Keywords: serious games; science education; games in education; augmented reality

Online: 9 November 2020 (11:29:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0146.v1

Performance Analysis of Heterogeneous Networks in Presence of Deliberate Jammers Using Reverse Frequency Allocation

Muhammad Ihsan Ur Rehman, Muhammad Qasim, Abdul Wakeel, Mehmood Alam, Mir Yasir Umair

Subject: Engineering, Electrical And Electronic Engineering Keywords: Heterogeneous Cellular Networks; Deliberate Jamming; Inter-cell Interference; Independent Homogenous Poisson Point Process; Coverage Probability; Reverse Frequency Allocation

Online: 8 September 2021 (11:57:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0392.v1

Novel Multi Epitope-based Vaccine against Monkeypox Virus: Vaccinomic approach

Shaza Shantier, Mujahed Mustafa, Abdelrahman Abdelmoneim, Hiba Fadl, Sahar Elbager, Abdelrafie Makhawi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Multi Epitope; monkeypox virus (MPXV); Vaccine; Immunoinformatics; In silico; Molecular docking

Online: 29 June 2022 (03:43:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0005.v1

Screening of Lemon Balm Extracts for Anti-Aflatoxigenic, Antioxidant and Other Biological Activities

Efstathia Skotti, Nefeli Sophia Sotiropoulou, Iliada Lappa, Maria Kaiafa, Dimitrios Tsitsigiannis, Petros Tarantilis

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Melissa officinalis; antioxidant activity; aflatoxins; anti-aflatoxigenic activity; GC/MS; LC/MS; lemon balm; in situ; Pistachia Vera

Online: 1 July 2019 (11:16:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0221.v1

Fully Kinetic Simulation of Ion-Temperature-Gradient Instability in Tokamaks

Youjun Hu, Matthew T. Miecnikowski, Yang Chen, Scott E. Parker

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: fully kinetic ions; ion temperature gradient instabilities; tokamak; gyrokinetics; particle-in-cell

Online: 27 March 2018 (06:03:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0489.v1

Heat Stress and its Impact on Plant Function: An Update

Anand Kumar, Prashant Kaushik

Subject: Biology And Life Sciences, Plant Sciences Keywords: Heat stress; molecular responses; morphological responses; physiological process; reproductive activity

Online: 25 August 2021 (11:46:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0192.v1

Economic Value Assessment and Optimal Sizing of an Energy Storage System in a Grid-Connected Wind Farm

Dong Gu Choi, Daiki Min, Jong-hyun Ryu

Subject: Engineering, Energy And Fuel Technology Keywords: wind farm; energy storage system; economic value assessment; optimal sizing; dynamic programming; Markov decision process

Online: 22 January 2018 (04:33:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0130.v1

Multiferroic Hysteresis Loop

Alexander Ruff, Alois Loidl, Stephan Krohns

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Multiferroicity; LiCuVO4; Spin-driven improper ferroelectricity; Hysteresis in magnetic fields, Multiferroic Hysteresis Loop

Online: 19 October 2017 (17:42:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0417.v1

Development Status of LASER Cladding and the New Metallic Alloys

Teresa Morgado, Catarina Valente

Subject: Engineering, Mechanical Engineering Keywords: LASER Cladding; manufacturing process; metallic alloys; innovation; state of the art

Online: 29 May 2018 (08:39:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0245.v1

Permeability of Novel Chitosan-g-poly (Methyl Methacrylate) Amphiphilic Nanoparticles in a Model of Small Intestine in Vitro

Imrit Noi, Inbar Schlachet, Murali Kumarasamy, Alejandro Sosnik

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Chitosan-g-PMMA amphiphilic nanoparticles; thiolated polymers; mucoadhesion; mucosal drug delivery; Caco2 and HT29-MTX cell lines; apparent permeability in vitro.

Online: 18 April 2018 (16:28:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0113.v1

Minding the Cyber-Physical Gap: Model-Based Analysis and Mitigation of Systemic Perception-Induced Failure

Yaniv Mordecai, Dov Dori

Subject: Engineering, Control And Systems Engineering Keywords: conceptual modeling; cyber-physical systems; cyber-physical gap; Object-Process Methodology; model-based systems engineering; Three Mile Island 2 Accident

Online: 26 June 2017 (04:59:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0140.v1

Aligning Strategy with Sustainable Development Goals (SDGs): Process Scoping Diagram for Entrepreneurial Higher Education Institutions (HEIs)

Elena Fleaca, Bogdan Fleaca, Sanda Maiduc

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: entrepreneurial sustainability strategy; system thinking; business process management; process improvements; innovation in higher education; sustainable organizational performance

Online: 16 January 2018 (10:44:40 CET)

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The sustainable development of our world has gain particular attention of a wide range of decisional factors, civil society, business sector, and scientific community, seeing that the prosperity of people and society is possible with the aid of sustained and inclusive economic growth of all countries and regions. Educational environment has a decisive impact on changes in the way that societies are coping with national, regional, and global challenges and opportunities brought by sustainable development. Looking at the implications of HE on the progress of society, the paper addressed the lack of HE institutional capacity to integrate the principles and practices of sustainable development into all aspects of education and learning. The scope of research problem was bounded on the capability of HEI as organization and school to act as entrepreneurial university by combining the scope of its responsibility within the value chain through a practical and effective mechanism needed to align the strategy with sustainable development goals (SDGs). Embarking on the path of SDGs requires HEI to design, launch, implement, and customize specific processes architectures to govern the advance of sustainability approach. The authors applied the process scoping diagram to capture and conceptualize the educational model needed to guide the HEI through the process of change to embrace sustainability into organizational culture and daily operations. It has been used the SIPOC method (Supplier, Input, Process, Output, Customer) with Visio software tool to articulate processes relationships embedded in the educational model of HEI. The benefits relied on the organized view of the work processes needed to be performed to incorporate SDGs into the strategy of any entrepreneurial HEI. Finally, the authors shared their views on the scalability of the model which may be customized and harmonized in accordance with different HE circumstances and priorities. Implementing the proposed educational model requires long-term institutional commitment, transparency, continuous performance improvement, and communicating the strategy for SDGs and its achievements to wider stakeholders.

Working Paper ARTICLE

A Linear Process Approach to Short-term Trading Using the VIX Index as a Sentiment Indicator

Yawo Mamoua Kobara, Cemre Pehlivanoglu, Okechukwu Joshua Okigbo

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Short-term trading; mean reversion; VIX; SPY; linear stochastic process; MACD; Bollinger Bands

Online: 29 July 2021 (16:24:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0003.v1

Strategies to Automatically Derive A Process Model From A Configurable Process Model Based on Event Data

Mauricio Arriagada-Benítez, Marcos Sepúlveda, Jorge Munoz-Gama, Joos C. A. M. Buijs

Subject: Computer Science And Mathematics, Information Systems Keywords: business workflows; discrete event systems; event logs; configurable process models; configurable process trees; process mining; business processes

Online: 1 September 2017 (17:14:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0268.v1

In silico Prediction and Cytotoxicity Evaluation of siRNAs Targeting Conserved Regions of MERS-CoV in Cell Culture

Sayed Sartaj Sohrab , Sherif Aly El-Kafrawy , Zeenat Mirza, Esam Ibraheem Azhar

Subject: Biology And Life Sciences, Virology Keywords: MERS-CoV, siRNAs, in silico design, Vero cells.

Online: 28 February 2019 (11:30:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0046.v1

Simultaneous Inertia Contribution and Optimal Grid Utilization with Wind Turbines

Clemens Jauch, Arne Gloe

Subject: Engineering, Electrical And Electronic Engineering Keywords: feed-in management; frequency domain; inertial energy; inertial response; power control; synthetic inertia; wind turbine

Online: 5 June 2019 (16:10:07 CEST)

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Working Paper ARTICLE

Locally LSR Over-Molding of Textile Integrated Actors and Sensors

Sebastian Micus, Hanne Pachl, Götz T. Gresser

Subject: Engineering, Electrical And Electronic Engineering Keywords: Injection molding, smart textiles, e-textiles, integration of electronics in textiles

Online: 26 August 2019 (13:48:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0138.v2

A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy

Wesley A. Williams, Ashley J. Denslow, Peter W. Radulovic, Daniel J. Denmark, Shyam S. Mohapatra

Subject: Chemistry And Materials Science, Nanotechnology Keywords: inorganic nanoparticles; in silico; optimization; theranostic; therapeutic; diagnostic; computation; coding; Python

Online: 7 September 2021 (11:57:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0012.v1

Integrated BIM-Based LCA for the Entire Building Process Using an Existing Structure for Cost Estimation

Anita Naneva, Marcella Bonanomi, Alexander Hollberg, Guillaume Habert, Daniel Hall

Subject: Engineering, Architecture, Building And Construction Keywords: Building Information Modelling (BIM); Life-Cycle Assessment (LCA); Building process; Level of Development (LOD); Embodied environmental impacts; Greenhouse Gas emissions (GHG); LCA databases; LCA values; LCA benchmarks; cost estimation structure

Online: 1 March 2020 (13:16:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0214.v1

Antitumour and Acute Toxicity Studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl)pyrimidin-2(1H)-one Against Ehrlich Ascites Carcinoma and Sarcoma-180

Dinesh Kumar, Pooja Sharma , Kunal Nepali, Girish Mahajan, Mubashir J. Mintoo, Amarinder Singh, Dilip M. Mondhe, Gurdarshan Singh, Subheet K. Jain, Girish K. Gupta, Fidele Ntie-Kang

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: antitumour; cancer; chalcone; DMPK; in silico; in vivo

Online: 23 January 2018 (09:46:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0670.v1

Hibiscus Anthocyanins Can Selectively Modulate Estrogen Receptor Activity with Favorable Toxicology: a Computational Analysis

Yahyea Baktiar Laskar, Monjur Ahmed Laskar, Pranab Behari Mazumder, Anupam Das Talukdar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: In silico; Estrogen Receptor; Hibiscus sabdariffa L.; Phytochemical; Anthocyanin; SERM

Online: 25 December 2020 (16:03:32 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202003.0395.v2

Beclabuvir can Inhibit the RNA-dependent RNA Polymerase of Newly Emerged Novel Coronavirus (SARS-CoV-2)

Kunal Dutta, Sergey Shityakov, Olga Morozova, Ibrahim Khalifa, Jin Zhang, Wei Zhu, Amiya Panda

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Novel coronavirus (SARS-CoV-2); RdRp; HCV; beclabuvir; in silico; molecular docking

Online: 2 April 2020 (11:25:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0353.v1

Analysis and Forecast of COVID-19 Pandemic in Pakistan

Abdul Bari Malik

Subject: Computer Science And Mathematics, Analysis Keywords: COVID-19; Epidemiology; COVID-19 Analysis and Forecast in Pakistan; Forecasting; Estimation; ARIMA; Prophet; SIRD; Diffusion; Analysis

Online: 29 June 2020 (10:50:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0163.v1

Shaping Light in Backward-Wave Nonlinear Hyperbolic Metamaterials

Alexander K. Popov, Sergey A. Myslivets, Vitaly V. Slabko, Victor A. Tkachenko, Thomas F. George

Subject: Physical Sciences, Optics And Photonics Keywords: optical metamaterials; fundamental concepts in photonics; light-matter interactions at the subwavelength and nanoscale; fundamental understanding of linear and nonlinear optical processes in novel metamaterials underpinning photonic devices and components; advancing the frontier of nanophotonics with the associated nanoscience and nanotechnology; nanostructures that can serve as building blocks for nano-optical systems; use of nanotechnology in photonics; nonlinear nanophotonics, plasmonics and excitonics; subwavelength components and negative index materials; slowing, store, and processing light pulses; materials with such capabilities that could be used for optical sensing, tunable optical delay lines, optical buffers, high extinction optical switches, novel image processing hardware, and highly-efficient wavelength converters

Online: 26 February 2018 (11:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0619.v1

Prevalence of Stress in Healthcare Professional During COVID-19 Pandemic in Northeast México: A Remote Fast Survey Evaluation, the Use of an Adapted COVID-19 Stress Scale

Juan Luis Delgado-Gallegos, Rene de Jesus Montemayor-Garza, Gerardo R. Padilla-Rivas, Hector Franco-Villareal, Jose Francisco Islas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 Mexico; stress in healthcare professionals; COVID-19 stress scale

Online: 26 September 2020 (08:07:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0021.v1

In Vitro Antibacterial Activities of Aniline Dithiocarbamate Crystals with its Corresponding Oxovanadium(IV) and Zinc(II) Coordination Compounds

Ayodele Odularu, Peter Adewale Ajibade, Albert Bolhuis

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Keywords: one-pot synthesis; single crystal x-ray crystallography; oxovanadium(IV); zinc(II); spectroscopic studies; in vitro antibacterial studies.

Online: 2 February 2018 (16:00:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0112.v1

Process Design Aspects for Scandium-Selective Leaching of Bauxite Residue with Mineral Acids

Konstantinos Hatzilyberis, Theopisti Lymperopoulou, Lamprini-Areti Tsakanika, Klaus-Michael Ochsenkühn, Paraskevas Georgiou, Nikolaos Defteraios, Fotios Tsopelas, Maria Ochsenkühn-Petropoulou

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: scandium; REEs; bauxite residue; selective leaching; process design aspects; thin film diffusion model; unyielding core; specific recovery

Online: 12 January 2018 (07:50:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0442.v1

On the Design of In-Wheel-Hub Motor Transmission Systems with Six-Link Mechanisms for Electric Vehicles

Ngoc-Tan Hoang, Hong-Sen Yan

Subject: Engineering, Mechanical Engineering Keywords: electric vehicles; configuration synthesis; motor transmission; in-wheel-hub motor; six-link mechanism

Online: 24 July 2018 (05:59:20 CEST)

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Working Paper CONCEPT PAPER

Process Design and Sustainable Development - a European Perspective

Peter Glavič, Zorka Novak Pintarič, Miloš Bogataj

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: process design; sustainable development; chemical industry; process industry; megatrends; design tools

Online: 5 January 2021 (11:32:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0567.v1

Polymeric Nanocomposites Membranes with High Permittivity Based on PVA-ZnO Nanoparticles for Potential Applications in Flexible Electronics

Roberto Ambrosio, Amanda Carrillo, Maria de la Luz Mota, Karla de la Torre, Richard TorreAlba, Mario Moreno, Hector Vazquez, Javier Flores, Israel Vivaldo

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: solution process; thin films; composite material; dielectric constant

Online: 24 October 2018 (10:48:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0474.v1

Offshore Wind Energy Potential for Bahrain via Multi-criteria Evaluation

Diane Palmer, Mohamed Elgabiri, Hanan Al Buflasa, Murray Thomson

Subject: Engineering, Energy And Fuel Technology Keywords: Offshore wind farm siting; Suitability maps; Geographical Information Systems (GIS); Multi-criteria; Analytic hierarchy process (AHP); Offshore wind energy potential.

Online: 18 December 2020 (14:54:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0110.v1

Assessing the Effectiveness of a Far-red Fluorescent Reporter for Tracking Stem Cells In Vivo

Jing Zhou , Jack Sharkey, Rajeev Shukla, Antonius Plagge, Patricia Murray

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Fluorescent reporter; E2-Crimson; mouse embryonic stem cells; knock-in; in vivo imaging

Online: 16 November 2017 (17:46:53 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202207.0329.v1

Biomanufacturing for Space-Exploration – What to Take and When to Make

Nils J.H. Averesch, Aaron J. Berliner, Shannon N. Nangle, Spencer Zezulka, Gretchen L. Vengerova, Davian Ho, Cameran A. Casale, Benjamin A.E. Lehner, Jessica E. Jessica Snyder, Kevin B. Clark, Lewis R. Dartnell, Craig S. Criddle, Adam P. Arkin

Subject: Engineering, Bioengineering Keywords: in-space biomanufacturing; space synthetic biology; space bioprocess engineering; biological life-support systems; in situ resource utilization; circular economy

Online: 21 July 2022 (11:01:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0072.v1

A Performance Study of Massive MIMO Heterogeneous Networks with Ricean/Rayleigh Fading

James Kweku Nkrumah Nyarko, Christian Ango Mbom

Subject: Engineering, Electrical And Electronic Engineering Keywords: Massive MIMO; Ricean Fading; Beamforming; Stochastic Process; Heterogeneous Network; Interference Coordination; Spectral Efficiency

Online: 3 May 2018 (12:15:16 CEST)

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Working Paper ARTICLE

On Absorption Modeling and Food Effect Prediction of Rivaroxaban, a BCS II Drug Orally Administered as an Immediate-Release Tablet

Varun Kushwah, Sumit Arora, Miklós Tamás Katona, Dattatray Modhave, Eleonore Fröhlich, Amrit Paudel

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: In vitro–In vivo Correlation; Physiologically Based Pharmacokinetic Model; BCS Class II; Rivaroxaban; Xarelto; Food Effect; Population Kinetics

Online: 25 January 2021 (09:41:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0155.v1

Augmented Virtuality for Coastal Management: An Holistic Use of In-Situ and Remote Sensing for Large Scale Definition of Coastal Dynamics

Sandro Bartolini, Alessandro Mecocci, Alessandro Pozzebon, Claudia Zoppetti, Duccio Bertoni, Giovanni Sarti, Andrea Caiti, Riccardo Costanzi, Filippo Catani, Andrea Ciampalini, Sandro Moretti

Subject: Engineering, Electrical And Electronic Engineering Keywords: Coastal Monitoring, Remote Sensing, In-Situ Sensing, Augmented Virtuality, AUV, Drones, RFID, Wireless Sensor Networks, 3D imaging

Online: 21 December 2017 (16:00:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0156.v4

Diophantine Equations with a Finite Number of Solutions: Craig Smorynski's Theorem, Harvey Friedman's Conjecture and Minhyong Kim's Guess

Apoloniusz Tyszka

Subject: Computer Science And Mathematics, Logic Keywords: Davis-Putnam-Robinson-Matiyasevich theorem, Diophantine equation which has at most finitely many solutions in \mbox{non-negative} integers, Hilbert's Tenth Problem, Hilbert's Tenth Problem for Q, Matiyasevich's theorem, recursively enumerable set, Smorynski's theorem

Online: 1 March 2019 (12:58:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0267.v1

Reflecting on Leadership Experiences: The Positive and Negative Journeys of Women in Leadership

Shamma Al Naqbi

Subject: Social Sciences, Education Keywords: Leadership Experiences; Women in Leadership; Adolescent experiences; UAE; Women; Leadership development; Qualitative research; Semi-structured interviews; Document analysis; Diary writing; Family upbringing; Cultural values; Education; Societal expectations

Online: 12 April 2023 (09:41:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0141.v1

Genome-Guided Analysis of the Syntrophic Acetate Oxidizer C. ultunense and Comparative Genomics Reveal Different Strategies for Acetate Oxidation and Energy Conservation in Syntrophic Acetate-Oxidising Bacteria

Shahid Manzoor, Anna Schnürer, Erik Bongcam-Rudloff, Bettina Müller

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: syntrophic acetate oxidation; energy conservation; methane production; hydrogen production; anaerobic digestion process

Online: 19 March 2018 (07:23:17 CET)

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Syntrophic acetate oxidation operates close to the thermodynamic equilibrium and very little is known about the participating organisms and their metabolism. Clostridium ultunense is one of the most abundant syntrophic acetate-oxidising bacteria (SAOB) found in engineered biogas processes operating with high ammonia concentrations. It has been proven to oxidise acetate in cooperation with hydrogenotrophic methanogens. There is evidence that the Wood-Ljungdahl (WL) pathway plays an important role in acetate oxidation. In this study we analysed the physiological and metabolic capacities of C. ultunense on genome scale and conducted a comparative study of all known characterised SAOB, namely Syntrophaceticus schinkii, Thermacetogenium phaeum, Tepidanaerobacter acetatoxydans and Pseudothermotoga lettingae. The results clearly indicated physiological robustness beneficial for anaerobic digestion environments and revealed unexpected metabolic diversity with respect to acetate oxidation and energy conservation systems., Unlike S. schinkii and Th. phaeum, C. ultunense clearly does not employ the oxidative WL pathway for acetate oxidation, as its genome (and that of P. lettingae) lack important key genes. In both those species, a proton motive force is likely formed by chemical protons involving putative electron-bifurcating [Fe-Fe] hydrogenases rather than proton pumps. No genes encoding a respiratory Ech hydrogenase, as involved in energy conservation in Th. phaeum and S. schinkii, were identified in C. ultunense and P. lettingae. Moreover, two respiratory complexes sharing similarities to the proton-translocating ferredoxin:NAD⁺ oxidoreductase (Rnf) and the Na+ pumping NADH:quinone hydrogenase (NQR) were predicted. These might form a respiratory chain involved in reduction of electron acceptors other than protons. However, involvement of these complexes in acetate oxidation in C. ultunense and P. lettingae needs further study. This genome-based comparison provides a solid platform for future meta-proteomics and meta-transcriptomics studies and for metabolic engineering, control and monitoring of SAOB.

Preprint ARTICLE | doi:10.20944/preprints201709.0140.v1

Study of the Influence of TiB Content and Temperature in the Properties of in Situ Titanium Matrix Composites

Cristina Arévalo, Isabel Montealegre-Melendez, Eva María Pérez-Soriano, Enrique Ariza, Michael Kitzmantel, Erich Neubauer

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: in situ Titanium composites, microstructure analysis, TiB precipitates

Online: 27 September 2017 (16:49:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0481.v1

Study of the Microstructure and Crack Evolution Behavior of Al-5Fe-1.5Er Alloy

Ming Li, Zhiming Shi, Xiufeng Wu, Huhe Wang, Yubao Liu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Al-5Fe-Er alloy; microstructure; in situ tension; crack evolution

Online: 20 November 2018 (05:20:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0522.v1

In Silico Phylogenetic and Structural Analysis of Plant Damps

Athanasia pavlopoulou, Ezgi Karaca, Alma Balestrazzi, Alexandros Georgakilas

Subject: Biology And Life Sciences, Plant Sciences Keywords: DAMPs; alarmins; innate immune response; plants; phylogeny; in silico

Online: 26 July 2018 (16:08:54 CEST)

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Working Paper ARTICLE

Simultaneous Estimation and Planning for Differential Drive Robot - Technical Report

Tai Hoang

Subject: Computer Science And Mathematics, Robotics Keywords: SLAM; Trajectory Optimization; Motion Planning; Gaussian Process; STEAP; GPMP2; Mobile Robot; Differential Drive Robot

Online: 7 January 2020 (05:25:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0762.v1

Real-Time Smoke Simulation based on Vortex Method

Fei Wan, Jingpu Zhang, Lizheng Guo, Yunchang Liu

Subject: Computer Science And Mathematics, Mathematics Keywords: smoke simulation; vortex method; Vortex-In-Cell (VIC)

Online: 31 May 2021 (12:11:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0541.v1

Anaerobic Digester Variation on Wastewater Treatment

Elida Novita, Hendra Andiananta Pradana, Sri Wahyuningsih, Bambang Marhaenanto, Moh. Wawan Sujarwo

Subject: Engineering, Chemical Engineering Keywords: anaerobic process; biogas; coffee wastewater; digester construction

Online: 31 August 2018 (05:47:42 CEST)

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Working Paper ARTICLE

Municipal Solid Waste Thermal Analysis – Pyrolysis Kinetics and Decomposition Reactions

Ewa Syguła, Kacper Świechowski, Małgorzata Hejna, Ines Kunaszyk, Andrzej Białowiec

Subject: Engineering, Energy And Fuel Technology Keywords: TGA, DTG, DSC, thermogravimetric analysis, differential scanning calorimetry, municipal solid waste, organic waste, proximate analysis, process kinetics, Coats–Redfern method

Online: 7 June 2021 (11:13:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0397.v1

A Practical Guidance for Biosimilars Approval--Strategy for the ROW

Sarfaraz K. Niazi, Waleed Mohammed Al-Shaqha, Zafar Mirza

Subject: Public Health And Healthcare, Health Policy And Services Keywords: biosimilars; regulatory process; animal studies; clinical efficacy testing; interchangeability; FDA; EMA; MHRA; MENA; cGMP

Online: 26 October 2022 (03:58:16 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201810.0465.v1

Improving Distribution Process Using Lean Manufacturing and Simulation: A Case of Mexican Seafood Packer Company

Julián I. Aguilar-Duque, Juan L. Hernandez-Arellano, Cesar Omar Balderrama-Armendariz, Guillermo Amaya-Parra, Liliana Avelar

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: production system; simulation manufacturing process; simulation model; work in process

Online: 22 October 2018 (04:56:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0527.v1

A Convenient, Soil-Free Method for the Production of Root Nodules in Soybean to Study the Effects of Exogenous Additives

Swarup Roy Choudhury, Sarah M. Johns, Sona Pandey

Subject: Biology And Life Sciences, Plant Sciences Keywords: soybean; nodulation; in vitro nodule development; phytohormones; ABA; JA; auxins; cytokinins; GA; BR

Online: 27 September 2018 (03:59:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0472.v1

Sentiment Analysis of Current Reports Texts with Use of Cumulative Abnormal Return and Deep Neural Network

Maciej A. Wujec

Subject: Business, Economics And Management, Economics Keywords: fundamental analysis supported by machine learning; financial texts sentiment analysis; natural language processing in finance

Online: 28 September 2021 (12:38:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0128.v1

Effect of Anisotropic Yield Functions on Prediction of Critical Process Window and Deformation Behavior for Hydrodynamic Deep Drawing of Aluminum Alloys

Chu Wang, Delun Li, Bao Meng, Min Wan

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: anisotropic yield criterion; hydrodynamic deep drawing; critical process window; aluminum alloy

Online: 8 March 2020 (04:03:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0262.v1

Forward Link Optimization for the Design of VHTS Satellite Networks

Flor G. Ortiz-Gomez, Ramón Martínez, Miguel A. Salas-Natera, Andrés Cornejo, Salvador Landeros-Ayala

Subject: Engineering, Electrical And Electronic Engineering Keywords: CCM; CINR; Cost per Gbps in orbit; Multibeam Satellite Communications; System Optimization; VCM; VHTS

Online: 18 February 2020 (08:53:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0514.v1

Preparation and Characterization of Hydrophobic Groups Grafted Starches by In-Situ Solid Phase Polymerization

Yinfeng Zuo, Xiaoyu He, Ping Li, Wenhao Li, Yiqiang Wu

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: corn starch; maleic anhydride; lactic acid; methyl acrylate; hydrophobically modified; in-situ solid phase polymerization

Online: 21 November 2018 (05:04:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0265.v1

Photovoltaic Energy in Colombia: Current Status of Supply Chain

Mateo Valderrama Mendoza, Pablo César Ocampo Vélez, Camilo Mejía Moncayo, Leonardo Rodríguez Urrego

Subject: Engineering, Energy And Fuel Technology Keywords: photovoltaics systems in Colombia; supply chain; non-nterconnected areas (ZNI); supply chain orientation (SCO); Petri Nets

Online: 21 May 2018 (10:50:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0202.v1

Precipitation of CaCO3 Polymorphs from Aqueous Solutions: The Role of pH and Sulphate Groups

Iris Cuesta Mayorga, José Manuel Astilleros, Lurdes Fernández-Díaz

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: CaCO3 polymorphs; sulphate; ageing process; aragonite; gypsum

Online: 21 February 2019 (10:45:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0004.v1

An Evaluation-Driven Design Process for Exhibitions

Wolfgang Leister, Ingvar Tjøstheim, Göran Joryd, Michel de Brisis, Syver Lauritzsen, Sigrun Reisæter

Subject: Arts And Humanities, Other Keywords: design process; installations; science centres; museums; visitor engagement

Online: 1 September 2017 (18:01:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0025.v1

Fuel Gas Network Synthesis Using Block Superstructure

Jianping Li, Salih Emre Demirel, M. M. Faruque Hasan

Subject: Engineering, Control And Systems Engineering Keywords: process integration; fuel gas network synthesis; block superstructure; optimization; MINLP

Online: 5 February 2018 (03:33:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0240.v1

Open or Ajar? Openness within the Neoliberal Academy

Kevin Sanders, Simon Bowie

Subject: Social Sciences, Library And Information Sciences Keywords: openness under neoliberalism; open-access licensing in capitalism; the politics of open-licensing

Online: 21 January 2020 (11:00:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0226.v1

New Frontiers and Relations between Religion, Culture and Politics in Western Europe

Alfonso Pérez-Agote

Subject: Social Sciences, Sociology Keywords: religion; culture; politics; differentiation; historical process; Western European countries

Online: 24 January 2018 (10:27:11 CET)

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Working Paper ARTICLE

A Comparison between Semisolid Casting Methods for Aluminium Alloys

Anders E. W. Jarfors

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Semisolid casting; RheoMetal process; GISS process; SEED process; production; capability; surface treatment; heat treatment; tool-life; productivity

Online: 19 September 2020 (05:15:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0285.v1

Callus Culture of Ocimum basilicum L. cv 'Thai Basil' Is an Effective Biological System for the Production of Antioxidants Compared to Leaves

Saher Nazir, Hasnain Jan, Duangjai Tungmunnithum, Samantha Drouet, Muhammad Zia, Christophe Hano, Bilal Haider Abbasi

Subject: Biology And Life Sciences, Plant Sciences Keywords: Antioxidants; Biological System; Caffeic Acid; Callus culture; Chicoric Acid; Phenolics; Plant in vitro Cultures; Rosmarinic Acid; Thai Basil

Online: 13 September 2020 (12:18:48 CEST)

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Thai basil is a renowned medicinal plant and a rich source of bioactive antioxidant compounds having several health benefits, with actions to prevent of cancer, diabetes and cardiovascular disease. Plant cell and tissue culture technologies can be routinely established as an important, sustainable and low-cost biomass source for the production of high-value phytochemicals. The current study aimed at developing an effective protocol for the production of Thai basil leaf derived callus cultures with sustainable and high production of biomass and antioxidants as an alternative of leaves production. MS basal medium with various concentrations of plant growth regulators (PGRs) compatible with nutraceutical applications (i.e., gibberellic acid (GA3) and 6-benzylaminopurine (BAP) either alone or in combination with naphthalene acetic acid (NAA)) were evaluated. Among all tested PGRs, the combination BAP:NAA (5 mg/L:1 mg/L) yield maximum biomass accumulation (fresh weight (FW): 190 g/L and dry weight (DW): 13.05 g/L) as well as enhanced phenolic (346.08 mg/L) production. HPLC quantification analysis indicated high productions of chicoric acid (35.77 mg/g DW) and rosmarinic acid (7.35 mg/g DW) under optimized callus culture conditions. Antioxidant potential was assessed using both in vitro cell free and in vivo cellular antioxidant assays. Maximum in vitro antioxidant activity DPPH (93.2 % of radical scavenging activity) and ABTS (1322 µM Trolox equivalent antioxidant capacity) was also observed for the extracts from callus cultures grown on optimal conditions. In vivo cellular antioxidant activity assay confirmed the effective protection against oxidative stress of the corresponding extract by the maximum inhibition of ROS and RNS production. Compared to commercial leaves, callus extracts showed higher production of chicoric acid and rosmarinic acid associated with higher antioxidant capacity. In addition, this biological system also has a large capacity for continuous biomass production, thus demonstrating its high potential for possible nutraceutical applications.

Preprint ARTICLE | doi:10.20944/preprints202104.0358.v1

The Obverse/Reverse Pavilion: An Example of Form-Finding With Isogeometric Analysis in the Design of Temporary, Low-Cost and Eco-Friendly Structure

Jerzy F. Łątka, Michał Święciak

Subject: Social Sciences, Anthropology Keywords: parametric design, paper in architecture, temporary architecture, pop-up structures, membrane structures, isogeometric analysis, fabrication

Online: 13 April 2021 (13:17:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0032.v1

Factors Affecting Human Capital in Singapore

S M Nazmuz Sakib

Subject: Business, Economics And Management, Economics Keywords: Human Capital; Human Capital Management; Human Capital Factors; Affecting Factors in Human Capital; Human Capital in Singapore

Online: 4 October 2021 (08:45:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0131.v1

In-Silico Methods for Investigating the Effect of Single Nucleotide Polymorphisms on the Structure and Function of Proteins: A Review

Ebenezer Asiedu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: single nucleotide polymorphism; docking; molecular dynamics; in-silico studies; protein dynamics; missense; prediction algorithm; mutation

Online: 10 December 2019 (07:56:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0125.v1

Comparative Study of Physicochemical and Antibacterial Properties of ZnO Nanoparticles Prepared by Laser Ablation of Zn Target in Water and Air

Ekaterina A. Gavrilenko, Daria A. Goncharova, Ivan N. Lapin, Anna L. Nemoikina, Valery A. Svetlichnyi, Ali A. Aljulaih, Neli Mintcheva, Sergei A. Kulinich

Subject: Chemistry And Materials Science, Nanotechnology Keywords: pulsed laser ablation in water; pulsed laser ablation in air; ZnO nanoparticles; biomedical materials; PLLA-scaffold; antibacterial properties

Online: 11 December 2018 (10:32:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0161.v2

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2

Olujide O. Olubiyi, Maryam Olagunju, Monika Keutmann, Jennifer Loschwitz, Birgit Strodel

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; docking; drug repurposing; natural products; in silico drug design; viral replication inhibition

Online: 1 June 2020 (02:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0165.v1

The Importance and Effectiveness of Carotid Endarterectomy in Ischaemic Stroke or TIA with Significant Carotid Stenosis

Muhammad Shohel Almamun, Mobashshereen Khan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco encephalopathy (CADASIL); Carotid Endarterectomy (CEA); Modified Rankin Scale (MRS); Computed Tomography(CT); Tissue plasminogen activator (tPA); Diffusion weighted Imaging (DWI); Recognition of Stroke in the Emergency Room (ROSIER) scale; Magnetic resonance Imaging (MRI); Internal Carotid Artery (ICA)

Online: 26 February 2018 (11:46:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0235.v1

An Integrated Approach to Water-Energy Nexus in Shale-Gas Production

Fadhil Y. Al-Aboosi, Mahmoud M. El-Halwagi

Subject: Engineering, Energy And Fuel Technology Keywords: cogeneration; process integration; solar energy; thermal storage; desalination; optimization

Online: 18 April 2018 (08:08:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0125.v1

A New Iterative Scheme for Approximation of Fixed Points of Suzuki's Generalized Nonexpansive Mappings

Shivam Rawat, Ramesh Chandra Dimri, Ayush Bartwal

Subject: Computer Science And Mathematics, Mathematics Keywords: Uniformly convex Banach space; Iteration process; Suzuki's generalized nonexpansive mapping; weak convergence; Strong convergence

Online: 7 May 2021 (09:05:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0254.v1

Online Demand Side Management with PEVs Using Stochastic Optimization

Moses Acquah, Byeonggu Yu, Sekyung Han

Subject: Engineering, Electrical And Electronic Engineering Keywords: demand-side management; peak demand control; dynamic-interval density forecast; stochastic optimization; dimension reduction; battery energy-storage system (BESS), plugged-in electric vehicles (PEV); vehicle-to-grid (V2G); building energy-management systems (BEMS)

Online: 15 June 2018 (13:01:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0459.v1

Laboratory Hydrogen-Beta Emission Spectroscopy for Analysis of Astrophysical White Dwarf Spectra

Christian G Parigger, Kyle A. Drake, Christopher M Helstern, Ghaneshwar Gautam

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: white dwarfs; burning in stars; plasma diagnostics; atomic spectra; plasma spectroscopy; laser spectroscopy; laser-induced breakdown spectroscopy

Online: 31 May 2018 (05:13:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0127.v2

A New Proof of Smoryński’s Theorem

Apoloniusz Tyszka

Subject: Computer Science And Mathematics, Logic Keywords: Davis-Putnan Robinson-Matiyasevich theorem; Diophantine equation which has at most finitely many solutions in non-negative integers; Diophantine equation which has at most finitely many solutions in positive integers; Diophantine equation which has at most finitely many integer solutions; Hilbert’s Tenth Problem; Matiyasevich’s theorem; recursively enumerable set; Smoryński’s theorem

Online: 27 September 2017 (04:05:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0367.v1

Nor-Lignans: Occurrence in Plants and Biological Activities - A Review

Claudio Frezza, Alessandro Venditti, Chiara Toniolo, Daniela De Vita, Marco Franceschin, Antonio Ventrone, Lamberto Tomassini, Sebastiano Foddai, Marcella Guiso, Marcello Nicoletti, Mauro Serafini, Armandodoriano Bianco

Subject: Biology And Life Sciences, Plant Sciences Keywords: nor-lignans; occurrence in plants; biological activities

Online: 29 November 2019 (03:27:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0462.v1

Unified Field Theory for Electromagnetic and Gravity Fields with the Introduction of Quantized Space–Time and Zero-Point Energy

Shinichi Ishiguri

Subject: Physical Sciences, Particle And Field Physics Keywords: unified field theory; zero-point energy; quantized space–time; quantized Einstein’s gravity equation; conservation of angular momentum in terms of quantized space–times

Online: 20 July 2020 (08:48:03 CEST)

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In our previous papers [1,3], using only the concepts of the zero-point energy and quantized space–times, all the fields including gravity were explained. However, the previous papers had the following limitations: First, the concept of the quantized space-time must be experimentally confirmed. Second, we should clarify the meaning of the quantized Einstein’s gravity equation, which is derived in [1]. Moreover, in another paper [2], we succeeded in describing the neutrinos’ self-energy and their oscillations. However, this paper assumes the rest energy of 3-leptons in advance, which is why we needed to uncover the reason why leptons have 3-generations. As mentioned, using the concepts of the zero-point energy and quantized space–times, we derived the quantized Einstein’s gravity equation in our previous paper [1]. The paper provides an analytical solution of this equalized Einstein’s equation, which implies the conservation of angular momentum in terms of quantized space–times. Employing this solution and without the standard big bang model, a unique form of acceleration equation for the acceleration-expansion universe is derived. Moreover, the temperature of the cosmic microwave background (CMB) emission is also obtained. Further, this solution results in an analytical (not numerical) derivation of the gravity wave. Moreover, based on the configuration of quantized space–times in terms of both electric and magnetic fields, we analytically attempted to calculate every equation in terms of electromagnetic and gravity fields, using the solution of the quantized Einstein’s gravity equation. As a result of this theory, first the calculated acceleration and temperature of CMB emission agree with the measurements. Furthermore, the analytical solution of the quantized Einstein’s gravity equation resulted in all the laws of electromagnetic and gravity fields in addition to the analytically derived gravity wave, which agrees well with the recent measurements. Moreover, the calculations of the energies in the basic configuration of the quantized space–times resulted in all 3-leptons’ rest energies. Considering this basic configuration is uniformly distributed everywhere in the universe, we can conclude that τ-particles or static magnetic field energy derived from the basic configuration of the quantized space–times is the identity of dark energy, which also distributes uniformly in the universe.

Preprint ARTICLE | doi:10.20944/preprints201809.0596.v1

Preparation and Properties of 3-Pentadecyl-phenol In-Situ Modified Foamable Phenolic Resin

Tiejun Ge, Kaihong Tang, Yang Yu, Xiapeng Tan

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: 3-pentadecyl-phenol; foamable phenolic resin; in-situ modification; toughness

Online: 30 September 2018 (05:34:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0177.v1

Morphological Indices as Urban Planning Tools in Northeastern Brazil

Ivanize Silva, Rafael Santos, António Lopes, Virgínia Araújo

Subject: Environmental And Earth Sciences, Environmental Science Keywords: morphological indices; urban climate; planning process

Online: 9 August 2018 (06:21:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0022.v1

Facile Low Temperature Hydrothermal Synthesis of BaTiO₃ Nanoparticles Studied by In Situ X-ray Diffraction

Ola Gjoennes Grendal, Anders Bank Blichfeld, Susanne Linn Skjarvø, Wouter van Beek, Sverre Magnus Selbach, Tor Grande, Mari-Ann Einarsrud

Subject: Chemistry And Materials Science, Nanotechnology Keywords: BaTiO3; hydrothermal synthesis; in situ; X-ray diffraction; nanoparticles

Online: 2 May 2018 (11:25:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0187.v1

Sustainable and Dynamic Competitiveness Towards Technological Leadership of Industry 4.0: Implications for East African Community

Ocident Bongomin, Eric Oyondi Nganyi, Mfanga Ramadhani Abswaidi, Emmanuel Hitiyise, Godias Tumusiime

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: 3D printing; Artificial intelligence; Big Data; Crafting the Future; Digital Strategy 2025; High-Tech Strategy 2025; ICT policy; Industry 4.0; Initiative; Internet of things; Made in China 2025; Make in India; M-Pesa; Public-private partnership; Society 5.0

Online: 12 April 2020 (09:08:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0007.v2

Discovering Business Processes from Email Logs Using fastText and Process Mining

Yaghoub Rashnavadi, Sina Behzadifard, Reza Farzadnia, Sina Zamani

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Process Mining; Business Processes; Natural Language Processing; Machine Learning

Online: 3 September 2021 (10:25:25 CEST)

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