Working Paper Article Version 2 This version is not peer-reviewed

Mechanisms of the Non-Thermal Exposure Effects of Non-Ionizing Millimeter Waves Radiation on Eukaryotic Cells for Improving Technological Precision Enabling Novel Biomedical Applications

Version 1 : Received: 18 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (07:13:48 CEST)
Version 2 : Received: 16 September 2020 / Approved: 17 September 2020 / Online: 17 September 2020 (07:08:47 CEST)

How to cite: Barbara, A.; Rajput, S.; Komoshvili, K.; Levitan, J.; Yahalom, A.; Liberman- Aronov, S. Mechanisms of the Non-Thermal Exposure Effects of Non-Ionizing Millimeter Waves Radiation on Eukaryotic Cells for Improving Technological Precision Enabling Novel Biomedical Applications. Preprints 2020, 2020080436 Barbara, A.; Rajput, S.; Komoshvili, K.; Levitan, J.; Yahalom, A.; Liberman- Aronov, S. Mechanisms of the Non-Thermal Exposure Effects of Non-Ionizing Millimeter Waves Radiation on Eukaryotic Cells for Improving Technological Precision Enabling Novel Biomedical Applications. Preprints 2020, 2020080436

Abstract

Nonionizing millimeter-waves (MMW) are reported to interact with cells in a variety of ways. Possible mechanisms of the inhibited cell division effect were investigated using 85-105 GHz MMW irradiation within the ICNIRP (International Commission on Non-Ionizing Radiation Protection) non-thermal 20 mW/cm2 safety standards. ~1.0 mW/cm2 exposure over 5-6 hours treatment on 50 cells/μl samples of Saccharomyces cerevisiae model organism, resulted in 62% growth rate reduction compared to control (sham). The effect was specific for 85-105 GHz range and energy dose and cell density dependent. Irradiation of wild type and Δrad52 (DNA damage repair gene) deletion cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm2) and compared to that of a compact waveguide (17.17 mW/cm2) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. Combinations of MMW mediated Structure Resonant Energy Transfer (SRET), membrane modulations eliciting signaling effects, and energetic resonance with biomolecules were indicated to be responsible for the observations reported. Our results provide novel mechanistic insights enabling innovative applications of nonionizing radiation procedures for eliciting targeted biomedical outcomes.

Subject Areas

non-ionizing radiation; millimeter waves; novel biomedical applications; yeast; non-invasive devices

Comments (1)

Comment 1
Received: 17 September 2020
Commenter: Stella Liberman Aronov
Commenter's Conflict of Interests: Author
Comment: We rewrite the article and change the title too.
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