Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202101.0568.v1

Perceived Help-Seeking Difficulty, Barriers, Delay, and Burden in Carers of People with Suspected Dementia

Carmen KM Ng, Dara KY Leung, Xinxin Cai, Gloria HY Wong

Subject: Business, Economics And Management, Accounting And Taxation Keywords: service accessibility; dementia knowledge; affordability; carer role strain; self-criticism; negative emotions

Online: 27 January 2021 (16:15:14 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202006.0279.v2

COVID-19 Testing – Impact of Prevalence, Sensitivity, and Specificity on Patient Risk and Cost

Zoe C. Brooks, Saswati Das

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID19; risk; clinical; metrics; cost; false-positive; false-negative; prevalence; sensitivity; specificity

Online: 9 July 2020 (15:57:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202004.0117.v1

Using Negative Pressure Wound Therapy in the Treatment of Wounds After Fasciotomy in Acute Compartment Syndrome - Retrospective Case Series Study

Jaroslaw P. Miszczuk, Maria Błońska-Staniec, Anna Michalska, Bartosz Stemplewski

Subject: Medicine And Pharmacology, Surgery Keywords: acute compartment syndrome; negative pressure wound therapy; vacuum assisted wound closure; fasciotomy

Online: 8 April 2020 (04:50:32 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201908.0225.v1

Analysis of Water Bodies under Partial Cloud Conditions Using Satellite Images

Rahul Neware, Mansi Thakare

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: water bodies; satellite images; vector data; SVM; positive and negative buffering; polygons

Online: 21 August 2019 (10:30:16 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202401.1788.v1

MicroRNA-Targeted Therapy

Francesco Nappi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: miRNAs; long non-coding RNAs; antimiRNAs; non-coding RNAs; ncRNA therapeutics

Online: 24 January 2024 (16:50:46 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1186.v1

Factors Contributing to Negative Outcomes Associated with Medications and Drug-Related Problems in Kidney Replacement Therapy. A Hospital-Based Prospective Observational Study

Alfonso Pereira-Céspedes, Alberto Jiménez-Morales, Aurora Polo-Moyano, Magdalena Palomares-Bayo, Fernando Martínez-Martínez, Miguel Ángel Calleja-Hernández

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: kidney replacement therapy; medication review; drug-related problems; negative outcomes associated with medication.

Online: 16 January 2024 (13:57:35 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1186.v1

Distinction between Effects of IR-Drop and Negative Capacitance of Fast Cyclic Voltammograms

Yuanyuan Liu, Koichi Jeremiah Aoki, Jingyuan Chen

Subject: Chemistry And Materials Science, Electrochemistry Keywords: IR-drop; negative capacitance; double layer capacitance; fast scan cyclic voltammograms; microelectrode reactions

Online: 16 August 2023 (10:44:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1601.v1

Antimicrobial Potential of the Microalgae Extracts

Alexander Lykov, Alexei Salmin, Ruslan Gevorgiz, Svetlana Zheleznova, Lyubov Rachkovskaya, Maria Surovtseva, Olga Poveshchenko

Subject: Biology And Life Sciences, Life Sciences Keywords: diatoms; cyanobacter; green microalgae; Gram-positive and Gram-negative bacteria; Mycobacteria; antimicrobial potential

Online: 24 July 2023 (10:46:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0858.v1

Mortality Due to Multi-Drug Resistant Gram Negative Bacteremia in an Endemic Region: No Better than Toss a Coin

Olga Tsachouridou, Dimitrios Pilalas, Sideris Nanoudis, Athanasios Antoniou, Isidora Bakaimi, Theofilos Chrysanthidis, Konstantinos Markakis, Angeliki Kassomenaki, Paraskevi Mantzana, Efthymia Protonotariou, Lemonia Skoura, Symeon Metallidis

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Gram-negative bacilli bacteremia; multidrug resistance; 28-day mortality; procalcitonin; rapid molecular diagnostics

Online: 11 May 2023 (13:34:03 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202101.0147.v1

A Proposed Model of Dehumanisation and Its Relevance to Dehumanisation in Dementia Care

Hana Speering, Lara Speering

Subject: Social Sciences, Psychology Keywords: Dehumanisation; dementia care; healthcare education; residential aged care facilities; positive dehumanisation; negative dehumanisation

Online: 8 January 2021 (11:23:42 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Negative Effective Mass in Plasmonic Systems, II: Elucidating of Optical and Acoustical Branches of Vibrations and the Possibility of Anti-Resonance Propagation

Edward Bormashenko, Irina Legchenkova, Mark Frenkel

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: metamaterials; negative effective mass; plasma oscillations; low frequency plasmons; optical and acoustical branches.

Online: 21 July 2020 (13:38:18 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201910.0255.v1

Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-negative (ESKAPEE) Bacteria

Akif Reza, J. Mark Sutton, Khondaker Miraz Rahman

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: antimicrobial resistance; biofilm; efflux pump inhibitors; antibiotic potentiation; eskapee pathogens; gram-negative bacteria

Online: 22 October 2019 (10:22:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201805.0026.v1

Weighted Negative Binomial Poisson-Lindley Distribution with Actuarial Applications

Hossein Zamani, Noriszura Ismail, Marzieh Shekari

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: weighted distribution; Poisson-Lindley distribution; discrete distribution; weighted negative binomial Poisson-Lindley distribution

Online: 2 May 2018 (11:47:51 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.0963.v1

Performance of Non-compliant Reinforced Concrete Frame Structures Under Seismic Loading

Edy Purwanto, Stefanus Adi Kristiawan, Senot Sangadji, Halwan Alfisa Saifullah

Subject: Engineering, Architecture, Building And Construction Keywords: Non-compliant; undamaged; performance

Online: 26 April 2023 (06:19:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0135.v1

An Investigation of Experimental Reports on the Relativistic Relation for Doppler Shift

James McKelvie

Subject: Physical Sciences, Theoretical Physics Keywords: Doppler; relativistic; non-relativistic

Online: 10 May 2022 (10:08:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0716.v2

Non-Commutative Key Exchange Protocol

Luis Adrián Lizama-Pérez, José Mauricio López Romero

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Non-commutative; matrix; cryptography

Online: 23 March 2022 (11:08:28 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0174.v1

Non-Commutative Key Exchange Protocol

Luis Adrián Lizama-Pérez, José Mauricio López Romero

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Non-commutative; matrix; cryptography

Online: 10 May 2021 (11:09:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0051.v9

Duality Principles and Numerical Procedures for a Large Class of Non-convex Models in the Calculus of Variations

Fabio Botelho

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Duality theory; non-convex analysis; numerical method for a non-smooth model

Online: 3 April 2023 (07:35:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0492.v1

Non-Archimedean Welch Bounds and Non-Archimedean Zauner Conjecture

K. Mahesh Krishna

Subject: Computer Science And Mathematics, Analysis Keywords: Non-Archimedean valued field; non-Archimedean Hilbert space; Welch bound; Zauner conjecture

Online: 29 August 2022 (12:35:07 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202011.0032.v3

Non-Ionizing Millimeter Waves Non-thermal Radiation of Saccharomyces Cerevisiae – Insights and Interactions.

Ayan Barbora, Sailendra Rajput, Konstantin Komoshvili, Jacob Levitan, Asher Yahalom, Stella Liberman- Aronov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Non-ionizing Radiation; Millimeter waves; Novel biomedical applications; Yeast; Non-invasive devices

Online: 16 April 2021 (14:52:04 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Mechanisms of the Non-Thermal Exposure Effects of Non-Ionizing Millimeter Waves Radiation on Eukaryotic Cells for Improving Technological Precision Enabling Novel Biomedical Applications

Ayan Barbara, Shailendra Rajput, Konstantin Komoshvili, Jacob Levitan, Asher Yahalom, Stella Liberman- Aronov

Subject: Biology And Life Sciences, Biophysics Keywords: non-ionizing radiation; millimeter waves; novel biomedical applications; yeast; non-invasive devices

Online: 17 September 2020 (07:08:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201902.0156.v4

Diophantine Equations with a Finite Number of Solutions: Craig Smorynski's Theorem, Harvey Friedman's Conjecture and Minhyong Kim's Guess

Apoloniusz Tyszka

Subject: Computer Science And Mathematics, Logic Keywords: Davis-Putnam-Robinson-Matiyasevich theorem, Diophantine equation which has at most finitely many solutions in \mbox{non-negative} integers, Hilbert's Tenth Problem, Hilbert's Tenth Problem for Q, Matiyasevich's theorem, recursively enumerable set, Smorynski's theorem

Online: 1 March 2019 (12:58:53 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202109.0083.v1

Is the Higgs Field a Positive and Negative Mass Planckion Condensate, and Does the LHC Produce Extreme Dark Energy?

Christopher Pilot

Subject: Physical Sciences, Particle And Field Physics Keywords: Winterberg Model; Quantum Vacuum; Higgs Condensate/Composite Model; Two-Component Superfluid/Supersolid Model for the Vacuum; Positive/Negative Planckion Mass, Q-Theory; Non- Linear Heisenberg Spinor Theory; LHC Energies, Dark Energy; Lattice Substructure for Space

Online: 6 September 2021 (10:38:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1876.v1

FXR agonism with bile acid mimetic reduces pre-clinical triple-negative breast cancer burden

Sydney Clarice Joseph, Samson Eugin Simon, Margaret Sue Bohm, Minjeong Kim, Madeline E Pye, Boston William Simmons, Dillon Garen Graves, Stacey Marchelle Thomas-Gooch, Ubaid A Tanveer, Jeremiah Ray Holt, Suriyan Ponnusamy, Laura M Sipe, D. Neil Hayes, Katherine Loree Cook, Ramesh Narayanan, Joseph F Pierre, Liza Makowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nuclear hormone receptor, agonist, bile acid receptor, FXR, TGR5, triple-negative breast cancer, TNBC

Online: 26 January 2024 (11:49:34 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0674.v1

Breast Cancer Bone Metastasis Lesion Segmentation on Bone Scintigraphy

Yi-You Chen, Po-Nien Yu, Yung-Chi Lai, Te-Chun Hsieh, Da-Chuan Cheng

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: bone metastasis segmentation; Double U-Net; pre-train; negative mining; transfer learning; deep learning

Online: 11 July 2023 (10:18:40 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202306.1209.v1

Medication Review With Follow-up for End-stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated With Medication. A Systematic Review

Alfonso Pereira-Céspedes, Alberto Jiménez-Morales, Magdalena Palomares-Bayo, Fernando Martínez-Martínez, Miguel Ángel Calleja-Hernández

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: End-stage renal disease; medication review; drug-related problems; negative outcomes associated with medication.

Online: 16 June 2023 (10:13:13 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.1664.v1

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Shanisa Naidoo, Arnold M Zwane, Ahmed Paruk, Timothy Craig Hardcastle

Subject: Medicine And Pharmacology, Surgery Keywords: Soft tissue; necrotizing infection; water borne; vibrio; fungal; aeromonas; debridement; negative pressure wound care

Online: 23 May 2023 (14:43:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0089.v6

Omnidimensional Convex Polytopes

Szymon Łukaszyk, Andrzej Tomski

Subject: Computer Science And Mathematics, Geometry And Topology Keywords: regular basic convex polytopes; circumscribed and inscribed polytopes; negative dimensions; fractal dimensions; complex dimensions; emergent dimensionality; mathematical physics

Online: 24 February 2023 (15:41:43 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0219.v1

Intragenic Duplication of DMRT1 in a SRY-Negative Boy with 46,XX Disorder of Sex Development

Veronica Bertini, Fulvia Baldinotti, Nina Tyutyusheva, Camillo Rosano, Cinzia Cosini, Adelaide Maria Caligo, Diego Peroni, Angelo Valetto, Silvano Bertelloni

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 46,XX disorder of sex development; SRY-negative male; Testis determination; DMRT1; DMRT1 duplication

Online: 14 December 2021 (07:58:55 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0094.v3

“Clinician’s Probability Calculator” to Convert Pre-Test to Post-Test Probability of COVID-19, Based on Method Validation from Each Laboratory

Zoe Brooks, Saswati Das, Tom Pliura

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS-COV-2; False-Positive; False-Negative; Likelihood Ratio; Probability; Calculator; Interpretation

Online: 3 March 2021 (10:08:27 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201801.0100.v1

Pressure Distribution during Negative Pressure Wound Therapy of Experimental Abdominal Compartment Syndrome in a Porcine Model

Adrienn Csiszkó, Klaudia Balog, Zoltán Attila Godó, Gyula Juhász, Katalin Pető, Ádám Deák, Mariann Berhés, Norbert Németh, Zsolt Bodnár, Zsolt Szentkereszty

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: intra-abdominal pressure; abdominal compartment syndrome; pressure sensor; negative pressure wound therapy; open abdomen;

Online: 11 January 2018 (09:17:10 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201706.0077.v1

Are Mobile Live Animal Programs Educationally Beneficial? A Critical Assessment of the Human Learning Component Underlying Traveling Animal Exhibits

Kathryn Sussman

Subject: Social Sciences, Education Keywords: zoo; mobile zoo; mobile animal exhibits; animal display; mobile live animal programs; negative education

Online: 16 June 2017 (05:32:18 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1751.v3

Firewalls, Hawking (Tolman) Radiation, and a Tentative Resolution of the Firewall-Mass Problem

Jack Denur

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Schwarzschild black holes; Schwarzschild non-black holes; Ruler distance; Planck units; Hawking radiation; Tolman radiation; Gravitational frequency shift; Firewall mass; Negative gravitational mass-energy; Birkhoff's Theorem; Thermodynamic equilibrium; First Law of Thermodynamics; Second Law of Thermodynamics

Online: 5 March 2024 (10:56:30 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0086.v1

Non-isocyanate Synthesis of Aliphatic Polyurethane by BiCl₃-Catalyzed Transurethanization Polycondensation

Bungo Ochiai, Yuriko Kobayashi

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polyurethane; bismuth; polycondensation; non-isocyanate

Online: 2 April 2024 (02:37:09 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202304.0273.v1

The Life of Non-Saccharomyces Yeasts in Wine

Sergi Maicas, José Juan Mateo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: non-Saccharomyces yeasts; wine; yeasts

Online: 12 April 2023 (11:55:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0494.v1

Non-invertible Public Key Certificates

Luis Lizama-Pérez, J. Mauricio López

Subject: Computer Science And Mathematics, Information Systems Keywords: Non-invertible; cryptography; certificate; PKI

Online: 21 December 2020 (10:33:19 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201804.0361.v1

Public Debt and Economic Growth Nexus: Evidence from South Asia

Saira Saeed, Tanweer Islam

Subject: Business, Economics And Management, Economics Keywords: endogeneity, non-linearity, threshold, FMOLS

Online: 27 April 2018 (15:17:46 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0297.v1

On a Generalized Gagliardo-Nirenberg Inequality with Radial Symmetry and Decaying Potentials

Mirko Tarulli, George Venkov

Subject: Computer Science And Mathematics, Mathematics Keywords: Fractional Laplacian; radially symmetric potential; non-homogeneous potential; Gagliardo-Nirenberg inequality; non-local noninearity

Online: 6 November 2023 (13:40:12 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0075.v1

Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing Into Liver Cirrhosis and Tumors

Qianqian Zheng, Masaya Kawaguchi, Hayato Mikami, Pan Diao, Xuguang Zhang, Zhe Zhang, Takero Nakajima, Takanobu Iwadare, Takefumi Kimura, Jun Nakayama, Naoki Tanaka

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatocellular carcinoma; cirrhosis; fibrosis; mouse model

Online: 2 May 2023 (09:00:10 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1215.v1

Surveillance of Bacterial Load and Multi-drug Resistant Bacteria on Surfaces of Public Restrooms

Khadega Ibrahim, Maisha Tahsin, Aninda Rahman, Shaikh Mizanoor Rahman, MD Mizanur Rahman

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Public Restrooms; Contamination; Coliforms; Gram-positive; Gram-negative; Antibiotic Sensi-tivity; Antibiotic Resistance; Multidrug Resistant

Online: 21 March 2024 (02:03:57 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0470.v1

A New Computational Algorithm for Assessing Overdispersion in Machine Learning Count Models with Python

Luiz Paulo Lopes Fávero, Alexandre Duarte, Helder Prado Santos

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Count data; Machine learning; Negative binomial regression; Overdispersion; Poisson regression; Python; Vuong Test; Zero inflation

Online: 8 March 2024 (09:30:50 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.0378.v1

The Triple ASCs–Exosomes [T.A.E.] Technology to control the invasion of the Triple–Negative Breast Cancer towards the surrounding tissues

Andrea Pagani, Dominik Duscher, Sebastian Geis, Silvan Klein, Leonard Knoedler, Adriana C. Panayi, Dmytro Oliinyk, Oliver Felthaus, Lukas Prantl

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Extracellular vesicles; Exosomes; Triple - negative Breast cancer; T.A.E. Technology; Adipose-derived Stem Cells; Tumor Microenvironment

Online: 7 March 2024 (09:50:48 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0180.v2

Theoretical and Numerical Investigation of Mechanical Properties of Auxetic S-structure under Transverse Load

Prasanna Mondal, Jayaganthan R.

Subject: Engineering, Mechanical Engineering Keywords: Negative Poisson’ s Ratio; Timoshenko Beam Theory; Semi-analytical model; Parametric Analysis; Elastic modulus; Transverse load

Online: 6 February 2024 (10:28:34 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202104.0688.v1

Direct Quantitation of SARS-CoV-2 Using Droplet Digital PCR in Suspected Samples With Very Low Viral Load

Michela Deiana, Chiara Piubelli, Antonio Mori, Gian Paolo Chiecchi, Giulia La Marca, Martina Leonardi, Davide Treggiari, Anna Beltrame, Lucia Moro, Zeno Bisoffi, Elena Pomari

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: droplet digital PCR; real time RT-PCR; SARS-CoV-2; false negative; viral load; diagnosis

Online: 26 April 2021 (20:09:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202004.0201.v2

Detecting the Coronavirus (COVID-19)

Pravin Pokhrel, Changpeng Hu, Hanbin Mao

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2 Detection, SARS-CoV-2 Antibody Test, SARS-CoV-2 Antigen Test, False Negative, False Positive, Sensitivity, Specificity, Point-of-care testing (POCT), SARS-CoV-2 Mutants

Online: 25 March 2021 (15:33:14 CET)

Show abstract| Download PDF| Share

The COVID-19 pandemic has created huge damage to society and brought panics around the world. Such panics can be ascribed to the seemingly deceptive features of the COVID-19: compared to other deadly viral outspreads, it has medium transmission and mortality rates. As a result, the severity of the causative coronavirus, SARS-CoV-2, was deeply underestimated by the society at the beginning of the COVID-19 outbreak. Based on this, in this review, we define the viruses with features similar to those of SARS-CoV-2 as the Panic Zone viruses. To contain those viruses, accurate and fast diagnosis followed by effective isolation and treatment of patients are pivotal at the early stage of virus breakouts. This is especially true when there is no cure or vaccine available for a transmissible disease, which is the case for current COVID-19 pandemic. As of January 2021, more than two hundred kits for the COVID-19 diagnosis on the market are surveyed in this review, while emerging sensing techniques for SARS-CoV-2 are also discussed. It is of critical importance to rationally use these kits for the efficient management and control of the Panic Zone viruses. Therefore, we discuss guidelines to select diagnostic kits at different outbreak stages of the Panic Zone viruses, SARS-CoV-2 in particular. While it is of utmost importance to use nucleic acid-based detection kits with low false negativity (high sensitivity) at the early stage of an outbreak, the low false positivity (high specificity) gains its importance at later stages of the outbreak. When a society is set to reopen from the lock-down stage of the COVID-19 pandemic, it becomes critical to have antibody based immunoassay kits with high specificity to identify people who can safely return to the society after their recovery of SARS-CoV-2 infections. Given that the emergence of mutant viruses at the beginning of 2021 has complicated current battle against the COVID-19, we also discussed approaches and guidelines to detect viral mutants in the middle of the second wave of the pandemic that started at the end of 2020. Finally, since a massive attack from a viral pandemic requires a massive defense from the whole society, we urge both government and private sectors to research and develop more affordable and reliable point-of-care testing (POCT) kits, which can be used massively by the general public (and therefore called as massive POCT) to contain Panic Zone viruses in future.

Preprint ARTICLE | doi:10.20944/preprints201608.0049.v2

Understanding Farmers’ Decision Making in Agricultural Water Fee Payment in China: The Role of Mental Accounting

Weikang Zhang, Xinhong Fu, Jing Lu, Lin Zhang, Kwamega Michael, Guoqiang Liu, Yuying Liu, Fan Yang

Subject: Business, Economics And Management, Economics Keywords: mental accounting; agricultural water fee; behavioral economics; decision making; information processing; representativeness; negative psychological externalities

Online: 25 August 2016 (10:12:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.1682.v1

Atezolizumab plus Bevacizumab Treatment Worsens Liver Reserve in Patients with Nafld/Nash-Associated Liver Cancer More than in Those with Non-nafld/Non-Nash-Associated Liver Cancer

Rie Sugimoto, Kenta Motomura, Takeaki Satoh, Yuki Tanaka, Shinsaku Yamashita, Nobito Higuchi, Toshimasa Koyanagi, Tsukasa Nakamura, Masatake Tanaka, Yuuki Azuma, Takeshi Goya, Akifumi Kuwano, Aritsune Ooho, Mari Ooe, Taiji Mutsuki, Masami Kuniyoshi, Kazuki Kurosaka, Yusuke Morita, Seiya Tada, Yoshifusa Aratake, Tsuyoshi Yoshimoto, Takeshi Senju, Tomoyuki Kurashige, Shigeru Harada, Akihiro Ueda, Masayuki Miyazaki, Makoto Nakamuta, Motoyuki Kohjima

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Atezolizumab; bevacizumab; non-alcoholic fatty liver disease; non-alcoholic steato hepatitis; albumin-bilirubin (ALBI) score

Online: 26 October 2023 (09:01:45 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202210.0116.v8

A Duality Principle and a Concerning Convex Dual Formulation Suitable for Non-convex Variational Optimization

Fabio Botelho

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Convex dual variational formulation; duality principle for non-convex optimization; model in non-linear elasticity

Online: 12 January 2023 (02:41:45 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202102.0114.v1

Influence of Material-Dependent Damping on Brake Squeal in the Specific Disc Brake System

Juraj Úradníček, Miloš Musil, Ľuboš Gašparovič, Michal Bachratý

Subject: Engineering, Automotive Engineering Keywords: brake squeal; dissipation induced instability; non-proportional damping; non-conservative system; complex eigen value analysis

Online: 3 February 2021 (10:41:34 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202009.0023.v1

Application of the Incremental Modal Analysis for Bridges (IMPAb) Subjected to Near-Fault Ground Motions

Alessandro Vittorio Bergami, Gabriele Fiorentino, Davide Lavorato, Bruno Briseghella, Camillo Nuti

Subject: Engineering, Civil Engineering Keywords: near field; pulse like ground motions; bridge, non-linear static analysis; non-linear dynamic analysis

Online: 2 September 2020 (04:51:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0561.v1

ECHO: Energy-Efficient Computation Harnessing Online Arithmetic – a MSDF-Based Accelerator for DNN Inference

Muhammad Sohail Ibrahim, Muhammad Usman, Jeong-A Lee

Subject: Computer Science And Mathematics, Hardware And Architecture Keywords: Computation pruning; early negative detection; CNN acceleration; convolution neural network; most-significant-digit first; online arithmetic.

Online: 8 April 2024 (14:46:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.0589.v1

Double Negative B lymphocytes are increased in patients with Systemic Lupus Erythematosus and they are correlated with early differentiated T lymphocyte subpopulations

Eleni Moysidou, Georgios Lioulios, Michalis Christodoulou, Aliki Xochelli, Stamatia Stai, Myrto Iosifidou, Artemis Iosifidou, Sophia Briza, Dimitria Ioanna Briza, Asimina Fylaktou, Maria Stangou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Systemic Lupus Erythematosus; Lupus nephritis; Double negative B lymphocytes; T lymphocytes; early differentiated cells; senescent lymphocytes

Online: 10 July 2023 (10:33:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202306.0507.v1

Immune Microenvironment and PD-L1 Expression in Breast Cancer: A Review of Current Evidence and Prognostic Implications from Pathologist’s Perspective

Giuseppe Angelico, Giuseppe Broggi, Giordana Tinnirello, Lidia Puzzo, Giada Maria Vecchio, Lucia Salvatorelli, Lorenzo Memeo, Angela Santoro, Gaetano Magro, Rosario Caltabiano

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; TILs; PD-L1; immunotherapy; chemotherapy, triple negative breast cancer; HER2; luminal breast cancer; CPS

Online: 7 June 2023 (08:04:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202211.0381.v1

Diversity and Safety Aspects of Coagulase Negative Staphylococci in Ventricina Del Vastese Italian Dry Fermented Sausage

Carmela Amadoro, Franca Rossi, Palmiro Poltronieri, Lucio Marino, Giampaolo Colavita

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: fermented sausage; Ventricina del Vastese; traditional production; coagulase negative staphylo-cocci; hazardous genetic traits; antibiotic resistance

Online: 21 November 2022 (07:31:16 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202208.0419.v1

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Keerthana Sureshkumar, Julian Guo, Michelle Tran, Sagunya Malhotra, Syed M Ahmad, Kabirullah Lutfy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alcohol; Dynorphin; Kappa Opioid Receptor; DYN/KOR; Anxiety; Depression; Negative Affective States; Withdrawal; Microdialysis; Dynorphin-immunoreactivity

Online: 24 August 2022 (10:52:52 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202207.0409.v1

MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans

Clayton Yates, Anusha Angajala, Aliyu Muhammad, Hughley Raymond, Shakir Md Ahmed, Saadia Haleema, Monira Haque, Honghe Wang, Rachel Martini, Balasubramanian Karanam, Andrea G. Kahn, Deepa Bedi, Melissa Davis, Ming Tan, Windy Dean-Colomb

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: QNBC (Quadruple negative breast cancer); AR (Androgen receptor); AA (African American); CA (Caucasian); BC (Breast cancer)

Online: 27 July 2022 (04:07:32 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202103.0570.v1

A Stochastic Condensation Mechanism for Inducing Underdispersion in Count Models

Chenangnon Frédéric Tovissodé, Romain Glele Kakai

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Erlang process; condensed distribution; probability generating function; algebraic moments; Poisson remainder distribution; negative binomial remainder distribution

Online: 23 March 2021 (12:57:21 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202004.0155.v1

COVID-19 Testing: Challenges, Limitations and Suggestions for Improvement

Emily Hu

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Coronavirus; False-negative; Nucleic Acid Test; Screening; Diagnostic Accuracy; Missed Diagnosis; Epidemic; Infectious Disease

Online: 9 April 2020 (14:37:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0366.v1

Energy-Momentum Tensor and Parameters in Cosmological Model

Ying-Qiu Gu

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: cosmological model; energy-momentum tensor; equation of state; cosmic curvature; cosmological constant; negative pressure; dynamic analysis

Online: 25 February 2020 (07:55:12 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201809.0595.v1

Nanoemulsion-Enabled Oral Delivery of Novel Anticancer ω-3 Fatty Acid Derivatives

Gabriela Garrastazu Pereira, Tristan Rawling, Michele Pozzoli, Curtis Pazderka, Yongjuan Chen, Colin R. Dunstan, Michael Murray, Fabio Sonvico

Subject: Chemistry And Materials Science, Nanotechnology Keywords: nanoemulsion; oral delivery; ω-3 polyunsaturated fatty acid derivative; MDA-MB-231; triple-negative breast cancer

Online: 30 September 2018 (05:14:34 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201809.0051.v2

Unbalanced Current Sharing Control in Islanded Low Voltage Microgrids

foad najafi, Matthias Fripp

Subject: Engineering, Electrical And Electronic Engineering Keywords: distributed generation; LV microgrid; negative-sequence current; zero-sequence current; power sharing; unbalance load; voltage control

Online: 5 September 2018 (05:55:55 CEST)

Show abstract| Download PDF| Share

This paper reports a new control strategy to improve sharing of unbalanced currents in islanded LV microgrids. This technique provides fast and effective sharing of positive-, negative- and zero-sequence currents, and is the first example of zero-sequence current sharing in the literature. The controllers are designed in the stationary frame. The control structure consists of four loops; 1)~the current controller; 2)~the voltage controller; 3)~the droop controller and the 4)~negative and zero sequence current controllers. The output current is considered unknown for the controller and is added to the control system as a disturbance. The proposed controller features a high gain in fundamental and harmonic frequencies, hence a good voltage quality is obtained in the presence of unbalanced and nonlinear loads. To this aim, a proportional-resonant (PR) controller is adopted as the current controller. By using a multi-resonant controller as current controller, a unified control structure is obtained which is suitable for both grid-connected and islanded modes. The voltage controller is designed using a resonant controller so that the voltage can have low VUF and THD in the presence of unbalanced and nonlinear loads. Furthermore, in this paper droop method is applied to the control structure to share real and reactive powers. Simulation studies show that the conventional droop method cannot share the oscillatory part of the output power that is due to the presence of unbalanced loads in the microgrid. This paper relies on using zero and negative sequence virtual impedance controller to share the oscillatory part of output power. By using zero-sequence virtual impedance controller (ZSVIC) and negative-sequence virtual impedance controller (NSVIC), the zero and negative sequence currents in the microgrid are controlled and shared effectively. By compensating zero- and negative-sequence currents locally, the flow of these currents in the microgrid is minimized, and the overall power quality of the islanded LV microgrid is improved.

Preprint ARTICLE | doi:10.20944/preprints202404.1496.v1

Design and Fabrication of Low-Pressure Abrasive Water Jet Cutting Machine

Muhammad Osama

Subject: Mechanical Engineering, Engineering Keywords: non-conventional machining; computational fluid dynamic

Online: 23 April 2024 (05:14:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0886.v1

Postprandial Plasma Glucose between 4 and 7.9 Hours May Be a Potential Diagnostic Marker for Diabetes

Yutang Wang, Yan Fang, Christopher L. Aberson, Fadi J. Charchar, Antonio Ceriello

Subject: Biology And Life Sciences, Life Sciences Keywords: postprandial; non-fasting; fasting; glucose; diabetes

Online: 15 April 2024 (04:31:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1136.v1

The Intermittency of Turbulence in Magneto-Hydodynamical Simulations and in the Cosmos

Pierre Lesaffre, Edith Falgarone, Pierre Hily-Blant

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: Turbulence; Intermittency; Dissipation; Non local Interactions

Online: 15 January 2024 (13:45:39 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0296.v1

Dynamic Output Feedback and Neural Network Control of a Non-Holonomic Mobile Robot

Manuel Cardona, Fernando E. Serrano

Subject: Computer Science And Mathematics, Robotics Keywords: Mobile Robot; Non-holonomy; Driftless Control

Online: 5 June 2023 (10:00:22 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202111.0170.v3

A Deep Dive into Genome Assemblies of Non-vertebrate Animals

Nadège Guiglielmoni, Ramón Rivera-Vicéns, Romain Koszul, Jean-François Flot

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genome assembly; sequencing; non-vertebrate animals

Online: 5 May 2022 (10:38:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0129.v1

Transcriptome-wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations

Jia Wen, Munan Xie, Bryce Rowland, Jonathan D. Rosen, Quan Sun, Amanda L. Tapia, Huijun Qian, Madeline H. Kowalski, Yue Shan, Kristin L. Young, Marielisa Graff, Maria Argos, Christy L. Avery, Stephanie A. Bien, Steve Buyske, Jie Yin, Hélène Choquet, Myriam Fornage, Chani J. Hodonsky, Eric Jorgenson, Charles Kooperberg, Ruth J.F. Loos, Yongmei Liu, Jee-Young Moon, Kari E. North, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Wei Zhao, Lulu Shang, Tao Wang, Xiang Zhou, Alexander P. Reiner, Laura M. Raffield, Yun Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TWAS; non-European; blood cell traits

Online: 4 June 2021 (09:56:45 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202002.0172.v1

Design of Tunnel Drier for the Non-centrifugal Sugar Industry

S.P. Raj, B Sravya, Morapakala Srinivas, K.S Reddy

Subject: Engineering, Mechanical Engineering Keywords: Non-centrifugal sugar; drying; tunnel dryer

Online: 13 February 2020 (12:54:49 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201903.0041.v1

Functional RNA Structures in the 3'UTR of Tick-Borne, Insect-Specific and No-Known-Vector Flaviviruses

Roman Ochsenreiter, Ivo L. Hofacker, Michael T. Wolfinger

Subject: Biology And Life Sciences, Virology Keywords: Flavivirus; non-coding RNA; secondary structure

Online: 4 March 2019 (10:37:46 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0104.v1

Factors Associated with Non-Adherence to Tuberculosis Pre-ventive Treatment among Adult Contacts of Pulmonary Tuberculosis Cases with Latent Tuberculosis Infection in Catalonia, Spain, in 2019−2021

Pere Plans-Rubió, Sofia Godoy, Diana Toledo, Angela Domínguez, Joan Caylà, Ignasi Parron, Joan Pau Millet, Pere Godoy

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: latent tuberculosis infection; tuberculosis; non-adherence to LTBI treatment; factors of treatment non-adherence; community health

Online: 2 February 2024 (04:53:50 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1287.v1

Recycled Brewer’s Spent Grains (BSG) and Grape Juice: A New Tool for Non-alcoholic (NAB) or Low Alcoholic (LAB) Craft Beer Using Non-conventional Yeasts

Laura Canonico, Alice Agarbati, Francesca Comitini, Maurizio Ciani

Subject: Biology And Life Sciences, Food Science And Technology Keywords: non-alcoholic beer; low alcoholic beer; Italian Grape Ale; non-Saccharomyces; brewer’ s spent grains

Online: 18 December 2023 (10:43:06 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202111.0045.v1

CybIQ: Secure Authentication Method

Raghavendra Devidas, Hrushikesh Srinivasachar

Subject: Computer Science And Mathematics, Computer Science Keywords: Pattern based access; Graphical password; safe password; non-intuitive password; non-static password; visually encrypted password

Online: 2 November 2021 (11:06:37 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0039.v1

A New R Package for Categorizing Coding and Non-Coding Genes

Masroor Bayati, Narges Rezaie, Mehrab Hamidi, Maedeh Sadat Tahaei, Hamid Rabiee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: somatic point mutations; non-coding RNA; biomarker discovery; driver genes; non-coding RNAs prioritization; health data analytics

Online: 4 January 2023 (02:22:00 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202106.0243.v1

New Concept of Factorials and Combinatorial Numbers and its Consequences for Algebra and Analysis

Mohamed Elmansour Hassani

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: factorials; binomial coefficients; combinatorial numbers; non-classical hypergeometric orthogonal polynomials; non-classical second-order hypergeometric linear DEs

Online: 9 June 2021 (07:39:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201704.0108.v1

Non-Equilibrium Phase Behavior of Hydrocarbons in Compositional Simulations and Upscaling

Ilya M. Indrupskiy, Olga A. Lobanova, Vadim R. Zubov

Subject: Engineering, Energy And Fuel Technology Keywords: non-equilibrium phase behavior; compositional flow simulations; phase transitions; upscaling; hydrocarbon mixtures; non-equilibrium constant volume depletion

Online: 18 April 2017 (04:05:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0830.v1

Development of a HPLC-MS/MS Method to Assess the Pharmacokinetics and Tumour Distribution of the Dimethylarginine Dimethylaminohydrolase 1 Inhibitors ZST316 and L-257 in a Xenograft Model of Triple Negative Breast Cancer

Tommaso Ceruti, Roberta Frapolli, Carmen Ghilardi, Alessandra Decio, Giulia Dellavedova, Sara Tommasi, Massimo Zucchetti, Arduino A Mangoni

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: ZST316; L-257; dimethylarginine dimethylaminohydrolase 1; DDAH1 inhibitors; triple negative breast cancer; pharmacokinetics; xenograft models; analytical chemistry

Online: 12 October 2023 (12:01:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1472.v1

Determination of Optimal Spatial Sample Sizes for Fitting Negative Binomial-Based Crash Prediction Models with Consideration of Statistical Modeling Assumptions

Mohammadreza Koloushani, Seyed Reza Abazari, Omer Arda Vanli, Eren Erman Ozguven, Ren Moses, Rupert Giroux, Benjamin Jacobs

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: Crash Prediction Model; Safety Performance Function; Highway Safety Manual; Negative Binomial Regression; Model Diagnostic; Context Classification System

Online: 21 August 2023 (12:01:58 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202306.2240.v2

An Atypical Presentation of Superficial Breast Cancer: A Case Report and Review of the Literature

Paolo Izzo, Luciano Izzo, Andrea Polistena, Simone Sibio, Massimo Codacci-Pisanelli, Daniele Crocetti, Raimondo Gabriele, Claudia De Intinis, Sara Izzo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: retroareolar breast tumor; modified radical mastectomy; case report; triple negative breast cancer (TNBC); chemotherapy; superficial infiltrating breast carcinoma; taxol

Online: 7 August 2023 (02:30:15 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202105.0546.v1

Atezolizumab and Pembrolizumab in Triple-Negative Breast Cancer: A Meta-Analysis

Mahwish Amin, Shaiza Sharif, Waleed Asghar, Humaira Sadaf, Azza Sarfraz, Zouina Sarfraz, Ivan Cherrez-Ojeda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; Pembrolizumab; Atezolizumab; chemotherapy; anti-PD-L1; biomarkers; targeted therapies; development of novel drugs

Online: 24 May 2021 (09:23:50 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202002.0424.v1

Insufficient Sensitivity of RNA Dependent RNA Polymerase Gene of SARS-CoV-2 Viral Genome as Confirmatory Test using Korean COVID-19 Cases

Soyoun Kim, Dong-Min Kim, Baeckseung Lee

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS-CoV-2; Korean COVID-19; Wuhan Corona virus; real time PCR Ct Value; Sensitivity; False Negative

Online: 28 February 2020 (12:03:13 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201705.0137.v1

Investigation on Development of Sliding Mode Controller for Constant Power Loads in Microgrids

Eklas Hossain, Ron Perez, Sanjeevikumar Padmanaban, Pierluigi Siano

Subject: Engineering, Electrical And Electronic Engineering Keywords: sliding mode control; constant power load; negative incremental impedance; robustness analysis; chattering reduction; microgrid stability; noise rejection

Online: 18 May 2017 (04:45:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0137.v1

Non-Fasting Plasma Triglycerides Are Positively Associated with Diabetes Mortality

Yutang Wang, Yan Fang, Xiulin Zhang, Na-Qiong Wu

Subject: Life Sciences, Biology And Life Sciences Keywords: Triglycerides; non-fasting; diabetes; mortality; risk factor

Online: 2 May 2024 (10:33:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1550.v1

Non-syndromic and Syndromic Defects in Children with Extracranial Germ Cell Tumors (eGCT): Data of 2,610 Children Registered with the German MAKEI 96/MAHO 98 Registry Compared to the General Population

Judit Schultewolter, Anke K. Rißmann, Dietrich Von Schweinitz, Michael Frühwald, Claudia Blattmann, Lars Fischer, Bjoern Soenke Lange, Rüdiger Wessalowski, Birgit Fröhlich, Wolfgang Behnisch, Irene Schmid, Harald Reinhard, Matthias Duerken, Patrick Hundsdoerfer, Martin Heimbrodt, Christian Vokuhl, Stefan Schönberger, Dominik T. Schneider, Guido Seitz, Ulrich Göbel, Rüdiger Von Kries, Heiko M. Reutter, Gabriele Calaminus

Subject: Pediatrics, Perinatology And Child Health, Medicine And Pharmacology Keywords: germ cell tumor; syndrome; non-syndromic defect

Online: 23 April 2024 (16:59:48 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202404.0237.v1

Rapid Non-Destructive Detection Technology in the Field of Meat Tenderness: A Review

Yanlei Li, Huaiqun Wang, Zihao Yang, Xiangwu Wang, Wenxiu Wang, Teng Hui

Subject: Biology And Life Sciences, Food Science And Technology Keywords: meat; tenderness; non-destructive; intelligent (AI); spectroscopy

Online: 2 April 2024 (17:30:46 CEST)

Show abstract| Download PDF| Share

Meat serves as a vital component of the human diet, offering a rich source of protein and essential trace elements. China stands as both a significant producer and consumer of meat on a global scale, leading the world in terms of total meat production and consumption. As the standard of living within the country continues to rise, there is a growing emphasis on the nutritional value and safety of meat consumption. The tenderness of meat is a critical factor influencing its overall quality. Traditionally, tenderness has been assessed through shear force testing, a method that is inherently destructive, inefficient, and results in considerable sample wastage. In light of these drawbacks, non-destructive testing techniques have emerged as a preferred alternative, promising greater accuracy, efficiency, and convenience without compromising the integrity of the samples. This paper delves into the application of five advanced non-destructive testing technologies in the realm of meat tenderness assessment. These include near-infrared spectroscopy, hyperspectral imaging, Raman spectroscopy, airflow optical fusion detection, and nuclear magnetic resonance detection. Each technology is scrutinized for its respective strengths and limitations, providing a comprehensive overview of their current utility and potential for future development. Moreover, the integration of these techniques with the latest advancements in artificial intelligence (AI) technology is explored. The fusion of AI with non-destructive testing offers a promising avenue for the development of more sophisticated, rapid, and intelligent systems for meat tenderness evaluation. This integration is anticipated to significantly enhance the efficiency and accuracy of quality assessment in the meat industry, ensuring a higher standard of safety and nutritional value for consumers. The paper concludes with a set of technical recommendations aimed at guiding the future direction of non-destructive, AI-enhanced meat tenderness detection, thereby contributing to the ongoing improvement of the meat industry in China and beyond.

Preprint ARTICLE | doi:10.20944/preprints202402.0556.v1

Angling for Causality behind Security: Natural Causes of Armed Conflict in Iraq

Ninoslav Malekovic, Maarten Vonk, Laura Birkman, Tim Sweijs, Anna Kononova, Thomas Baeck

Subject: Social Sciences, Government Keywords: Causality; Methodology; Conflict modeling; Non-experimental observations

Online: 9 February 2024 (07:25:42 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0231.v1

Title Arnica D30 – an Alternative for Managing Procedural Pain in Full-Term Neonates

Penka Vasileva Petleshkova, Maya Bogdanova Krasteva, Iliyana Hristova Pacheva, Snezhana Stefanova Dragusheva, Margarita Lyubenova Ruseva

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; procedural pain; non-pharmacological methods; homeopathy

Online: 5 February 2024 (11:05:18 CET)

Show abstract| Download PDF| Share

Background: Despite scientific advances, the management of procedural pain in neonates remains suboptimal. Applying adequate therapy to control pain during the neonatal period is a moral and ethical act. In recent decades, ample evidence has accumulated regarding the risks, associated with both untreated pain and the use of more aggressive analgesic therapy. Thus, the emphasis in neonatal clinical practice is on non-aggressive pain management techniques, including homeopathic agents. The efficacy and safety of homeopathic agents for reducing procedural pain in neonates is the subject of the present study. Materials and Methods: Healthy full-term newborn babies with an average age of 72-84 hours were included. They were divided into three study groups: group (A) – not anesthetised, /n= 67/, group (B) – anesthetised with Arnica D30 /n=40/ and group (C)- anesthetised with Sol.Glucose 25% /n=40/. The severity of the pain was assessed using the multimodal - Neonatal Infant Pain Scale (NIPS) and the unimodal - Neonatal Facial Coding System (NFCS) scale. Assessments were done 30s before, 30 seconds after, and 5 minutes after the painful stimulus caused by the heel prick. Heart rate, transcutaneous oxygen saturation, respiratory rate and blood pressure were examined at the same intervals. The results obtained were processed statistically by descriptive analysis and ANOVA at a significance level of p< 0.05. Results: 5 minutes after heel prick both scales showed a statistically significant lower score in those given Arnica D30, compared to those who received Sol.Glucose 25%. When monitoring the physiological indicators, we found a significant increase in the heart rate 30 seconds after the procedure.5 minutes after the heel prick we recorded significantly respiratory rate and systolic blood pressure in all three groups compared to pre-procedural values. Conclusions: Arnica D30 has better analgesic effects compared to Sol.Glucose 25% for newborn babies after heel prick tests.

Preprint REVIEW | doi:10.20944/preprints202401.1777.v1

Postoperative Myocardial Infarction After Non-cardiac Surgery. An Update.

Carlo Rostagno, Anna Craighero

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: non-cardiac surgery, myocardial infarction/injury, troponin

Online: 24 January 2024 (14:24:42 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.1030.v1

Calcium, Potassium and Magnesium in the Induction of Nutraceutical Quality in Tomato Grafted and Cultivated in the NFT System

Héctor Manuel Rodríguez, Marcelino Cabrera de la Fuente, Adalberto Benavides, Valentín Robledo, Alberto Sandoval, Susana González-Morales, Rafael Delgado

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: enzymatic antioxidants; non-enzymatic antioxidants; foliar; graft

Online: 14 January 2024 (16:03:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0540.v1

Biofilm Growth of Pseudomonas aeruginosa TGC04 Exposed to Metformin and Variations in COD Content

Luiz Gustavo Pragana, João Antônio Carvalho Bandeira, Kaíque Yago Gervazio de Lima, Ulrich Vasconcelos

Subject: Biology And Life Sciences, Aquatic Science Keywords: Emerging contaminants; Non-antibiotic drugs; Antimicrobial activity.

Online: 8 January 2024 (10:10:30 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.1602.v1

Multi-Omics Mining of LNC-RNAs With Biological and Clinical Relevance in Cancer

Ivan Salido-Guadarrama, Sandra L. Romero-Cordoba, Bertha Rueda-Zarazua

Subject: Biology And Life Sciences, Life Sciences Keywords: long non-coding RNAs; cancer; multi-omics

Online: 25 October 2023 (08:02:42 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.1286.v1

Small Bowel Diverticulosis and COVID-19: Awareness Is the Key. A Case Series and Review of the Literature

Petros Bangeas, Nikolaos Konstantinidis, Tania Chrisopoulou, Despoina Karatzia, Alexandros Giakoustidis, Vassileios Papadopoulos

Subject: Medicine And Pharmacology, Surgery Keywords: Small bowel non meckelian; Diverticulitis; COVID-19

Online: 19 October 2023 (20:16:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0036.v1

Beyond Words: The Neuroscientific and Multifaceted World of Non-Verbal Communication in Modern Society

Davide Saggese

Subject: Social Sciences, Cognitive Science Keywords: Non-verbal communication; neuroscience; body language; gestures

Online: 2 October 2023 (08:37:59 CEST)

Show abstract| Download PDF| Share

This publication delves into the intricate world of human communication, extending beyond the realm of spoken and written language to explore the profound influence of non-verbal communication. Focusing on body language—comprising gestures, facial expressions, postures, and movements—it reveals the pivotal role it plays in conveying emotions, intentions, and psychological states. The rapidly evolving fields of neuroscience and cognitive science are investigating the neural mechanisms and cognitive processes that underpin the interpretation and utilization of these non-verbal cues. Notably, the amygdala's involvement in processing emotional facial expressions has provided a neurological foundation for our emotional understanding in non-verbal communication. Concurrently, cognitive psychology sheds light on how perception, attention, and memory influence our interpretation of non-verbal cues and communication strategies.In our modern, technologically advancing society characterized by global interconnectivity and cultural diversity, the significance of non-verbal communication, especially in digital and virtual contexts, is paramount. The transformation of non-verbal expression into digital symbols like emoticons and emojis raises questions regarding its ability to maintain authenticity and emotional understanding. This publication endeavors to comprehensively explore the fundamental role of body language and non-verbal communication in contemporary society. By integrating insights from psychology, neuroscience, social sciences, and digital technologies, it aims to elucidate the underlying mechanisms guiding non-verbal communication. Additionally, it delves into the implications of non-verbal communication across diverse domains, including interpersonal communication, the workplace, politics, advertising, and the virtual world.The research presented herein strives to offer a thorough understanding of interpersonal dynamics, relationships, and social behavior, with the goal of promoting the development of more effective, conscious, and ethically guided communication strategies. Ultimately, this analysis aspires to inspire further interdisciplinary research and reflection, addressing emerging challenges and fully leveraging the potential of non-verbal communication in modern society. This, in turn, guides our path towards a communication landscape that is more inclusive, authentic, and empathetic.

Preprint REVIEW | doi:10.20944/preprints202309.1108.v1

Investigation and Causes of Spontaneous (Non-diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid

Maiar Elghobashy, Rousseau Gama, Raashda Ainuddin Sulaiman

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: hypoglycaemia; spontaneous hypoglycaemia; neuroglycopaenia; non-diabetic; adult

Online: 19 September 2023 (03:50:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0615.v1

ConF: A deep learning model based on BiLSTM, CNN, and cross multi-head attention mechanism for Non-coding RNA Families Prediction

SHORYU TERAGAWA, Lei Wang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: non-coding RNA; deep learning; Gene expression

Online: 8 August 2023 (11:36:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0063.v1

A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management

Ashish Shetty, Gayathri Delanerolle, Heitor Cavalini, Yinshan Qui, Amy Boyd, Yassine Bouchareb, Anish Thillainathan, Seung Kim, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; non-pharmaceutical pain management; interventions

Online: 1 June 2023 (08:13:11 CEST)

Show abstract| Download PDF| Share

Background: Chronic, non-cancer pain represents a serious public health and economic issue affecting approximately 20% of the global population. Chronic pain can affect many aspects of patient’s lives, including mental health, employment, and relationships. Current medical management is largely focussed on investigating and managing acute pain. Patients and clinicians are now increasingly aware of the potential benefits of combined treatments or complex interventions in alleviating chronic pain. These approaches include both physical interventions, such as exercise or yoga, as well as psychological support including cognitive behavioural therapy (CBT) and talking therapies. Methods: This study used network meta-analyses to explore the prevalence of complex interventions in pain management, and the effects of these interventions on quality of life, using outcome measures including intensity of chronic pain, assessment of functional disability and participant’s psychological state. Results: Psychological interventions were associated with improvements in pain intensity and depression. Exercise and manipulation technique-based treatments provided a statistically significant reduction in pain intensity. This effect was enhanced when exercise and CBT were combined. Mensendieck somatocognitive therapy (MSCT) plus standard gynaecological treatment (STGT) treatments appeared to have a better effect on chronic pain than multimodal exercise plus CBT treatment. Combined MSCT and STGT treatment, and multimodal exercise plus CBT treatments, reduced pain intensity, whilst MSCT+STGT treatments had a slightly better effect than exercise plus CBT treatment.Conclusions: Complex interventions have become more popular with patients as the risks associated with other interventions including surgery and pharmacological management have become better understood. These interventions can have a significant positive effect both on the physical and psychological health of patients. The analysis presented in this study suggests that further work is warranted in this area and that additional studies are required, both in more geographically diverse locations, and with larger cohorts.

Preprint REVIEW | doi:10.20944/preprints202305.0062.v1

Biocontrol and Probiotic Function of Non-saccharomyces Yeasts: New Insights in Agri-Food Industry

Francesca Comitini, Laura Canonico, Alice Agarbati, Maurizio Ciani

Subject: Biology And Life Sciences, Food Science And Technology Keywords: biocontrol; non-Saccharomyces yeasts; functional yeasts; probiotics

Online: 2 May 2023 (05:41:37 CEST)

Show abstract| Download PDF| Share

Preprint CONCEPT PAPER | doi:10.20944/preprints202210.0376.v2

Characteristics of Real-world Non-exhaust Particulates from Vehicles

Sunhee Mun, Hwansoo Chong, Jongtae Lee, Yunsung Lim

Subject: Engineering, Automotive Engineering Keywords: Non-exhaust particle, Rubber, Vinylcyclohexene, Dipentene, Metal

Online: 26 December 2022 (01:48:35 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202209.0226.v1

A Survey of GNN in Bioinformation Data

Zhenyi Zhu

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Graph Neural Networks, Non-Euclidean Data, Bioinformation

Online: 15 September 2022 (08:49:51 CEST)

Show abstract| Download PDF| Share

Working Paper ARTICLE

New Bounds for the Hausdorff Dimension of a Dynamically Defined Cantor Set

Fernando José Sánchez-Salas

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: non conformal repellers; dimension theory; thermodynamic formalism

Online: 2 April 2021 (13:53:28 CEST)

Show abstract| Download PDF| Share

Search Results

1336 articles found