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Preprint ARTICLE | doi:10.20944/preprints202306.1106.v1

An Explainable Vision Transformer Model Based White Blood Cells Classification and Localization

Oguzhan Katar, Ozal Yildirim

Subject: Engineering, Other Keywords: Vision Transformers; white blood cells; explainable AI models; deep learning; Score-CAM

Online: 15 June 2023 (08:42:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2150.v1

Chloroplast Genome Comparison and Evolution Analysis of Dendrobium (Orchidaceae) among Multiple Photosynthetic Pathways

Yajun Lin, Shibao Zhang, Jun Duan, Jingshan Shi, Ding-Kun Liu, Siren Lan, Zhong-Jian Liu, Ming-He Li

Subject: Biology And Life Sciences, Plant Sciences Keywords: Dendrobium; Orchidaceae; Chloroplast genome; CAM evolution

Online: 29 December 2023 (01:05:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1226.v1

Clinical Applications of CAD-CAM Materials in Restorative and Prosthetic Dentistry: A Narrative Review

Imena Rexhepi, Manlio Santilli, Gianmaria D’Addazio, Giuseppe Tafuri, Eugenio Manciocchi, Sergio Caputi, Bruna Sinjari

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: CAD-CAM materials; digital dentistry; prosthodontics

Online: 18 July 2023 (11:30:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2052.v1

Geomicrobiological Control on Arsenic Heterogeneity – The Taciturn Factor Controlled by Rural Sanitation System

Pinaki Ghosh, Debjani Mandal, Mina Aghababaei, Jishnu Adhikari, Indranil Saha, Jayanta Kumar Biswas, Debashis Chatterjee, Abhishek Basu, Santanu Majumder

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Groundwater; Surface water; Arsenic; Sanitary risk score; Fecal coliform score

Online: 28 June 2023 (15:54:39 CEST)

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Arsenic (As) contamination of groundwater is a common problem in BDP. The alkaline pH of the groundwater provides favourable condition for geomicrobiochemical processes, where organic matter also plays an important role in mobilization of As. The total arsenic content (AsT) of the groundwater is in the range of 69-178 µgL-1 with mean value of 118.58 µgL-1. The groundwater quality of monitored drinking water wells are related to local land–use pattern and rural sanitation installation and practices (which can have a strong influence on microbial contamination). The study indicates that As heterogeneity, probably a consequence of microbial heterogeneity is a feature of the study area. The excessive total and fecal coliform (TC and FC) count of the ponds possibly suggest uncontrolled surface run offs and sewage leakage, notably from nearby pit-latrine, which increased the microbial contamination in these water sources. The tube wells located in close proximity (~ 2-3 m) of the surveyed ponds are also contaminated with high TC and FC values, due to faulty water supply system, pond water infiltration and cracked tube well platforms. Coliforms may influence geomicrobiological processes in groundwater and thereby, contribute in As release and mobilization. The TC and FC values of monitored tube wells and ponds show seasonal variation, with high TC and FC values during wet season. Attempt has been made to focus on sanitation risk of the monitored wells (based on sanitation and fecal coliform scores) which is usually less explored. The sanitary risk score reveal the need of immediate attention to all the sites, as 25.0 %, 58.3 %, 11.1 % and 5 % of tube wells of the six sites fell under very high risk (sanitary risk score ≥ 9), high risk (sanitary risk score 6-8), intermediate risk (sanitary risk score 3-5) and low risk category (sanitary risk score 0-2), respectively. Fecal coliform score classified all the sites under intermediate risk category (FC count 10-100 per 100 ml of water). The predominance of As heterogeneity particularly in areas under high risk category (showing high TC and FC contamination) is observed along with the similar sinusoidal pattern of TC, FC and AsT content. Finally, this study shed light on the factors responsible for unsafe nature of monitored tube wells and the influence of anthropogenic activities on the microenvironment of the groundwater, which could be a probable reason behind the As heterogeneity in the groundwater of the study area.

Preprint ARTICLE | doi:10.20944/preprints202210.0002.v1

Therapeutic Approach of Anticoagulants and Acute Blood Purification for Patients with Sepsis-Induced Disseminated Intravascular Coagulation: Post-marketing Surveillance Data of Antithrombin Supplementation

Yutaka Eguchi, Hiroyuki Nagafuchi, Toshiaki Ikeda

Subject: Medicine And Pharmacology, Hematology Keywords: antithrombin; recombinant thrombomodulin; SOFA score; JAAM DIC score; PMX-DHP

Online: 1 October 2022 (07:09:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0456.v1

Systemic Inflammatory Response and the Noble and Underwood (Nun) Score as Early Predictors of Anastomotic Leakage after Esophageal Reconstructive Surgery

Elke Van Daele, Hanne Vanommeslaeghe, Flo Decostere, Louise Beckers Perletti, Esther Beel, Yves Van Nieuwenhove, Wim Ceelen, Piet Pattyn

Subject: Medicine And Pharmacology, Surgery Keywords: NUn score; esophagectomy; anastomotic leakage; risk score; esophageal cancer; inflammatory biomarkers

Online: 5 January 2024 (10:38:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0209.v1

Characterization of Microbiota in Bronchiectasis Patients with Different Disease Severities

Sang Hoon Lee, YeonJoo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Choon-Taek Lee, Jae Ho Lee

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: bronchiectasis; FACED score; microbiome

Online: 10 October 2018 (08:14:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1229.v1

Role of Protein Tyrosine Phosphatase Receptor Type E (PTPRE) in Chemoresistant Retinoblastoma

Lars Mohren, Annika Doege, Natalia Miroschnikov, Oliver Dräger, Maike Anna Busch, Nicole Dünker

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: PTPRE; miR631; retinoblastoma; CAM assay; etoposide; chemoresistance; tumorigenesis

Online: 20 March 2024 (13:13:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0455.v1

Biofilm Formation on Hybrid, Resin–Based CAD/CAM Materials for Indirect Restorations: A Comprehensive Review

Konstantinos Tzimas, Christos Rahiotis, Eftychia Pappa

Subject: Chemistry And Materials Science, Biomaterials Keywords: CAD/CAM; biofilm; resin-based biomaterials; dental materials

Online: 8 March 2024 (03:54:42 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202209.0409.v1

Comparison of 0.12% Chlorhexidine and a New Bone Bioactive Liquid, BBL, Mouthrinses on Oral Wound Healing: A Randomized, Double Blind Clinical Human Trial

Eduard Ferrés-Amat, Ashraf Al Madhoun, Elvira Ferrés-Amat, Neus Carreo, Miguel Barrajas, Areej Said Al-Madhoun, Eduard Ferrés-Padró, Carles Marti, Maher Atari

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chlorhexidine; bioactive liquid; oral wound healing; pain index score; early wound healing score

Online: 27 September 2022 (03:37:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0351.v1

Smoking Topography among Korean Smokers: Intensive Smoking Behavior with Larger Puff Volume and Shorter Interpuff Interval

Sungroul Kim, Sol Yu

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: topography; cotinine; fagerstrom score; addiction

Online: 27 April 2018 (06:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0846.v1

Impact of Technology Teaching in the Dental Predoctoral Curriculum on Students’ Perception of Digital Dentistry

Leonardo M. Nassani, Sompop Bencharit, Fernanda Schumacher, Wei-En Lu, Rodrigo Resende, Gustavo Vicentis Oliveira Fernandes

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Digital Dentistry; CAD/CAM; Technology; Dental studentds; Practice management

Online: 10 January 2024 (14:41:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1181.v1

In-Vitro Comparative Study of Compressive Strength in CAD/CAM Dental Materials

Antonela Marcela Berar, Mircea Cristian Dudescu, Matthieu Carbonel, Vlad Bocanet, Smaranda Dana Buduru

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: CAD/CAM; nanoceramic resin; graphene-reinforced polymer; compressive strength

Online: 19 September 2023 (05:20:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0430.v1

CAM Model: Intriguing Natural Bioreactor for Sustainable Research and Reliable/Versatile Testing

Carla Palumbo, Federica Sisi, Marta Checchi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: chorioallantoic Membrane (CAM); angiogenesis; organotypic culture; engineered 3D scaffold

Online: 7 August 2023 (03:01:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0141.v1

Comparative Fracture Resistance Analysis of Translucent Monolithic Zirconia Dioxide Milled in a CAD/CAM System

Cristian Abad-Coronel, Ángeles Paladines, Analiz Ulloa, Cesar A. Paltán, Jorge I. Fajardo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: zirconia; monolithic; multilayer zirconia; fracture resistance; CAD/CAM materials.

Online: 3 May 2023 (11:06:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1318.v1

Naples Prognostic Score Is a Useful Tool to Assess the Surgical Treatment in Non-small Cell Lung Cancer

Stefano Elia, Alexandro Patirelis, Georgia F. Hardavella, Antonella Santone, Federica Carlea, Eugenio Pompeo

Subject: Medicine And Pharmacology, Surgery Keywords: Non-small cell lung cancer; prognosis; Naples Prognostic Score; thoracic surgery; survival; prognostic score.

Online: 22 November 2023 (07:45:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0320.v1

Performance Analysis of Segmentation and Classification of CT scanned Ovarian Tumours using UNet and Deep Convolutional Neural Networks

Ashwini Kodipalli, Vaishnavi Gururaj, Shriya VR, Steven L Fernandes, Santosh Dasar

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Ovarian Tumours; UNet; Convolutional Neural Networks; VGG 16; DenseNet; ResNet; Dice score; Jaccard score

Online: 13 April 2023 (10:50:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1832.v1

Development and Validation of a Machine Learning Model for Predicting Endoscopic Intervention in Upper Gastrointestinal Bleeding

Omran A. Abu-Dhaim, Abdel-Latif Mughrabi Sabbagh, Yaman B. Ahmed, Daoud O. Al Aruri, Owais Ghammaz, Yaser M. Rayyan, Omar Alqudah, Mu'taz M Massad, Karam I. Khraim, Mustafa Q. Khasawneh, Laith F. Alquran, Batool N. AlQadri, Qasim N. Mhaidat, Hamza Alhawamleh, Own M. Al-Ajlouni, Khalil I. Hamarneh, Mohammad A. Hussein, Lina N. Mustafa, Basel E. Al-Bkoor, Amro Alkhatib, Layla Abu Joudeh, Osama Alghafri, Niazy Abu Farsakh

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: upper gastrointestinal bleeding; machine learning; endoscopic intervention; gradient boosting classifier; Glasgow Blatchford Score; Rockall Score

Online: 29 March 2024 (11:53:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1533.v1

Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience

Masaya Ito, Chiyoko Makita, Takayuki Mori, Hirota Takano, Tomoyasu Kumano, Masayuki Matsuo, Koji Iinuma, Makoto Kawase, Keita Nakane, Masahiro Nakano, Tomoyasu Kumano

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostate cancer; brachytherapy; lower urinary tract symptom; international prostate symptom score (IPSS); overactive bladder symptom score (OABSS)

Online: 22 May 2023 (16:28:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0552.v1

Assessment of Contemporary Fabrication Technologies for Post and Core Restorations - A Narrative Review

Mariya Dimitrova, Angelina Vlahova, Rada Kazakova

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: post and core restorations; CAD/CAM; semi-digital; prosthodontics; digital dentistry

Online: 8 April 2024 (15:44:33 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202402.1402.v1

The Accuracy of 3D-Printed Fixed Dental Restorations

Amirah Alammar, Wael Att, Florian Beuer

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: 3d-printing; polymer-based materials; accuracy; FDPs; DLP; SLA; CAD/CAM

Online: 27 February 2024 (10:15:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1603.v1

The making of Surgical Guides for TADs

Michiko Aonuma, Shingo Shirahama, Atsumoto Shimizu, Cristian Romanec, George Anka

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: TADs; Surgical guides; Anatomical places; 3D movement; CAD/CAM; 3D printer

Online: 24 July 2023 (11:14:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1722.v1

Biofilm Adhesion and Micromorphology Analysis After Professional Oral Hygiene Procedures on Cad/Cam Milled and Veneered Zirconia Restorations – In Vitro Study

Mirjana Perić, Aleksandra Čairović, Aleksandra Špadijer Gostović, Dragan Stanimirović, Marina Kostić, Marija Ivanov, Ana Ćirić, Jasmina Glamocija, Vladimir B. Pavlovic

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: Zirconia; CAD/CAM; ultrasonic scaling; SEM; surface micro topography; microbial biofilm;

Online: 25 June 2023 (07:13:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0267.v1

A CNN-Based Approach for the Driver Drowsiness Detection by Real-Time Eye State Identification

Ruben Florez, Facundo Palomino-Quispe, Roger Jesus Coaquira-Castillo, Julio Cesar Herrera-Levano, Thuanne Paixão, Ana Beatriz Alvarez

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Driver Monitoring System; Drowsiness Detection; Convolutional Neural Network; Grad-CAM Visualization

Online: 5 June 2023 (08:26:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0711.v1

A Novel Irrigation System to Reduce Heat Generation During Guided Implantology: An In Vitro Study

Somayeh Parvizi, Andrew Cameron, Santosh Tadakamadla, Carlos Marcelo S. Figueredo, Peter Reher

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental implants; surgical guide; irrigation channels; Thermocouples; 3D printing; CAD/CAM

Online: 10 May 2023 (08:23:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0285.v1

The Chick Embryo Xenograft Model for Malignant Pleural Mesothelioma: A Cost and Time Efficient 3Rs Model for Target and Compound Evaluation

Sarah E Barnett, Anne Herrmann, Elisabeth Gash, Harish Poptani, Joseph J Sacco, Judy M Coulson

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: mesothelioma; chick embryo; CAM; xenograft; bioluminescence; fluorescence; histology; MRI; preclinical; 3Rs

Online: 20 September 2022 (02:48:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0296.v1

Clinical Performance of CAD/CAM All-ceramic Tooth-supported Fixed Dental Prostheses: A Systematic Review and Meta-analysis

Babak Saravi, Andreas Vollmer, Maja Hartmann, Gernot Lang, Ralf-Joachim Kohal, Martin Boeker, Sebastian B. M. Patzelt

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: CAD/CAM; dental restoration; ceramic; all-ceramic; survival; fixed dental prosthesis

Online: 13 May 2021 (13:18:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0402.v1

Comparison of Time Required for Guided Implant Site Preparation with Two Different Template Designs and Dedicated Surgical Kits: An In Vitro Study

Łukasz Zadrożny, Marta Czajkowska, Eitan Mijiritsky, Marco Tallarico, Leopold Wagner

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: digital guides; CAD/CAM; metal sleeves; dental implants; time of surgery

Online: 16 December 2020 (10:18:10 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201710.0069.v1

Treatment of Severely Resorbed Maxilla Due to Peri-Implantitis by Guided Bone Regeneration Using a Customized Allogenic Bone Block: A Case Report

Oliver Blume, Lisa Hoffmann, Phil Donkiewicz, Sabine Wenisch, Michael Back, Reinhard Schnettler, Mike Barbeck

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: bone block; allograft; tissue reaction; Guided Bone Regeneration (GBR); CAD/CAM

Online: 11 October 2017 (12:12:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0821.v1

Prediction of Difficult Airway Using Arne Score and Flexible Laryngoscopy in Patients with Laryngeal Pathology

Danica Zlatimir Markovic, Maja Šurbatović, Dušan Milisavljević, Vesna Marjanović, Biljana D. Stošić, Milan Stankovic

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Laryngoscopy; Airway Assessment; Intubation; difficult; Risk Score

Online: 14 March 2024 (09:32:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0495.v1

Movement Analysis to Predict Broiler Walking Ability

Danilo Florentino Pereira, Irenilza de Alencar Nääs, Nilsa Duarte da Silva Lima

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: computing image analysis; gait score; unrest index

Online: 19 April 2021 (14:17:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0164.v1

Decentralization and Transboundary Pollution: Evidence from the Change of Water Pollution Levels in China

Yongliang Yang, Manhong Shen

Subject: Business, Economics And Management, Economics Keywords: Boundary effect; Transboundary pollution; Propensity Score Matching

Online: 20 March 2017 (17:33:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1153.v1

Fracture Resistance Analysis of 3D-Printed and Prefabricated Artificial Teeth for Removable Dentures

Mariya Dimitrova, Rada Kazakova, Angelina Vlahova

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: 3D – printing; CAD/CAM; fracture resistance; removable dentures; prefabricated teeth; fracture toughness

Online: 17 April 2024 (13:23:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0585.v1

Effect of Spindle Speed and Feed Rate on Surface Roughness and Milling Duration in Fabrication of the Milled Complete Dentures: An In Vitro Study

Yo Akiyama, Maiko Iwaki, Yuriko Komagamine, Shunsuke Minakuchi, Manabu Kanazawa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: CAD/CAM; milled denture; surface roughness; spindle speed; feed rate; fabrication time

Online: 9 November 2023 (09:14:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1456.v1

Effect of Laser Irradiation to Surfaces of CAD/CAM Resin Blocks Coated with Silane Coupling Agent on Bond Strengths between the Resin Blocks and Composite Resin

Hiroshi Ohno, Masaya Suzuki, Koichi Shinkai

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: CAD/CAM resin blocks; silane heat treatment; shear bond strength; semiconductor laser

Online: 24 October 2023 (04:04:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1681.v1

Delayed Orbital Floor Reconstruction Using a Mirroring Technique and patient-specific implants: a prospective clinical study.

Diana D'Alpaos, Giovanni Badiali, Francesco Ceccariglia, Achille Tarsitano

Subject: Medicine And Pharmacology, Surgery Keywords: orbital reconstruction, enophthalmos, CAD-CAM technique, titanium mesh, HDPE implant, personalized surgery.

Online: 25 July 2023 (11:44:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0547.v1

3D Printed Orthodontic Distalizer with Individual Base for Tooth-Borne Hybrid Approach in Class II Unilateral Malocclusions Treatment

Andrej Thurzo, Wanda Urbanová, Bohuslav Novák, Iveta Waczulíková, Ivan Varga

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: biocompatible 3D printing; photopolymers; orthodontics; distalizer; CAD/CAM; personalized treatment; computer modeling

Online: 29 November 2021 (15:38:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0892.v1

Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors

Lara M. Ruiz Belmonte, Patricia Carrera-Lasfuentes, Alberto Cebollada-Solanas, Carmelo Scarpignato, Angel Lanas, Carla J. Gargallo-Puyuelo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: colorectal neoplasia; cardiovascular risk; risk factors; predictive score

Online: 15 April 2024 (08:56:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1599.v1

Şengül Demiral, Meltem Nazıroğlu, Nurper Özbar, Cüneyt Taşkın

Subject: Social Sciences, Other Keywords: score analysis; competitive performance; performance analysis; covid-19

Online: 28 February 2024 (07:59:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1394.v1

Distributed Subgraph Query Processing Using Filtering Scores on Spark

Kyoungsoo Bok, Minyoung Kim, Hyeonbyeong Lee, Dojin Choi, Jongtae Lim, Jaesoo Yoo

Subject: Computer Science And Mathematics, Computer Science Keywords: subgraph query; search order; distributed graph; filtering score

Online: 20 July 2023 (08:17:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0539.v1

Communication Networks used by Smallholder Livestock Farmers in Disease Outbreaks: Case Study of the Free State, South Africa

Christopher Nwafor, Ifeoma Nwafor

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Correlation; Disease; Extension; Information-Score; Livestock; Perceived-Usefulness

Online: 25 August 2020 (05:01:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0431.v2

Prediction of Postoperative Outcomes Following Hip Fracture Surgery: Independent Validation and Recalibration of the Nottingham Hip Fracture Score

William J. Doherty, Thomas A. Stubbs, Andrew Chaplin, Mike R. Reed, Avan A. Sayer, Miles D. Witham, Antony K. Sorial

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Hip fracture; Casemix; Validation; Discrimination; Risk score; Calibration

Online: 9 July 2020 (17:23:04 CEST)

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Objectives Independent validation of risk scores after hip fracture is uncommon, particularly for evaluation of outcomes other than death. We aimed to assess the Nottingham Hip Fracture Score (NHFS) for prediction of mortality, physical function, length of stay and postoperative complications. Design Analysis of routinely collected prospective data partly collected by follow-up interviews. Setting and Participants Consecutive hip fracture patients were identified from the Northumbria hip fracture database between 2014-2018. Patients were excluded if they were not surgically managed or if scores for predictive variables were missing. Methods C-statistics were calculated to test the discriminant ability of the NHFS, Abbreviated Mental Test Score (AMTS), and ASA grade for in-hospital, 30- and 120-day mortality, functional independence at discharge, 30-days and 120-days, length of stay, and postoperative complications. Results We analysed data from 3208 individuals, mean age 82.6 (SD 8.6). 2192 (70.9%) were female. 194 (6.3%) died during the first 30-days, 1686 (54.5%) were discharged to their own home, 211 (6.8%) had no mobility at 120-days, 141 (4.6%) experienced a postoperative complication. The median length of stay was 18 days (IQR 8-28). For mortality, c-statistics for the NHFS ranged from 0.68-0.69, similar to ASA and AMTS. For postoperative mobility, the c-statistics for the NHFS ranged from 0.74-0.83, similar to AMTS (0.61-0.82) and better than the ASA grade (0.68-0.71). Length of stay was significantly correlated with each score (p<0.001 by Jonckheere-Terpstra test); NHFS and AMTS showed inverted U-shaped relationships with length of stay. For postoperative complications, c-statistics for NHFS (0.54-0.59) were similar to ASA grade (0.53-0.61) and AMTS (0.50-0.58). Conclusions and Implications The NHFS performed consistently well in predicting functional outcomes, moderately in predicting mortality, but less well in predicting length of stay and complications. There remains room for improvement by adding further predictors such as measures of physical performance in future analyses.

Preprint ARTICLE | doi:10.20944/preprints201810.0171.v3

Clinical Relevance of Genome-Wide Polygenic Score may Be Less than Claimed

David Curtis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genome-wide polygenic score; coronary artery disease; AUC

Online: 6 December 2018 (07:06:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0398.v1

Trajectory of Type 2 Diabetes in Sepsis Outcome: Impacts of Diabetic Complication Burdens, Initial Glucose Level, and HbA1c: Population-Based Cohort Study Combining with Nationwide and Hospital-Based Database

Ming-Shun Hsieh, Sung-Yuan Hu, Chorng-Kuang How, Yi-Tzu Lee, Chen-June Seak, Vivian Chia-Rong Hsieh, Jen-Huai Chiang, Chiann-Yi Hsu, Sheng-Hsiang Ma, Pau-Chung Chen

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetes mellitus; sepsis; diabetes complication severity index score

Online: 22 July 2018 (10:54:29 CEST)

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Background Diabetic patients have an increased risk of infections; however, the association between type 2 diabetes and hospital outcomes of sepsis remains controversial when the diabetes severity is not considered. We examined this association using nationwide and hospital-based databases concomitantly. Methods The first part of this study was conducted using 2 nationwide databases: the Longitudinal Cohort of Diabetes Patients and the Longitudinal Health Insurance Database 2000. The diabetic complication burden was evaluated using the adapted Diabetes Complications Severity Index score (aDCSI score). In the second part, we used the hospital-based database with laboratory data, such as initial blood glucose and HbA1c levels, to make comparisons between surviving and dead patients with type 2 diabetes and sepsis. Results The nationwide study included 19,719 type 2 diabetic sepsis patients and an equal number of non-diabetic patients. The diabetic sepsis patients had an increased odds ratio (OR) of 1.14 (95% CI 1.1-1.19) for hospital mortality. The OR for mortality increased as the complication burden increased (diabetic sepsis patients with aDCSI scores of 0, 1, 2, 3, 4, and ≥5 had ORs of 0.91, 0.87, 1.14, 1.25, 1.56, and 1.77 for mortality, respectively (all P<0.001 and P for trend <0.001)). A total of 1,054 diabetic sepsis patients were included from the hospital-based database. Initial blood glucose levels in the surviving and dead diabetic sepsis patients did not differ significantly: 273.9 ± 180.3 versus 266.1 ± 200.2 (mg/dL) (P=0.095). Moreover, the surviving diabetic sepsis patients did not have a lower HbA1c (%): 8.4 ± 2.6 versus 8.0 ± 2.5 (P=0.078). Conclusions In the case of type 2 diabetic sepsis patients, the diabetes-related complication burden is the major determinant of hospital mortality rather than the diabetes itself. Contrary to popular belief, initial blood glucose and HbA1c levels may not be as important as previously thought.

Preprint ARTICLE | doi:10.20944/preprints201902.0193.v1

Some of the Latest Active Strengthening Techniques for Masonry Buildings: A Critical Analysis

Elena Ferretti, Giovanni Pascale

Subject: Engineering, Civil Engineering Keywords: retrofitting; earthquakes; masonry; historical buildings; active reinforcement; Mohr’s circles; CAM system; Φ system

Online: 20 February 2019 (12:18:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0093.v1

Comparative Analysis of Surface Topography of Custom CAD/CAM ZirconiaAbutments by means of Optical Profilometry

Peter Gehrke, Wolfgang Kaiser, Carsten Fischer, Günter Dhom

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: CAD/CAM implant abutments; zirconia; surface roughness; soft tissue adhesion; focus variation microscopy

Online: 20 September 2017 (05:28:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0958.v1

The Efficacy of Intrathecal Dexmedetomidine VS Fentanyl on Post-Operative Pain: A Retrospective Study

Lou’i Al-Husinat, Sarah Al Sharie, Mohammad Araydah, Lana Talafha, Abbas Baydoun, Zaid AL Modanat, Giovanna Grasso, Silvia Tripepi, Maria Rosaria Cuomo, Mohammad Wasfi Amir, Domenico Gammaldi, Antonella Paladini, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: dexmedetomidine; fentanyl; spinal anesthesia; post-operative pain; VAS score

Online: 12 January 2024 (05:23:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0816.v1

Recalibration of Framingham Risk Score for Predicting 10-Year Cardiovascular Disease Risk in a South Indian Population

Thirunavukkarasu Sathish, Midhun Sasikumar, Getu Debalkie Demissie, Thyparambil Aravindakshan ParmodKumar, Brian Oldenburg, Anu Mary Oommen

Subject: Public Health And Healthcare, Other Keywords: Framingham Risk Score; cardiovascular disease; prediction; risk factors; recalibration

Online: 12 October 2023 (16:24:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1083.v1

Impact of Policy Packages on Beef Cattle Breeding in China: Evidence from 297 Beef Cattle Farmers

Junru Li, Zizhong Shi

Subject: Business, Economics And Management, Economics Keywords: beef cattle farming; supportive policies; evaluation; propensity score matching

Online: 18 September 2023 (05:52:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0820.v1

Dietary Pattern, Nutrition-Related Knowledge and Attitudes of Working Women in Western Province, Sri Lanka

Ayesha Salwathura, Faruk Ahmed

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Dietary Pattern; Dietary Diversity Score; Nutrition Knowledge; Nutrition Attitudes

Online: 12 June 2023 (10:13:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0305.v1

Polygenic Risk Score and Risk Factors for Gestational Diabetes

Marija Majda Perisic, Klemo Vladimir, Mario Storga, Ali Mostashari, Raya Khanin

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: gestational diabetes; pregnancy; polygenic risk score; gwas; machine learning

Online: 20 July 2022 (12:09:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0441.v1

The Moderating Role of CSR On the Antecedents And Out Come of Earnings Management in The Iraqi Firm

Mohammed Ghanim Ahmed, Yuvaraj Ganesan, Fathyah Hashim

Subject: Business, Economics And Management, Accounting And Taxation Keywords: board independence; audit committee; meeting frequency; M-score model

Online: 24 November 2021 (08:08:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0289.v3

Internet Access and Nutritional Intake: Evidence from Rural China

Ping Xue, Xinru Han, Ehsan Elahi, Yinyu Zhao, Xiudong Wang

Subject: Business, Economics And Management, Economics Keywords: internet access; nutritional intake; rural China; propensity score matching

Online: 11 June 2021 (14:54:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0314.v3

Financial Performance Analysis of Distressed Banks in Ghana: Exploration of Financial Ratios and Z-score

Juabin Matey

Subject: Business, Economics And Management, Economics Keywords: Bank; , Debt; Distress; Performance; Credit Management Practice; Z-score

Online: 19 December 2019 (13:05:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0091.v1

The Government Support and the Innovation of the New Energy Firms

Weijian Du, Mengjie Li

Subject: Business, Economics And Management, Economics Keywords: Government support; Innovation probability; Innovation destiny; Propensity score matching

Online: 10 May 2017 (18:04:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0960.v1

Bridging the Gap: Exploring Interpretability in Deep Learning Models for Brain Tumor Classification from MRI Images

Wandile Nhlapho, Marcellin Atemkeng, Yusuf Brima, Jean-Claude Ndogmo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: transfer learning; deep learning; brain tumor classification; explanability and interpretability; Grad-Cam++; integrated gradients

Online: 19 February 2024 (10:21:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1509.v1

The Surgical Guides for TADs: The Rational and Laboratory Procedures

Aonuma Michiko, Shingo Shirahama, Atsumoto Shimizu, Cristian Romanec, George Anka

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: surgical guide; orthodontics; TADs; CBCT; DICOM; SLT; CAD/CAM; 3D digital printer; dentistry; miniscrews

Online: 22 September 2023 (05:48:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1513.v1

In-situ Evaluation of Different CAM Plants as Plant Microbial Fuel Cells for Recovery Energy in Atacama Desert

Felipe M. Galleguillos Madrid, Norman Toro, Ingrid Jamett, Gilda Carrasco, Sergio Carvajal, Edward Fuentealba, Sebastián Salazar - Avalos, Douglas Olivares, Carlos Portillo, Alvaro Soliz, Luis Caceres, Mauricio Trigo

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: plant microbial fuel cell (PMFC); CAM plant; Atacama Desert; solar energy; environmental engineering; sustainability

Online: 22 August 2023 (07:23:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0002.v1

Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner Through Secreted Calpastatin

Justin N Williams, Mavis Irwin, Yong Li, Anuradha Valiyakambrath, Brett T Mattingly, Sheel Patel, Mizuho Kittaka, Rebecca N Collins, Nicholas Clough, Emma H Doud, Amber L Mosley, Teresita M Bellido, Angela Bruzzaniti, Lilian I. Plotkin, Jonathan C. Trinidad, William R Thompson, Lynda F. Bonewald, Uma Sankar

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Extracellular calpastatin, Ca2+/ calmodulin (CaM)-dependent protein kinase kinase 2, osteocytes, osteoclasts, bone remodeling

Online: 1 February 2023 (01:11:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0490.v1

Recent Advancements in CAD/CAM Same-Day Dentistry in Practice and Education

Sompop Bencharit, Wendy A Clark, Lisa O Stoner, Gautam Chiang, Taiseer A. Sulaiman

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: CAD/CAM; dental ceramics; dental technology; digital dentistry; dental education; dental innovation; disruptive technology

Online: 25 November 2021 (20:06:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1052.v1

Identification of the Best Predictive Model for Mortality in Outborn Neonates – Retrospective Cohort Study

MARIA LIVIA OGNEAN, IOANA ANDRADA RADU, BIANCA COSMINA COTOVANU, DUMITRU ALIN TEACOE, SAMUEL BOGDAN TODOR, CRISTIAN ICHIM, IRIS CODRUTA MURESAN, ADRIAN GHEORGHE BOICEAN, RADU GALIS, MANUELA CUCEREA

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; outborn; sick neonatal score; mortality; neonatal transportation; scoring system

Online: 17 October 2023 (12:06:27 CEST)

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Background: Neonatal transportation of sick newborns is a major predictor of outcome. Prompt identification of the sickest newborns allows immediate corrective intervention and outcome optimization. Multiple severity scores were developed, however an optimal score has not yet been identified. Aim: To identify a rapid, accurate, and easy to perform score predictive for neonatal mortality in outborn neonates. Material and methods: All neonates, irrespective of gestational age, admitted by transfer in our level III regional neonatal unit between 01.01.2015 and 31.12.2021 were included. Infants with congenital critical abnormalities were excluded. Sick neonatal score (SNS) was calculated and compared between survivors and non-survivors. Gestational age (GA), birth weight (BW), gender, Apgar score, place of birth, time between delivery and admission (AT), early onset sepsis were collected from medical records and compared between study groups. Subgroup analysis was performed based on gestational age (preterm versus term infants). A new score was elaborated, including GA, BW, and AT, namely MSNS-AT score, to further improve mortality prediction. The main outcomes were mortality prediction using SNS and MSNS-AT score. Univariable and multivariable analysis, including Cox regression, were performed using SPSS Statistic 22.0. P-value was considered statistically significant if <0.05, 95% confidence intervals, odds ratio and hazard ratios were calculated were appropriate. Results: A total of 418 outborn infants were admitted during study period; 15 infants were excluded due to critical congenital defects. Out of 403 outborn infants, 217 born prematurely (53.8%), 224 males (55.6%), 20 died (4.96%). Compared to the survivors, the non-survivor neonates had significantly lower GA, BW, and SNS score (p<0.05), although only SNS score remained significantly lower in all subgroups (preterm vs term infants). A SNS score ≤8 was associated with mortality both in the whole study group and in subgroups (p<0.001). Time to admission was significantly associated with increased mortality rate in the whole group (p<0.05) and in preterm infants but not in term ones (p>0.05). In univariable and multivariable Cox regression models, MSNS-AT score, with a cut-off optimal value of ≤10 was more precise in predicting mortality compared to SNS (AUC 0.735 vs. 0.775) when applied to the entire group, had a lower accuracy in the term infants (AUC 0.765 vs 0.809) and a better accuracy the preterm infants group (AUC 0.885 vs. 0.810). Conclusions: The MSNS-AT score – calculated by adding GA, BW, and AT to the SNS score - significantly improved mortality prediction at admission in the whole study group as compared to SNS score. The best accuracy prediction of MSNS-AT score was observed in preterm infants suggesting that, besides GA and BW, TA may be decisive for the outcome of outborn preterm infants. Further studies are necessary to confirm the predictive value of MSNS-AT score and to identify variables that can improve its value in term infants without affecting the simplicity, ease, and rapidity of the scoring system.

Preprint REVIEW | doi:10.20944/preprints202307.0111.v1

Interpretation of Tumor Response Grade Following Preoperative Therapy for Gastric Cancer: An Overview

Vasileios Tsagkalidis, Maryjka B. Blaszczyk, Haejin In

Subject: Medicine And Pharmacology, Surgery Keywords: tumor response grade (TRG); gastric cancer; RECIST; tumor regression score

Online: 3 July 2023 (14:25:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0010.v1

Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA≤6

Jaume Baldirà, Juan Carlos Ruiz-Rodríguez, Adolfo Ruiz-Sanmartin, Luis Chiscano, Alejandro Cortés, Diego Angeles-Sistac, Roser Ferrer-Costa, Imma Comas, Yolanda Villena, M.Nieves Larrosa, Juan José González-López, Ricard Ferrer

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: Sepsis biomarkers; mortality; MR-proADM; SOFA score; Lactate; molecular diagnosis

Online: 3 July 2023 (08:10:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2111.v1

Impact of Homegrown School Feeding Program on Smallholders' Farmer Household Food Security in Northeastern Nigeria

Bulus Barnabas, Sylvester Amoako Agyemang, Edwin Zhllima, Miroslava Bavorova

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: smallholder farmers; food security; school feeding; Nigeria; propensity score matching

Online: 30 May 2023 (10:31:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0251.v1

Comprehensive Study of Thunderstorm Indices Threshold Favorable for Thunderstorms During Monsoon Season Using WRF-ARW Model and ERA5 Over India

Unashish Mondal, Anish Kumar, S. K. Panda, Devesh Sharma, Someshwar Das

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Thunderstorm Indices; WRF-ARW; Lightning; Optimal Threshold; Model Skill Score

Online: 4 May 2023 (10:01:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0187.v1

Workload in the Care of a Patient with Congenital Diaphragmatic Hernia and the Patient’s Need for Nursing Care

Paulina Szydłowska-Pawlak, Dorota Maria Kilańska, Remigiusz Kozlowski, Roman Załuska, Monika Borzuchowska, Michał Marczak

Subject: Public Health And Healthcare, Nursing Keywords: nurse; workload; staff workload; nursing intensive care; nursing activities score

Online: 10 February 2023 (07:53:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0026.v1

Tracking Obesity Phenotypes in Korean Adults Based on KNHANES (2015-2019)

Jieun Shin, Okhyun Kim, Myoungsook Lee

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity phenotypes, obesogenic environments, metabolic syndrome, K-score, food pattern

Online: 1 November 2022 (09:36:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0108.v1

Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS). Part II

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Adrian M. E. Pilatz, Kurt G. Naber, Florian M. E. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women

Online: 6 September 2021 (17:02:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0559.v1

Comparative Analysis of Lenvatinib and Hepatic Arterial Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multi-Center, Propensity Score Study

Jaejun Lee, Ji Won Han, Pil Soo Sung, Soon Kyu Lee, Hyun Yang, Hee Chul Nam, Sun Hong Yoo, Hae Lim Lee, Hee Yeon Kim, Sung Won Lee, Jung Hyun Kwon, Jeong Won Jang, Chang Wook Kim, Soon Woo Nam, Jung Suk Oh, Ho Jong Chun, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hepatocellular carcinoma; Lenvatinib; Hepatic arterial infusion chemotherapy; Propensity score matching

Online: 26 July 2021 (09:59:34 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202105.0402.v2

I Can Achieve Intrauterine Growth Rete if You Give Me Enough Nutrition: Preterm Infant Born at ≤29 Weeks Gestation

Angela Hoyos

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Very preterm infants; Z-score on weight; neonatal nutrition; appropriate intrauterine neonatal growth

Online: 30 July 2021 (15:00:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0295.v1

Veridical Causal Inference for Comparative Effectiveness Research Using Medical Claims

Ryan Ross, Xu Shi, Megan Caram, Pheobe Tsao, Paul Lin, Amy Bohnert, Min Zhang, Bhramar Mukherjee

Subject: Medicine And Pharmacology, Other Keywords: insurance claims; reproducibility; propensity score; veridical data science; sensitivity analysis

Online: 24 June 2020 (09:51:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0298.v2

A Hierarchical Machine Learning Model to Discover Gleason Grade Group-specific Biomarkers in Prostate Cancer

Osama Hamzeh, Abedalrhman Alkhateeb, Julia Zheng, Srinath Kandalam, Crystal Lueng, Govindaraja Aikukke, Dora Cavallo-Medved, Nallasivam Palanisamy, Luis Rueda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: classification; prostate cancer; gleason score; machine learning; next-generation sequencing

Online: 26 November 2019 (04:01:21 CET)

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1) Background: One of the most common cancer that affects men worldwide and North American men is prostate cancer. Gleason score is a pathological grading system to examine the potential aggressiveness of the disease in the prostate tissue. The advancement in computing and next-generation sequencing technology now allow us to study the genomic profiles of patients in association with their different Gleason score more accurately and effectively. 2) Methods: In this study, we used a novel machine learning method to analyze gene expression of prostate tumors with different Gleason scores, and identify potential genetic biomarkers for each Gleason group. We obtained a publicly-available RNA-Seq dataset of a cohort of 104 prostate cancer patients from the National Center for Biotechnology Information’s (NCBI) Gene Expression Omnibus (GEO) repository, and categorized patients based on their Gleason scores to create a hierarchy of disease progression. A hierarchical model with standard classifiers in different Gleason groups, also known as nodes, was developed to identify and predict nodes based on their mRNA or gene expression. In each node, patient samples were analyzed via class imbalance and hybrid feature selection techniques to build the prediction model. The outcome from analysis of each node is a set of genes that can differentiate each Gleason group from the remaining groups. To validate the proposed method, the set of identified genes are used to classify a second dataset of 499 prostate cancer patients collected from cBioportal [1]. 3) Results: The overall accuracy of applying this novel method to the first dataset was 93.3%, and further validated to 87% accuracy using the second dataset. This method also identified genes that were not previously reported as potential biomarkers for specific Gleason groups. In particular, PIAS3 was identified as a potential biomarker for Gleason score 4+3=7, and UBE2V2 for Gleason score 6. 4) Insight: Previous reports show that the genes predicted by this newly proposed method strongly correlate with prostate cancer development and progression. Furthermore, pathway analysis shows that both PIAS3 and UBE2V2 share similar protein interaction pathways, the JAK/STAT signaling process.

Preprint ARTICLE | doi:10.20944/preprints201911.0223.v1

Identification and Preference of Game Styles in LaLiga Associated with Match Outcomes

Julen Castellano Paulis, Miguel Pic

Subject: Social Sciences, Education Keywords: match analysis; team sport; key performance indicator; interaction; elite; score

Online: 19 November 2019 (03:57:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1508.v1

Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Therapy: Formulation Development and In Vitro and Ex Vivo Therapeutical Efficacy and Safety Assessment

Maria Beatriz Pinto, Patrícia C. Pires, Ricardo C. Calhelha, Ana Rita Silva, Maria João Sousa, Miguel Vilas-Boas, Soraia I. Falcão, Francisco Veiga, Pooyan Makvandi, Ana Cláudia Paiva-Santos

Subject: Chemistry And Materials Science, Nanotechnology Keywords: anti-inflammatory; anticancer; antitumor; bee venom; HET-CAM; in vitro; nanosystems; nanotechnology; natural compounds; niosomes

Online: 27 February 2024 (13:33:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0165.v1

A Comparison of Trueness and Precision of 9 Intra-Oral Digital Scanners and 4 Lab Digital Scanners

Adam Brian Nulty

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Intraoral Scanners; Intra-Oral Scanners; CAD/CAM; Digital Dentistry; Trueness; Precision; Accuracy; Scanners; Lab Scanners

Online: 10 May 2021 (10:44:19 CEST)

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(1) Background: The purpose of this study is to evaluate the full arch scan accuracy (precision and trueness) of nine digital intra-oral scanners and four lab scanners. Previous studies have compared the accuracy of some intra-oral scanners, but as this is a field of quickly developing technologies, a more up-to-date study was needed to assess the capabilities of currently available models.; (2) Methods: The present in vitro study compared nine different intraoral scanners (Omnicam 4.6; Omnicam 5.1; Primescan; CS 3600; Trios 3; Trios 4; Runyes; i500 and DL206) as well as four lab light scanners (Einscan SE; 300e; E2 and Ineos X5) to investigate the accuracy of each scanner by examining the overall trueness and precision. Ten aligned and cut scans from each of the intra-oral and lab scanners in the in vitro study were brought into CloudCompare. A comparison was made with the master STL using the CloudCompare 3D analysis best-fit algorithm. The results were recorded along with individual standard deviation and a colorimetric map of the deviation across the surface of the STL mesh; a comparison was made to the master STL, quantified at specific points. ; (3) Results: In the present study, the Primescan had the best overall trueness (17.3 ± 4.9). Followed by (in order of increasing deviation) the Trios 4 (20.8 ± 6.2), i500 (25.2 ± 7.3), CS3600 (26.9 ± 15.9), Trios 3 (27.7 ± 6.8), Runyes (47.2 ± 5.4), Omnicam 5.1 (55.1 ± 9.5), Omnicam 4.6 (57.5 ± 3.2) and Launca DL206 (58.5 ± 22.0). Regarding the lab light scanners, the Ineos X5 had the best overall trueness with (0.0 ± 1.9). Followed by (in order of increasing deviation) the 3Shape E2 (3.6 ± 2.2), Up3D 300E (12.8 ± 2.7), and Einscan SE (14.9 ± 9.5); (4) Conclusions: This study confirms that all current generations of intra-oral digital scanners can capture a reliable, reproducible full arch scan in dentate patients. Out of the intra-oral scanners tested, no scanner produced results significantly similar in trueness to the Ineos X5. However, the Primescan was the only one to be statistically of a similar level of trueness to the 3Shape E2 lab scanner. All scanners in the study had mean trueness of under 60-micron deviation. While this study can compare the scanning accuracy of this sample in a dentate arch, the scanning of a fully edentulous arch is more challenging. The accuracy of these scanners in edentulous cases should be examined in further studies.

Preprint ARTICLE | doi:10.20944/preprints202304.0239.v2

Insights into Current Education of Acupuncture as a Non-conventional Therapy in Portugal

Xiao Ye, Lara Lopes, Ricardo Teixeira, Ying Wang, Jorge Pereira Machado

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: acupuncture; healthcare education; healthcare legislation; non-conventional therapies; complementary and alternative medicine; CAM; Portugal; European Union

Online: 13 April 2023 (03:36:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1025.v1

Pre-infection Nutritional Status, Oxidative Stress, and One-Year Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study

Natalia Stepanova, Lesya Korol, Tetyana Ostapenko, Valeriia Marchenko, Olga Belousova, Lyudmila Snisar, Iryna Shifris, Mykola Kolesnyk

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: long COVID; hemodialysis; controlling nutritional status score; undernutrition; oxidative stress; persistence

Online: 16 April 2024 (11:10:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1968.v1

Effect of Agricultural Production Trusteeship on Agricultural Carbon Emission Reduction

Xiaoyan Sun, Shuya Guang, Jingjing Cao, Fengying Zhu, Jianxu Liu, Songsak Sriboonchitta

Subject: Social Sciences, Other Keywords: agricultural production trusteeship; agricultural carbon emission reduction; propensity score matching (PSM)

Online: 28 June 2023 (08:34:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1847.v1

Inverse Association between Dairy Product Consumption and Lower Cognitive Function in Community-Dwelling Japanese Older Adults Based on a Cross-Sectional Study

Hunkyung Kim, Yosuke Osuka, Narumi Kojima, Hiroyuki Sasai, Kentarou Nakamura, Chisato Ohba, Mayuki Sasaki, Takao Suzuki

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: dairy product consumption; mini-mental state examination score; lower cognitive function

Online: 27 June 2023 (04:58:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1735.v1

Framework for Simulation Study Involving Volatility Estimation: The GAS Approach

Richard T. A. Samuel, Charles Chimedza, Caston Sigauke

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: consistency; efficiency; score driven model; simulation design; time-varying parameter estimation

Online: 26 June 2023 (04:40:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0484.v1

Promotion Effect of Agricultural Production Trusteeship on High-quality Production of Grain——Evidence from the Perspective of Farm Households

Xiaoyan Sun, Youchao Wang, Fengying Zhu, Xiaoyu Liu, Jianxu Liu, Songsak Sriboonchitta

Subject: Business, Economics And Management, Economics Keywords: agricultural production trusteeship; high-quality production of grain; propensity score matching

Online: 7 June 2023 (04:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0094.v1

A Randomized, Placebo Controlled, Double Blinded, Parallel Group Clinical Study to Evaluate the Efficacy and Safety of AEV01 for Mild COVID19 in Elderly Patients at Risk of Complications

RAMESH KANNAN, VANITHA MURALIKUMAR, VAMSEEDHAR ANNAM, SAKTHI BALAN, ARAVINDA KUMAR, SEKHAR MM, RENU MEDASANI

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; Picrorhiza kurroa; AEV01; NEW Score; Immunomodulatory; unvaccinated elderly population

Online: 7 May 2022 (05:47:32 CEST)

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Background: While several drugs are in the pipeline for treatment of various grades of COVID-19 disease, none of them have shown promise until now. Medicinal plants are crucial in developing and developed countries for their primary and basic health needs owing to better tolerability, superior compatibility with human body and having lesser side effects. AEV01 , a speciality extract of kutki (Picrorhiza kurroa), is one potential medicinal herb which can be effective for mild COVID19 in elderly patients at risk of complications and aging immunity. Purpose: The efficacy and safety of AEV01 for mild COVID-19 in elderly patients at risk of complications was investigated in this study. Study design: A prospective, phase 3, randomized, multicentric, placebo controlled double blinded parallel group interventional trial. Methods: This study was conducted in elderly patients diagnosed as COVID-19 with mild symptoms. 70 patients were randomized into two groups to receive AEV01 capsule (100mg) and placebo respectively thrice daily for 30 days along with standard care of treatment as per national WHO/ICMR guidelines. Clinical improvement timelines and corresponding scores using 8-point ordinal scale and NEWS were assessed for efficacy and safety of AEV01 in COVID-19 patients. Results: AEV01 group showed a significant improvement (P=0.0001) in the normalization of the SpO₂ rate and relief from cough. There was also significant difference in time to recovery, with patients in the AEV01 drugtreated group recovering in 4.5 days as compared to Placebo in 9.1 days. ESR, LDH, serum ferritin, Neutrophil-Lymphocyte ratio (NLR), TNF- alpha, IL-6 and CD4 cell counts, which are considered as prognostic markers in COVID19 infected patients, showed a significant improvement in patients treated with AEV01. The AEV01 drug treated group showed significant clinical improvement in the 8-point ordinal scale severity rating and NEW Score from day 3 onwards which continued up to end of study. Conclusion: AEV01 has shown a significant improvement in clinical and laboratory parameters. There was also reduction in the progression of the COVID-19 disease in unvaccinated elderly patients from mild to moderate when treated at an earlier stage.

Preprint CONCEPT PAPER | doi:10.20944/preprints202202.0114.v1

Why D-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections Preliminary Considerations and Conclusions from a Non-interventional Study

Florian Wagenlehner, Horst Lorenz, Oda Ewald, Peter Gerke

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: urinary tract infection; cystitis; D-mannose; antibiotics; acute cystitis symptom score

Online: 8 February 2022 (13:25:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0211.v1

Development and Validation of a Risk Score to Predict Low Birthweight Using Characteristics of the Mother: A Prospective Cohort Study

Hamid Y. Hassen, Bilal S. Endris, Meselech A. Roro, Seifu H. Gebreyesus, Jean-Pierre Van Geertruyden

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: prediction; model; risk score; low birthweight; pregnant women; decision curve analysis

Online: 13 April 2020 (11:15:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0356.v1

Initial Review and Analysis of COVID-19 Host Genetics and Associated Phenotypes

Yosuke Tanigawa, Manuel Rivas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; host genetics; genetics; polygenic risk score

Online: 24 March 2020 (08:36:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0181.v1

A Democratic Method and Index to Rationalize Authorship Decisions and Determine the Order of Authors

Thorsten Schmidt

Subject: Social Sciences, Library And Information Sciences Keywords: Authorship contributions, Authorship Score, Authorship Conflicts, First Author, Decision Making, Bibliometry

Online: 9 October 2018 (09:45:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2047.v3

Design and Utilization of a 3D printed Tooth-Borne Orthodontic Molar Distalizer Library

Bregt Smeets, Tim Smeets

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: distalizer; orthodontics; digital; biocompatible 3D printing; dental biocompatible resin; CAD/CAM; computer modelling; class II; molar derotation

Online: 13 February 2024 (09:22:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0596.v1

Quantification and Influence by IL-1β of the Pain and Inflammatory Response after Placement of a Cement-Screw-Retained Restoration

Serafín Maza-Solano, María Baus-Domínguez, Raquel Gómez-Díaz, Gonzalo Ruiz-de-Leon-Pacheco, Daniel Torres-Lagares, María-Angeles Serrera-Figallo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Screw-cemented retained implant prothesis; customised CAD-CAM abutments; peri-implant crevicular fluid; healing abutments; dental implants.

Online: 9 February 2024 (13:54:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0068.v1

Deep Learning for Detecting Building Defects Using Convolutional Neural Networks

Husein Perez, Joseph H.M. Tah, Amir Mosavi

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: deep learning; convolutional neural networks (CNN); transfer learning; class activation mapping (CAM); building defects; structural-health monitoring

Online: 6 August 2019 (04:18:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0194.v1

Combined Strengthening Techniques to Improve the Out-of-Plane Performance of Masonry Walls

Elena Ferretti, Giovanni Pascale

Subject: Engineering, Civil Engineering Keywords: masonry buildings; out-of-plane strength; hammering actions; seismic retrofitting; bracing; dissipative systems; CAM system; CFRP strips

Online: 20 February 2019 (12:22:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0043.v1

CA-125 KELIM as a tool to identify which patients can benefit from PARPi in high grade serous advanced ovarian cancer: A retrospective diagnostic accuracy study.

Dimitrios Zouzoulas, Dimitrios Tsolakidis, Panagiotis Tzitzis, Kimon Chatzistamatiou, Vasilis Theodoulidis, Iliana Sofianou, Grigoris Grimbizis, Eleni Timotheadou

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: KELIM score; Homologous recombination deficiency (HRD); Poly (ADP-ribose) polymerase inhibitors (PARPi).

Online: 1 April 2024 (11:12:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0679.v1

Predicting and Analyzing Rainfall Patterns in Ethiopia Using Linear Regression Modeling

Moges Tsegaw Melesse, Gezahegn Mulusew Delele

Subject: Computer Science And Mathematics, Computer Science Keywords: Rainfall patterns; Ethiopia; Linear regression modeling; R-squared score; Mean squared error

Online: 14 March 2024 (05:28:48 CET)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202308.0886.v1

Estimating Multivariate models for Association between soil Major and minor Micronutrients

Rajarathinam Arunachalam, Ramji Madhaiyan

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Kaiser-Meyer-Olkin Test; Pearson correlation; Eigenvalue; Score plot; PCA; FA; CCA

Online: 11 August 2023 (03:39:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1103.v1

Clinical Implication of Bilateral and Unilateral Multifocality in Papillary Thyroid Carcinoma: A Propensity Score-Matched Study

Youngmin Kim, Solji An, Joonseon Park, Ja Seong Bae, Jeong Soo Kim, Kwangsoon Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bilaterality; unilateral multifocality; papillary thyroid carcinoma; disease-free survival; propensity score matching

Online: 15 June 2023 (08:22:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1053.v2

Food Front-of-pack Labelling and the Nutri-Score Nutrition Label—Poland-wide Cross-sectional Expert Opinion Study

Mariusz Panczyk, Hubert Dobrowolski, Beata I. Sińska, Alicja Kucharska, Mariusz Jaworski, Iwona Traczyk

Subject: Biology And Life Sciences, Food Science And Technology Keywords: consumer awareness; dietary choices; front-of-pack label; Nutri-Score; nutrition labelling

Online: 8 June 2023 (10:06:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1335.v1

Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft

Filip Dulguerov, Tamila Abdurashidova, Emeline Christophel-Plathier¹, Barbara Pitta-Gros, Anna Nowacka, Ziyad Gunga, Raymond Pfister, Mario Verdugo-Marchese, Valentina Rancati, Lars Niclauss, Piergiorgio Tozzi, Albert Adelin, Zied Ltaief, Samuel Rotman, Philippe Meyer, Roger Hullin, Matthias Kirsch

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart Transplantation; Cardiac Preservation Solutions; Inotropic Score; Early Results; Mid-term Results

Online: 18 May 2023 (10:50:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0372.v1

Improvement in the Multiple Sclerosis Functional Composite Score by Multi-Function Swing Suspension Training Program

Sara Sepehri far, Banafsheh Amiri, Mansour Sahebozamani, Hossein Ali Ebrahimi

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Multiple sclerosis; Multiple Sclerosis Functional Composite Score; Multi-Function Swing Suspension Training

Online: 27 May 2022 (08:59:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0038.v1

Percutaneous Radiofrequency Ablation with or without Chemolipiodolization for Early-stage Hepatocellular Carcinoma: A Propensity Score-matched Analysis

Kota Takaki, Masahito Nakano, Kazuta Fukumori, Yoichi Yano, Yuki Zaizen, Takashi Niizeki, Kotaro Kuwaki, Masaru Fukahori, Takahiko Sakaue, Sohei Yoshimura, Mika Nakazaki, Takuji Torimura

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; percutaneous radiofrequency ablation; chemolipiodolization; risk factors; propensity score-matched analysis

Online: 4 October 2021 (10:19:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0012.v1

Living Donor Liver Transplantation for Budd-Chiari Syndrome: A Propensity Score-Matched Analysis

Vasanthakumar Gunasekaran, Mettu Srinivas Reddy, Ashwin Rammohan, Naresh P Shanmugam, Deepashree Thirchunapalli, Rathnavel G Kanagavelu, Ilankumaran Kaliamoorthy, Mohamed Rela

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Budd-Chiari syndrome; Living donor; Liver transplantation; Propensity score-Matched Analysis; Outcomes

Online: 1 October 2021 (11:52:48 CEST)

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