Preprint Article Version 1 NOT YET PEER-REVIEWED

Preparation and Evaluation of an Elusive Polymorph of Mefenamic Acid by High Pressure Techniques

Version 1 : Received: 8 March 2017 / Approved: 8 March 2017 / Online: 8 March 2017 (08:58:38 CET)

A peer-reviewed article of this Preprint also exists.

Abbas, N.; Oswald, I.D.H.; Pulham, C.R. Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation. Pharmaceutics 2017, 9, 16. Abbas, N.; Oswald, I.D.H.; Pulham, C.R. Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation. Pharmaceutics 2017, 9, 16.

Journal reference: Pharmaceutics 2017, 9, 16
DOI: 10.3390/pharmaceutics9020016

Abstract

High pressure crystallization technique has been successfully used to prepare an elusive form II of a non-steroidal anti-inflammatory drug, Mefenamic acid. Single crystal of form II was grown at 0.3 GPa from an 4:1 methanol/ ethanol mixture as a solvent using Diamond Anvil Cell. Comparison of crystal structures show that the efficient packing of MA molecules in Form II results from the structural flexibility of MA acid molecules. Compression studies performed on the single crystal of form I resulted in 14 % decrease of unit cell volume up to 2.5 GPa. No phase transition was observed up to this pressure. A reconstructive phase transition is required to induce conformational changes in the structure, which is confirmed by crystallization at high pressure results.

Subject Areas

mefenamic acid; diamond anvil cell; high-pressure; polymorphism; high-pressure crystallization; non-steroidal anti-inflammatory drugs

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