Preprint Article Version 1 This version not peer reviewed

In Vitro Antibacterial Activities of Aniline Dithiocarbamate Crystals with its Corresponding Oxovanadium(IV) and Zinc(II) Coordination Compounds

Version 1 : Received: 2 February 2018 / Approved: 2 February 2018 / Online: 2 February 2018 (16:00:10 CET)

How to cite: Odularu, A.; Ajibade, P.A.; Bolhuis, A. In Vitro Antibacterial Activities of Aniline Dithiocarbamate Crystals with its Corresponding Oxovanadium(IV) and Zinc(II) Coordination Compounds. Preprints 2018, 2018020021 (doi: 10.20944/preprints201802.0021.v1). Odularu, A.; Ajibade, P.A.; Bolhuis, A. In Vitro Antibacterial Activities of Aniline Dithiocarbamate Crystals with its Corresponding Oxovanadium(IV) and Zinc(II) Coordination Compounds. Preprints 2018, 2018020021 (doi: 10.20944/preprints201802.0021.v1).

Abstract

Abstract Antibacterial activities can be improved using mixed ligands. Mixed ligands involved in this research are sodium sulfadiazine (Na-sfz) and dithiocarbamate (ai-dtc). One-pot synthesis was used to synthesize ligand of aniline dithiocarbamate (ai-dtc) and the corresponding coordination compounds of [VO(sfz)(ai-dtc)] and [Zn(sfz)(ai-dtc)]. Crystals of ai-dtc, which grew from the solution when refrigerated after five days, were diffracted with technique of single crystal x-ray crystallography to reveal the structure. Other characterization techniques involving physicochemical parameters, FT-IR, UV-Vis and NMR (1H NMR and 13C NMR) were carried out on ligands of ai-dtc, sfz and corresponding coordination compounds. Differences in results of FT-IR, UV-Vis and NMR between ligands and their respective metal ions confirmed the coordination. The in vitro antibacterial studies showed that the ligands (not the metal complexes) had modest activity against Gram negative bacteria: Staphylococcus aureus, whereas, the coordination compounds had modest activities against the Gram negative bacteria: Escherichia coli and Pseudomonas aeruginosa.

Subject Areas

Keywords: one-pot synthesis; single crystal x-ray crystallography; oxovanadium(IV); zinc(II); spectroscopic studies; in vitro antibacterial studies.

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