Version 1
: Received: 22 July 2022 / Approved: 27 July 2022 / Online: 27 July 2022 (04:07:32 CEST)
How to cite:
Yates, C.; Angajala, A.; Muhammad, A.; Raymond, H.; Md Ahmed, S.; Haleema, S.; Haque, M.; Wang, H.; Martini, R.; Karanam, B.; G. Kahn, A.; Bedi, D.; Davis, M.; Tan, M.; Dean-Colomb, W. MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans . Preprints2022, 2022070409. https://doi.org/10.20944/preprints202207.0409.v1.
Yates, C.; Angajala, A.; Muhammad, A.; Raymond, H.; Md Ahmed, S.; Haleema, S.; Haque, M.; Wang, H.; Martini, R.; Karanam, B.; G. Kahn, A.; Bedi, D.; Davis, M.; Tan, M.; Dean-Colomb, W. MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans . Preprints 2022, 2022070409. https://doi.org/10.20944/preprints202207.0409.v1.
Cite as:
Yates, C.; Angajala, A.; Muhammad, A.; Raymond, H.; Md Ahmed, S.; Haleema, S.; Haque, M.; Wang, H.; Martini, R.; Karanam, B.; G. Kahn, A.; Bedi, D.; Davis, M.; Tan, M.; Dean-Colomb, W. MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans . Preprints2022, 2022070409. https://doi.org/10.20944/preprints202207.0409.v1.
Yates, C.; Angajala, A.; Muhammad, A.; Raymond, H.; Md Ahmed, S.; Haleema, S.; Haque, M.; Wang, H.; Martini, R.; Karanam, B.; G. Kahn, A.; Bedi, D.; Davis, M.; Tan, M.; Dean-Colomb, W. MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans . Preprints 2022, 2022070409. https://doi.org/10.20944/preprints202207.0409.v1.
Abstract
Background: We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA-mRNA profile in QNBC patients based on race. Methods: Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT. Results: miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-β, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. Conclusion: Thus, QNBC tumors have an altered gene signature implicated in racial disparity and poor survival.
Keywords
QNBC (Quadruple negative breast cancer); AR (Androgen receptor); AA (African American); CA (Caucasian); BC (Breast cancer)
Subject
LIFE SCIENCES, Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.