Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Keerthana Sureshkumar
ORCID logo ,
Julian Guo
,
Michelle Tran
,
Sagunya Malhotra
,
Syed M Ahmad
ORCID logo ,
Kabirullah Lutfy
* ORCID logo
Version 1 : Received: 22 August 2022 / Approved: 24 August 2022 / Online: 24 August 2022 (10:52:52 CEST)

A peer-reviewed article of this Preprint also exists.

Sureshkumar, K.; Go, J.; Tran, M.; Malhotra, S.; Ahmad, S.M.; Lutfy, K. The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol. Psychoactives 2022, 1, 46–63, doi:10.3390/psychoactives1020006. Sureshkumar, K.; Go, J.; Tran, M.; Malhotra, S.; Ahmad, S.M.; Lutfy, K. The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol. Psychoactives 2022, 1, 46–63, doi:10.3390/psychoactives1020006.

Abstract

Alcohol use disorder (AUD) represents major public and socioeconomic issues. Alcohol exerts its phar-macological effects by altering different neurotransmitter systems, such as g-aminobutyric acid (GABA), glutamate, opioids, etc. Recent evidence suggests that the dynorphin (DYN)/kappa opioid receptor (KOR) system mediates the negative affective states associated with alcohol withdrawal. This system is also in-volved in stress-mediated alcohol intake in alcohol-dependent subjects. The DYN/KOR system probably exerts its action in the central nucleus of the amygdala (CeA) to mediate the negative affective states as-sociated with alcohol withdrawal. This article aims to review the current literature regarding the role of the DYN/KOR system in the actions of alcohol. We first review the literature regarding the effect of alcohol on the level of the peptide and its receptor, and the role of the endogenous DYN/KOR system in alcohol reward and negative affective states associated with alcohol withdrawal is then discussed. We also review the literature regarding the effects of KOR ligands on these processes.

Keywords

Alcohol; Dynorphin; Kappa Opioid Receptor; DYN/KOR; Anxiety; Depression; Negative Affective States; Withdrawal; Microdialysis; Dynorphin-immunoreactivity

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.