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Preprint ARTICLE | doi:10.20944/preprints202110.0343.v1

The Relevance between Iodine Nutritional Status and BRAFV600E Mutation on Papillary Thyroid Cancer

Yan-Yu Lin, Yu-Shan Hsieh

Subject: Biology And Life Sciences, Food Science And Technology Keywords: iodine nutritional status; BRAFV600E; papillary thyroid cancer

Online: 25 October 2021 (10:57:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0040.v1

Breast Cancer and Anaesthesia: Genetic Influence

Aida Raigon Ponferrada, Jose Luis Guerrero Orriach, Juan Carlos Molina Ruiz, Salvador Romero Molina, Jose Cruz Mañas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Anesthetic drugs and techniques, opioids, propofol, volatile agent, breast cancer, cancer recurrence, Biomarkers, miRNA.

Online: 1 June 2021 (15:06:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0950.v1

Sensitive and Specific Analyses of Colorectal Cancer Recurrence through Multiplex superRCA Mutation Detection in Blood Plasma

Emma Sandberg, Luís Nunes, Per-Henrik Edqvist, Lucy Mathot, Lei Chen, Tomas Edgren, Shahed Al Nassralla, Bengt Glimelius, Ulf Landegren, Tobias Sjöblom

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: colorectal cancer; recurrence; cfDNA; ctDNA

Online: 11 January 2024 (16:06:31 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201911.0200.v1

Somatic BRCA Mutation in Cholangiocarcinoma Patient Utilized to Individualize an HBOC Syndrome

Angelo Paradiso, Margherita Patruno, Maria Digennaro, Stefania Tommasi, Brunella Pilato, Antonella Argentiero, Oronzo Brunetti, Nicola Silvestris

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: BRCA1; BRCA2; biliary tract cancers; ereditary BRCA cancer; somatic mutations

Online: 17 November 2019 (10:44:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.2239.v1

CT-Based Radiomics to Predict the KRAS Mutation in CRC patients. A Retrospective Study

Jacobo Porto Álvarez, Eva Cernadas, Rebeca Aldaz Martínez, Manuel Fernández-Delgado, Emilio Huelga Zapico, Victor González-Castro, Sandra Baleato González, Roberto Garcia-Figueiras, J Ramon Antunez-Lopez, Miguel Souto-Bayarri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: KRAS mutation; colorectal cancer; texture analysis; radiomics, radiogenomics.

Online: 30 June 2023 (11:25:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0457.v1

Genetic Predisposition to Differentiated Thyroid Cancer among Polish Population

Martyna Borowczyk, Mateusz Sypniewski, Joanna Szyda, Małgorzata Braszka, Katarzyna Ziemnicka, Marek Ruchała, Michalina Oszywa, Zbignie J. Król, Paula Dobosz

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: thyroid cancer; whole-genome sequencing; non-medullary thyroid cancer; germline; genetics

Online: 7 September 2023 (03:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0130.v1

Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective

Wei Li

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: PD-1; PD-L1; Cancer-linked genetic mutation; Electrostatic repulsion; Structural evolution

Online: 12 January 2020 (16:58:35 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202112.0327.v1

Predicting and Visualizing STK11 Mutation in Lung Adenocarcinoma Histopathology Slides Using Deep Learning

Runyu Hong, Wenke Liu, David Fenyö

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: keyword; histopathology; deep learning; machine learning; cancer; lung adenocarcinoma; immune; computational pathology

Online: 21 December 2021 (12:28:44 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0115.v2

Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment

Rudolph E. Willis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oncogenes; oncogene addiction; carcinogenesis; transcription factor; cancer genome; gene fusion; cancer genetics; cancer stem cell; targeted cancer therapy; personalized medicine

Online: 14 September 2016 (08:30:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0519.v1

Genetic Risk Scores and Missing Heritability in Ovarian Cancer

James P Brody, Yasaman Fatapour

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ovarian cancer; machine learning; germ line; genetic risk scores

Online: 28 January 2023 (06:58:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0972.v1

Genetic polymorphisms and tumoral mutational profile over survival in advanced colorectal cancer patients: an exploratory study

Juan Pablo Cayún, Leslie Carol Cerpa, Alicia Colombo, Dante Daniel Cáceres, José Luis Leal, Felipe Reyes, Carolina Gutierrez, Susan Calfunao, Nelson Miguel Varela, Luis Abel Quiñones

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: colorectal cancer; pharmacogenomics; biomarkers

Online: 14 July 2023 (08:19:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2204.v1

Genome-Wide Association Mapping of Oil Content and Seed Related Traits in Shea Tree (Vitellaria paradoxa subsp. nilotica) Population

Juventine Boaz Odoi, Emmanuel Amponsah Adjei, Michael Teye Barnor, Richard Edema, Samson Gwali, Danguah Agyemang, Thomas Lapaka Odong, Prasad S. Hendre

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Linked; marker association; annotation; Genes

Online: 31 May 2023 (08:41:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0385.v1

Impact of BRAFV600E Mutation on Event Free Survival in Patients with Papillary Thyroid Carcinoma: A Retrospective Study in a Romanian Population

Adela Nechifor-Boila, Ancuta Cota, Claudia Banescu, Valeriu Moldovan, Doina Piciu, Septimiu Voidazan, Angela Borda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: papillary thyroid cancer; BRAFV600E mutation; lymph node metastasis; prognosis; outcomes.

Online: 6 July 2023 (07:14:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0042.v1

RAS, BRAF and EGFR Related Genetic Mutations as Predictive Biomarkers in Colorectal Cancer

Adriana Ionescu, Liviu Bilteanu, Ovidiu Ionut Geicu, Florin Iordache, Loredana Stanca, Aurelia Magdalena Pisoschi, Adrian Miron, Andreea Iren Serban, Valentin Calu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Colorectal cancer; ddPCR; KRAS; NRAS; BRAF; EGFR

Online: 5 May 2022 (15:24:14 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202103.0113.v1

Viewpoint: The Current Advances and Future Optimization of Blood-based Tumor Mutation Burden as a Biomarker for Cancer Immunotherapy

Anlin Li

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: blood-based mutation burden (bTMB); cancer immunotherapy; immune checkpoint inhibitor (ICI); biomarker; mutation

Online: 2 March 2021 (21:45:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1473.v1

Uncovering Pathogenic Variants in Cancer Susceptibility Genes through Genetic Testing for Pancreatic Cancer Patients

Kevisa Potska, Anastasia Katseli, Konstantinos Agiannitopoulos, Christina Ntogka, Georgios N. Tsaousis, Nikolaos Tsoulos, Adina Emilia Croitoru, Dimitrios Ziogas, Maria Theochari, Christos Christodoulou, Epaminondas Samantas, Dimitrios Janninis, Ilias Athanasiadis, Angelos Koutras, Eirini Papadopoulou, Onder Kirca, Muharrem Okan Cakir, Gholam Hossein Ashrafi, George Nasioulas, Mustafa Ozdogan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hereditary; Pancreatic cancer; Next Generation Sequencing (NGS)

Online: 25 March 2024 (09:58:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1079.v1

Virtual Screening of Different Subclasses of Lignans with Anticancer Potential and Based on Genetic Profile

Mayara dos Santos Maia, Francisco Jaime Bezerra Mendonça-Junior, Gabriela Cristina Soares Rodrigues, Adriano Soares da Silva, Niara Isis Pereira de Oliveira, Pablo Rayff da Silva, Cícero Francisco Bezerra Felipe, Ana Pavla Almeida Diniz Gurgel, Anuraj Nayarisseri, Marcus Tullius Scotti, Luciana Scotti

Subject: Medicine And Pharmacology, Pharmacy Keywords: lignans; cancer; single nucleotide polymorphisms; virtual screening

Online: 16 June 2023 (05:10:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0421.v1

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

Paule Bénit, Judith Goncalves, Riyad El Khoury, Malgorzata Rak, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Mitochondria; Respiratory chain; Krebs cycle; Succinate; Cancer; Encephalopathy; SDH, SDHI; pesticides

Online: 30 June 2022 (08:31:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1215.v1

Detection of Germline Mutations in a Cohort of 250 Relatives of Mutation Carriers in Multigene Panel: Impact of Pathogenic Variants in Other Genes beyond BRCA1/2

S. Di Rado, R. Giansante, M. Cicirelli, L. Pilenzi, A. Dell'Elice, F. Anaclerio, M. Rimoldi, A. Grassadonia, S. Grossi, Nicole Canale, P. Ballerini, L. Stuppia, Ivana Antonucci

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: NGS Multigene panel; hereditary cancer; healthy collateral family members

Online: 19 October 2023 (04:23:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2077.v1

Illuminating Dersimelagon: A Novel Agent in the Treatment of Erythropoietic Protoporphyria and X-Linked Protoporphyria

Katelyn E Madigan, Sean R Rudnick, Matthew A Agnew, Numra Urooj, Herbert L Bonkovsky

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Erythropoietic Protoporphyria; X-linked protoporphyria, oral, dersimelagon

Online: 29 September 2023 (05:48:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0595.v1

Estimating the Total Number of Residential Fire-Related Incidents and Underreported Residential-Fire Incidents in New South Wales, Australia by Using Linked Administrative Data

Nargess Ghassempour, W. Kathy Tannous, Gulay Avsar, Kingsley E. Agho, Lara A. Harvey

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Residential Fire; Linked Data; Health Economics; Epidemiology

Online: 24 June 2021 (08:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1057.v1

Genetic Polymorphisms of ACE1 rs4646994 Associated with Lung Cancer in Patients with Pulmonary Nodules: A Case Control Study

Rong Qiao, Siyao Sang, Jiajun Teng, Hua Zhong, Hui Li, Baohui Han

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic polymorphism; ACE1 rs4646994; lung cancer; pulmonary nodules

Online: 27 April 2023 (07:47:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0050.v2

Impact of Genetic Polymorphism of Sulpha Transferase Genes (SULT1A) Genes on the Risk of Females with Breast Cancer in Jordan

Mona Bustami, Abdel-Ellah Al-Shudifat, Nagham Hussein, Mohannad Yacoub, Eiad Atwa, Israr Sabri, Rania Abu-Hamdah, Walid Abu-Rayyan, Tawfiq Arafat, Adnan Badran, Luay Abu-Qatouseh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: polymorphism; risk for breast cancer; SULT1A allele

Online: 9 November 2018 (04:28:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0502.v1

Reprogramming Megakaryocyte Gene Expression to Release Platelet-Like Particles with Opposite Biological Activities: Carrying Single-Chain Thromboxane A2 Receptor-G-Protein Complex with Therapeutic Potentials

Renzhong Lu, Yan Li, Anna Xu, Bridgette King, Ke-He Ruan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: platelet linked particles; megakaryocyte; G protein coupled recepto

Online: 7 August 2023 (10:07:34 CEST)

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In this study, we reported that novel single-chain fusion-proteins linked thromboxane A2 (TXA2) receptor (TP) to a selected G-protein α-subunit q (SC-TP-Gαq), or s (SC-TP-Gαs) could be stably expressed in megakaryocytes (MK). We tested the MK-released platelet-linked particles (PLPs) to be used as a vehicle to deliver the over-expressed SC-TP-Gαq), or s (SC-TP-Gαs) to regulate human platelet function. To understand how the single-chain TP-Gα fusion proteins could regulate opposite platelet activities by an identical ligand TXA2, we used dual-binding domains linked to different signaling pathways within a single polypeptide chain using a 3D structural model. The immature MKs were cultured and transfected with cDNAs constructed from structural models of the individual SC-TP-Gαq and SC-TP-Gαs, respectively. After transient expression was identified, the immature MKs stably expressing SC-TP-Gαq or SC-TP-Gαs (stable cell lines) were selected. The stable cell lines were induced into mature MKs which released PLPs. Western blot analysis confirmed that the released PLPs were carrying the recombinant SC-TP-Gαq or SC-TP-Gαs. Flow cytometry analysis showed the PLPs carrying SC-TP-Gαq were able to perform the activity by promoting platelet aggregation. In contrast, PLPs carrying SC-TP-Gαs reversed Gq to Gs signaling to inhibit platelet aggregation. This is the first time demonstrating that SC-TP-Gαq and SC-TP-Gαs were successfully overexpressed in MK cells and released as PLPs with proper folding. This bio-engineering led to the formation of two sets of biologically active PLP forms, which mediate calcium and cAMP signaling, respectively. As a result, these PLPs are able to bind to identical endogenous TXA2 with opposite activities, inhibiting and promoting platelet aggregation as required for therapeutic process.The results also demonstrated the nucleus-free PLPs could be used to deliver recombinant membrane-bound GPCRs to regulate cellular activity in general.

Preprint ARTICLE | doi:10.20944/preprints202106.0099.v1

A Proposal of Linked Data for Smart Metering System

Juan Carlos Olivares Rojas, Enrique Reyes Archundia, José Antonio Gutiérrez Gnecchi

Subject: Engineering, Automotive Engineering Keywords: JSON-LD; Linked Data; Smart Meters; Transactive Energy

Online: 3 June 2021 (11:20:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0419.v1

Modeling Analytical Streams for Social Business Intelligence

Indira Lanza-Cruz, Rafael Berlanga, María José Aramburu

Subject: Computer Science And Mathematics, Information Systems Keywords: social business intelligence; data streaming models; linked data

Online: 26 June 2018 (12:48:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0078.v1

Operational Analysis of an Axial and Solid Double-Pole-Tweeted-Rotor Configuration in a PM Flux Switching Generators

Manuel Pedro Garcia Neto, Francisco Ferreira Silva, P. J. da Costa Branco

Subject: Engineering, Electrical And Electronic Engineering Keywords: Switched Flux Generator; Oscillatory Torque; Linked Flux; Torque Density

Online: 3 March 2024 (18:20:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1722.v1

Cultural Itineraries Generated by Smart Data on the Web

Mauro Mazzei, Cosmo Capodiferro, Massimo De Maria, Matteo Spreafico, Oleg V. Bik, Armando Palma, Anna V. Solovyeva

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Linked Open Data; SPARQL; GeoSPARL; Geocoding; OpenStreetMap; web-GIS

Online: 22 December 2023 (14:30:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0355.v1

X-linked Gusher Disease DFNX2 in Children, a Rare Inner Ear Dysplasia with Conductive Hearing Loss

Soumit Dasgupta, James Hong, Rhyanna Morris, Javed Iqbal, Amy Lennox, Jeyasakthy Saniasiaya

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Third window; X-linked gusher; hearing loss; audiovestibular; POU3F4

Online: 6 July 2023 (09:16:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0298.v1

A Composite Hybrid Feature Selection Learning-Based Optimization of Genetic Algorithm For Breast Cancer Detection

Ahmed Abdullah Farid, Gamal Selim, Hatem Khater

Subject: Computer Science And Mathematics, Information Systems Keywords: Data Mining; Breast Cancer; Hybrid Feature Selection; Machine learning; Support Vector Machine; Optimize Genetic Algorithm; boosting algorithms

Online: 19 March 2020 (11:13:15 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0351.v3

Organogenesis: A New Theme to Study Genetic Expression in Adult Liver Regeneration After Partial Hepatectomy

Haydar Witwit

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: organogenesis, adult liver, translational, regeneration, homeobox, hox, Wnts, growth factors, theme, gene expression, cancer, hepatectomy, three-dimensional, organoid

Online: 16 January 2019 (09:14:06 CET)

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Working Paper ARTICLE

Outcomes of a Cluster Randomized Trial in Young Breast Cancer Survivors and Blood Relatives: Surveillance and Genetic Services

Maria C. Katapodi, Chang Ming, Laurel L. Northouse, Sonia A. Duffy, Debra Duquette, Kari E. Mendelsohn-Victor, Kara J. Milliron, Sofia D. Merajver, Ivo D. Dinov, Nancy K. Janz

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: HBOC; statewide random sampling; cancer survivorship; targeted intervention; tailored intervention; black participants; family recruitment

Online: 5 September 2019 (16:16:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1504.v1

Stabilization of the Metastable Prefusion Conformation of SARS-CoV-2 Spike Glycoprotein through N-linked Glycosylation on S2 Subunit

Fuwen Zan, Yao Zhou, Ting Chen, Yahan Chen, Zhixia Mu, Zhaohui Qian, Xiuyuan Ou

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; S protein; N-linked glycosylation; Syncytia; Stability

Online: 20 December 2023 (09:02:50 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1230.v1

Epstein-Barr Virus-negative Diffuse Large B Cell Lymphoma in a X-linked Severe Combined Immunodeficiency Patient: A Very Rare Condition

Dina Rochate, Sara Duarte, Rita S. Gomes, Rita Pinho Peixeiro, João Vaz Silva, Ângelo Rodrigues, Luís Leite, Rosa Branca, Sónia Lemos, Joana Guimarães, Susana Roncon, Ana Maia Ferreira, Carlos Pinho Vaz

Subject: Medicine And Pharmacology, Transplantation Keywords: DLBCL; X-linked SCID; allogeneic stem cell transplantation; infant; lymphoma

Online: 18 December 2023 (13:00:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0593.v2

Hospital Admissions From Care Homes in England During the COVID-19 Pandemic: A Retrospective, Cross-Sectional Analysis Using Linked Administrative Data

Fiona Grimm, Karen Hodgson, Richard Brine, Sarah R Deeny

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Hospital admissions; care homes; COVID-19; linked data; administrative data

Online: 25 May 2021 (10:33:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0202.v1

The Metabolic Bone Disease X-Linked Hypophosphatemia: Case Presentation, Pathophysiology and Pharmacology

Jon Vincze, Brian W Skinner, Katherine A Tucker, Jonathan W Lowery, Julia M Hum

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: metabolic bone disease; burosumab; KRN23; x-linked hypophosphatemia; crysvita; xlh

Online: 10 May 2021 (14:37:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0124.v1

Detection of Microcystins in Lake Manatee and Lake Washington – Two Florida Drinking Water Systems

Rajesh Melaram, Brandon Lopez-Dueñas

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Drinking water; Enzyme-linked immunosorbent assay; Harmful algal blooms; Microcystin

Online: 5 April 2021 (12:25:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0004.v1

Development of an Indirect ELISA to Detect Equine Antibodies to Theileria haneyi

Reginaldo G. Bastos, Kelly P. Sears, Kelcey D. Dinkel, Lowell Kappmeyer, Massaro W. Ueti, Donald P. Knowles, Lindsay M. Fry

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Equine theileriosis; Theileria haneyi; enzyme-linked immunosorbent assay (ELISA), serology

Online: 1 February 2021 (09:41:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0210.v1

Pharmacokinetics and Tissue Distribution Kinetics of Puerarin in Rats Using Indirect Competitive ELISA

Hui Kong, Xueqian Wang, Rongfeng Shi, Yan Zhao, Jinjun Cheng, Xin Yan, Xiaoman Liu, Yongzhi Wang, Meiling Zhang, Qingguo Wang, Huihua Qu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pharmacokinetics; tissue distribution; indirect competitive enzyme-linked immunosorbent assay; puerarin

Online: 30 May 2017 (07:47:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0307.v1

Bringing onco-innovation to Europe’s healthcare systems: the unexploited potential of biomarker testing, real world evidence and the potential of Tumour Agnostics. The lesson from BRCA1/2 genetic testing

Denis Horgan, Gennaro CILIBERTO, Pierfranco Conte, Giuseppe CURIGLIANO, Luis Seijo, Luis M. Montuenga, Luis Paz-Ares, Marina Chiara Garassino, Penault-Llorca Frederique, Fabrizia GALLI, Isabelle Ray-Coquard, Denis Querleu, David R. Baldwin, Susana Banerjee, Peter H.J. Riegman, Keith Kerr, Benjamin Horbach, Reinhard Büttner, Hendrik Van Poppel, Anders Bjartell, Giovanni Codacci-Pisanelli, Westphalen Christoph Benedikt, Fabien CALVO, Jasmina Koeva-Balabanova, Stephen Hall, Angelo Virgilio Paradiso, Dipak. Kalra, Christa M. Cobbaert, Rocio Varea Mendez, Zorana Maravic, Vassiliki Fotaki, Jaafar Bennouna, Estelle Cauchin, Núria Malats, Iñaki Gutiérrez-Ibarluzea, Benjamin Gannon, Ken Mastris, Chiara Benini, William M. Gallagher, Simonetta Buglioni, Alastair Kent, Elisabetta Munzone, Ivica Belina, Jan P. van Meerbeeck, Michael Joe Duffy, Elzbieta. Sarnowska, Beata Jagielska, Sarah Mee, Ettore Domenico Capoluongo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer biomarkers, BRCA1/2, genomics; European recommendation

Online: 14 August 2020 (04:27:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1792.v1

Synthesis and Characterization of Bromine- and Hydroxyl-Functionalized Polyaminals for CO₂ Capture

Maha M. Alotaibi, Abeer M. Alharthi, Nazeeha S. Alkayal, Maymounah A. Alrayyani

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: porous organic polymer, polyaminal-linked polymers, melamine, surface area, CO2 capture

Online: 25 December 2023 (09:24:20 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.0216.v1

Epitope Mapping of an Anti-CD44v4 Monoclonal Antibody (C₄₄Mab-108) using Enzyme-Linked Immunosorbent Assay

Hiroyuki Suzuki, Mayuki Tawara, Aoi Hirayama, Nohara Goto, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CD44; CD44 variant 4; monoclonal antibody; epitope; enzyme-linked immunosorbent assay

Online: 3 November 2023 (06:38:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2006.v1

A Case Study on Enhancing the Expertise of Artificial Intelligence Education for Pre-Service Teachers

Jungho Park

Subject: Social Sciences, Education Keywords: AI Literacy; AI Expertise; Subject-linked; Pre-service Teacher; Micro-teaching

Online: 29 May 2023 (10:51:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0344.v1

Transforming Points of Single Contact Data into Linked Data

Pavlina Fragkou, Leandros Maglaras

Subject: Computer Science And Mathematics, Information Systems Keywords: Linked (open) Data; Semantic Interoperability; Data Mapping; Governmental Data; SPARQL; Ontologies

Online: 25 May 2022 (08:18:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0519.v1

Whole-Exome Analysis Reveals X-linked Recessive Mutations underlying Premature Ovarian Failure Using Galaxy Platform

Rashid Saif, Tania Mahmood, Aniqa Ejaz, Saeeda Zia, Saqer Alotaibi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: WES analysis; POF; Galaxy platform; GEMINI tool; X-linked recessive; ClinVar

Online: 21 May 2021 (10:13:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0337.v1

Integration of Web APIs and Linked Data using SPARQL Micro-Services. Application to Biodiversity Use Cases

Franck Michel, Catherine Faron Zucker, Olivier Gargominy, Fabien Gandon

Subject: Computer Science And Mathematics, Information Systems Keywords: Web API; SPARQL; micro-service; Data Integration; Linked Data; REST; Biodiversity

Online: 14 November 2018 (10:59:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0178.v1

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Melissa Davis, Rachel Martini, Lisa Newman, Olivier Elemento, Jason White, Akanksha Verma, Indrani Datta, Indra Adrianto, Kevin Gardner, Hyung-Gyoon Kim, Windy Dean-Colomb, Isam Eldin Eltoum, Andra R Frost, William E. Grizzle, Andrea Sboner, Upender Manne, Clayton Yates

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; African Ancestry; RNAseq analysis; oncologic pathways

Online: 12 April 2020 (04:22:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0258.v2

Asians Do Not Exhibit Elevated Expression or Unique Genetic Polymorphisms for ACE2, the Cell-Entry Receptor of SARS-CoV-2

Ying Chen, Kejia Shan, Wenfeng Qian

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SARS-CoV-2; cell-entry receptor; ACE2; The Cancer Genome Atlas; susceptibility; demographic factors; polymorphism

Online: 25 February 2020 (06:30:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1709.v1

A Lateral-Flow Device for the Rapid Detection of Scedosporium Species

Genna E. Davies, Christopher R. Thornton

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Scedosporium; scedosporiosis; monoclonal antibody; biomarker; lateral-flow device; enzyme-linked immunosorbent assay

Online: 28 March 2024 (06:56:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0189.v1

Determination of the Binding Epitope of an Anti-mouse CCR9 Monoclonal Antibody (C9Mab-24) using the 1 × alanine and 2 × alanine-substitution Method

Hiyori Kobayashi, Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Mika K. Kaneko, Yukinari Kato

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mouse CCR9, monoclonal antibody, epitope mapping, alanine scanning, enzyme-linked immunosorbent assay

Online: 12 December 2022 (03:54:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0202.v1

Intermixing the OPN1LW and OPN1MW Genes Disrupts the Exonic Splicing Code Causing an Array of Vision Disorders

Maureen Neitz, Jay Neitz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: colorblindness; color vision; myopia; cone photopigment; exon skipping; X-linked cone dysfunction

Online: 8 July 2021 (13:27:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0666.v1

Immunotechniques for the Group Determination of Macrolide Antibiotics Traces in the Environment Using a Volume-Mediated Sensitivity Enhancement Strategy

Maksim A Burkin, Anna N Tevyashova, Elena N Bychkova, Artem O Melekhin, Inna A Galvidis

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: macrolide antibiotics; group recognition; hapten design; enzyme-linked immunosorbent assay; immunobeads assay; immunofiltration

Online: 11 September 2023 (10:40:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0023.v1

Overexpression of the X-linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury

David Reigada, Rodrigo M. Maza, Teresa Muñoz-Galdeano, María Asunción Barreda-Manso, Altea Soto, Dan Lindholm, Rosa Navarro-Ruíz, Manuel Nieto-Díaz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: spinal cord injury; X-linked inhibitor of apoptosis protein; neuroprotection; apoptosis; transgenic mice

Online: 1 December 2022 (09:59:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0268.v1

Novel Approaches to Chemically Cross-Linked Phosphazene Structures: Hydrosilylation vs Piers–Rubinsztajn Reaction

Andrey S. Esin, Anna I. Chernysheva, Mikhail A. Soldatov, Ekaterina A. Karpova, Vyacheslav V. Kireev, Igor S. Sirotin, Mikhail V. Gorlov

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: phosphazenes; cross-linked; hydrosilylation; Piers–Rubinsztajn reaction; eugenol; siloxanes; model compounds; siloxane-phosphazene

Online: 14 January 2021 (13:12:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0213.v1

Clinical Application of the Association Between Genetic Alteration and Intraoperative Fluorescence Activity of 5-Aminolevulinic Acid During the Resection of Brain Metastasis of Lung Adenocarcinoma

Hyeon Yeong Jeong, Won Jun Suh, Kim Seung Hwan, Nam Taek Min, Ji Hwan Jang, Kim Kyu Hong, Seok Hyun Kim, Young Zoon Kim

Subject: Biology And Life Sciences, Life Sciences Keywords: brain metastasis; lung cancer; 5-aminolevulinic acid; genetic alteration; next-generation sequencing; infiltration; cell cycle regulation; proliferation

Online: 5 December 2023 (04:44:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1563.v1

Ion-cross-linked Hybrid Photochromic Hydrogels with Enhanced Mechanical Properties and Shape Memory Behaviour

Shijun Long, Fan Chen, Han Ren, Yali Hu, Yiwang Huang, Chao Chen, Xuefeng Li

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: photochromic hydrogels; ion-cross-linked hybrid hydrogels; double network; high mechanical strength; shape memory

Online: 27 February 2024 (17:57:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0226.v4

Laboratory Techniques for Hepatic Diseases Diagnosis

Antonella Elisa Chesca, Aigul Medetova, Galiya Abdulina, Berik Kouchebekov, Saule Ahmetova, Tim Sandle

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatitis C virus (HCV); liver; blood; electrochemiluminescence (ECL); ELISA method (Enzyme-Linked Immunosorbent Assay)

Online: 19 October 2023 (10:53:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0064.v1

Microcystins and Daily Sunlight: Predictors of Chronic Liver Disease and Cirrhosis Mortality

Rajesh Melaram

Subject: Environmental And Earth Sciences, Environmental Science Keywords: microcystins; climatic factors; chronic liver disease and cirrhosis; daily sunlight; enzyme-linked immunosorbent assay

Online: 3 July 2019 (11:46:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0422.v1

Polyamine Homeostasis in Snyder-Robinson Syndrome

Tracy Murray Stewart, Matthew Dunworth, Jackson R. Foley, Charles E. Schwartz, Robert A. Casero, Jr.

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: snyder-robinson syndrome; spermine synthase; X-linked intellectual disability; polyamine transport; spermidine; spermine; transglutaminase

Online: 19 November 2018 (06:49:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0870.v1

Prognostic Value of Genotype-Phenotype Correlations in X-linked Myotubular Myopathy and Use of the Face2Gene Application as an Effective Non-Invasive Diagnostic Tool

Katarína Kušíková, Andrea Soltysova, Andrej Ficek, René G. Feichtinger, Johannes A. Mayr, Martina Škopková, Daniela Gašperíková, Miriam Kolnikova, Karoline Ornig, Ognian Kalev, Serge Weis, Denisa Weis

Subject: Medicine And Pharmacology, Other Keywords: MTM1 gene; myotubularin; X-linked myotubular myopathy; centronuclear myopathy; genotypephenotype correlations; DeepGestalt technology; Face2Gene application

Online: 14 November 2023 (09:29:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0027.v1

The Plant Specific Insert as an Unconventional Signal in the Route to Plant Vacuoles

Vanessa Vieira, Bruno Peixoto, Mónica Costa, Susana Pereira, José Pissarra, Cláudia Pereira

Subject: Biology And Life Sciences, Plant Sciences Keywords: plant specific insert; aspartic proteinase; vacuolar sorting; unconventional trafficking; endoplasmic reticulum; Golgi, N-linked glycosylation

Online: 2 August 2019 (10:05:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0467.v1

The Use of Translocator protein 18 kDa (Tspo) as a Biomarker in Various Human Cancers

Nimisha H. Bhoola, Zukile Mbita, Rodney Hull, Zodwa Dlamini

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Tspo; prostate cancer; stomach cancer; colon cancer; liver cancer; lung cancer; kidney cancer; breast cancer; brain cancer

Online: 31 May 2018 (10:59:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2076.v1

Effectiveness of Adjunctive Hyaluronic Acid Application in Surgical Treatment of Gingival Recession Sites: A Systematic Scoping Review

Mattia Manfredini, Mario Beretta, Carlo Maiorana, Marco Tandurella, Federica Euegnia Salina, Pier Paolo Poli

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: gingival recession; linear hyaluronic acid; cross-linked hyaluronic acid; root coverage procedure; surgical treatment of recession

Online: 30 May 2023 (08:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0381.v2

Identification of 22 N-glycosites on Spike Glycoprotein of SARS-CoV-2 and Accessible Surface Glycopeptide Motifs: Implications on Vaccination and Antibody Therapeutics

Dapeng Zhou, Ruibing Qi, Wen Zhang, Xiaoxu Tian, Chao Peng

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS-CoV2; corona virus; glycopeptide; N-linked glycans; mass spectrometry; antibody; cryo-EM structure; crystal structures; epitope prediction

Online: 13 April 2020 (11:09:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1213.v1

The Influence of Microbiome on Urological Malignancies: A Systematic Review

Joao G. Porto, Maria Camila Suarez, Brandon Peña, Archan Khandekar, Ankur Malpani, Bruno Nahar, Sanoj Punnen, Chad R. Ritch, Mark L. Gonzalgo, Dipen J. Parekh, Robert Marcovich, Hemendra N. Shah

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: microbiome; prostate cancer; bladder cancer; kidney cancer; testicular cancer; penile cancer

Online: 18 September 2023 (19:21:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0732.v1

A Real-World, Observational, Prospective Study to Assess the Molecular Epidemiology of Epidermal Growth Factor Receptor (EGFR) Mutations upon Progression on or after First-Line Therapy with a First or Second Generation EGFR Tyrosine Kinase Inhibitor in EGFR Mutation-Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer: The ‘LUNGFUL’ Study

Giannis Mountzios, Anna Koumarianou, Alexandros Bokas, Dimitrios Mavroudis, Epaminondas Samantas, Evangelos Georgios Fergadis, Helena Linardou, Panagiotis Katsaounis, Elias Athanasiadis, Michalis V. Karamouzis, George Pentheroudakis, Sofia Lampaki, Marios Froudarakis, Eleni-Isidora A. Perdikouri, Alvertos Somarakis, Foteini Papageorgiou, Zoe Paparepa, Aristeidis Nikolaou, Konstantinos N. Syrigos

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Epidermal Growth Factor Receptor (EGFR); mutations, EGFR tyrosine kinase inhibitor; molecular epidemiology; Non-small-cell lung cancer

Online: 28 April 2021 (07:55:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0196.v1

Anti-Islet Autoantibodies in Type 1 Diabetes

Eiji Kawasaki

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Enzyme-linked immunosorbent assay; Epitope, Glutamic acid decarboxylase; Latent-autoimmune diabetes in adults; Prediction; Type 1 diabetes

Online: 4 May 2023 (05:18:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0430.v1

In BRCA1 and BRCA2 Breast Cancers, Chromosome Breaks Occur near Herpes Tumor Virus Sequences

Bernard Friedenson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Breast cancer infection; breast cancer immunity; breast cancer virus; nasopharyngeal cancer; EBV cancer; hereditary breast cancer; BRCA1; BRCA2

Online: 20 July 2021 (09:29:06 CEST)

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Inherited mutations in BRCA1 and BRCA2 genes increase risks for breast, ovarian, and other cancers. Both genes encode proteins for accurately repairing chromosome breaks. If mutations inactivate this function, broken chromosomes may not be restored correctly, allowing breaks to persist or rearrange chromosomes. These abnormalities are potentially catastrophic events that can originate from viral infections. I used bioinformatic analyses of publicly available breast cancer patient data to show that the distribution of chromosome breaks in hereditary breast cancers differs markedly from sporadic breast cancers. Then I tested hereditary breast cancer sequence data around chromosome breaks for DNA similarity to all known viruses. Human DNA flanking breakpoints usually had decisive matches to Epstein-Barr virus (EBV / HHV4) tumor variants HKHD40 and HKNPC60. Many breakpoints were near EBV genome anchor sites, human EBV tumor-like sequences, EBV-associated epigenetic marks, and some fragile sites. On chromosomes 2 and 12, sequences near EBV genome anchor sites accounted for 90% and 88% of breakpoints (p<0.0001), respectively. On chromosome 4, 51/52 inter-chromosomal breakpoints were close to EBV-like sequences in 19 hereditary breast cancers. In contrast, 19 sporadic breast cancers only had 12 interchromosomal breakpoint regions on chromosome 4 near EBV-like sequences. On various other chromosomes, five EBV genome anchor sites were near hereditary breast cancer breakpoints at precisely defined, disparate gene or LINE locations. Independent evidence further implicating EBV in hereditary breast cancer breakpoints is that 25 breast cancer break positions are within 1.25% of breakpoints in model EBV cancers. In addition to BRCA1 or BRCA2 mutations, all the hereditary breast cancers had mutated genes essential for immune responses. This compromise facilitates reactivation of herpes viruses which produce nucleases capable of breaking chromosomes. EBV also causes other deleterious effects: anchored EBV episomes can interfere with normal replication and obstruct DNA break repairs; even very early infection causes massive transcription changes. The results, therefore, imply proactive treatment and prevention of herpes viral infections may prevent some chromosome breaks and benefit BRCA mutation carriers.

Preprint REVIEW | doi:10.20944/preprints201709.0069.v1

Glyoxalases in Urological Malignancies

Cinzia Antognelli, Vincenzo Nicola Talesa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Glyoxalases; urological malignancies; prostate cancer; kidney cancer; bladder cancer testicular cancer

Online: 15 September 2017 (14:28:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1775.v1

The Multidisciplinary Approach and Surgical Management of GE Junction Adenocarcinoma

Meher Oberoi, MD Sibat Noor, Eihab Abdelfatah

Subject: Medicine And Pharmacology, Surgery Keywords: GE junction cancer; Esophagogastric cancer; Gastroesophageal cancer; Esophageal cancer; Gastric cancer; Esophagectomy; Gastrectomy; Proximal gastrectomy

Online: 29 November 2023 (04:58:57 CET)

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Working Paper REVIEW

Micronutrients and Breast Cancer Progression: A systematic Review

Olga Cuenca, Carmen Aceves

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: breast cancer; micronutrients; cancer

Online: 2 November 2020 (13:50:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0470.v1

Temporal Dissection of Altered Pathways during the Evolution of Cancer

Johanne Ahrenfeldt, Ditte S. Christensen, Mateo Sokač, Judit Kisistók, Nicholas McGranahan, Nicolai J. Birkbak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: metastasis; cancer evolution; bioinformatics; cancer biology; cancer genomics

Online: 31 October 2022 (07:06:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0205.v1

Cancer Vaccines for Genitourinary Tumors: Recent Progresses and Future Possibilities

Brigida Anna Maiorano, Giovanni Schinzari, Davide Ciardiello, Maria Grazia Rodriquenz, Antonio Cisternino, Giampaolo Tortora, Evaristo Maiello

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: prostate cancer, renal cancer, urothelial cancer, vaccines, immunotherapy

Online: 10 May 2021 (14:54:43 CEST)

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Working Paper HYPOTHESIS

Cancer Prevention and Treatment with Immune System Boosting Interventions

Mohan Doss

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cancer; Cancer Prevention; Cancer Therapy; Immune Boosting Interventions

Online: 30 April 2021 (15:52:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1223.v1

Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers

Guzel Rafikova, Irina Gilyazova, Kadriia Enikeeva, Valentin Pavlov, Julia G. Kzhyshkowska

Subject: Biology And Life Sciences, Life Sciences Keywords: cancer genetics; cancer epigenetic; tumor microenvironment; monocytes; TAMs; prostate cancer; cancer biomarkers

Online: 16 June 2023 (10:42:15 CEST)

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Epidemiological data highlight prostate cancer as a significant global health issue, with high incidence and substantial impact on patients' quality of life. The prevalence of this disease is associated with various factors, including age, heredity, and race. Recent research in prostate cancer genetics has identified several genetic variants that may be associated with an increased risk of developing the disease. However, despite the significance of these findings, genetic markers for prostate cancer are not currently utilized in clinical practice as reliable indicators of the disease. In addition to genetics, epigenetic alterations also play a crucial role in prostate cancer development. Aberrant DNA methylation, changes in chromatin structure, and microRNA (miRNA) expression are major epigenetic events that influence oncogenesis. Existing markers for prostate cancer, such as prostate-specific antigen (PSA), have limitations in terms of sensitivity and specificity. The cost of testing, follow-up procedures, and treatment for false-positive results and overdiagnosis contributes to the overall healthcare expenditure. Improving the effectiveness of prostate cancer diagnosis and prognosis requires either narrowing the risk group by identifying new genetic factors or enhancing the sensitivity and specificity of existing markers. Immunological biomarkers (both circulating and intra-tumoral), including markers of immune response and immune dysfunction, represent a potentially useful area of research for enhancing the diagnosis and prognosis of prostate cancer. Our review emphasizes the need for developing novel immunological biomarkers to improve the diagnosis, prognosis, and management of prostate cancer. We highlight the most recent achievements in the identification of biomarkers provided by circulating monocytes and tumor-associated macrophages (TAMs). We highlight that monocytes-derived and TAMs-derived biomarkers can enable to establish the missing links between genetic predisposition, hormonal metabolism and immune responses in prostate cancer.

Preprint REVIEW | doi:10.20944/preprints202203.0107.v1

The Potential Implementation of Biosensors for the Diagnosis of Biomarkers of Various Cancer

Sameer Quazi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Nanobiotechnology; Biomarkers; Biosensors; Lung cancer; Skin Cancer; Colorectal Cancer

Online: 7 March 2022 (15:03:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0029.v1

Gambogic Acid as Anticancer Agent: A Review

Syed Amir Gilani, Muhammad Imran, Iahtisham-ul Haq, Riffat Mehboob, Wafa Fatima, Amber Hassan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Gambogic acid; phytochemical; breast cancer; pancreatic cancer; glioma cancer

Online: 3 July 2020 (09:05:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0044.v1

Alcohol-containing Mouthwashes and Oral Cancer: A Mechanistic Explanation

José Manuel Calderón-Montaño, Julio José Jiménez-Alonso, Emilio Guillén-Mancina, Estefanía Burgos-Morón, Miguel Lopez-Lazaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer prevention; carcinogenesis; oral cancer; pharynx cancer; mouthrinses; ethanol.

Online: 6 March 2018 (14:28:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0047.v1

The Human Sustainability of ICT and Management Changes: Evidence for the French Public and Private Sectors

Maëlezig Bigi, Nathalie Greenan, Sylvie Hamon-Cholet, Joseph Lanfranchi

Subject: Business, Economics And Management, Economics Keywords: organizational changes; ICT; management tools; work experience; employee outcomes; comparison of public and private sectors; linked employer-employee survey

Online: 6 March 2018 (16:30:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0399.v1

Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer

Emilio Guillén-Mancina, Julio José Jiménez-Alonso, José Manuel Calderón-Montaño, Víctor Jiménez-González, Patricia Díaz-Ortega, Estefanía Burgos-Morón, Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Amino acids, lipids, diet, low-fat diet, cancer therapy, cancer metabolism, triple-negative breast cancer, lung cancer, melanoma, colorectal cancer, ovarian cancer, metastasis

Online: 21 December 2022 (10:05:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0676.v1

Microbiome Dysbiosis Associates to Castration Resistance and Cancer Stemness in Metastatic Prostate Cancer

Matthew Uzelac, Ruomin Xin, Weg M. Ongkeko

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: prostate cancer; castration-resistant prostate cancer; microbiome; cancer stem cells

Online: 12 February 2024 (10:44:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0711.v1

Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression

Juan Carlos Quintero, Néstor Fabián Díaz, Mauricio Rodríguez-Dorantes, Ignacio Camacho-Arroyo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cancer Stem Cell; Androgen Receptor; Prostate Cancer; Breast Cancer; Glioblastoma

Online: 12 September 2023 (03:15:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0369.v1

Cancer Screening and Treatment Delays During the COVID-19 Pandemic and the Role of Health Literacy in Care Re-Engagement: Findings from an NCI-Designated Comprehensive Cancer Center Sample

Jessica Keim-Malpass, Rick D. Vavolizza, Wendy F. Cohn, Erin M. Kennedy, Shayna L. Showalter

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Covid-19; health literacy; cancer screening; cancer care; cancer prevention

Online: 25 October 2022 (02:02:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0176.v2

Differences and Similarities in Breast and Colorectal Cancer Screening Uptake among Municipalities in Flanders, Belgium

Allegra Ferrari, Ngan Thuy Tran, Sarah Hoeck, Marc Peeters, Mathieu Goossens, Guido Van Hal

Subject: Social Sciences, Behavior Sciences Keywords: colorectal cancer screening; breast cancer screening; BC; CRC; cancer prevention; cancer screen-ing; FOBT; mammography; Flanders

Online: 20 May 2022 (12:03:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0590.v1

Estimates of Cancer Mortality Attributable to Carcinogenic Infections in Italy

Pietro Ferrara, Sara Conti, Fernando Agüero, Luciana Albano, Cristina Masuet-Aumatell, Josep Maria Ramon-Torrell, Lorenzo Giovanni Mantovani

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: burden of cancer mortality; cancer epidemiology; cancer etiology; cancer prevention; carcinogenic infections; modifiable risk factors

Online: 28 October 2020 (12:13:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0490.v1

In BRCA1 and BRCA2 Breast Cancers, Chromosome Breaks Occur Near Herpes Tumor Virus Sequences

Bernard Friedenson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Breast cancer infection; breast cancer immunity; breast cancer virus; genome biochemistry; nasopharyngeal cancer; herpes viruses; hereditary breast cancer; BRCA1; BRCA2; Burkitt's lymphoma; homologous recombination; DNA repair; viral cancer; chromosome breaks; Breast cancer infection; breast cancer immunity; breast cancer virus; nasopharyngeal cancer; hereditary breast cancer; BRCA1; BRCA2; Burkitt's lymphoma

Online: 20 May 2021 (12:43:11 CEST)

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Inherited mutations in BRCA1 and BRCA2 genes increase risks for breast, ovarian, and other cancers. Both genes encode proteins for accurately repairing chromosome breaks. If mutations inactivate this function, chromosome fragments may not be restored correctly. Resulting chromosome rearrangements can become critical breast cancer drivers. Because I had data from thousands of cancer structural alterations that matched viral infections, I wondered whether infections contribute to chromosome breaks and rearrangements in hereditary breast cancers. There are currently no interventions to prevent chromosome breaks because they are thought to be unavoidable. However, if chromosome breaks come from infections, they can be treated or prevented. I used bioinformatic analyses to test publicly available breast cancer sequence data around chromosome breaks for DNA similarity to all known viruses. Human DNA flanking breakpoints usually had the strongest matches to Epstein-Barr virus (EBV) tumor variants HKHD40 and HKNPC60. Many breakpoints were near sites that anchor EBV genomes, human EBV tumor-like sequences, EBV-associated epigenetic marks, and fragile sites. On chromosome 2, sequences near EBV genome anchor sites accounted for 90% of breakpoints (p<0.0001). On chromosome 4, 51/52 inter-chromosomal breakpoints were close to EBV-like sequences. Five EBV genome anchor sites were near breast cancer breakpoints at precisely defined, disparate gene or LINE locations. Breakpoint flanking regions resembled known EBV-cancers. Twenty-five breakpoints in breast cancers were within 1.25% of EBV cancer breakpoints. In addition to BRCA1 or BRCA2 mutations, all the breast cancers had mutated genes essential for immune responses. Because of this immune compromise, herpes viruses can activate and produce nucleases that break chromosomes. Alternatively, anchored viral episomes can obstruct break repairs, whatever the cause. The results, therefore, imply proactive treatment and prevention of herpes viral infections may prevent some chromosome breaks and benefit BRCA mutation carriers.

Preprint ARTICLE | doi:10.20944/preprints202402.0600.v1

Synthesis of α,ω-Bis-mercaptoacyl poly(alkyl oxide)s and Development of Thioether Cross-Linked Liposome Scaffolds for Sustained Release of Drugs

Spyridon Mourtas, Georgios Kourmoulakis, Stavros Kremezis, Pavlos Klepetsanis, Sophia G. Antimisiaris

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: S-4-methoxytityl mercapto acids; α ,ω -homofunctional mercaptoacyl poly(alkyl oxide)s; thia-Michael addition; thioether cross-linked liposomes

Online: 9 February 2024 (16:14:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0498.v1

SARS-CoV-2 Virus-Like Particles (VLPs) specifically detect humoral immune reactions in an ELISA based platform

Stefan Hirschberg, Hannes Bauer, Julian Kamhieh-Milz, Frauke Ringel, Christoph Harms, Omar Kamal Eddin, Axel Pruß, Katja Hanack, Kai Schulze-Forster

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Virus-Like Particle (VLP); SARS-CoV-2; in vitro diagnostic device (IVD); Enzyme-linked Immunosorbent Assay (ELISA); Immune reaction; Antibodies

Online: 28 November 2022 (07:06:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1989.v1

Cancer Treatments: Past, Present, and Future

Dmitriy Sonkin, Anish Thomas, Beverly Teicher

Subject: Biology And Life Sciences, Life Sciences Keywords: cancer; cancer treatment; cancer treatments history; cancer therapy; oncology; immunology; chemotherapy; radiation therapy; ADC; CART; BiTE; targeted therapy; cancer genetics

Online: 30 January 2024 (03:28:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0088.v1

Manipulation of Amino Acid Levels With Artificial Diets Induces Anticancer Activity in Mice With Renal Cell Carcinoma

José Manuel Calderón-Montaño, Emilio Guillén-Mancina, Julio José Jiménez-Alonso, Víctor Jiménez-González, Estefania Burgos-Morón, Alfonso Mate, María Concepción Pérez-Guerrero, Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Amino acids; cancer; cancer metabolism; cancer therapy; kidney cancer; renal adenocarcinoma; renal cancer; metastasis; selective amino acid restriction therapy; restriction

Online: 3 August 2022 (11:16:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1255.v1

Survivin as a Therapeutic Target for the Treatment of Human Cancer

Qiang Wang, Mark I. Greene

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: survivin; cancer; mitosis; apoptosis; Cancer therapy

Online: 21 March 2024 (10:43:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1410.v1

Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation

Weiyuan Wang, Melanie Cristina Lopez McDonald, Rajashree Hariprasad, Tiara Hamilton, David A. Frank

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: STAT3; STAT5; cancer, immunity, cancer therapy

Online: 26 February 2024 (09:40:00 CET)

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Preprint EDITORIAL | doi:10.20944/preprints201608.0130.v1

What Is the Main Cause of Cancer?

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: carcinogenesis; cancer; age distribution of cancer

Online: 11 August 2016 (11:40:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1449.v1

COVID-19–Sensitive Tumour Response – 2-Year Assessment of the SARS-CoV-2 Humoral Response in Cancer Patients in Oncology Hospital in Poland

Piotr Kosiorek, Bożena Mikołuć, Samuel Stróż, Anna Hryniewicz, Dorota Elżbieta Kazberuk, Robert Milewski, Anna Grzeszczuk, Magdalena Joanna Borkowska, Anna Stasiak-Barmuta

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: breast cancer; lung cancer; colon cancer; SARS-CoV-2; COVID-19

Online: 19 January 2024 (04:45:55 CET)

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Background: So far, vaccination has been considered the most crucial defense against viral infection, including SARS-CoV-2. Numerous reports have demonstrated the effectiveness of the above vaccines in oncology patients. It has also been proven that, apart from vaccinations and oncological therapy, the course of the cancer process itself influences the magnitude of the humoral response, especially in people after infection with SARS-CoV-2. Objective: This study aimed to answer the question about the impact of the cancer process on the humoral response in oncological patients vaccinated against SARS-CoV-2 infection and in patients after COVID-19. Material and methods: 1,668 people were observed. Over two years, 5,082 SARS-CoV-2 IgG and IgM antibody samples were determined. The concentration of antibodies was assessed in three groups of oncological patients: those undergoing anticancer therapy after contracting COVID-19 and those after vaccination against the SARS-CoV-2 infection. Results: The obtained results indicate a naturally more significant humoral response in oncological patients who have not been vaccinated and have not undergone anticancer therapy, such as radiotherapy, chemotherapy, or surgical intervention. The above observation applies to patients with breast, lung, and colon cancer, although the response varies significantly depending on the type of cancer. Summary: The size of the humoral response and the presence of specific antibodies directed against the SARS-CoV-2, IgM, and IgG, in response to the supply of the vaccine antigen or assessed after COVID-19, is an indicator of adequate immune protection against reinfection. This study highlights for the first time the phenomenon of increased humoral response in response to a viral infection in patients with certain types of cancer that are assumed to be sensitive to oncological therapy, the initiation of which, according to generally accepted principles, was blocked by infection with the SARS-CoV-2. The phenomenon we observe seems to confirm the presence of a "natural" defence potential in a cancer patient's body, in this case, directed against infection with a viral pathogen. A "stronger" antiviral response also seems to explain the asymptomatic course of SARS-CoV-2 infection in some of the above patients. It remains an open question to what extent the SARS-CoV-2 infection weakened the "natural" potential of the anticancer response in these patients.

Preprint ARTICLE | doi:10.20944/preprints202105.0142.v1

The Advance Cancer Immunotherapy Techniques and the Future Perspective of Modified T Cell Therapy

Md. Al Saber, Partha Biswas, Dipta Dey, Md. Abu Kaium, Md. Aminul Islam, Miss Ismoth Ara Tripty, MD. Hasanur Rahman, Tanjim Ishraq Rahaman, Md. Yeaman Biswas, Priyanka Paul, Md. Ataur Rahman, Md. Nazmul Hasan, Bonglee Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cancer Immunotherapy; Cancer Vaccine; Cancer Antigens; CRISPR-Cas9; Engineered T Cells.

Online: 7 May 2021 (11:10:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0163.v1

STAT3 and Its Pathways Dysregulation – Underestimated Role in Urological Tumors

Maciej Golus, Piotr Bugajski, Joanna Chorbińska, Wojciech Krajewski, Artur Lemiński, Jolanta Saczko, Julita Kulbacka, Tomasz Szydełko, Bartosz Małkiewicz

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: STAT3; prostate cancer; bladder cancer; upper tract urothelial carcinoma; renal cell carcinoma; penile cancer; testicular cancer

Online: 8 August 2022 (15:09:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0052.v1

New Targeted Therapies and Combinations of Treatments for Cervical, Endometrial and Ovarian Cancers: A Year in Review

Adelina Silvana Dragomir, Elena Adriana Dumitrescu, Isabela Anda Komporaly, Raluca Ioana Mihăilă, Cristian Virgil Lungulescu, Dana Lucia Stănculeanu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cervical cancer; endometrial cancer; ovarian cancer; 2021 update; novel targeted therapies; immunotherapy

Online: 3 February 2022 (13:02:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0052.v1

Heterogeneity Aspects of Breast for Breast Cancer Patients Change due to COVID-19

Shawni Dutta, Samir Kumar Bandyopadhyay

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19; Breast Cancer; Breast Cancer (Suspected); Mammogram Images and Invasive Cancer

Online: 5 July 2020 (07:40:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0331.v1

A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer based upon its Hydrogen Ion Dynamics

Salvador Harguindey, Khalid Alfarouk, Julián Polo Orozco, Kevin Hardonniere, Daniel Stanciu, Stefano Fais, Jesús Devesa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pH and breast cancer; breast cancer etiology; breast cancer etiopathogenesis; breast cancer treatment; pH-centric anticancer paradigm; hydrogen ion dynamics of cancer; cancer proton reversal; MDR integral approach

Online: 27 November 2019 (04:57:00 CET)

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Preprint REVIEW | doi:10.20944/preprints201707.0074.v1

The Stem Cell Division Theory of Cancer

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer etiology; carcinogenesis; cancer prevention; stem cells; cancer stem cells; stem cell environment; cells of origin in cancer; somatic mutation theory of cancer

Online: 26 July 2017 (08:42:41 CEST)

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All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and this cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the disease and has important implications for cancer prevention and therapy.

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