MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans

Clayton Yates; Anusha Angajala; Aliyu Muhammad; Hughley Raymond; Shakir Md Ahmed; Saadia Haleema; Monira Haque; Honghe Wang; Rachel Martini; Balasubramanian Karanam; Andrea G. Kahn; Deepa Bedi; Melissa Davis; Ming Tan; Windy Dean-Colomb

doi:10.20944/preprints202207.0409.v1

How to cite: Yates, C.; Angajala, A.; Muhammad, A.; Raymond, H.; Md Ahmed, S.; Haleema, S.; Haque, M.; Wang, H.; Martini, R.; Karanam, B.; G. Kahn, A.; Bedi, D.; Davis, M.; Tan, M.; Dean-Colomb, W. MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans. Preprints 2022, 2022070409. https://doi.org/10.20944/preprints202207.0409.v1 Yates, C.; Angajala, A.; Muhammad, A.; Raymond, H.; Md Ahmed, S.; Haleema, S.; Haque, M.; Wang, H.; Martini, R.; Karanam, B.; G. Kahn, A.; Bedi, D.; Davis, M.; Tan, M.; Dean-Colomb, W. MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans. Preprints 2022, 2022070409. https://doi.org/10.20944/preprints202207.0409.v1

Abstract

Background: We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA-mRNA profile in QNBC patients based on race. Methods: Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT. Results: miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-β, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. Conclusion: Thus, QNBC tumors have an altered gene signature implicated in racial disparity and poor survival.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans

Abstract

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