Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Relevance between Iodine Nutritional Status and BRAFV600E Mutation on Papillary Thyroid Cancer

Version 1 : Received: 21 October 2021 / Approved: 25 October 2021 / Online: 25 October 2021 (10:57:18 CEST)

How to cite: Lin, Y.; Hsieh, Y. The Relevance between Iodine Nutritional Status and BRAFV600E Mutation on Papillary Thyroid Cancer. Preprints 2021, 2021100343 (doi: 10.20944/preprints202110.0343.v1). Lin, Y.; Hsieh, Y. The Relevance between Iodine Nutritional Status and BRAFV600E Mutation on Papillary Thyroid Cancer. Preprints 2021, 2021100343 (doi: 10.20944/preprints202110.0343.v1).

Abstract

Papillary thyroid carcinoma (PTC) accounts for approximately 85%-90% of all thyroid cancers. BRAFV600E mutation is a highly specific target for papillary thyroid carcinoma (PTC) and may have a reciprocal causative relationship with iodide-metabolizing genes. Here, we performed a review of studies published in the past 10 years to determine the relationship between iodine intake and BRAFV600E mutation in patients with PTC. We searched the MEDLINE, PubMed, and EMBASE databases for studies published from 2009 to 2019; seven partially matched the selection criteria and were suitable for review, and five passed all selection criteria. We divided the patients into three groups by iodine intake: low (urinary iodine concentration [UIC] <100 μg/L), adequate (UIC 100–200 μg/L), and high iodine intake groups (UIC ≥200 μg/L). Between-group analysis revealed no significant differences in the odds ratio of the prevalence of BRAFV600E mutation between the high and adequate/low iodine intake groups and between the adequate and low iodine intake groups. To further analyzed the results of studies, they exhibited U-shaped curves in the relation of deficient and excessive dietary iodine intake in BRAFV600E mutation. The results might suggest that iodine intake slightly influences the prevalence of BRAFV600E mutation in patients with PTC despite the heterogeneity of studies. Further research should explore potential mechanisms underlying the associations between iodine intake and BRAF mutation in PTC. The systematic review was registered in PROSPERO (CRD42021279462).

Keywords

iodine nutritional status; BRAFV600E; papillary thyroid cancer

Subject

MEDICINE & PHARMACOLOGY, Nutrition

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