Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications

Version 1 : Received: 4 June 2020 / Approved: 8 June 2020 / Online: 8 June 2020 (10:17:36 CEST)

How to cite: Hauschild, J.; Peterson, A.C.; Couzijn, E.; Denisov, E.; Chernyshev, D.; Hock, C.; Stewart, H.; Hartmer, R.; Grinfeld, D.; Thoeing, C.; Reitemeier, B.; Kreutzmann, A.; Lange, O.; Balschun, W.; Venckus, A.; Kanngiesser, S.; Kholomeev, A.; Quiring, G.; Czemper, F.; Wouters, E.; Belford, M.; Mueller, M.; Grote, J.; Arrey, T.N.; Kraegenbring, J.; Strupat, K.; Mohring, S.; Crone, C.; Harder, A.; Robitaille, A.; Gajadhar, A.; Motamed, K.; Liu, Y.; Lopez Ferrer, D.; Damoc, N.E.; Criscuolo, A.; Srzentic, K.; George, E.; Yang, C.; Ntai, I.; Souza, A.; Wieghaus, A.; Makarov, A. A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications. Preprints 2020, 2020060111 (doi: 10.20944/preprints202006.0111.v1). Hauschild, J.; Peterson, A.C.; Couzijn, E.; Denisov, E.; Chernyshev, D.; Hock, C.; Stewart, H.; Hartmer, R.; Grinfeld, D.; Thoeing, C.; Reitemeier, B.; Kreutzmann, A.; Lange, O.; Balschun, W.; Venckus, A.; Kanngiesser, S.; Kholomeev, A.; Quiring, G.; Czemper, F.; Wouters, E.; Belford, M.; Mueller, M.; Grote, J.; Arrey, T.N.; Kraegenbring, J.; Strupat, K.; Mohring, S.; Crone, C.; Harder, A.; Robitaille, A.; Gajadhar, A.; Motamed, K.; Liu, Y.; Lopez Ferrer, D.; Damoc, N.E.; Criscuolo, A.; Srzentic, K.; George, E.; Yang, C.; Ntai, I.; Souza, A.; Wieghaus, A.; Makarov, A. A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications. Preprints 2020, 2020060111 (doi: 10.20944/preprints202006.0111.v1).

Abstract

The rapidly increasing adoption of high-resolution accurate-mass methods in analytical laboratories has fueled demand for instruments that combine high performance and reliability with small size and greater ease-of-use. This paper presents the major design principles that are driving the evolution of the hybrid quadrupole-Orbitrap instrument architecture to enable a greater range of applications and users. These principles may be summarized as follows: better usage of physical space and better access for service by means of size reduction of pumping and ion optics; expanded use of technologies from electronics in ion-optical design; flexibility in performance via modularity of design of the hardware and software components; and, harmonization of interfaces with other instruments to facilitate sharing and transferability of analytical workflows. The design of a novel family of hybrid mass spectrometers is described in detail, and performance evaluation is carried out on a wide variety of samples for its three representatives: the Orbitrap Exploris 120, Orbitrap Exploris 240 and Orbitrap Exploris 480 mass spectrometers.The new instrument family is shown to offer compelling potential not only for high-end proteomics and biopharmaceutical applications, but also for screening, trace, targeted and clinical analysis by liquid chromatography/mass spectrometry methods.

Subject Areas

Orbitrap mass spectrometry; high resolution; accurate mass

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