Salido-Guadarrama, I.; Romero-Cordoba, S.L.; Rueda-Zarazua, B. Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer. Int. J. Mol. Sci.2023, 24, 16600.
Salido-Guadarrama, I.; Romero-Cordoba, S.L.; Rueda-Zarazua, B. Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer. Int. J. Mol. Sci. 2023, 24, 16600.
Salido-Guadarrama, I.; Romero-Cordoba, S.L.; Rueda-Zarazua, B. Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer. Int. J. Mol. Sci.2023, 24, 16600.
Salido-Guadarrama, I.; Romero-Cordoba, S.L.; Rueda-Zarazua, B. Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer. Int. J. Mol. Sci. 2023, 24, 16600.
Abstract
In this review, we will cover a general overview of the current panorama on lncRNAs with an actual or potential role as biological markers in cancer. We will discuss examples of multi-omics approaches that integrates information on somatic aberrations, gene expression and epigenomics, with the scope of providing a more comprehensive view of the functional impact of lncRNA profiles and how these paradigm can be exploited for the discovery and selection of lncRNAs with a functional role and their use as variables informing on progression and prognostic and help guiding the selection of therapeutic strategies for cancers. Finally, we propose a perspective for future evolution of the study of lncRNAs and the discovery of their functional and harnessing their potential to assist in clinical management of malignancies.
Keywords
long non-coding RNAs; cancer; multi-omics
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
