Version 1
: Received: 11 April 2024 / Approved: 15 April 2024 / Online: 15 April 2024 (04:31:45 CEST)
How to cite:
Wang, Y.; Fang, Y.; Aberson, C.L.; Charchar, F.J.; Ceriello, A. Postprandial Plasma Glucose between 4 and 7.9 Hours May Be a Potential Diagnostic Marker for Diabetes. Preprints2024, 2024040886. https://doi.org/10.20944/preprints202404.0886.v1
Wang, Y.; Fang, Y.; Aberson, C.L.; Charchar, F.J.; Ceriello, A. Postprandial Plasma Glucose between 4 and 7.9 Hours May Be a Potential Diagnostic Marker for Diabetes. Preprints 2024, 2024040886. https://doi.org/10.20944/preprints202404.0886.v1
Wang, Y.; Fang, Y.; Aberson, C.L.; Charchar, F.J.; Ceriello, A. Postprandial Plasma Glucose between 4 and 7.9 Hours May Be a Potential Diagnostic Marker for Diabetes. Preprints2024, 2024040886. https://doi.org/10.20944/preprints202404.0886.v1
APA Style
Wang, Y., Fang, Y., Aberson, C.L., Charchar, F.J., & Ceriello, A. (2024). Postprandial Plasma Glucose between 4 and 7.9 Hours May Be a Potential Diagnostic Marker for Diabetes. Preprints. https://doi.org/10.20944/preprints202404.0886.v1
Chicago/Turabian Style
Wang, Y., Fadi J. Charchar and Antonio Ceriello. 2024 "Postprandial Plasma Glucose between 4 and 7.9 Hours May Be a Potential Diagnostic Marker for Diabetes" Preprints. https://doi.org/10.20944/preprints202404.0886.v1
Abstract
Postprandial glucose levels between 4 and 7.9 hours (PPG4–7.9h) correlate with mortality from various diseases including hypertension, diabetes, cardiovascular disease, and cancer. This study aimed to assess if predicted PPG4–7.9h could diagnose diabetes. Two groups of participants were involved: Group 1 (4420 participants) had actual PPG4–7.9h, while Group 2 (8422 participants) lacked this measure but had all the diabetes diagnostic measures. Group 1 underwent multiple linear regression to predict PPG4–7.9h using 30 predictors, achieving accuracy within 11.1 mg/dL in 80% of the participants. Group 2 had PPG4–7.9h predicted using this model. Receiver operating characteristic curve analysis showed that predicted PPG4–7.9h could diagnose diabetes with an accuracy of 87.3% in Group 2, with a sensitivity of 75.1% and specificity of 84.1% at the optimal cutoff of 102.5 mg/dL. Simulation on 10,000 random samples from Group 2 revealed that 175 participants may be needed to investigate PPG4–7.9h as a diabetes diagnostic marker with a power of at least 80%. In conclusion, predicted PPG4–7.9h appears to be a promising diagnostic indicator for diabetes. Future studies seeking to ascertain its definitive diagnostic value might require a minimum sample size of 175 participants.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
