Working Paper Article Version 2 This version is not peer-reviewed

Treatment Strategies for Reducing Damages to Lungs in Coronavirus and Other Lung Infections

Version 1 : Received: 6 February 2020 / Approved: 9 February 2020 / Online: 9 February 2020 (17:43:00 CET)
Version 2 : Received: 19 March 2020 / Approved: 23 March 2020 / Online: 23 March 2020 (06:34:44 CET)

How to cite: Wu, J.; Zha, P. Treatment Strategies for Reducing Damages to Lungs in Coronavirus and Other Lung Infections. Preprints 2020, 2020020116 Wu, J.; Zha, P. Treatment Strategies for Reducing Damages to Lungs in Coronavirus and Other Lung Infections. Preprints 2020, 2020020116

Abstract

We conducted many model simulations to understand the causes of the damages of coronavirus (COVID-19) to lung tissue and constructed a diagram showing apparent viral reproduction, immune response and damage accumulation curves. We found that lung damages include virus-caused damage, tissue damage caused by immune responses and tissue damage caused by accumulated wastes. The virus-caused damage is proportional to the phase lag between the viral reproduction curve and the delayed adaptive immune response curve, while waste-induced damage is attributed to imbalance in removing viral, cellular and metabolic by-products. We found that treatment strategies should slow down viral reproduction and speed up immune response, and improve blood micro-circulation in the lungs. Consistent with the strategies, measures are taken to void direct lung infection, strengthen innate responses, promote immune responses, dilute viral concentration in lung tissue, maintain waste removal balance, protect heart and kidneys, control other infections, avoid allergic reactions and other inflammation, etc. We show that medical, dietary, emotional, lifestyle, environmental, mechanical factors, etc. may be simultaneously used to mitigate lung damages and prove that multiple factor health optimization method is magnitudes more powerful than a single factor treatment. Such a method does not depend on molecular specificity and can be used in parallel to antiviral drugs.

Subject Areas

coronavirus COVID-19; SARS; MERS; viral reproduction; immune response; lung infection influenza; deep breathing; diet; emotional stress; lifestyle

Comments (1)

Comment 1
Received: 23 March 2020
Commenter: Jianqing Wu
Commenter's Conflict of Interests: Author
Comment: (1) Abstract wording (2) Add and rearrange references order (3) Add a drawing to Section E and rearrange this part (4) Keywords include COVID-19 All key elements are not changed and the core concept is the same.
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