Preprint Article Version 3 Preserved in Portico This version is not peer-reviewed

Non-Ionizing Millimeter Waves Non-thermal Radiation of Saccharomyces Cerevisiae – Insights and Interactions.

Version 1 : Received: 1 November 2020 / Approved: 2 November 2020 / Online: 2 November 2020 (11:26:14 CET)
Version 2 : Received: 22 January 2021 / Approved: 22 January 2021 / Online: 22 January 2021 (14:31:18 CET)
Version 3 : Received: 15 April 2021 / Approved: 16 April 2021 / Online: 16 April 2021 (14:52:04 CEST)

How to cite: Barbora, A.; Rajput, S.; Komoshvili, K.; Levitan, J.; Yahalom, A.; Liberman- Aronov, S. Non-Ionizing Millimeter Waves Non-thermal Radiation of Saccharomyces Cerevisiae – Insights and Interactions.. Preprints 2020, 2020110032 (doi: 10.20944/preprints202011.0032.v3). Barbora, A.; Rajput, S.; Komoshvili, K.; Levitan, J.; Yahalom, A.; Liberman- Aronov, S. Non-Ionizing Millimeter Waves Non-thermal Radiation of Saccharomyces Cerevisiae – Insights and Interactions.. Preprints 2020, 2020110032 (doi: 10.20944/preprints202011.0032.v3).

Abstract

Nonionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85-105 GHz MMW irradiation within the ICNIRP (International Commission on Non-Ionizing Radiation Protection) non-thermal 20 mW/cm2 safety standards. Irradiation using a power density of about 1.0 mW/cm2 , SAR over 5-6 hours on 50 cells/μl samples of Saccharomyces cerevisiae model organism resulted in 62% growth rate reduction compared to the control (sham). The effect was specific for 85-105 GHz range, and was energy and cell density dependent. Irradiation of wild type and Δrad52 (DNA damage repair gene) deleted cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause permanent genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm2) and compared to that of a compact waveguide (17.17 mW/cm2) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. We have shown that non-thermal MMW radiation has potential for future use in treatment of yeast related diseases and other targeted biomedical outcomes.

Subject Areas

Non-ionizing Radiation; Millimeter waves; Novel biomedical applications; Yeast; Non-invasive devices

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