Working Paper Article Version 1 This version is not peer-reviewed

Plant-derived bioactives and oxidative stress-related disorders: a key trend towards health and longevity promotion

Version 1 : Received: 30 May 2019 / Approved: 3 June 2019 / Online: 3 June 2019 (09:58:55 CEST)

How to cite: Salehi, B.; Azzini, E.; Zucca, P.; Varoni, E.M.; V. Anil Kumar, N.; Dini, L.D.; Panzarini, E.P.; Rajkovic, J.; Valere Tsouh Fokou, P.; Peluso, I.; Prakash Mishra, A.; Nigam, M.; El Rayess, Y.; El Beyrouthy, M.; N. Setzer, W.; Polito, L.; Iriti, M.; Martorell, M.; Martins, N.; M Estevinho, L.; Sharifi-Rad, J. Plant-derived bioactives and oxidative stress-related disorders: a key trend towards health and longevity promotion. Preprints 2019, 2019060015 Salehi, B.; Azzini, E.; Zucca, P.; Varoni, E.M.; V. Anil Kumar, N.; Dini, L.D.; Panzarini, E.P.; Rajkovic, J.; Valere Tsouh Fokou, P.; Peluso, I.; Prakash Mishra, A.; Nigam, M.; El Rayess, Y.; El Beyrouthy, M.; N. Setzer, W.; Polito, L.; Iriti, M.; Martorell, M.; Martins, N.; M Estevinho, L.; Sharifi-Rad, J. Plant-derived bioactives and oxidative stress-related disorders: a key trend towards health and longevity promotion. Preprints 2019, 2019060015

Abstract

Plants and its corresponding botanical preparations have been used for centuries due to their remarkable potentialities in both treatment and prevention of numerous affections. Hundreds of biologically active constituents are present in each whole plant matrice, working in synergism and conferring both its own protection against invaders and even providing promissory bioactive effects for human beings. The worldwide population has devoted increasing attention and preference by medicinal plants use for health promotion and disease prevention, and more recently for oxidative-stress related disorders protection. Indeed, oxidative stress-related disorders, like cardiovascular and (neuro) degenerative disorders, and even cancer have raised exponentially. Although oxidative stress is in itself intrinsic to our own metabolism, allarming sources of free radicals are daily affecting us. In fact, plant-derived bioactives present a broad spectrum of biological effects, and its antioxidant, anti-inflammatory and more recently anti-aging effects have been considered a hot topic among the medical and scientific community. Nonetheless, and although its numerous biological effects, it should not also be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview on plant-derived bioactives in oxidative stress-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is its therapeutic relevance in disease prevention. Finally, an eye-opening look in overall evidence in humans is also ensured.

Subject Areas

medicinal plants; bioactive molecules; phenolic compounds; Oxidative stress; Antioxidants; chronic disorders; health maintenance; longevity

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