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Preprint ARTICLE | doi:10.20944/preprints201711.0166.v1

SWOT Analysis for Architectural and Structural Solutions Interaction Assessment in High-Rise Buildings Design

Jolanta Tamošaitienė, Ernestas Gaudutis

Subject: Engineering, Civil Engineering Keywords: high-rise buildings; architecture; structural solutions; interaction; SWOT analysis

Online: 26 November 2017 (12:45:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0346.v1

The Molecular Story of COVID-19; NAD⁺Depletion Addresses All Questions in this Infection

Shirin Kouhpayeh, Laleh Shariati, Maryam Boshtam, Ilnaz Rahimmanesh, Mina Mirian, Mehrdad Zeinalian, Azhar Salari-jazi, Negar Khanahmad, Mohammad Sadegh Damavandi, Parisa Sadeghi, Hossein Khanahmad

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; nCoV 19; oxidative stress; PARP; PARG; TRPM2

Online: 23 March 2020 (07:40:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0111.v1

A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications

Jan-Peter Hauschild, Amelia Corinne Peterson, Erik Couzijn, Eduard Denisov, Denis Chernyshev, Christian Hock, Hamish Stewart, Ralf Hartmer, Dmitry Grinfeld, Christian Thoeing, Bastian Reitemeier, Arne Kreutzmann, Oliver Lange, Wilko Balschun, Aivaras Venckus, Sebastian Kanngiesser, Alexander Kholomeev, Gregor Quiring, Frank Czemper, Eloy Wouters, Michael Belford, Mathias Mueller, Jens Grote, Tabiwang N. Arrey, Julia Kraegenbring, Kerstin Strupat, Siegrun Mohring, Catharina Crone, Alexander Harder, Aaron Robitaille, Aaron Gajadhar, Khatereh Motamed, Yang Liu, Daniel Lopez Ferrer, Nicolaie Eugen Damoc, Angela Criscuolo, Kristina Srzentic, Ed George, Charles Yang, Ioanna Ntai, Amanda Souza, Andreas Wieghaus, Alexander Makarov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Orbitrap mass spectrometry; high resolution; accurate mass

Online: 8 June 2020 (10:17:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0217.v1

A Study on OpenFOAM's Overset Mesh Support Using Flow Past NACA 0018 Airfoil

Praveen Laws, Jaskaran Singh Saini, Ajit Kumar

Subject: Engineering, Mechanical Engineering Keywords: OpenFOAM; overset meshing; NACA 0018; high Reynolds number; CFD

Online: 18 July 2019 (11:29:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0359.v1

Mechanical Behavior of Inconel 625 at Elevated Temperatures

Mauro M. de Oliveira, Antônio A. Couto, Gisele F. C. Almeida, Danieli A. P. Reis, Nelson B. de Lima, Renato Baldan

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Inconel; high temperature; tensile test; creep; serrated; dynamic strain aging

Online: 31 December 2018 (09:41:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0418.v1

Analyzing academic stress in adolescence and their relationship with students’ psychological and physical well-being: Development and validation of the Questionnaire of Academic Stress in Secondary Education

Rafael García-Ros, Francisco Pérez-González, José M. Tomás

Subject: Social Sciences, Psychology Keywords: academic stress; psychological and physical well-being; adolescence; secondary education; validity; reliability; gender and age differences

Online: 23 August 2018 (15:32:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0179.v1

Explicit Treatment of Non Michaelis-Menten and Atypical Kinetics in Early Drug Discovery

Bharath Srinivasan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Non Michaelis-Menten Kinetics; High-throughput screening; allostery; cooperativity; processive kinetics; distributive kinetics; single-molecule; auto-catalytic; drug discovery

Online: 8 October 2020 (13:34:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0162.v1

A Review of Geological Applications of High-Spatial-Resolution Remote Sensing Data

Chunming Wu, Xiao Li, Weitao Chen, Xianju Li

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: High-spatial-resolution images; Geology; Deep learning; Remote sensing

Online: 7 November 2018 (13:17:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0351.v1

Simulation of Turbulent Flow around a Generic High-Speed Train Using Hybrid Models of RANS Numerical Method with Machine Learning

Alireza Hajipour, Arash Mirabdolah Lavasani, Mohammad Eftekhari Yazdi, Amir Mosavi, Shahaboddin Shamshirband, Kwok-Wing Chau

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: machine learning; aerodynamics; high-speed train; hybrid machine learning; Prediction Turbulence model; deep learning

Online: 26 December 2019 (05:23:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201702.0083.v2

Plant Responses to Salt Stress: Adaptive Mechanisms

Jose Ramón Acosta-Motos, Maria Fernanda Ortuño, Agustina Bernal-Vicente, Pedro Diaz-Vivancos, Maria Jesus Sanchez-Blanco, Jose Antonio Hernandez

Subject: Biology And Life Sciences, Plant Sciences Keywords: Adaptive mechanisms; antioxidative metabolism; chloroplast; osmotic regulation; oxidative stress; photosynthesis; salinity; water relations

Online: 24 February 2017 (10:21:50 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0045.v1

Risks of Climate Change on the Singapore-Malaysia High Speed Rail System

Sazrul Leena Binti Sa’adin, Sakdirat Kaewunruen, David Jaroszweski

Subject: Engineering, Civil Engineering Keywords: railway infrastructure; high-speed rail; tracks; risk; management and monitoring; climate change; global warming; adaptation; operational readiness

Online: 5 August 2016 (05:11:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0440.v1

COVID-19: A Drug Repurposing and Biomarker Identification by Using Comprehensive Gene-Disease Associations through Protein-Protein Interaction Network Analysis

Suresh Kumar

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; 2019-nCoV; novel corona virus; drug repurposing; chloroquine; high-risk group; asymptomatic

Online: 30 March 2020 (07:24:16 CEST)

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COVID-19 (2019-nCoV) is a pandemic disease with an estimated mortality rate of 3.4% (estimated by the WHO as of March 3, 2020). Until now there is no antiviral drug and vaccine for COVID-19. The current overwhelming situation by COVID-19 patients in hospitals is likely to increase in the next few months. About 15 percent of patients with serious disease in COVID-19 require immediate health services. Rather than waiting for new anti-viral drugs or vaccines that take a few months to years to develop and test, several researchers and public health agencies are attempting to repurpose medicines that are already approved for another similar disease and have proved to be fairly effective. This study aims to identify FDA approved drugs that can be used for drug repurposing and identify biomarkers among high- risk and asymptomatic groups. In this study gene-disease association related to COVID-19 reported mild, severe symptoms and clinical outcomes were determined. The high-risk group was studied related to SARS-CoV-2 viral entry and life cycle by using Disgenet and compared with curated COVID-19 gene data sets from the CTD database. The overlapped gene sets were enriched and the selected genes were constructed for protein-protein interaction networks. Through interactome, key genes were identified for COVID-19 and also for high risk and asymptomatic groups. The key hub genes involved in COVID-19 were VEGFA, TNF, IL-6, CXCL8, IL10, CCL2, IL1B, TLR4, ICAM1, MMP9. The identified key genes were used for drug-gene interaction for drug repurposing. The chloroquine, lenalidomide, pentoxifylline, thalidome, sorafenib, pacitaxel, rapamycin, cortisol, statins were proposed to be probable drug repurposing candidates for the treatment of COVID-19. However, these predicted drug candidates need to be validated through randomized clinical trials. Also, a key gene involved in high risk and the asymptomatic group were identified, which can be used as probable biomarkers for early identification.

Preprint ARTICLE | doi:10.20944/preprints201703.0131.v1

Effects of Cold Stress on the Photosynthesis and Antioxidant System of Rhododendron chrysanthum Pall.

Xiaofu Zhou, Silin Chen, Hui Wu, Hongwei Xu

Subject: Biology And Life Sciences, Plant Sciences Keywords: Rhododendron chrysanthum Pall.; cold stress; chlorophyll fluorescence; photosynthesis; antioxidant enzymes

Online: 17 March 2017 (04:46:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0055.v1

Numerical Simulation of Hypervelocity Impact FEM-SPH Algorithm Based on Large Deformation of Material

Aimin Yang, Jinze Li, Hengheng Qu, Yuhang Pan, Yanhong Kang, Yuzhu Zhang

Subject: Computer Science And Mathematics, Analysis Keywords: finite element method; smoothed particle method; fem-sph algorithm; large deformation; super high speed collision

Online: 14 October 2016 (11:05:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0064.v1

Restoration Experience Measurement Methods in Contact with Green Open Spaces

Fahimeh Malekinezhad, Hasanuddin bin Lamit

Subject: Social Sciences, Geography, Planning And Development Keywords: restoration experience; Biophilia Hypothesis; Stress Recovery Theory (SRT); Attention Restoration Theory (ART); Supportive Environment Theory (SET)

Online: 8 January 2018 (10:58:02 CET)

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Preprint REVIEW | doi:10.20944/preprints201812.0145.v1

Methodology of Drought Stress Research: Experimental Setup and Physiological Characterization

Natalia Osmolovskaya, Julia Shumilina, Ahyoung Kim, Anna Didio, Tatiana Grishina, Tatiana Bilova, Olga A. Keltsieva, Vladimir Zhukov, Igor Tikhonovich, Elena Tarakhovskaya, Ludger A. Wessjohann, Andrej Frolov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: drought stress; drought models; drought tolerance; oxidative stress; phytohormones; polyethylene glycol (PEG); stress markers

Online: 12 December 2018 (12:19:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0252.v1

An Innovative Bidirectional DC-AC Converter to Improve Power Quality in a Grid-Connected Microgrid

Sebastien Bissey, Sebastien Jacques, Cedric Reymond, Jean-Charles Le Bunetel

Subject: Engineering, Electrical And Electronic Engineering Keywords: Smart home electricity management system; bidirectional DC-AC converter; high power quality; high efficiency.

Online: 14 July 2018 (20:25:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0014.v1

Review of the Effects of Drought Stress on Plants: A Systematic Approach

Priyanka Bijalwan, Meenakshi Sharma, Prashant Kaushik

Subject: Biology And Life Sciences, Plant Sciences Keywords: drought stress; reactive oxygen species; climate change

Online: 1 February 2022 (12:53:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0019.v1

The BCC/B2 Morphologies in AlxNiCoFeCr High-Entropy Alloys

Yue Ma, Beibei Jiang, Chunling Li, Qing Wang, Chuang Dong, Peter K Liaw, Fen Xu, Lixian Sun

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: high-entropy alloys; Al-Ni-Co-Fe-Cr alloys; microstructure; precipitation morphology; mechanical property

Online: 4 January 2017 (10:30:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0078.v1

High Step-up Voltage Gain Converter with Ripple-free Input Current for Renewable Energy Sources

Zhangyong Chen, Yong Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: input current ripple-free; boost converter; coupled-inductor; voltage-doubler cell; passive lossless clamp circuits; high voltage gain; renewable energy

Online: 17 January 2017 (11:10:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0274.v2

Ultra-Low-Loss Silicon Waveguides for Heterogeneously Integrated Silicon/III-V Photonics

Minh Tran, Duanni Huang, Tin Komljenovic, Jonathan Peters, Aditya Malik, John Bowers

Subject: Physical Sciences, Optics And Photonics Keywords: ultra-low-loss waveguide; silicon photonics; heterogeneous integration; narrow linewidth lasers; high Q resonators.

Online: 16 July 2018 (15:14:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0364.v1

Seed Priming Technology as a Key Strategy to Increase Crop Plant Production under Adverse Environmental Conditions

Daniel Garcia, Samiah Arif, Yinglei Zhao, Shuo Zhao, Lin Chau Ming, Danfeng Huang

Subject: Biology And Life Sciences, Horticulture Keywords: stress tolerance; biological mechanisms; biotic/Abiotic stress; hybrid priming; high-quality seeds

Online: 21 September 2021 (14:02:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202101.0366.v1

High Volume Injection (Hydrodissection) for Tarsal Tunnel Syndrome Using Peripheral Nerve Stimulation: Treatment Protocol

Ian Reilly, Akram Uddin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: tarsal tunnel syndrome; compression neuropathy; high volume injection; hydrodissection; hydrodilatation; nerve stimulator

Online: 19 January 2021 (09:00:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0145.v1

Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells

Liang Cai, Li-Fang Wang, Jun-Ping Pan, Xiang-Nan Mi, Zheng Zhang, Hai-Ju Geng, Jia-Hui Wang, Song-Hui Hu, Wei Zhang, Qin Gao, Wu-Tian Wu, Huan-Min Luo

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: methyl 3,4-dihydroxybenzoate; oxidative stress; apoptosis; neuroprotection; nuclear factor erythroid 2-related factor 2

Online: 15 August 2016 (10:42:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0377.v1

Development of a 3D-Printable Ultra-High Performance Fiber-Reinforced Concrete for Digital Construction

Ravendran Arunothayan, Behzad Nematollahi, Ravi Ranade, Shin Hau Bong, Jay Sanjayan

Subject: Engineering, Architecture, Building And Construction Keywords: ultra-high-performance fiber-reinforced concrete (UHPFRC); mechanical properties; extrusion; 3D concrete printing (3DCP)

Online: 29 November 2019 (10:45:46 CET)

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Preprint REVIEW | doi:10.20944/preprints201801.0223.v1

Potassium: A Vital Regulator of Plant Responses and Tolerance to Abiotic Stresses

Mirza Hasanuzzaman, M.H.M. Borhannuddin Bhuyan, Kamrun Nahar, Md. Shahadat Hossain, Jubayer Al Mahmud, Md. Shahadat Hossen, Abdul Awal Chowdhury Masud, Moumita Moumita, Masayuki Fujita

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: abiotic stress; antioxidant defense; enzyme regulations; oxidative stress; plant nutrients; reactive oxygen species; soil fertility

Online: 24 January 2018 (07:01:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0075.v1

Eﬀects of Probiotic Bacillus on Growth Performance, Immune Response and Disease Resistance in Aquaculture

Ashikur Rahman, Shoaibe Hossain Talukder Shefat, Mohammed Anas Chowdhury

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Probiotics; Bacillus subtilis; growth performance; immune-hematological parameters; stress resistance

Online: 2 March 2021 (11:06:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0120.v1

Large Scale Screening of Southern African Plant Extracts for the Green Synthesis of Gold Nanoparticles using Microtitre-Plate Method

Abdulrahman M. Elbagory, Christopher N. Cupido, Mervin Meyer, Ahmed Hussein

Subject: Chemistry And Materials Science, Other Keywords: green nanotechnology; gold nanoparticles; biosynthesis; high resolution transmission electron microscopy; Cape flora

Online: 11 August 2016 (09:53:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0479.v1

Open Source High-Temperature RepRap for 3-D Printing Heat-Sterilizable PPE and Other Applications

Noah G. Skrzypczak, Nagendra G. Tanikella, Joshua M. Pearce

Subject: Engineering, Mechanical Engineering Keywords: open source; open hardware; COVID-19; medical hardware; RepRap; 3-D printing; open source medical hardware; high temperature 3-D printing; additive manufacturing; ULTEM; polycarbonate

Online: 31 May 2020 (16:18:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0224.v2

Propeller Cavitation in Non-Uniform Flow and Correlation with the Near Pressure Field

Francisco Alves Pereira, Fabio Di Felice, Francesco Salvatore

Subject: Engineering, Marine Engineering Keywords: propeller; cavitation pattern; unsteady cavitation; induced pressure fluctuations; high-speed visualization; volume acceleration; cavitation-pressure correlations

Online: 5 September 2016 (09:37:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0011.v1

Curcumin Ameliorates Furazolidone Induced DNA Damage and Apoptosis in Human Hepatocyte L02 Cells via Inhibiting ROS Production and Mitochondrial Pathway

Chongshan Dai, Daowen Li, Lijing Gong, Xilong Xiao, Shusheng Tang

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: curcumin; furazolidone; oxidative stress; DNA damage; mitochondrial pathway

Online: 2 August 2016 (05:59:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0137.v1

An Efficient and High-Resolution Topology Optimization Method Based on Convolutional Neural Networks

Liang Xue, Jie Liu, Guilin Wen, Hongxin Wang

Subject: Computer Science And Mathematics, Mathematics Keywords: topology optimization; convolutional neural network; high-resolution

Online: 12 October 2019 (03:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0236.v1

An Assessment of Couple Stress Theories

Ali R. Hadjesfandiari, Gary F. Dargush

Subject: Physical Sciences, Applied Physics Keywords: couple stress theory; size-dependent mechanics; indeterminacies; curvature tensor; torsion tensor

Online: 9 November 2018 (04:01:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201607.0038.v1

Exploring The Magnetic Field Configuration Close To The Central Engines Using GMVA

Bindu Rani, Thomas Krichbaum, J. Hodgson, Shoko Koyama, Anton J. Zensus, Alan Marscher, Svetlana Jorstad, Lars Fuhramnn

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: active galaxies; BL Lacertae object: BL Lac; jets; GMVA: high-resolution VLBI; magnetic field; polarization

Online: 15 July 2016 (10:06:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0117.v1

Transcriptomic and Metabolomics Analyses Show that High Carbohydrate Induces Fatty Liver in Blunt Snout Bream (Megalobrama amblycephala)

Wassana Prisingkorn, Panita Prathomya, Han Liu, Fang-Yu Deng, Yu-Hua Zhao, Wei-Min Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: blunt snout bream; high carbohydrate; transcriptome; metabolomics; insulin resistance; fatty liver disease

Online: 26 January 2017 (03:52:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0466.v1

A Review on Response Mechanism of Plants to Drought Stress

Xinyi Yang, Meiqi Lu, Yvfei Wang, Yiran Wang, Zhijie Liu, Su Chen

Subject: Biology And Life Sciences, Plant Sciences Keywords: Drought stress; Osmotic regulation; LEA protein; ROS; Signaling; Drought-responsive gene

Online: 22 February 2021 (12:38:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0072.v1

Batch Fermentation Options for High Titer Bioethanol Production from a SPORL Pretreated Douglas-fir Forest Residue without Detoxification

Mingyan Yang, Hairui Ji, J.Y. ZHU

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: forest residue; pretreatment; liquefaction; enzymatic hydrolysis/saccharification; fermentation; high titer bioethanol; detoxification

Online: 8 August 2016 (10:39:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0322.v1

Comparative Analysis of Compiler Performances and Program Efficiency

Paul Tawo Bukie, Chinedu Leonard Udeze, Iwara Ofem Obono, Edim Bassey Edim

Subject: Computer Science And Mathematics, Computer Science Keywords: java virtual machine (jvm); high level programming languages; high performance computing (hpc); php framework; compiler

Online: 29 September 2019 (05:01:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0227.v2

Foliar Application of Y-Aminobutyric Acid (GABA) Improves Vegetative Growth, and the Physiological and Antioxidative Potential of Daucus Carota L. under Water Deficit Conditions

Rohina Bashir, Hafiza Naila Riaz, Muhammad Shafiq, Nusrat Parveen, Mekhled Mutiran Alenazi, Sumera Anwar, Abdullah Issa Alebidi

Subject: Biology And Life Sciences, Horticulture Keywords: oxidative stress; enzymatic antioxidants; malondialdehyde; membrane permeability; chlorophyll

Online: 28 March 2019 (11:15:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0292.v1

A Critical Review of the Material Characteristics of Additive Manufactured IN718 for High Temperature Application

Ching Kiat Yong, Gregory J. Gibbons, Geoff West

Subject: Chemistry And Materials Science, Biomaterials Keywords: laser powder bed fusion; Inconel 718; high temperature; material characterisation; laser shock peening

Online: 14 October 2020 (09:11:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0022.v1

Therapeutic Gardens – A healing environment for optimizing the health care experience of Alzheimer’s and dementia patients: A narrative review

Patrick Uwajeh, Mukaddes Polay, Timothy Onosahwo Iyendo

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Alzheimer’s disease; dementia; therapeutic environment; Virtual reality; Stress recovery; therapeutic gardens

Online: 2 October 2018 (11:03:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0044.v1

Effect of Constitutive Equations on Prediction Accuracy for Springback in Cold Stamping of TRIP1180

Ki-Young Seo, Jae-Hong Kim, Hyun-Seok Lee, Ji Hoon Kim, Byung-Min Kim

Subject: Engineering, Mechanical Engineering Keywords: advanced high strength steel; yield function; hardening model; springback; deformation mode

Online: 8 March 2017 (04:51:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0093.v1

Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-regulating Nrf2 Expression

Phiwayinkosi V. Dludla, Christo J. F. Muller, Elizabeth Joubert, Johan Louw, M. Faadiel Essop, Kwazi B. Gabuza, Samira Ghoor, Barbara Huisamen, Rabia Johnson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: diabetes mellitus; cardiomyopathy; hyperglycemia; oxidative stress; aspalathin; Nrf2

Online: 17 November 2016 (11:07:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202001.0025.v1

The Pathogenesis of Duodenal Ulcer and the Role of Helicobacter pylori in This Disease: A Systematic Review

Simon Xin Min Dong, Katelynn Jean Rowe, Connie Ching Yuen Chang

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: duodenal ulcer; pathogenesis; gastric acid; helicobacter pylori; psychosomatic disease; psychological stress

Online: 3 January 2020 (09:00:37 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0043.v1

Arms Race between Enveloped Viruses and the Host ERAD Machinery

Dylan A. Frabutt, Yong-Hui Zheng

Subject: Biology And Life Sciences, Virology Keywords: enveloped viruses; viral glycoproteins; endoplasmic reticulum-associated degradation; ERAD; unfolded protein response; UPR; ER stress

Online: 4 August 2016 (11:44:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0038.v1

On the Reynolds-Averaged Navier-Stokes Equations

Bohua Sun

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: turbulence; the Reynolds stress tensor; turbulence closure problem

Online: 2 July 2019 (09:53:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0023.v1

Observing---and Imaging---Active Galactic Nuclei with the Event Horizon Telescope

Vincent Fish, Kazunori Akiyama, Katherine Bouman, Andrew Chael, Michael Johnson, Sheperd Doeleman, Lindy Blackburn, John Wardle, William Freeman

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: jets---Galaxy: center---techniques: high angular resolution---techniques: image processing---techniques: interferometric

Online: 12 July 2016 (09:41:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0061.v1

Ozlem Koseoglu Ornek, Erdem Sevim

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Work-related stress; occupational stress; coping profile; garment workers; textile workers

Online: 7 February 2018 (10:26:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0138.v1

Danggui-Shaoyao-San, a Traditional Chinese Medicine, Relieved Depression and Cognitive Disorder Induced by Chronic Restraint Stress Involved in Regulating Dendritic Spines Remodeling

Kecheng Zhou, Junbin Yin, Huanghui Wu, Wei Hu, Zhen Gao, Fang Li, An'an Wu, Wen Wang, Junping Kou

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Danggui-Shaoyao-San, chronic restraint stress, learning and memory, anxiety/depression, structural plasticity

Online: 31 January 2017 (15:30:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0208.v1

Oligonol Attenuates Diabetes-Induced Pancreatic Damage by Inhibiting Inflammatory Responses via Oxidative Stress-Dependent MAPK/NF-kB Signaling

Chan Hum Park, Joo Young Lee, Sung Ho Shin, Min Yeong Kim, Eun Suk Lee, Yu Su Shin, Young Ock Kim, Sang Won Lee, Jae Sue Choi, Takako Yokozawa

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: oligonol; diabetes; pancreas; antioxidative stress; anti-inflammation

Online: 30 May 2017 (06:29:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201701.0121.v1

Development of Propulsion Inverter Control System for High-Speed Maglev Based on LS-LSM

Jeong-Min Jo, Jin-Ho Lee, Young-Jae Han, Chang-Young Lee, Kwan-Sub Lee

Subject: Engineering, Electrical And Electronic Engineering Keywords: high speed maglev; long-stator synchronous motor; propulsion inverter control system position estimator

Online: 26 January 2017 (08:58:39 CET)

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Preprint REVIEW | doi:10.20944/preprints201802.0104.v1

Myeloperoxidase as an Active Disease Biomarker: Its Recent Biochemical and Pathological Perspectives

Amjad A. Khan, Mohammad A. Alsahli, Arshad H. Rahmani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: myeloperoxidase, leukocytes, inflammation, oxidative stress, chronic diseases, disease biomarker

Online: 15 February 2018 (16:54:25 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0454.v1

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Jhoti Somanah-Bhugowandeen, Manish Putteeraj, Okezie Aruoma, Theeshan Bahorun

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Carica papaya; fermented papaya preparation (FPP); free radical scavenging; antioxidant; oxidative stress; anti-diabetic; anti-carcinogenic

Online: 24 July 2018 (11:39:50 CEST)

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Working Paper REVIEW

Overview of HVDC Technology

Neville Watson

Subject: Engineering, Electrical And Electronic Engineering Keywords: High Voltage Direct Current transmission (HVDC); Multi-terminal HVDC; Voltage Source Converter (CSC); Voltage Source Converter (VSC)

Online: 19 July 2020 (20:28:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0050.v1

Preparation and Evaluation of an Elusive Polymorph of Mefenamic Acid by High Pressure Techniques

Nasir Abbas, Iain Oswald, Colin R. Pulham

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: mefenamic acid; diamond anvil cell; high-pressure; polymorphism; high-pressure crystallization; non-steroidal anti-inflammatory drugs

Online: 8 March 2017 (08:58:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0023.v1

Effects of Biomimetic Shear Stress by Self-Assembled Gelatin Oleic Nanoparticles Containing Paclitaxel on the Behavior of Cancer Cell Lines in a Microfluidic System

Taehee Kang, Thuy Thi Thanh Tran, Kyung Taek Oh, Han-Gon Choi, Beom-Jin Lee

Subject: Chemistry And Materials Science, Nanotechnology Keywords: gelatin-oleic conjugate; self-assembled biodegradable nanoparticles; biomimetic shear stress; cell dynamic environment; cellular drug delivery; paclitaxel

Online: 4 April 2017 (10:59:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0074.v1

Novel Step-up DC-to-DC Converter with Isolated Transformer and Switched-Clamp Capacitor Techniques for Renewable Systems

Yong-Seng Wong, Jiann-Fuh Chen, Kuo-Bin Liu

Subject: Engineering, Electrical And Electronic Engineering Keywords: high voltage gain; switch-clamp capacitor; DC–DC converter; renewable energy

Online: 18 October 2016 (09:45:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0219.v1

Mapping Informal Settlements in the Middle East Environment using an Object-Based Machine-Learning Approach

Ahmad Fallatah, Simon Jones, David Mitchell

Subject: Computer Science And Mathematics, Information Systems Keywords: informal settlement indicators; very high resolution (VHR); urbanisation; sustainable development goals; object-based image analysis (OBIA); machine learning (ML); random forest (RF)

Online: 12 September 2018 (12:32:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0123.v1

Time Domain Strain/Stress Reconstruction Based on Empirical Mode Decomposition: Numerical Study and Experimental Validation

Jingjing He, Yibin Zhou, Xuefei Guan, Wei Zhang, Wei Fang Zhang, Yongming Liu

Subject: Engineering, Civil Engineering Keywords: limited sensor data; structural health monitoring; strain/stress response reconstruction; empirical mode decomposition

Online: 11 August 2016 (11:06:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0395.v1

V483a – an Emerging Mutation Hotspot of Sars-Cov-2

Omar Ashwaq, Pratibha Manickavasagam, Sk Manirul Haque

Subject: Biology And Life Sciences, Virology Keywords: Spike protein, V483A, substitution mutation, virus-host cell interaction, high transmission, infectivity.

Online: 17 September 2020 (10:43:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0122.v1

Performance Enhancement Techniques for Patch Antennas of Small Satellites

Zizung Yoon, Mayank Mayank, Enrico Stoll

Subject: Engineering, Electrical And Electronic Engineering Keywords: satellite communication, antenna optimization, high gain antenna

Online: 3 March 2021 (09:59:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201611.0087.v1

Critical Minireview: The Fate of tRNA^Cysduring Oxidative Stress in Bacillus subtilis

Juan Campos Guillen, George H. Jones, Carlos Saldaña Gutierrez, José Luis Hernández Flores, Julio Alfonso Cruz Medina, José Humberto Valenzuela Soto, Sergio Pacheco Hernández, Sergio Romero Gómez, Verónica Morales Tlalpan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bacillithiol; Bacillus; oxidative stress; tRNA

Online: 17 November 2016 (10:40:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0081.v1

Development and Application of a Wireless Sensor for Space Charge Density Measurement in an Ultra-High-Voltage, Direct-Current Environment

Encheng Xin, Yong Ju, Haiwen Yuan

Subject: Engineering, Control And Systems Engineering Keywords: Ultra High-voltage direct-current (UHVDC); space charge density; energy consumption; wireless communication; Zigbee

Online: 20 October 2016 (06:02:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0469.v1

Human Resource Information System and Work Stress during COVID-19 Pandemic

Misnal Munir, Amaliyah Amaliyah, Moses Glorino Rumambo Pandin

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: Hi-Tech HR; Human resources management; Work Stress; Covid-19

Online: 18 December 2020 (13:47:41 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0444.v1

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach

Aileen Hill, Sebastian Borosch, Carina Benstöm, Christina Neubauer, Patrick Meybohm, Pascal Langlois, Neill KJ Adhikari, Daren K Heyland, Christian Stoppe

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: vitamin C; ascorbic acid; cardiac surgery; antioxidant therapy; nutrient; oxidative stress; organ dysfunction; multi organ failure

Online: 27 June 2018 (12:29:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0097.v1

The Impact of Pelvic Floor Muscles Exercises with and without Synergistic Muscles on Quality of Life of Women with Stage I Stress Urinary Incontinence

Magdalena Ptak, Agnieszka Brodowska, Sylwester Ciećwież, Iwona Rotter

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: LUTS; stress urinary incontinence; perimenopause; pelvic floor

Online: 27 February 2017 (17:41:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0249.v1

The Influence of Stress on Professional Satisfaction of Multigrade Teachers: Evidence from the Philippines

Erwin Rotas

Subject: Business, Economics And Management, Accounting And Taxation Keywords: stress; professional satisfaction; multigrade

Online: 13 October 2020 (16:13:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0043.v1

Machine Learning for Stress Detection from Electrodermal Activity: A Scoping Review

Roberto Sánchez-Reolid, María T. López, Antonio Fernández-Caballero

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Electrodermal activity; Stress detection; Machine learning; Scoping review

Online: 2 November 2020 (13:37:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201708.0094.v2

Treatment, Palliative Care or Euthanasia? Comparing End of Life Issues in Veterinary and Human Medicine

Ruth E. Eyre-Pugh

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: euthanasia; veterinary ethics; medical ethics; end-of-life; assisted suicide; palliative care; assisted dying; moral stress

Online: 1 December 2017 (16:58:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0174.v1

An Agent-Based Modeling Framework for Simulating Human Exposure to Environmental Stresses in Urban Areas

Liang Emlyn Yang, Peter Hoffmann, Jürgen Scheffran, Sven Rühe, Jana Fischereit, Ingenuin Gasser

Subject: Social Sciences, Geography, Planning And Development Keywords: environmental stress; human exposure; agent-based model; air pollution; urban heat wave; exposure modeling; climate change

Online: 27 February 2018 (05:12:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0251.v1

Analysis of Morphological, Physiological, and Biochemical Traits of Salt Stress Tolerance in Asian Rice Cultivars at Different Stages

Maha A. Alshiekheid, Yheni Dwiningsih, Jawaher Alkahtani

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Asian rice; salt stress; morphology; physiology; biochemistry

Online: 14 March 2023 (06:51:35 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201805.0300.v1

Rett Syndrome: Treatment with IGF-1, Melatonin, Blackcurrant Extracts, and Rehabilitation

Jesús Devesa, Olga Devesa, María Carrillo, Nerea Casteleiro, Ana Devesa, David Llorente, Cristina González

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: IGF-1; MT; Blackcurrant extracts; Oxidative stress; Mecp2; Speech therapy; Neurostimulation; cyclic glycine-proline; GPE.

Online: 22 May 2018 (11:25:58 CEST)

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Working Paper ARTICLE

Treatment Strategies for Reducing Damages to Lungs in Coronavirus and Other Lung Infections

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: coronavirus COVID-19; SARS; MERS; viral reproduction; immune response; lung infection influenza; deep breathing; diet; emotional stress; lifestyle

Online: 23 March 2020 (06:34:44 CET)

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Preprint REVIEW | doi:10.20944/preprints201710.0185.v3

Epigenomics of Plant’s Responses to Environmental Stress

Suresh Kumar

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: epigenome; DNA modification; cytosine methylation; gene regulation; histone modification; 5-methylcytosine; stress response

Online: 25 December 2017 (09:43:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0099.v1

Advanced Glycation Endproducts form During Ovalbumin Digestion in the Presence of Fructose

Alejandro Gugliucci, Yasmin Bains, Russell Caccavello

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: ovalbumin, allergy; advanced glycation; fructose; fructositis; receptor for advanced glycation end products; inflammation; asthma; chlorogenic acid; Ilex paraguariensis; high fructose corn syrup

Online: 28 February 2017 (10:41:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0216.v1

A Dysbiotic Mycobiome Dominated by Candida albicans is Identified within Oral Squamous Cell Carcinomas

Manosha Perera, Nezar Noor Al-hebshi, Irosha Perera, Deepak Ipe, Glen Ulett, David J. Speicher, Tsute Chen, Newell W. Johnson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 18S rRNA; fungi; mycobiome; carcinoma; High-Throughput Nucleotide Sequencing; microbiome; mouth; squamous cell

Online: 30 March 2017 (05:37:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0077.v1

Agro-Industrial Avocado (Persea americana) Waste Biorefinery

Anthony Mora-Sandí, Abigail Ramírez-González, Luis Castillo-Henríquez, Mary Lopretti-Correa, José Roberto Vega-Baudrit

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: biorefinery; bioprocess; agro-industry; high-value products; Avocado

Online: 2 April 2021 (15:35:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0426.v1

When water runs dry and temperature heats up: Understanding the mechanisms in rice tolerance to drought and high temperature stress conditions

Roel Rabara, Joseph Msanne, Marilyn Ferrer, Supratim Basu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: rice, abiotic stress, high temperature, drought, physiological responses, molecular mechanisms, systems biology

Online: 26 June 2018 (15:30:20 CEST)

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Working Paper REVIEW

A New Perspective of Genetic Associations to the Cause of Multiple Sclerosis: The Role of Genes Expressed on Chromosomes 2 and 5

Robin Terese Montesano

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: multiple sclerosis; MS; cause; genes; polygenic; heredity; autoimmune; diet; depression; fatigue; suicide; seizures; bowel disorders; thyroid; mitochondria; chromosome 2; chromosome 5; glial cells; sunlight; vitamin D3; ultraviolet radiation; melanocyte stimulating hormone; melanocyte concentrating hormone; stress

Online: 22 July 2019 (04:37:27 CEST)

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The literature on the causation of multiple sclerosis (MS), both genetic and environmental, extends over hundreds of years, with no firm conclusions on the exact role of autoimmunity and lifestyle. The epidemiology of MS was the basis for this review, but with a new, extensive examination of genes pertaining to each disorder, and disease of first, and second, degree relatives of those with MS. The author’s motivation was to discover some relationship between MS, and notable familial conditions, as the heredity of MS is concluded to be 30%, and the disorders had a chronic and/or idiopathic nature. This investigation hoped to further understand the randomness of MS- who acquires it, and what symptoms develop- after the author’s decades of observing several incidences of multiple members developing MS in a single family. Online databases for the human genome were used to link genes to MS, and symptoms, including excessive depression, fatigue and suicide rates, in coordination with linking genes for specific familial conditions including seizures, stroke, mental illness, bowel disorders, and thyroid conditions. Interesting associations were found, notably a cluster of Th2 cytokines, known to cure the animal model of MS, important receptors for neurotransmitters and hormones, a gene specific to Epstein Barr Virus, and potential genes for mitochondrial dysfunction. The results surprised the author, showing polygenic regions of chromosome 2 and 5, especially a cluster at loci 5q31-q33, may be dysregulated. The conclusion agrees with past hypotheses MS results not from a single gene, but from various genes, including those expressed in glial cells. The individual theories to the causation of MS, starting with Charcot may be explained by multiple pathways converging into a single disease outcome. In coordination with a sunlight factor, chromosome 2 appears to mediate the immune system, and inflammation, through ultraviolet radiation producing vitamin D3 in the skin, but additionally through peptides formed in the melanocyte stimulating and concentrating hormone class. The impact of stress in MS could be primary, given the loci of several stress-related and stress-modulated genes on these chromosomes, and calls for more appreciation of, and greater care for, the MS patients’ state of mind.

Preprint ARTICLE | doi:10.20944/preprints201703.0024.v1

Inflammatory Bacteriome Featuring Fusobacterium nucleatum and Pseudomonas aeruginosa Identified in Association with Oral Squamous Cell Carcinoma

Nezar Noor Al-hebshi, Akram Thabet Nasher, Mohamed Yousef Maryoud, Husham E. Homeida, Tsute Chen, Ali Mohamed Idris, Newell W. Johnson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 16S rRNA; bacteria; bacteriome; carcinoma; High-Throughput Nucleotide Sequencing; microbiome; mouth; squamous cell

Online: 6 March 2017 (04:47:15 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201807.0221.v1

Combination High Energy with Stability: Polynitrogen Explosives N14 and N18

Jifeng Chen, Yi Yu, Yuchuan Li, Siping Pang

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: N14; N18; density functional theory (DFT); high energy; stability

Online: 13 July 2018 (03:35:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0016.v1

Nrf2 Inhibits Periodontal Ligament Stem Cell Apoptosis under Excessive Oxidative Stress

Yanli Liu, Hongxu Yang, Yinhua Zhao, Min Zhang, Yongjin Chen

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: periodontitis; the periodontal ligament stem cells; the nuclear factor-erythroid 2-related factor 2; oxidative stress; apoptosis

Online: 4 April 2017 (08:58:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0019.v1

A Model of Extracting Building from High Resolution Remote Sensing Image Based on Bayesian Convolutional Neural Networks

Xiaoxia Yang , Chengming Zhang, Shuai Gao, Fan Yu, Dejuan Song, Qingdi Wei, Yan Chen, Shouyi Wang

Subject: Computer Science And Mathematics, Analysis Keywords: high resolution remote sensing image; convolutional neural networks; full convolution networks; Bayesian convolutional neural networks; building extraction; conditional probability density function

Online: 3 January 2018 (04:46:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0111.v1

A Y-Shaped Microfluidic Device to Study the Combined Effect of Wall Shear Stress and ATP Signals on Intracellular Calcium Dynamics in Vascular Endothelial Cells

Zong-Zheng Chen, Zheng-Ming Gao, De-Pei Zeng, Bo Liu, Yong Luan, Kai-Rong Qin

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Y-shaped microfluidic device; wall shear stress; adenosine triphosphate (ATP) signal; combined effect; vascular endothelial cells; calcium dynamics

Online: 22 November 2016 (09:51:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0674.v1

Correlation Analysis of Different Measurement Places of Galvanic Skin Response in Test Groups Facing Valence and Arousal Changes

Andres Sanchez-Comas, Kåre Synnes, Diego Molina-Estren, Alexander Troncoso-Palacio, Zhoe Comas-González

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Stress; Wearable; Sensor; Physiological Signals; Galvanic Skin Response; GSR; Electrodermal activity; EDA; Valence and Arousal; Correlation

Online: 26 December 2020 (11:07:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0025.v1

Microorganisms: A Potential Source of Bioactive molecules for Antioxidants and Antimicrobial Applications

Alka Rani, Khem Chand Saini, Felix Bast, Sanjeet Mehariya, Shashi Kant Bhatia, Roberto Lavecchia, Antonio Zuorro

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Astaxanthin; natural antioxidant; bacteriocins; hispidin; oxidative stress

Online: 4 January 2021 (12:15:33 CET)

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Oxidative stress is an elevated intracellular level of free oxygen radicals that cause lipid peroxidation, protein denaturation, DNA hydroxylation, and apoptosis, ultimately negotiating cells viability. Antioxidants can scavenge such free radicals, thus reducing the oxidative stress and eventually prevent cellular damage. Medicinal plants, fruits, and spices remain the prioritized sources of antioxidants and antimicrobial properties since the time immemorial, but in contrast to plants, microorganisms can be grown at a faster rate under controlled conditions. They are non-toxic, non-carcinogenic, and biodegradable as compared to synthetic antioxidants. Microorganisms including actinomycetes, archaea, bacteria, protozoa, yeast, and fungi are auspicious source of vital bioactive compounds. The list comprises ample of bioactive components from microorganisms. One of them is bacteriocins, which are ribosomally synthesized antimicrobial peptides product of Eurotium sp., Streptomyces parvulus, S. thermophiles, Lactococcus lactis, etc. It has a great potential as next-generation antibiotics targeting the multiple-drug resistant pathogens. Pneumocandins are antifungal lipohexapeptides derived from the fungus Glarea lozoyensis, and inhibit 1,3-β-glucan synthase of the fungal cell wall and act as a precursor for the synthesis of caspofungin. It is widely used against invasive fungal infections and has been recently approved by the FDA. Taxol (paclitaxel), a chemotherapeutic drug derived from the bark of Taxus brevifolia can also be produced by endophytic fungi Taxomyces andreanae and Nodulisporium sylviforme. It is known to inhibit several fungi such as Pythium, Aphanomyces and Phytophthora. Hispidin and its derivate isolated from P. hispidus, reduce inducible nitric oxide synthase (iNOS) expression, obstruct the transcriptional activity of NF-κB, and also decrease the production of reactive oxygen species (ROS) in macrophages. Astaxanthin, known as an “aquatic” carotenoid produced by H. pluvialis, also has excellent ROS quenching activity. This study mainly focuses on fascinating antioxidant and antimicrobial compounds that have been scarcely investigated in microorganisms and discuss the promise and challenges of microorganisms as providers of health benefits.

Preprint ARTICLE | doi:10.20944/preprints201801.0021.v1

A New Biochemical Approach to Detect Oxidative Stress in Infertile Women Undergoing Assisted Reproductive Technology Procedures

Matteo Becatti, Rossella Fucci, Amanda Mannucci, Victoria Barygina, Marco Mugnaini, Luciana Criscuoli, Claudia Giachini, Francesco Bertocci, Rita Picone, Paolo Evangelisti, Francesca Rizzello, Cinzia Cozzi, Niccolò Taddei, Claudia Fiorillo, Maria Elisabetta Coccia

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: oxidative stress; in vitro fertilization (IVF); infertile women; follicular fluid (FF); granulosa cells

Online: 3 January 2018 (06:37:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0644.v1

Stress Classification of ECG-Derived HRV Features Extracted from Wearable Devices

Kayisan Mary Dalmeida, Giovanni Luca Masala

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: stress; wearable device; machine learning; smart watch; heart rate variability; electrocardiogram

Online: 25 March 2021 (16:24:00 CET)

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Preprint REVIEW | doi:10.20944/preprints201702.0047.v1

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

Manuela Aragno, Raffaella Mastrocola

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: advanced glycation end products; fructose; glucose; lipogenesis; sphingolipids; NLRP3; Nrf2; mitochondrial dysfunction; oxidative stress

Online: 14 February 2017 (08:38:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0072.v1

Three-Dimensional Modeling Interaction of Shock Wave with Fin at Mach 5

Amjad A. Pasha

Subject: Engineering, Mechanical Engineering Keywords: high speed flows; shock wave; turbulent boundary layer; shock-unsteadiness; separation bubble; turbulence modeling; single fin

Online: 26 July 2017 (07:48:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0140.v1

Host Availability, Repulsive Companion Planting, and Predation Interact and Shape How a Parthenogenetic Aphid Population Responds to a Stratified Ecological Challenge

Mouhammad Shadi Khudr, Lea Fliegner ‎, Oksana Y. Buzhdygan, Samuel Alexander Purkiss

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: shallot; cabbage; green peach aphid; lacewing; bio-stress; companion planting

Online: 13 January 2020 (15:47:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0070.v1

Oxidation of Human Serum Albumin Exhibits Inter-Individual Variability after an Ultra-Marathon Mountain Race

Ypatios Spanidis, Alexandros Priftis, Dimitrios Stagos, George A. Stravodimos, Demetres D. Leonidas, Demetrios Kouretas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: albumin; oxidative stress; exercise; ultra-marathon mountain race; protein oxidation

Online: 17 February 2017 (15:02:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0088.v2

Plasmonic Refractive Index Sensor with High Figure of Merit Based on Concentric-Rings Resonator

Zhaojian Zhang, Junbo Yang, Xin He, Jingjing Zhang, Jie Huang, Dingbo Chen, Yunxin Han

Subject: Physical Sciences, Optics And Photonics Keywords: plasmonic sensor; high figure of merit; concentric double rings resonator

Online: 20 December 2017 (10:07:32 CET)

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Working Paper ARTICLE

Plant-derived bioactives and oxidative stress-related disorders: a key trend towards health and longevity promotion

Bahare Salehi, Elena Azzini, Paolo Zucca, Elena Maria Varoni, Nanjangud V. Anil Kumar, Luciana Dini Dini, Elisa Panzarini Panzarini, Jovana Rajkovic, Patrick Valere Tsouh Fokou, Ilaria Peluso, Abhay Prakash Mishra, Manisha Nigam, Youssef El Rayess, Marc El Beyrouthy, William N. Setzer, Letizia Polito, Marcello Iriti, Miquel Martorell, Natália Martins, Leticia M Estevinho, Javad Sharifi-Rad

Subject: Biology And Life Sciences, Plant Sciences Keywords: medicinal plants; bioactive molecules; phenolic compounds; Oxidative stress; Antioxidants; chronic disorders; health maintenance; longevity

Online: 3 June 2019 (09:58:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0555.v1

Stress and Burnout Among Social Workers in The VUCA world of COVID-19 Pandemic

Gabriela Dima, Luiza Meseșan Schmitz, Marinela Cristina Șimon

Subject: Business, Economics And Management, Accounting And Taxation Keywords: COVID-19; social work/er; stress; burnout; VUCA

Online: 20 April 2021 (17:50:05 CEST)

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This paper aims to contribute to the advancement of scientific knowledge about the impact of the COVID-19 pandemic on social workers and the social work profession in Romania. Research has shown that social work is a profession at high risk for developing the burnout syndrome, which has many detrimental effects on both social workers and the clients that they serve. Two conceptual models are used to frame the discussion: the theoretical framework of VUCA (volatility, uncer-tainty, complexity, and ambiguity) to discuss the challenges of the unprecedented context the COVID-19 pandemic has created for social workers; stress and burnout to explain the negative impact of this period of time. Based on convergent mixt methods, the study sample consisted of 83 social workers employed in statutory and private social services in Romania, from different fields of intervention. Results show that 25,3% of respondents suffer from a high level of burnout and 44.6% scored in a range that indicate a medium level of burnout. A group of 31.1% have managed to handle stress factors in a healthy manner. Main stressors found are especially personal (fear of contamination, personal and family) and work-related factors (workload, new legislative rules and decisions, inconsistency, instability, ambiguity of managerial decisions, or even their absence or non-assumption, lack of clarity of working procedures, limited managerial and supervisory support, limited financial resources), less than client related factors (lack of direct contact, risk of contami-nation in two ways, managing beneficiaries fears, difficulties related to technology and digital skills). Study results point to the importance of organizational support and developing a self-care plan that help protect against occupational stress and burnout. Recommendations are made putting forward the voice of fieldworkers and managers fostering initiatives and applications of sustainability-based measures and activities designed to deal with the challenges of the VUCA environment.

Preprint ARTICLE | doi:10.20944/preprints201711.0035.v1

Comparison of Compressive Stress-Relaxation Behavior in Osteoarthritic (ICRS Graded) Human Articular Cartilage

Rajesh Kumar, David M. Pierce, Vidar Isaksen, Catharina de Lange Davies, Jon O. Drogset, Magnus B. Lilledahl

Subject: Physical Sciences, Applied Physics Keywords: stress relaxation; polymer dynamics; biomechanical characterization; articular cartilage; osteoarthritis

Online: 6 November 2017 (06:44:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0255.v1

A Review on Mental Stress Assessment Methods Using EEG Signals

Rateb Katmah, Fares Al-Shargie, Usman Tariq, Fabio Babiloni, Fadwa Al-Mughairbi, Hasan Al-Nashash

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental stress; EEG; data analysis; connectivity network; machine Learning

Online: 12 July 2021 (12:06:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0268.v1

Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease

Ayokanmi Ore, Oluseyi Adeboye Akinloye

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Liver; NAFLD; NASH; Biomarkers; Reactive Species; Oxidative Stress; Lipid Peroxidation; Antioxidants.

Online: 14 September 2018 (14:11:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0119.v1

Antioxidant and Anti-inflammatory Mechanisms of Astaxanthin in Cardiovascular Diseases

Carolina Parga Martins Pereira, Ana Carolina Remondi Souza, Andrea Rodrigues Vasconcelos, Pietra Sacramento Prado, José João Name

Subject: Biology And Life Sciences, Food Science And Technology Keywords: astaxanthin; cardiovascular disease; atherosclerosis; inflammation; oxidative stress; carotenoids; antioxidant

Online: 5 August 2020 (09:53:14 CEST)

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